In the instructions for the use of the drug “Kapoten”, the manufacturer indicates that the product is among those capable of lowering blood pressure. The active substance is competitive, inhibits ACE, is characterized by increased specificity. The main mechanism of action is to prevent the reaction of the transformation of the first angiotensin into the second, which can narrow blood vessels.
Dynamics
The manufacturer in the instructions for use for the drug "Kapoten" explains that the tool can reduce pre-, afterload, reduces the resistance in the vessels of the respiratory system. Against the background of the use of the composition, the cardiac output becomes longer, the person's ability to tolerate physical activity increases.
Prolonged use of the drug reduces the excess volume of the left ventricular myocardium. The use of tablets amid insufficient functioning of the heart makes it possible to slow down the progress of the condition. Through the active components of the Kapoten preparation, the rate of progression of dilatation of the cardiac ventricle on the left decreases.
Kinetics
As the manufacturer explains in the instructions for the use of “Kapoten”, at high pressure the medication shows a pronounced and quick effect, since the active substance is absorbed quite quickly. The quality of the process is estimated at an average of 75%. Absorption occurs in the digestive tract. The maximum concentration in the blood serum is achievable within an hour after taking the tablets. The suction process is somewhat slower if you use Kapoten during a meal - the speed changes by a third, sometimes a little more.
In the instructions for use for Kapoten tablets, it is mentioned that on average, a quarter of the volume of active substance that enters the body enters into stable bonds with serum proteins. The elimination half-life is estimated at three hours, but can become longer if the kidneys are not working efficiently. Up to 95% of all medication received in the body is eliminated by the kidneys. Almost half leaves the patient's body in its original form, and the rest in the form of products of transformation reactions.
What's on sale?
According to the instructions for the use of Kapoten, the drug is very effective at high pressure. In pharmacies, it is presented in tablet form. This means that it is convenient to take, no special assistance is required. Tablets can be used by people whose injections, syringes, needles cause fear or other reactions of mental rejection. The use of tablets is rarely necessary, so it is easy to adhere to a stable schedule.
In the instructions for use for Kapoten tablets, the manufacturer notes that the main substance that ensures the effectiveness of the drug is captopril. In one tablet, it is present in an amount of 25 mg.
Application Nuances
As follows from the instructions for use, “Kapoten” for pressure should be taken carefully, given the possible treatment by other means. The annotation says that the effectiveness of the drug can increase if the patient simultaneously uses adrenergic blockers. The effect of “Kapoten” may become more significant when taking diuretics and vasodilators. A similar effect is shown by a combination with ganglion blockers.
The manufacturer draws attention to the fact that a decrease in effectiveness is possible when combined with non-steroidal anti-inflammatory drugs. The abstract contains information about the possibility of reducing the effect of the drug when combined with drugs containing clonidine.
Too much!
Studies have shown that an overdose of Kapoten is possible. The main symptom is a persistent decrease in pressure above normal. To alleviate the condition of the patient, it is urgent to do a blood dialysis and use drugs to replace the plasma.
Strongly impossible!
In the instructions for use of the Kapoten medication, the manufacturer draws attention to the impossibility of using the tablets by persons suffering from hypersensitivity, immunity of any substance present in the medication. You can not use "Kapoten" with increased sensitivity to ACE inhibitors, including those identified in the past. It is unacceptable to use the drug for angioedema due to a genetic factor or observed during the treatment of ACE inhibitors in the past.
As follows from the instructions for use "Kapoten" at high pressure is prohibited if the patient has revealed liver and kidney dysfunction. You can not take the drug if the potassium content is increased in the circulatory system.
"Kapoten" is dangerous with bilateral stenosis of the arteries that feed the kidneys, with stenosis of a single artery, if the kidney is only one. The tool is not used if azotemia is prone to development.
"Kapoten" is prohibited after a kidney transplant. The instructions for use of Kapoten (25 mg - the dosage of the active substance in one tablet) indicate that the drug is not used in the presence of obstructions, due to which the outflow of blood is difficult. One example of this condition is aortic stenosis.
Kapoten is not intended to treat women during the period of bearing a child and breastfeeding.
Important Nuances
The manufacturer does not indicate in the instructions for use "Kapoten" at what pressure it is necessary to use the medication. The tool is intended to adjust high blood pressure, but the fact of its appointment remains strictly at the discretion of the doctor. The doctor will explain at what indicators in a particular case an adjustment is needed - the pressure parameters normal for a person vary quite a lot. This explains why it is unacceptable to use Kapoten at its discretion.
