Pilobact, regardless of its form, is a medication widely used in the field of gastroenterology to treat ulcerative lesions localized in the stomach and intestines and provoked by Helicobacter pylori. In order to rationalize therapy, the drug should be taken in strict accordance with the requirements specified in the instructions for use.
Structure
According to the instructions for use with Pilobact, the active substances in any form are: omeprazole, amoxicillin or tinidazole, clarithromycin.
In various forms of the drug, active substances are contained in various quantities. So, in the composition of "Pilobact" clarithromycin is contained in an amount of 250 mg, omeprazole - 20 mg, tinidazole - 500 mg. As part of Pilobact NEO, omeprazole is contained in an amount of 20 mg. Clarithromycin - 500 mg, amoxicillin - 1000 mg. Pilobact AM contains omeprazole in an amount of 20 mg, clarithromycin - 500 mg, amoxicillin - 500 mg.
As additional components in the composition of the drug “Pilobact” are used: sodium phosphates, sodium citrates, sugar, gelatin, gum, dextrins, dyes, povidone, titanium oxide, magnesium stearate, vanillin, parmesil, starch, silica, stearic acid, PEG, talc, cellulose.
Pharmacological forms
As indicated by the instructions for use, "Pilobact" is a combination medicine, produced in the form of combi-packs containing separately light yellow tablets of clarithromycin, orange extended-release tablets of amoxicillin or tinidazole tablets, blue-pink omeprazole capsules. There are 7 blisters in each cardboard package, each blister holds 2 tablets of each drug. A set of tablets of one blister is a daily dosage.
Pharmacological effects
In accordance with the instructions for use, “Pilobact” in its pharmacological group refers to combination preparations designed to neutralize and remove from the gastrointestinal tract provoking peptic ulcer disease Helicobacter pylori according to a triple therapy regimen involving the use of three drugs.
The drugs have the following pharmacological effects:
- The secretory activity of the stomach decreases.
- The condition of the mucous membranes lining the intestines and stomach is normalized.
- An antimicrobial effect develops (also in relation to Helicobacter pylori).
- The synthesis of bacterial RNA (also Helicobacter pylori) is inhibited.
The indicated mechanisms of exposure are provided by each drug that is part of the Pilobact capsules. Antibiotics and omeprazole act on the intestines, the stomach in a complex manner, due to which there is an irradiation of bacterial pathogens, the structure of the mucous membranes improves, and the irritating effect of hydrochloric acid is eliminated.
Indications for use
What else can you learn from the instructions for use? "Pilobact" is prescribed to patients with the goal of treating the following diseases:
- Gastritis in a chronic form, provoked by Helicobacter pylori.
- Lesions of the intestines and stomach of a ulcerative nature.
Contraindications
“Pilobact” should not be used in the treatment of patients who have such physiological or pathological conditions as:
- Children's age (up to 16 years).
- Pregnancy.
- Lack of liver and kidney functionality.
- The lactation period.
- An allergy or sensitivity to any component that is part of the medication.
- Blood diseases of various origins.
Using
Pilobact tablets must be taken twice a day, it should be taken before meals. Preliminary grinding of drugs is prohibited, swallowing tablets is important in its entirety. Before lunch, the patient should take one capsule of each type, before dinner - the same.
On each package of "Pilobact NEO" there are inscriptions indicating a set of tablets used in the morning and evening. This allows us to ensure the convenience and correct use of the drug.
Adult patients are most often prescribed a weekly course of using Pilobact. After it is finished, it is recommended to take 20 mg of Omeprazole daily for three weeks.
special instructions
In case of a stomach ulcer or pain of an unclear nature, it is important to exclude the malignant process in the gastrointestinal tract before treatment is started so that the treatment does not mask the symptoms and does not delay the start of adequate therapy. Reception at the same time as "Tsizaprid", "Terfenadine", "Astemizole" is unacceptable in patients with heart pathologies. When combined with "Warfarin" should regularly monitor prothrombin time.
Overdose
The symptomatology of an overdose depends on what kind of drug that is part of Pilobact provoked it.
With an overdose of amoxicillin , the patient develops vomiting, diarrhea, and renal dysfunction. An overdose of omeprozole provokes dizziness, vomiting, abdominal pain, nausea, headaches. Against the background of an overdose of clarithromycin, vomiting, diarrhea, abdominal pain occurs. When using an excessive amount of tinidazole, development of stool disorders, nausea, and vomiting are noted.
