Ofloxacin (solution, tablets, capsules, eye drops) is prescribed if infectious processes in the human body are diagnosed. The drug is indicated for damage to the respiratory system, ENT organs, skin, articular, bone, soft tissues. The drug shows pronounced effectiveness if the process is accompanied by suppuration. It costs quite inexpensively - from 20 rubles and more per package, but improper use can easily cause a deterioration, so Ofloxacin is used only under the supervision of a doctor and in accordance with the manufacturer’s accompanying documentation.
Will it help or not?
Ofloxacin tablets (400 mg), capsules, infusion solution are prescribed for pneumonia and bronchitis. The drug is effective for sinusitis, sore throat, otitis media. It can be used if the foci of the disease are localized in the trachea. Ofloxacin is effective for laryngitis.
The drug is indicated if the foci of infection are detected in the abdominal cavity, if the pathways anatomically designed for the flow of bile are affected. True, Ofloxacin cannot be used for enteritis caused by infection with bacteria.
Understanding what “Ofloxacin” helps, it is necessary to note renal diseases - the remedy is often prescribed for pyelonephritis. The drug is indicated for infection of the urinary tract, as well as pelvic organs. You can use the medication for oophoritis, prostatitis. Quite often it is prescribed if cervicitis or infection of the organs of the reproductive system (for example, colpitis) is detected.
Ofloxacin is indicated for gonorrhea and chlamydia infection. The medication is effective for blood poisoning, if you use a solution for injection into a vein. You can apply the composition for meningitis. Ofloxacin is indicated as a prophylactic to persons with a weakened immune system.
Are there any analogues?
According to reviews, Ofloxacin is a powerful and effective tool available to the masses - the price of packaging is relatively low. If the doctor prescribed “Ofloxacin”, but for some reason there is no possibility to purchase it, it is worth considering the preparations “Phloxal” and “Dancil”.
Before purchasing an alternative option, you should consult your doctor. It is likely that an analog selected by a non-specialist will be ineffective in a particular case. It is necessary to inform the doctor why it is impossible to use Ofloxacin, and on the basis of his advice to stop at a substitute.
Ofloxacin: what is this remedy?
If the doctor recommends this drug, as a rule, the patient immediately determines which group Ofloxacin belongs to. This is not surprising - many are allergic to the tetracycline series, while others do not tolerate penicillin. Ofloxacin is based on the eponymous component belonging to the class of fluoroquinolones. The medication belongs to the antimicrobial group.
On sale “Ofloxacin” is presented in the form of a solution intended for infusion into a vein, tablets and capsules for oral use, as well as substances for instillation into the eyes.
It is impossible!
Ofloxacin's instruction is strictly forbidden to use the drug if hypersensitivity, immunity, an allergic reaction to the main active substance or any other component present in the composition of the drug are detected. Ofloxacin should not be used if a deficiency in the body of glucose-6-phosphate dehydrogenase has been established. It is not allowed to use an antimicrobial drug if a person is sick with epilepsy, or in the medical history there is a mention in the past of seizures similar to it.
Ofloxacin injections, pills and any other form are prohibited if the person is in a situation where the threshold of convulsions is lowered. This is possible against the background of injuries, foci of inflammation in the central nervous system, with a recent stroke.
The described drug is not used until reaching adulthood, since a negative effect on the processes of growth and development of the skeleton is possible. Ofloxacin is strictly prohibited during pregnancy. Do not prescribe it during breastfeeding. If it is not possible to replace Ofloxacin with a safer drug during this period, the issue of transferring the child to artificial nutrition is resolved.
Contraindications to the use of the medication are atherosclerosis localized in the brain, blood flow disorders in this organ in the past. “Ofloxacin” should not be used for organic violation of the integrity of the central nervous system, chronic PN.
How to use?
The drug must be used following the instructions for Ofloxacin applied by the manufacturer to any form of release. The accompanying documentation is present in a carton containing a container with a medicinal product. The manufacturer draws attention to the fact that the choice of dose in each individual case is unique and individual. The doctor assesses the area of localization of the disease, the severity of its course, the features of pathological life forms that multiplied in the focus of infection. It is necessary to take into account the general condition of the patient, the quality of renal, hepatic functionality.
The introduction of Ofloxacin into a vein begins with a dose of 200 mg. The procedure is carried out once. The drug is administered drip, the duration is from half an hour to twice as much time. If the patient's condition becomes better, the next dose is prescribed in the form of tablets.
Doses and rules
Among the indications for the use of Ofloxacin is urinary tract infection. With this diagnosis, the drug is administered intravenously in an amount of 100 mg once or twice a day. If the disease is localized in the kidneys or organs of the reproductive system, 100-200 mg are used twice a day. 200 mg twice a day are indicated for other diagnoses if the effectiveness of the active compound with a specific set of microflora is confirmed. If this amount of medication does not show a pronounced result, it is allowed to increase it using 400 mg of the drug twice a day.