“Kapoten” can be used if the patient has collagenosis, but the use is possible only under the supervision of a doctor and with a regular check of vital signs. Consider that drug therapy can be accompanied by undesirable side effects, including quite severe ones.
In the instructions for use of “Kapoten” 25 mg, the manufacturer mentions that in rare cases the remedy can be used if the ratio between key electrolytes is violated in the patient’s circulatory system. In the presence of such a condition, tablets are used only after taking primary measures to correct failures. The use of "Kapoten" is undesirable to combine with the use of diuretics, leading to the accumulation of potassium. "Kapoten" is not combined with potassium-based products. Particularly high risks of side effects with such a combination of drugs in people suffering from significant impaired renal function.
The subtleties of therapy
As already mentioned, the manufacturer does not indicate in the instructions for use "Kapoten" at what pressure the drug can be used, however, it is noted here that the drug is intended for the treatment of hypertension. It is mentioned that the active substance has a pronounced effect on pressure, but can provoke angioedema. Such reactions are possible when using various ACE inhibitors, captopril is no exception. Edema can cover the larynx, mucous membranes, pharynx, face. If the face, lips swell, the patient’s condition returns to normal on their own when they stop taking the pills.
To slightly alleviate the patient's condition with angioedema, antihistamines are allowed to be used against the background of using the described agent. In the instructions for the use of Kapoten, the manufacturer focuses on the need for medical monitoring of the patient's condition until the symptoms disappear completely.
If the swelling extends to the pharynx, covers the tongue, larynx, if there is a possibility of obstruction of the pathways of the air in the lungs, it is necessary to inject adrenaline subcutaneously.
According to the instructions, the use of Kapoten should be combined with a diet that involves minimizing the intake of sodium in the body.
If acetone is detected in urine, “Kapoten” can provoke false positive results.
Pediatrics
The manufacturer does not indicate in the instructions for use "Kapoten" at which pressure the drug is allowed to be given to children. The manufacturer clarifies that the tool has not been tested in pediatric practice, there is no official information about its safety for children, its effectiveness at any pressure.
In order to avoid possible risks and harm the patient, you should abandon the use of Kapoten for the treatment of children, choose a safer and more reliable alternative, the effectiveness of which has been proven by clinical trials.
When will it help?
Although the manufacturer does not specifically indicate in the instructions for use at what pressure “Kapoten” will help, it is mentioned here that the drug is intended for the treatment of arterial hypertension. The drug can be used both as an independent tool, and as an element of a combined course. Most often they combine Kapoten and diuretics from the thiazide class.
In the instructions for use, "Kapoten" is allowed for chronic heart failure. With this diagnosis, tablets are used as one of the elements of complex therapy.
If myocardial infarction is detected, Kapoten can be used to normalize the function of the left ventricular heart, thereby partially compensating for the consequences of the heart attack. Tablets are used after clinical stabilization of the patient's condition.
The medication is effective for nephropathy against diabetes mellitus. Instructions for use "Kapoten" is recommended for microalbuminuria per day from 30 mg and above. Tablets are used only in the presence of insulin-dependent diabetes.
Are there any analogues?
Instructions for use "Kapoten" states that the main component of the drug is captopril. Captopril tablets of the same name are based on it. If it is necessary to choose a Kapoten replacement, it is most often recommended to dwell on them. The drug “Captopril” is cheaper than “Kapoten”, the difference is relatively significant: the drug in question is sold at a price of 120 rubles per package, while “Captopril” can be found at a price of only 7 rubles.
The specific prices depend on the manufacturer, dosage, number of tablets in one pack, on the pricing policy of the point of sale.
Possible analogues of Kapoten are also drugs:
- "Angiopril."
- Epsitron.
- "Alkadil."
Is it worth buying?
Usually responsible patients, before starting to use the composition prescribed by the doctor, carefully study the list of analogues, reviews, instructions for use. “Kapoten”, as can be seen from the responses of those who used it, is considered a reliable and effective tool. Among the most common side effects, users note a dry cough - this phenomenon often develops against the background of almost all ACE inhibitors.
