What is Kaffetin Cold medicine? The composition and features of this drug will be discussed below. We will also tell you about how to take the medication mentioned and for what diseases it is prescribed.
Form, packaging, composition
The drug "Kaffetin Cold" goes on sale in the form of oblong and biconvex tablets (with a risk on one side), coated with a blue film coating. They are placed in a perforated blister, consisting of aluminum foil and a three-layer transparent film, which is located in a cardboard bundle.
What does a medicine like Caffetine Cold contain? The composition of this medication is as follows:
- dextromethorphan hydrobromide (15 mg);
- pseudoephedrine hydrochloride (30 mg);
- ascorbic acid (60-62 mg) in the form of a granulate, which contains 97% vitamin C and 3% hydroxypropyl methylcellulose;
- paracetamol (500-555 mg) in the form of granules, 90% consisting of the aforementioned substance, as well as auxiliary components in the form of gelatinized starch, stearic acid and povidone.
It should also be noted that Kaffetin Cold as additional ingredients includes magnesium stearate, colloidal silicon dioxide , microcellulose, croscarmellose sodium and talc.
The film coating of this medication is made of blue dye, macrogol, titanium dioxide, polyvinyl alcohol and talc.
Drug pharmacology
What properties are characteristic for Kaffetin Cold tablets? The instruction states that this tool is capable of exhibiting analgesic and antitussive properties.
The mechanism of action of this medication is due to the presence of the above components in it. Consider their features right now:
- Paracetamol has an analgesic and antipyretic effect on the body. This element is able to block COX in the central nervous system. This happens through a direct effect on the centers of pain and thermoregulation.
A distinctive feature of this ingredient from NSAIDs is the complete absence of an anti-inflammatory effect. Paracetamol does not irritate the gastrointestinal mucosa, and also does not affect the water-salt metabolism, since it does not negatively affect the synthesis of prostaglandins in peripheral tissues.
- What else is remarkable about Kaffetin Cold? The extraction of pseudoephedrine can have a constricting effect on the vessels that are in the mucous membrane of the pharynx and nasal cavity. Also, this element significantly reduces swelling, due to which secretion in the nasopharynx is reduced and nasal breathing is facilitated.
- Ascorbic acid contained in this product helps to restore vitamin C deficiency, which is very often observed during colds.
- Dextromethorphan has an effect on the cough center. It reduces the severity of dry cough, which is associated with irritation of the mucous membrane of the nasopharynx with colds.
Kinetic properties
How is the absorption of the drug "Kaffetin Cold"? Reviews of experts indicate that the absorption of most of paracetamol occurs in the small intestine. At the same time, its highest concentration in blood plasma is observed within 30-90 minutes after oral administration.
The metabolism of the substance in question (approximately 90–95%) occurs in the liver. As a result of this, inactive derivatives are formed (due to the conjugation reaction with glucuronic acid and sulfates). They can have a blocking effect on the enzyme systems of the liver, as well as provoke the death of their cells.
The half-life of this component from the human body is 1-4 hours. Paracetamol and its metabolites are excreted by the kidneys. In old age, there may be a decrease in clearance of the drug, as well as an increase in half-life.
After dextromethorphan has entered the human body, it is almost immediately absorbed into the bloodstream. The highest concentration of this element in plasma is observed 130 minutes after taking the tablets. This substance is metabolized in the liver. Its metabolites are excreted in the urine.
Pseudoephedrine is also rapidly absorbed into the systemic circulation after oral administration. The highest plasma concentration of this substance is reached after approximately 2 hours. The half-life of pseudoephedrine is about 6 hours. It is metabolized in the liver (partially), as a result of which a derivative is formed, which is subsequently excreted from the body with urine.
As for ascorbic acid, it is also absorbed from the digestive tract and is rapidly distributed throughout all tissues. This component is reversibly oxidized to dehydroxyascorbic acid. At the same time, some of the vitamin C entering the body is metabolized to an element called ascorbate-2-sulfate.
This substance is excreted from the body with urine.
Indications
The drug Kaffetin Cold is used for symptomatic treatment of influenza and colds, including the occurrence of unpleasant symptoms such as headache, dry cough, muscle pain, sore throat, runny nose, fever, congestion of the paranasal sinuses and nose .
Contraindications
The drug "Kaffetin Cold" can not be prescribed to patients in the following conditions:
- pregnancy;
- hypersensitivity to the drug;
- congenital deficiency of glucose-6-phosphate dehydrogenase;
- arterial hypertension, ischemic heart disease, angina pectoris;
- severe violations in the work of the kidneys and liver, hepatitis;
- the simultaneous use of antidepressants, monoamine oxidase inhibitors and drugs that are used in antiparkinsonian treatment;
- lactation;
- age up to 12 years.