If an overdose occurs as a result of exceeding the dose of “Pilobact”, the patient should be prescribed gastric lavage, hemodialysis, and administration of enterosorbents. Subsequently, symptomatic treatment is necessary.
Are there any side effects of Pilobact?
Negative impact
As a rule, all components are well tolerated by patients, however, it is impossible to completely exclude the development of negative manifestations. Against the background of the use of the drug, the following negative manifestations may develop:
- Muscle aches, joint pains.
- Sleep disturbance.
- Abdominal pains.
- Diarrhea
- Vomiting, nausea.
- Depressive conditions.
- Skin rash.
- Impaired consciousness.
- Headache.
- Anemia.
- Jade
- Jaundice.
- Allergic reaction.
- Hepatitis.
- Taste disorder.
- Teeth and tongue black.
- Candidiasis, in particular intestinal.
- Dry mucous membranes.
- Itching in the perianal region.
- Cramps.
- Dizziness.
These negative manifestations are temporary and disappear without a trace after the use of the drug is completed. Given that the duration of therapy is relatively short, negative effects are quite rare.
However, if they occur, the patient is better to consult with a specialist.
Interaction with other medicines
Possible interactions with other medicines depend on the drugs that make up Pilobact
Interactions of amoxicillin with other drugs:
- The concentration of the substance in the blood increases with its simultaneous use with acetylsalicylic acid, sufinpyrazone.
- Combination with oral contraceptives, methotrexate, digoxin, anticoagulants, disulfiram, allopurinol is prohibited.
- The effectiveness of Amoxicillin decreases when used together with diuretic drugs.
Interactions of clarithromycin with other medicines:
- It is contraindicated to combine the substance with ergot alkaloids, terfenadine, pinoside, astemizole, cisapride.
- The effectiveness of clarithromycin decreases when combined with etravirine, ritonavir, neviramine, St. John's wort, rifabutin, phenobarbital, phenytoin, carbamazepine, rifampicin.
- It is important to be careful when combining clarithromycin with warfarin, terfenadine, tacrolimus, simvastatin, carbamazepine, sildenafil, lovastatin, antiarrhythmics.
Pharmacological interactions of omeprazole:
- The effectiveness of the substance increases with the simultaneous use of diazepam, warfarin, phenytoin.
- Efficiency decreases with the parallel use of ketoconazole, ampicillin, iron-containing medications.
Pharmacological interactions of tinidazole:
- With the parallel use of tinidazole with ethanol, ethionamide, indirect anticoagulants, the effectiveness of the latter increases.
- The effectiveness of tinidazole increases with the parallel use of phenobarbital.
Analogues of Pilobact
Currently, there are quite a few drugs whose effects are similar. The most common is Peptipac, which has a similar composition and mechanism of action.
As an analogue, you can use a combination of tablets "Clarithromycin", "Omeprazole" and "Amoxicillin."
Also, the drug can be replaced (if necessary) with Ezoxium, Peptic, Ornistat, Clatinol.
It is important to remember that any of these Pilobact analogues has its own list of contraindications and is able to provoke the occurrence of negative reactions. Therefore, you should not replace the drug yourself - it should be agreed with the doctor.
Cost
In Russian pharmacies, the average cost of a medicine depends on its form, region of distribution, and the pricing policy of the pharmacy network. So, the package “Pilobact AM” will cost an average of 990 rubles, “Pilobact” - 1000 rubles, Pilobact NEO ”- 1100 rubles.
Patient reviews about Pilobact
A large number of reviews left by patients and doctors indicate the high efficiency of using Pilobact in the treatment of gastrointestinal ulcerative lesions. The drug neutralizes bacterial pathogens in just a week's course of use, while promoting the healing of ulcers. Relapses of the disease, as a rule, do not occur.
Separately, the fact that the drug rarely provokes negative manifestations is noted. A negative characteristic of a drug is its rather high cost.
It is important to remember that the appointment of a medical device should be carried out by a doctor, taking into account the etymology of the disease, the results of clinical studies, contraindications. Self-medication is fraught with the occurrence of complications.
What helps Pilobact, now, we hope, is known.