What is the medicine "Mesipol"? Instructions for the use of this tool, its contraindications and indications will be discussed in this article. You will also learn about whether this medication has side effects, what will happen in case of an overdose, in what form it goes on sale and what substances it contains.
Forms of the drug and its composition
The drug "Mesipol" goes on sale in two different forms: tablets and a solution for intramuscular injection. The principle of their action is the same. If oral administration is not possible, injections are used.
Mesipolum solution has such an active element as meloxicam. It also includes the following auxiliary components: glycofurol, meglumin, sodium chloride, poloxamer 188, sodium hydroxide, glycine and water for injection.
The solution is yellow or greenish yellow. It is transparent. He also has a characteristic smell. There are 3 ampoules (1.5 ml) in a carton.
By the way, in addition to tablets and solutions for intramuscular injections, pharmaceutical companies began to produce Mesipol suppositories and suspensions, which are intended for oral administration.
Pharmacological characteristics of the drug
The medicine "Mesipol" is a non-steroidal anti-inflammatory drug. The drug is able to have an analgesic and antipyretic effect. The anti-inflammatory effect of this drug is associated with a decrease in the enzymatic activity of cyclooxygenase-2, which is involved in the biosynthesis of prostaglandins in the inflamed area.
To the least extent, the active element meloxicam acts on cyclooxygenase-1, which is directly involved in the synthesis of prostaglandin, which protects the mucous membrane of the digestive tract and affects the regulation of blood flow in the kidneys.
Pharmacokinetics of the drug
The drug "Mesipolum" (injections and tablets) is completely absorbed. The bioavailability of the drug is 100%. After intramuscular injection (about 15 mg of meloxicam), maximum absorption is reached after 65 minutes.
The drug under consideration binds to plasma proteins, including albumin (in 99%). It easily passes through the histohematological barriers, and also penetrates into the synovial fluid. The concentration in it is 50% of the concentration of the drug in plasma.
The active substance of the drug is almost completely metabolized in the liver. In this case, four inactive pharmacological metabolites are formed.
After use, the drug is equally excreted by the intestines and kidneys (in the form of metabolites). The average half-life of the active substance is 20 hours.
Indications for the use of the medication
In what cases is Mesipol prescribed? The instruction for use states that most often NSAIDs are recommended for symptomatic treatment of diseases such as:
- osteoarthrosis;
- rheumatoid arthritis;
- spondylitis ankylosing (or ankylosing spondylitis).
Among other things, the drug "Mesipolum" (injections and tablets) is often prescribed for other degenerative and inflammatory diseases of the joints, which are accompanied by severe pain.
Contraindications to the use of a non-steroidal drug
In what cases can not use the medicine "Mesipol"? Instructions for use contain a huge list of contraindications. These include the following:
- hypersensitivity to the active element of the drug or its auxiliary components;
- incomplete or complete combination of bronchial asthma, intolerance to acetylsalicylic acid, polyposis (relapsing) of the paranasal sinuses and nasal cavity, as well as other NSAIDs, including a history of;
- children's age (up to 16-18 years);
- ulcerative or erosive lesions of the mucosa of the duodenum or stomach;
- period of breastfeeding;
- cerebrovascular bleeding or bleeding of a different origin;
- active bleeding in the intestines or stomach;
- the period of gestation (pregnancy);
- inflammatory bowel diseases (for example, with Crohn's disease or ulcerative colitis);
- progressive kidney disease, including hyperkalemia (confirmed);
- the period after coronary artery bypass grafting;
- renal failure (severe) in people who have not undergone dialysis (CC less than 30 ml / min);
- decompensated heart failure;
- active progression of liver disease or liver failure (severe).
Use with extreme caution!
Now you know in which cases you can use the drug "Mesipol" (tablets, injections), and in which it is contraindicated. However, there are situations when the medication we are considering should be prescribed with extreme caution. Consider a list of such cases:
- advanced age (from 60 years);
- coronary heart disease;
- chronic heart failure;
- cerebrovascular diseases;
- diabetes;
- dyslipidemia or hyperlipidemia;
- peripheral artery disease;
- creatinine clearance less than 60 ml / min;
- smoking;
- a history of ulcerative lesions of the digestive system;
- prolonged use of non-steroidal drugs, as well as their uncontrolled use in large dosages;
- the presence of an infection called Helicobacter pylori;
- regular consumption of alcoholic beverages (even with a low alcohol content);
- simultaneous administration of oral glucocorticosteroids, including the drug "Prednisolone";
- severe somatic abnormalities;
- simultaneous administration of anticoagulants (for example, the drug "Warfarin"), antiplatelet agents (for example, acetylsalicylic acid and the drug "clopidogrel"), as well as inhibitors of (selective) reuptake of serotonin (including drugs "Citmedialopram", "Fluoxetine", "Paroxetine" and Sertraline).
Non-steroidal anti-inflammatory drug "Mesipol": instructions for use
Intramuscular administration of the medication we are considering is indicated only during the first 3 days of treatment. In the future, therapy is continued using oral forms of the drug, that is, tablets.
The recommended dosage of this drug is 7.5 mg or 15 mg once a day. One or another volume of the drug depends on the intensity of the pain syndrome, as well as the severity of the inflammatory process. The medication is administered through deep intramuscular injection.
Can the drug “Mesipol” (injections) be combined with other drugs? The instruction of this medication states that the contents of ampoules should in no case be mixed in the same syringe with other solutions. This is due to the fact that there is a high probability of incompatibility of the active substance meloxicam with other medicinal elements.