With caution, this medicine is recommended for:
- arrhythmias;
- benign hyperbilirubinemia ;
- hyperthyroidism;
- viral hepatitis;
- prostatic hyperplasia;
- alcoholism;
- diabetes mellitus;
- chronic obstructive pulmonary disease;
- bronchial asthma;
- exhaustion.
Medication "Kaffetin Cold": instructions for use
The agent in question is intended for oral administration only.
The dosage of the drug for adults and adolescents from 12 years old is 1 tablet four times a day. At one time, it is permissible to use no more than 2 tablets.
The time interval between using the medication should not be less than 4 hours. In this case, the daily dosage of the drug should not exceed 8 tablets.
If an elevated body temperature is observed for more than 3 days from the start of therapy, and a dry cough does not go away for 5 days, then you should immediately seek medical help.
Side effects
Adverse reactions after taking the drug in question can manifest themselves in different ways, on the part of almost all organs and systems of the body:
- nausea, dry mouth, epigastric pain;
- drowsiness, agitation, irritability, dizziness;
- allergy in the form of skin itching, skin rash, angioedema, urticaria;
- increased blood pressure, the development of tachycardia;
- anemia, thrombocytopenia, agranulocytosis, pancytopenia;
- nephrotoxic effect, which is manifested by renal colic, the development of papillary necrosis or interstitial nephritis.
Drug overdose
When taking high doses of the drug, the patient may experience nausea, tinnitus and pain in the stomach. Also, when the dosages of the drug are exceeded, the patient's skin becomes pale, his sweating increases and his heartbeat increases.
The described cases require urgent gastric lavage. Also, the patient is prescribed a dose of activated carbon corresponding to the weight of the patient. If required, symptomatic therapy is performed.
Interaction
Taking paracetamol in large doses enhances the effect of anticoagulants.
The use of drugs that belong to microsomal oxidation inducers (for example, Phenytoin, ethanol, barbiturates, Rifampicin, Phenylbutazone, tricyclic antidepressants), and hepatotoxic drugs significantly increase the formation of active hydroxylated metabolic products of paracetamol, which increases the likelihood of severe intoxication , including when taking small doses of the drug.
Long-term use of barbiturates reduces the effectiveness of paracetamol.
The combination of paracetamol and salicylates increases the risk of developing cancer of the bladder or kidney.
Prolonged use of NSAIDs and paracetamol contributes to the appearance of analgesic nephropathy, papillary renal necrosis, and also significantly brings closer the terminal stage of renal failure.
The use of "Diflunisal" leads to a hepatotoxic effect of the drug.
The parallel use of pseudoephedrine and other sympathomimetic agents can contribute to the occurrence of toxic effects, as well as have an additive effect. The combination of this component with monoamine oxidase inhibitors often leads to the development of a hypertensive crisis. In this regard, the use of the drug in question is allowed no earlier than 14 days after the administration of monoamine oxidase inhibitors was discontinued.
The parallel use of "Propranolol" enhances the pressor effect, which turns out to be pseudoephedrine. In addition, when using the latter, the antihypertensive effect of such drugs as Methyldopa, Reserpine, Mekamilamin, etc., may decrease.
Special information
Now you know what a drug like Kaffetin Cold is.
Pervitin is meth. It is a psychostimulant and causes a high dependence, and therefore is classified as a narcotic substance. Some people are trying to remove this component from Caffetine Cold. There are many ways to fight off a drug. Its reception causes euphoria and at the same time adversely affects all systems and organs of a person.
In the course of treatment with the drug in question, it is necessary to monitor the functional state of the patient’s liver, as well as peripheral blood counts.
During the entire treatment, the patient is forbidden to drink alcohol, as this can lead to hepatotoxic effect of the drug. The same goes for caffeinated products and products.
The medication in question has a direct impact on the patient's ability to drive transport and engage in any other activities that require an increased concentration of attention.
The drug "Kaffetin Cold": a vacation from pharmacies
Due to the fact that this medication is often used as a narcotic, it is dispensed only after presenting a doctor's prescription. By the way, finding such a drug in pharmacies is quite difficult. Usually it is delivered after pre-order.
Similar drugs
There are many tools that can replace the drug in question. The most popular include the following: Amicitron Forte, Antigrippin, Bol-Run Premium, Vocasept, Grippo, Grippkold-N, Gripotsitron Forte, Gripplu, Dolaren, Cold-N ”,“ Coldrex ”,“ Coldfree ”,“ Lemcip Lemon ”,“ Novalgin ”,“ Panadol Extra ”,“ Rinza ”,“ Tamipul ”,“ Pharmacitron ”and others.