Efficiency, effectiveness, reliability of pressure adjustment - all this is reported by patients using tablets in their reviews of “Kapoten”. Instructions for use calls for the use of the drug strictly under the supervision of a doctor. From the responses it can be seen that people who used the tablets on their own, without prior consultation with a specialist, were more often faced with the negative consequences of drinking, including quite severe ones. Patients who used Kapoten under the supervision of a physician note its effectiveness and safety.
How to use correctly?
When writing out the drug, at the reception the doctor will explain how to take it and at what pressure. Instructions for use "Kapoten" does not contain precise instructions on this subject - you must fully focus on the recommendations of the doctor. The doctor chooses the dosage of the drug. In the general case, Kapoten is used orally one hour before a meal.
With high blood pressure, it is necessary to use the medicine first in a minimum dosage of 12.5 mg. The drug is taken twice a day, carefully controlling so that between the releases of the substance into the body 12 hours pass. In rare cases, the starting dosage is 6.25 mg twice daily.
Despite the presence of instructions for use in the Kapoten package, people sometimes don’t know how to properly take the product so as not to harm themselves. It is important in this case to listen to the recommendations of the doctor. He will pay attention to the need to control the state of the body after the first dose. It is especially important to monitor the change in condition during the first hour after taking the pill. There is a risk of hypotension. In this case, it is important to immediately take a horizontal position. Such an organism response is considered relatively normal and does not require interruption of the course. If Kapoten is used as the only medicine, you can increase the effectiveness of the program by limiting the intake of sodium ions in the body.
Treatment features
According to the instructions for use, the dosage of Kapoten should be determined by the attending physician. The doctor takes into account various features of a particular case. In particular, if it is necessary to use Kapoten in old age, the starting dose is 6.25 mg twice daily.
With mild and moderate increased pressure, when the diastole varies within the limits of 95-114 units, the maintenance amounts are 12.5 mg twice a day or twice as much.
If Kapoten is used as a course, an increase in volumes is allowed with a frequency of once every 2-4 weeks. The maximum amount of the drug is 50 mg three times a day.
At what pressure does the instructions for use of Kapoten allow the combination of the drug with other agents? As a rule, this applies to especially severe cases when the diastole exceeds 115 units. Kapoten can be used simultaneously with other drugs to lower blood pressure. Most often, the drug is combined with diuretics from the thiazide class. If hydrochlorothiazide is prescribed, for it, the dosage for the day is chosen in the range of 25-50 mg. The amount of diuretic used can be increased once a week or two, until the maximum dose that is permissible under high pressure is reached.
"Kapoten" to normalize the heart
So, you already know when it is necessary to take medicine and at what pressure. "Kapoten" (instructions for use discussed above) will help to stabilize the patient's condition, if the doctor's instructions are followed. You also need to remember about the possibility of using the drug in the treatment of heart failure. As a rule, with this diagnosis, the drug is combined with diuretics. In some cases, “Kapoten” is prescribed in a combined course with digitalis-based products. This helps prevent an overly strong drop in blood pressure in the arteries. As a rule, before the first use of Kapoten tablets, diuretics completely cancel or reduce the dose, and then increase the volume of the diuretic, if necessary.
The starting dose for heart failure is 6.5 mg or twice as much as three times daily. A gradual increase to 25 mg three times every day is allowed. For a day, a maximum of 150 mg of the active substance.
In case of disruption of the functioning of the left ventricle, according to the instructions for use, "Kapoten" under the tongue is indicated after a heart attack, when it was possible to stabilize the patient's condition. As a rule, a medication is prescribed on the fourth day after a heart attack. The initial intake is 6.25 mg per day, gradually increasing the dosage to 25 mg three times daily. The maximum per day is 150 mg of the drug.
Differences and Nuances
If hypertension is developed, over time, you may need to adjust the dose of “Kapoten” to the lower side. The use of 150 mg of the active drug per day after a dosage reduction is possible only after assessing the tolerance of the drug to a specific patient.
If nephropathy is established against diabetes mellitus, Kapoten must be used daily in an amount of 75-150 mg.
If creatinine clearance exceeds 30 ml / min, Kapoten is allowed in the amount of 75-100 mg per day. In case of impaired renal function in a more pronounced form, the initial volume is 12.5 mg per day with the possibility of increasing the dose in the future, if necessary. Correction is carried out as rarely as possible, the smallest volumes of those showing the desired effect are used.
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