It should be especially noted that in patients who have an increased risk of developing adverse reactions, as well as with renal failure (severe) undergoing hemodialysis, the dosage of the non-steroid drug should not be higher than 7.5 mg per day.
It is also necessary to remember that the medicine "Mesipol", the analogues of which we will consider later, in no case should be administered intravenously.
The maximum daily dosage of the active element of meloxicam should be 15 mg. The same amount of medication should be followed with the combined use of tablets, suspension for oral administration, suppositories and intramuscular injections.
Overdose cases
Have there been cases of overdose from the use of the drug "Mesipol"? Injections (reviews about them will be presented at the very end of the article), tablets, suppositories and suspensions can cause a person to feel unwell if they are used uncontrollably and in large volumes.
Overdose symptoms may include the following conditions: nausea, impaired consciousness, epigastric pain, acute renal failure, vomiting, bleeding in the stomach or intestines, liver failure, asystole, and respiratory arrest.
What to do in case of overdose? Experts recommend rinsing the stomach, as well as symptomatic therapy.
By the way, in the course of clinical studies, it was proved that colestyramine promotes accelerated elimination of meloxicam. Hemodialysis in case of an overdose is ineffective, since there is a high bond with blood proteins.
Side effects
Can the drug “Mesipol” (injections) cause side effects? Instructions for use of this non-steroidal drug say that it can cause a large number of negative consequences. Let's consider them in more detail:
- Digestive tract: dyspepsia, diarrhea, nausea, perforation of the gastrointestinal tract, abdominal pain, vomiting, flatulence, constipation, transient increase in transaminase (liver) activity, belching, hyperbilirubinemia, ulcerative or erosive lesions of the digestive system, esophagitis, stomatitis, stenosis, from the digestive tract, colitis, gastritis and hepatitis.
- Skin: urticaria, pruritus, bullous rashes, skin rash, photosensitivity, Stevens-Johnson syndrome, erythema multiforme, epidermal toxic necrolysis.
- Hematopoietic system: anemia, thrombocytopenia, a change in blood count and leukopenia.
- Allergy: angioedema and anaphylactic reactions.
- Nervous system: vertigo, dizziness, confusion, headache, emotional lability, tinnitus, disorientation and drowsiness.
- Respiratory system: bronchospasm.
- Cardiovascular system: flushing of the face, peripheral edema, palpitations and increased blood pressure.
- Organs of vision: blurred or impaired vision, conjunctivitis.
- Urinary system: acute renal failure, hypercreatininemia or increased blood urea, interstitial nephritis, hematuria and albuminuria.
- Local reactions: pain and burning at the site of intramuscular injection.
Interaction with other drugs
- With a single use with other non-steroidal agents and with acetylsalicylic acid, the risk of ulcerative and erosive lesions of the digestive tract, as well as bleeding in them, increases.
- With the simultaneous use of a medication with antihypertensive drugs, there is a likelihood of a decrease in the effectiveness of the latter.
- The concomitant use of the medicine “Mesipol” with lithium preparations promotes the development of cumulation of the latter and an increase in its toxic effect.
- When used simultaneously with Methotrexate, its side effect on the hematopoietic system is enhanced.
- The simultaneous use of the drug "Mesipol" with diuretics causes a risk of renal failure.
- Concomitant use with cyclosporine enhances the nephrotoxic effect of the active substance to meloxicam.
- With simultaneous use with intrauterine contraceptives, the effectiveness of the latter decreases.
- With a single use with anticoagulants and thrombolytic agents, the risk of bleeding increases.
- The simultaneous use of the non-steroidal drug “Mesipol” with colestyramine enhances its excretion through the digestive tract. This occurs as a result of the binding of meloxicam.
- A single dose of a drug with serotonin reuptake inhibitors (selective) significantly increases the risk of bleeding from the digestive tract.
- Myelotoxic drugs increase the manifestation of hematotoxicity of the active substance to meloxicam.
Special instructions for the use of the drug
- The drug "Mesipol" should be prescribed with extreme caution to patients with peptic ulcer of the intestine and stomach, as well as to people who are on anticoagulant therapy.
- During treatment with this medication, it is necessary to monitor the performance of the kidneys, especially in the elderly and patients with chronic heart failure.
- Patients taking diuretics and Mesipol at the same time should drink plenty of fluids.
- If the patient has an allergy during therapy, then the medication should be discontinued.
Analogs and price of the drug
How much is the drug we are considering? In the pharmacy, the injection form of the drug can be purchased for 400 Russian rubles. As for tablets, suspensions and suppositories, their price is slightly lower.
What to do if you were not able to purchase the drug "Mesipol"? Analogues of this tool are sold in almost all pharmacies. Among them are the following drugs: Amelotex, Exen-Sanovel, Arthrosan, Mataren, M-Kam, Liberum, Medsikam, Melbek, Melox, Bi- xikam ”,“ Meloxicam ”,“ Meloxam ”,“ Meloflam ”,“ Mixol-Od ”,“ Mirlox ”,“ Movalis ”,“ Movasin ”,“ Movix ”,“ Lem ”,“ Oksikamoks ”and so on.
Mesipol: reviews about the drug
Now you know what the drug under consideration is. It's time to find out what patients say about the drug "Mesipol". Reviews about this anti-inflammatory non-steroidal drug are mixed. On the one hand, patients claim that it relieves pain syndromes that are characteristic of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and other degenerative and inflammatory joint diseases. On the other hand, patients often complain that this drug causes a rather large number of side effects, as a result of which they were forced to stop taking it.
In general, the medication Mesipol considered by us completely copes with its task.