Do you know what a disease like glaucoma is? According to experts, the mentioned disease is characterized by periodic or regular increase in pressure (intraocular) with subsequent atrophy of the optic nerve, the development of visual field defects and a decrease in its severity.
Today, there are many drugs that can cure this disease. One of them includes the drug "Dorzopt Plus." Instructions for use, analogues, release form of this tool will be presented below.
The form of the drug, its composition, description and packaging
In what form do Dorzopt Plus medicines be made? The instructions for use claim that this product is in the form of eye drops, which are a colorless, transparent and slightly viscous solution.
The active substances of this drug are dorzolamide hydrochloride and timolol maleate. As auxiliary components, the solution contains hyetillose, citric acid monohydrate, benzalkonium chloride, purified water, sodium hydroxide, mannitol and hydrochloric acid.
Dorzopt Plus drops, the composition of which was presented above, can be purchased in polymer dropper bottles, which are placed in cardboard packs.
Pharmacology
How do Dorzopt Plus Eye Drops work? The instruction claims that it is an anti-glaucoma drug containing two active components, each of which reduces high blood pressure (intraocular). This happens due to a decrease in the secretion of intraocular fluid.
Consider the properties of the active substances of the drug in more detail.
Dorzolamide is a selective carbonic anhydrase inhibitor. This component reduces the secretion of intraocular fluid. According to experts, this action occurs due to a decrease in the formation of bicarbonate ions, which ultimately leads to a slowdown in the transport of sodium and intraocular fluid.
As for timolol, it is a non-selective beta-blocker. Its principle of action has not yet been studied.
After applying the medicine, a decrease in intraocular pressure is observed after 20 minutes and lasts for a day.
Kinetics
Are Dorzopt Plus drops absorbed into the systemic circulation? The instruction reports that the kinetics of the active substances of this medicine can vary significantly.
Dorzolamide penetrates the eye through the cornea. Its systemic absorption is very low. When a substance enters the bloodstream, it quickly penetrates red blood cells.
The connection of dorzolamide with plasma proteins is 33%. Dorzolamide is excreted by the kidneys within 4 months.
Timolol is also absorbed into the systemic circulation. Its concentration in plasma is observed only when applied twice a day.
Indications
In what cases is Dorzopt Plus prescribed? Instructions for use reports that this tool is used with increased intraocular pressure, which is observed with:
- pseudoexfoliation glaucoma;
- open angle glaucoma.
Contraindications
Are there any contraindications for Dorzopt Plus drops? Instructions for use indicate the following prohibitions:
- cardiogenic shock;
- breastfeeding time;
- bronchial asthma;
- severe heart failure;
- severe obstructive chronic pulmonary disease;
- sinus bradycardia;
- pregnancy period;
- AV blockade of the third and second degree;
- dystrophic processes in the cornea;
- severe renal failure;
- minor age;
- hypersensitivity to elements.
When using the drug, special care should be taken for people with liver failure, in old age and with diabetes.
Drops for eyes "Dorzopt Plus": instructions for use
Reviews of the local medicine will be presented later.
The drug in question is instilled into the conjunctival sac , 1 drop twice a day.
If several local ophthalmic agents are used during the treatment of glaucoma, then their instillation is carried out with an interval of 10 minutes.
The duration of treatment with this tool is set by the doctor depending on the patient's condition.
Side effects
Dorzopt Plus eye drops, the instructions for which are enclosed in a cardboard package, can cause unwanted reactions.
Due to the presence of dorzolamide in the drug, the following side effects occur:
- lacrimation, inflammation of the eyelid, peeling and irritation of the eyelid, pinpoint keratitis, iridocyclitis, pharyngeal irritation, transient myopia, which occurs after drug withdrawal;
- dry mouth, angioedema, rash;
- urticaria, bronchospasm, itching;
- nosebleeds, headaches, asthenia, paresthesia, fatigue.
As for such an active substance as timolol, it provokes the manifestation of the following reactions:
- conjunctivitis, blepharitis, paresthesia, keratitis, decreased sensitivity of the cornea, cardiac arrhythmias, changes in the refractive power of the eye, ptosis, diplopia;
- ringing in the ears, headache, dry eye syndrome, memory loss, asthenia, nightmares, fatigue, depression, dizziness, increased signs of myasthenia gravis, insomnia;
- Raynaud's syndrome, visual disturbances, fainting, arrhythmia, cardiac arrest, decreased blood pressure, edema, decreased temperature of the legs and arms;
- bronchospasm, chest pain, cough;
- alopecia, exacerbation of psoriasis, psoriasis-like rash;
- anaphylaxis, urticaria, angioedema, generalized or local rash;
- diarrhea, dry mouth, dyspepsia;
- decreased libido, systemic lupus erythematosus, Peyronie's disease.
Overdose cases
What are the symptoms of an overdose of Dorzopt Plus? Instructions for use report such reactions as dizziness, bronchospasm, headache, bradycardia, shortness of breath and cardiac arrest.
Acidosis, electrolyte imbalance, asthenia, paresthesia, and fatigue may also develop.
In such conditions, maintenance therapy is performed.
Drug interaction
Studies on the interaction of the drug in question with other drugs have not been conducted. Therefore, to combine Dorzopt Plus drops with other agents should only be after consultation with a doctor.
Special recommendations
Before prescribing the drug for the eyes, Dorzopt Plus should provide the patient with adequate control of the state of the heart and vascular system. People with pathologies in this area should be under the constant supervision of specialists.
The medication in question contains a preservative benzalkonium chloride. It can settle on soft contact lenses and have a damaging effect on the tissues of the visual organs. Therefore, people who use eyesight improvers, before using the drops, need to remove them and install them only after 20 minutes after instillation of the drug.
With special care, Dorzopt Plus is prescribed for people with diabetes. This is due to the fact that beta-blockers mask signs of acute hypoglycemia.
Before carrying out a planned surgical operation, it is required to gradually cancel the medicine two days before general anesthesia, since beta-blockers can enhance the effect of muscle relaxants.
Analogues of the drug and its cost
What can replace Dorzopt Plus eye drops? Its analogues are Trusopt and Phloxal. However, the use of these funds should only be prescribed by a specialist.
The cost of the drug in question is quite high. In a pharmacy it can be purchased for 400-450 rubles.
Eye Drop Reviews
Consumer reviews about the tool in question are not very many. The advantages of this medication include high efficiency and effectiveness, as well as accessibility (sold in almost any pharmacy).
It should also be noted that Dorzopt Plus drops also have negative responses from patients. Many of them complain that after applying a local remedy, local or systemic adverse reactions quite often develop. Therefore, experts do not recommend using the drug on their own. To achieve the best therapeutic result, he should be prescribed only by an experienced doctor. Only with the right treatment regimen can side effects be avoided.