Many modern drugs contain a component such as fenpiverinia bromide. This substance has a lot of useful properties, can relieve spasm and eliminate pain. Naturally, many people are looking for additional information about this tool. For example, it is not a secret for anyone that this substance is part of such drugs as Novospasm and Spazmalgon.
What does this component help from? How does it affect the body? Are there any contraindications? Can any complications appear during therapy? The answers to these questions are important.
general information
Many anticholinergic and vegetotropic drugs contain precisely this component. By the way, they are available in the form of tablets and solutions and are used in a variety of situations. The full chemical name is 1- (3-carbamoyl-3,3-diphenylpropyl) -1-methylpiperidinium bromide.
Fenpiverinia bromide: pharmacological properties
Of course, it is worth familiarizing yourself with the basic properties of the substance. So, what is the effect of fenpiverinia bromide? This substance has m-anticholinergic properties and has a myotropic effect on the smooth muscles of internal organs, vascular walls, etc.
Studies have shown that after oral administration of Fenpiverinii bromidum is quickly absorbed by the walls of the digestive tract. The maximum concentration of this substance in the blood is observed after about an hour, although the first effect appears after a few minutes.
It is worth noting that this component of a variety of drugs does not pass through the blood-brain barrier, so it does not have a serious effect on the central nervous system. The substance is processed by liver cells. Most of fenpiverinium and its metabolites are excreted by the kidneys (part of the substance penetrates the bile and, accordingly, the digestive system). The half-life is 10 hours.
What drugs contain fenpiverinia bromide? Analogs, combined means
It’s worth mentioning right away that this substance is not used in its pure form - it is an active component of many combination drugs along with other chemical compounds.
- To begin with, we note that fenpiverinium is part of the widely used drug Spazmalgon. What helps the drug? He copes with pain, due to spasms of smooth muscles. By the way, other active components are present in its composition, including pitophenone and sodium metamizole. Other medicines have the same composition: Spazmaton, Maksigal, Braralgin, Trinalgin, Revalgin, Spazgan, and Bral.
- Medicines such as Novospasm, Novigan, and Spazgan Neo contain fenpiverinium bromide, as well as pitophenone and ibuprofen. The drugs not only quickly eliminate spasm, but also have anti-inflammatory properties.
The main indications for use
Fenpiverinia bromide as part of various combination preparations is used in many cases:
- With mild or moderate pain syndrome, which is associated with spasm of smooth muscles of internal organs. Indications include spasm of the bladder and ureter, biliary, renal and intestinal colic, chronic colitis, various diseases of the pelvic organs, biliary dyskinesia, algomenorrhea.
- As part of complex therapy, such drugs are used for myalgia, neuralgia, as well as sciatica and arthralgia.
- Medicines with the above component are used to eliminate pain after various diagnostic procedures and surgical interventions.
How to take the medicine?
How to take fenpiverinia bromide? Instructions for use directly depend on which combination medicine a person takes. For example, when it comes to the use of the drug "Spazmalgon", then patients are recommended to take 1-2 tablets about 2-3 times a day (it all depends on the severity of the pain syndrome). But in the case of "Bralangin" a single dose is 2 tablets (patients, as a rule, take the medicine four times a day).
It should be noted that if we are talking about the long-term use of fenpiverinium bromide (more than seven days), then it is extremely important to monitor the functioning of the liver and changes in peripheral blood.
Contraindications
Although drugs with this component are sold over-the-counter, they are not always safe, especially if the patient has contraindications:
- hypersensitivity (before starting therapy, it is worth examining the full composition of the selected medicine, since allergies can also develop when auxiliary components enter the body);
- severe renal failure;
- severe forms of liver failure;
- violation of blood formation in the bone marrow;
- collapse;
- some diseases of the circulatory system, including severe forms of angina pectoris, tachyarrhythmia, as well as decompensated forms of heart failure;
- intestinal obstruction, regardless of origin;
- prostate hyperplasia (in the event that clinical manifestations of pathology occur);
- angle-closure glaucoma;
- period of pregnancy and breastfeeding.
There are age restrictions on the use of this substance, but in this case it all depends on the type of drug taken, the form of release and other factors.
Are complications possible during therapy?
Is it safe to take medications that contain fenpiverinium bromide? The official instruction and the results of scientific research indicate that the appearance of complications during therapy is possible. The list of adverse reactions is very impressive:
- Perhaps the appearance of disorders of the organs of vision and the nervous system. For example, some patients complain of headaches and frequent dizziness. Perhaps a violation and paresis of accommodation, various visual impairment.
- There is a possibility of disorders of the functioning of the cardiovascular system. The list of side effects includes increased heart rate, tachycardia, decreased blood pressure, hyperemia and cyanosis.
- Perhaps the development of agranulocytosis during therapy. Such a pathology is accompanied by a rapid, inexplicable increase in body temperature, chills, sore throat, problems with swallowing, the development of stomatitis, vaginitis, proctitis.
- Sometimes there is a violation of the digestive system. This is accompanied by vomiting (sometimes with blood impurities), constipation and other disorders of the stool, dry mouth, pain and discomfort in the abdomen, burning in the stomach. More serious complications include exacerbations of existing gastritis, ulceration on the mucous membrane, and bleeding in the intestines.
- The substance can affect the respiratory system, which sometimes leads to spasm of the bronchi.
- Therapy sometimes affects the organs of the genitourinary system. Some patients complain of urinary retention, problems with urination. Anuria, proteinuria, polyuria develops. Functional disorders of the kidneys and the development of interstitial nephritis are considered more serious complications.
- Allergic reactions are also possible. The most common is urticaria, in which the rash appears not only on the skin, but also on the conjunctiva and mucous tissues of the nasopharynx. There is a risk of developing malignant exudative erythema, as well as toxic epidermal necrolysis. In some patients, after taking the medicine, angioedema, anaphylactic shock appears.
- Other complications include a decrease in the amount of secreted sweat, as well as asthenia.
- If we are talking about intravenous or intramuscular administration, pain, redness, swelling at the injection site are possible.
Of course, complications are rare. But if you notice any deterioration in yourself, you should stop taking the tablets (or other dosage forms) immediately and see a doctor.
Overdose information
If too much fenpiverinium bromide is consumed, various complications may occur. Overdose patients complain of severe abdominal pain, nausea, and tinnitus. There is hypothermia, severe shortness of breath, a sharp decrease in blood pressure, as well as drowsiness and impaired consciousness, sometimes even to delirium. In more severe cases, taking a large amount of the drug is associated with convulsions, the development of acute renal and liver failure, and paralysis of the respiratory muscles. Treatment in this case is symptomatic. First, the patient undergo gastric lavage, after which sorbents are administered. In severe cases, the patient requires hemodialysis. With convulsions, the use of "Diazepam" is possible.
Additional Information
It is worth saying that this substance in one way or another affects the speed of psychomotor reactions and the ability to concentrate. This information needs to be taken into account, for example, for drivers, as well as for people who work with equipment that requires a quick reaction.
As for the drug interaction, fenpiverinium bromide should not be taken simultaneously with phenothiazine, tricyclic antidepressants, quinidine, butyrophenones, as this enhances its m-anticholinergic effect.