Rheumatoid arthritis is a disease in a chronic stage of development. It can not be cured, but you can slow down the progression of the pathology and prevent the occurrence of complications. In this situation, immunosuppressive treatment is performed . These are precisely the drug Methodogect. Reviews for rheumatoid arthritis note that the medicine does not act immediately, but after 2-6 months.
"Methodology": composition, release form
Produced in the form of a solution for injection, the drug "Method". Reviews for rheumatoid arthritis say that the drug with regular use gradually relieves joint swelling. Helps return to normal.
The effect of the drug is based on the active component of methotrexate disodium. Minor ingredients are distilled water, as well as sodium chloride and hydroxide.
The medicine is made in a hermetically sealed syringe intended for injection. In the syringe may be 7.5-25 mg injection solution. In a cardboard box is:
- glass syringe;
- plastic nozzle;
- needle packed in a special blister;
- instructions for use.
The solution has a shelf life of two years. It is made in Germany.
Pharmacological properties
The drug Metoject refers to immunosuppressants and antimetabolites (reviews for rheumatoid arthritis indicate that the medication after administration into the body can cause nausea and dizziness). The drug is characterized by an antitumor property. It is a folic acid antagonist. Reduces dihydrofolate reductase, which is involved in the reconstruction of dihydrofolate into tetrahydrofolate. The active substance here serves as a carrier of carbon fragments, indispensable for the reunion of purine nucleotides, as well as their derivatives.
The drug interferes with DNA repair and synthesis. Inhibits cellular mitosis. Methotrexate has a greater effect on rapidly proliferating cells related to bone marrow, fetal tissue, malignant tumors and mucous membranes of the epithelium.
The tool is effective in psoriatic and rheumatoid arthritis. In the treatment of these diseases, the drug exhibits an immunosuppressive and anti-inflammatory character. The positive effect of therapy is explained by an increase in the concentration of adenosine in the area of the inflammatory process.
Indications for use
Testimonial reviews of Methoject indicate the effectiveness of the drug. It is noted that it is well tolerated by patients and rarely causes side effects.
A medicine is used for rheumatoid arthritis and polyarthritis, accompanied by complex juvenile arthritis in a chronic form and actively developing.
Indications for injection are psoriatic arthritis, as well as generalized psoriasis. In the latter case, Metoject is used if standard treatment methods have failed.
Contraindications
It is noted that the drug "Metzhekt" helps with rheumatoid arthritis, reviews. You can not use the medicine for violation of the liver, alcohol abuse, kidney failure, which is in a difficult stage of development.
You should not prescribe a medication for bone marrow hypoplasia, severe anemia, leukopenia and thrombocytopenia. You can not do injections for infectious pathologies that are chronic and acute in nature. Do not prescribe the drug for ulcerative lesions of the oral cavity and gastrointestinal tract.
Do not use the medicine for severe immunodeficiency, pregnant and lactating women. Drug treatment is not carried out simultaneously with the formation of live vaccines. Contraindication to use is hypersensitivity to the constituent elements of the medication.
Use the medicine with caution should people suffering from ascites, gastrointestinal obstruction, dehydration. Under the supervision of a physician, patients with pleural or peritoneal effusion, as well as people with kidney failure, should be. With caution, the drug is used for infectious, fungal, bacterial and parasitic diseases. This also includes people suffering from herpes simplex and herpes zoster, measles, patients with chickenpox, patients with strongyloidoside and amoebiasis.
Adult patients of childbearing age should use reliable contraception when using medication. It should be protected after the end of therapy, for six months. If a woman became pregnant during the treatment period, then the risk of adverse effects of the drug on the fetus must be taken into account.
Methotrexate passes into breast milk and may be dangerous for the baby. When treating with Metoject, you should stop breastfeeding for the period of treatment.
Mode of application
The Metodzhekt drug is administered subcutaneously, intravenously and intramuscularly. Instructions for use and reviews recommend using the medicine once a week, at the same time. The duration of treatment is regulated by the doctor.
For adults with rheumatoid arthritis, the medication is prescribed 7.5 g once a week. The route of administration may be any. Begin with a minimum dose. If it is well tolerated by the patient, then the dosage is gradually increased at 2.5 mg per week. The weekly maximum rate is 25 mg.
The result is observed after 4-8 weeks from the start of treatment. After it was possible to remove the symptoms of the disease, the dose is gradually reduced to a minimum. The therapeutic course can last up to ten years or more.
In the treatment of psoriatic arthritis, as well as psoriasis, a week before the start of therapy, it is recommended to introduce a test dose of 5-10 mg of the solution to detect side effects.