Indications for the use of Ofloxacin include the prevention of infectious diseases in individuals with lowered immune status. In this condition, the substance is injected into a vein in an amount of 400-600 mg per day.
If you want to inject the drug drip into a vein, 200 mg is diluted in five percent dextrose. The duration of the procedure is at least half an hour. It is allowed to use freshly prepared solutions. If it was not possible to start the administration immediately after preparation of the drug, it is necessary to dispose of the drug.
Rules of use. Tablets
According to the instructions, Ofloxacin in tablet form is used in adulthood in an amount of 200-800 mg per day. The duration of this course is from a week to one and a half. The daily dose is divided into two doses. If the doctor prescribed Ofloxacin in an amount of not more than 400 mg, you can use the entire volume at a time. It is advisable to take pills in the morning.
If gonorrhea is detected, Ofloxacin is used once. Dosage - 400 mg.
In case of impaired renal function and creatinine clearance in the range of 20-50 ml / min, the Ofloxacin instruction is shown in the amount of half the average dose for a person with healthy kidneys. The drug is used twice a day. If you choose to use a full single dose, then the tablets are used once a day in the morning.
When blood hemodialysis, peritoneal dialysis according to the instructions of Ofloxacin is used in an amount of 100 mg every day.
In case of liver failure for a day, no more than 400 mg of the drug is allowed.
How to use?
Ofloxacin tablets are intended for oral use. Each instance must be swallowed completely. No need to chew tablets or otherwise disrupt the integrity of the shell. Ofloxacin is taken during meals or in front of her.
The duration of the therapeutic course depends on the characteristics of the causative agent of the disease, its inherent sensitivity to the substance. The doctor also analyzes the clinical picture. After the disappearance of the manifestations of the disease, normalization of temperature, Ofloxacin is taken for another three days. This avoids the appearance of superinfection.
If Salmonella infestation is established, Ofloxacin is taken within a week. When infecting the lower urinary tract, not accompanied by complications, a course of 3-5 days is sufficient.
It's curious
Not only the use of the drug in modern medicine is widespread, but also the use of Ofloxacin in veterinary medicine. For animals produce special forms of medication. It is strongly not recommended to use them on your own - it is better to show a sick animal to a doctor. The doctor will determine whether Ofloxacin will help in a particular case, correctly administer the drug and explain how to continue treatment.
Pharmacology
Ofloxacin belongs to the class of antimicrobials. It features a vast spectrum of efficiency. This is a representative of fluoroquinolones. Once in the body, it affects the DNA gyrase of a pathological life form, which means it violates the stability of DNA, which provokes its death. Efficacy is rated as bactericidal.
The activity of Ofloxacin has been proven with respect to a wide range of microorganisms, the vital activity of which is associated with the production of beta-lactamase. You can use eye drops “Ofloxacin”, a solution for intravenous infusion, tablets for invasion of atypical life forms that can grow and multiply quickly.
The effectiveness of the use of Ofloxacin in infection with Staphylococcus, Klebsiella, Neisseria, Proteus, Enterobacter was revealed. You can use the drug if laboratory tests show the presence of Escherichia, Citrobacter, Salmonella, Shigella. The medication in various forms of release (Ofloxacin eye drops, tablets, injection) is effective in identifying Campylobacter, Yersinia, Plesiomonas colonies.
Negative consequences
Side effects inherent to Ofloxacin are most often the answer from the digestive system. Some patients have impaired stools or poor appetite. Possible vomiting, nausea, sometimes stomach pain, increased activity of liver enzymes in the circulatory system. There is a risk of colitis, jaundice.
“Ofloxacin” can provoke trembling, hallucinations. Some patients complained that during treatment they were sick, dizzy, movements became less confident, the speed of reactions slowed down, bad dreams disturbed.
Against the background of the use of Ofloxacin in various forms, there is a risk of myalgia, a violation of the integrity of the tendon. In some patients, the ability to perceive color, smell, taste, hearing is impaired. Imbalance and diplopia are possible. Occasionally, patients noted a correction in pressure, frequency, and heart rate.
If the risk of developing an allergic reaction. Skin manifestations of intolerance, angioedema, fever, anaphylactic shock are possible. On the skin, the appearance of pinpoint hemorrhages, bullous rash, papules, indicating joint disorders.
There are cases when thrombocytopo-, leuko-, pancytopenia, and anemia developed during the administration of Ofloxacin. There is a risk of jade, increased urea in the circulatory system, a violation of the bacterial composition of the intestinal microflora. Reception of Ofloxacin is accompanied by the risk of superinfection. In diabetes mellitus, the drug can provoke hypoglycemia.