Unless otherwise prescribed by your doctor, you should start with 7.5 mg once a week. The dosage is gradually increased. Do not inject more than 25 mg of solution per week. The maximum allowable weekly dose for psoriasis is 30 mg. The result is observed after 2-6 weeks. After achieving the desired effect, the dosage is reduced.
People with renal and hepatic insufficiency, as well as the elderly, the drug should be used with caution.
Children under the age of sixteen with a diagnosis of juvenile arthritis should take medicine at a rate of 10-15 mg / m 2 from the surface of the body. The dose may increase to a maximum standard of 20 mg / m 2 . Children are recommended to administer the drug intramuscularly.
To prevent side effects, doctors prescribe folic acid intake the next day after the injection over the next five days. Before injection and on the day the drug is developed, vitamin B9 can not be drunk.
Drugs with a similar effect
If Metoject does not fit the treatment, then the doctor can replace this drug with another one that is similar in composition and effect. Common counterparts to the MetoJect include:
- Vero-Methotrexate.
- Zeksat.
- "Metortrite."
- "Methotrexate."
- "Methotrexate-Teva."
- "Treksan."
- "Trixile."
- Evetrex.
These and other analogues easily replace the drug, but they must be selected by the attending physician.
Cost
Pay attention to the high cost of the drug "Method" reviews. With rheumatoid arthritis (the price of this medicine varies in the region of 600-750 rubles for 0.75-1 ml, for 800-1400 rubles you can purchase from 1.5 to 2.5 ml of the drug) you do not have to choose especially. The disease requires intensive care. Which, unfortunately, is quite expensive.
Warns that you need to enter the weekly means "Method" instruction for use. Reviews (the price of the above items may vary depending on the pharmacy) note that the cost of the medicine is quite high, but, despite this, the medicine gives a good result.
Drug effectiveness
It is noted that the drug "Methodet" acts as a real savior in the fight against rheumatoid arthritis, reviews. The effectiveness of the tool has been confirmed by many people.
Injecting the drug allows the drug to be absorbed directly into the blood, bypassing the stomach and intestines. Such a regimen is more effective than oral medication.
"Metoject" based on methotrexate refers to basic antirheumatic modifying agents. It has a strong anti-inflammatory property. It can be prescribed at different stages of rheumatoid arthritis. Changes the course of the disease. Used for pain, stiffness and swelling in the joints.
The drug helps many people live a normal life, keep working. Slows down the development of the disease and the process of damage to the articular and cartilage tissue. The effect of the drug is observed after six months.
Doctors reviews
Doctors often prescribe a Metoject to treat rheumatoid arthritis. Reviews of doctors note that it rarely causes side effects and is well tolerated by patients. It is considered one of the best immunosuppressants. It can be used to maintain health continuously for several years.
The drug is toxic, and therefore, when using it, doctors advise you to follow the administration schedule and dose. Increase and decrease the dosage gradually and only under medical supervision. This will prevent possible complications. Doctors recommend the use of reliable contraception to all women undergoing the Metoject treatment with the drug, since the drug can negatively affect the fetus.
Reviews on the use of children
Should be used only as prescribed by the doctor, the drug "Method". Reviews for rheumatoid arthritis in children indicate a positive result that the medicine gives. In childhood, it is prescribed 2 ml once a week. Some guys who previously had problems with the joints begin to run after injections and become more active. They manage to achieve long-term remission and slow down the course of the disease.
The kids who were treated with Methodoject are no different from their peers. They play a lot, and joint pain ceases to bother them. Their limbs and ankles swell less. Improvement does not occur immediately, but after 3-4 injections.
Some mothers say that if you inject before eating, you may experience nausea and dizziness. After meals, the medicine is better tolerated by children. Despite the effectiveness of the drug, it does not give 100% cure.
The medicine "Method": reviews for rheumatoid arthritis
Opinions about this drug were mostly positive. Patients say that the drug prevents the development of the disease, but, when it is used, you must constantly be under medical supervision.
The medicine eliminates edema, relieves pain, but not everyone has pain completely. Some are forced to take additional analgesics. The drug retains its effect for a week and if an injection is not done on time, then the symptoms of the disease may appear again. Patients feel relief after the 5th injection.
There are people in whom a dose reduction and drug withdrawal caused negative consequences. They manifested themselves in the form of poor health, pain, dizziness and nausea. These individuals note that the dose should be reduced gradually and only after achieving complete remission.
More patients complain that the medicine is difficult to get in pharmacies and has to be specially ordered. Many are not satisfied with the high price of the drug. They note that patients with rheumatoid arthritis should be given medication for free, since not everyone can afford to buy it.
In general, for the treatment of severe joint diseases, one of the strongest and most modern drugs is Metoject. Reviews (with rheumatoid arthritis in children and adults, this is especially important) claim that it prevents the development of pathology and helps to achieve long-term remission.