Too much!
With an overdose, it can hurt, dizzy. Some people get confused. Against the background of excessive intake of Ofloxacin, a person becomes inhibited, loses orientation space. Possible urge to vomit. Some are drawn to sleep.
If an overdose is detected, it is necessary to rinse the stomach urgently and prescribe a set of tools to eliminate the symptoms inherent in a particular case.
For external use
If necessary, topical application can be used according to the instructions ofofloxacin ointment. The drug is sold under the trade name "Phloxal". Since it is based on the same antimicrobial component, the substance has a pronounced bactericidal effect. Its use without prior approval from the doctor is unacceptable. It is important to follow the instructions. Ofloxacin ointment is available for the eyes.
Note!
If pneumonia is established, it is revealed that the disease is provoked by pneumococci, Ofloxacin is not used. The tool can not be used if the patient has developed tonsillitis in acute form.
Do not use the drug for more than two months in a row. During the course of treatment, it is necessary to avoid ultraviolet radiation, not to visit a solarium, not to fall under the influence of mercury-quartz lamps. If possible, be less exposed to direct sunlight.
While taking "Ofloxacin" it is strictly forbidden to use ethanol. Women are advised to avoid hygienic tampons during the course. When using them, the risk of thrush is increased.
If taking the drug is accompanied by negative effects from the nervous system, if the patient has an allergic reaction or symptoms of colitis, Ofloxacin is canceled immediately. After a colonoscopy or histology confirming colitis, it is necessary to use drugs containing metronidazole and vancomycin orally.
Occasionally, with the use of Ofloxacin, tendonitis is observed. This condition can cause tendon rupture. From statistics it is known that the Achilles tendon suffers more often. The risk of this complication is higher in the elderly. At the first manifestations of tendonitis, the use of Ofloxacin is discontinued, the Achilles tendon is immobilized. The patient is sent for examination to an orthopedist.
If a person is sick with myasthenia gravis, the administration of Ofloxacin can provoke a worsening of the condition. If there is a predisposition to porphyria, it is possible to increase seizures while taking the medicine.
In bacteriological tests for the detection of tuberculosis, Ofloxacin may cause false negative results.
In case of impaired renal function, the liver, it is important to regularly monitor the concentration of the active component in the blood plasma. If the failure of these organs is observed to a pronounced degree, the likelihood of a toxic effect increases. To prevent negative consequences, it is necessary to adjust the dosage.
Little patients
Very rarely, Ofloxacin is prescribed for children. This is permissible only if there is a threat to the patient’s life and there is no more effective means that can help the patient. The doctor is obliged to evaluate the benefits of such treatment, all possible risks associated with the use of Ofloxacin, notify the parents of the child, report possible negative consequences, side effects from the use of the drug. If in a particular case it is objectively impossible to resort to a less toxic medication, Ofloxacin is used. For a day, the dose is calculated based on body weight - 7.5 mg of the active component per kilogram of weight. The maximum dosage is twice as much.
Application Nuances
When undergoing treatment with Ofloxacin, it is important to carefully manage the transport and work with devices that require an increased concentration of attention, as well as engage in potentially dangerous types of activity. To ensure maximum safety for yourself, it is reasonable to completely abandon any actions that require a quick psychomotor reaction, increased concentration of attention.
What is going on in the body?
Soon after taking Ofloxacin, the active component is absorbed into the circulatory system. For tablets, absorption is estimated at 95%. Bioavailability is over 96%. The active substance for a quarter enters in strong bonds with whey proteins. The maximum concentration when using the tablet form is achievable in an hour or two. Specific indicators are determined by dosage. With a single use of 200 mg in the circulatory system, 2.5 μg / ml ofloxacin is observed, with a twice as large dose - 5 μg / ml, with a triple dose - 6.9 μg / ml. The absorption process can be slower if Ofloxacin tablets are used during a meal, but its quality does not change, bioavailability does not become less due to food intake.
The volume of distribution is estimated at approximately 100 liters, that is, the main dose of a substance ingested into the body easily enters the cells. Accumulation is characteristic of liquids, organic tissues. High dosages are found in the skin, organs of the respiratory, urinary system, salivary secrets, and prostate glands. «» , – . . «» , .
, . 5 % , . , . 4,5-7 . .
, – 90 % . 4 % . 20 %.
With a single use of 200 mg, the active substance of the drug is detected in urine for about another day. With a failure of the liver and kidneys, excretion processes may take a longer time. There is no cumulative effect. Dialysis of blood allows you to remove from the body 10-30% ofloxacin.