In order to weaken the muscle tone, which is characteristic of most neurological syndromes, osteochondrosis and arthrosis, doctors prescribe a drug called Midokalm to patients. This medicine is safe, and at the same time highly effective in the treatment of neurological or osteochondrosis pains. Among other things, it is widely used for trophic disorders or muscle hypertonicity. Consider the detailed instructions for the use of injections "Midokalm". In addition, we learn what patients write about treatment with this medication.
Drug description
It is a Hungarian drug and is manufactured by the company Gedeon Richter. The active component of Midokalm injections effectively relieves muscle spasms, reduces and inhibits pain. The local analgesic effect contributes, as a rule, to lowering the pain threshold. This tool normalizes the sensitivity of the affected area. Additionally, the agent has a vasodilating effect, thereby improving blood flow.
Neurologists actively use this medicine in everyday practice, it successfully cures various cases that are difficult to treat. I must say that the scope of injections "Midokalm" is becoming more widespread every day.
To anesthetize the injection area, the drug package contains lidocaine. Immediately before the first injection, patients need a scarification test, that is, a diagnostic test to detect allergic reactions.
Therapeutic effect
Injections of "Midokalm" can have an analgesic and relaxing effect on the human body, helping to increase and alleviate motor ability. This drug does not affect the patient's consciousness or his vigor. That is, injections of "Midokalm" do not cause inhibition of psychomotor or other similar conditions in people.
In general, these injections can provide a local anesthetic and membrane stabilizing effect, which improves lymphatic and blood circulation, achieves a vasodilating effect, and at the same time muscle cramps become less intense. Thanks to the drug presented in patients, muscle hypertonus decreases along with rigidity in osteochondrosis and motor activity is facilitated.
The main active ingredient in the drug is tolperisone. This ingredient is highly related to human nerve tissue. Its effect is aimed at reducing the sensitivity of nerve endings, and in addition, to relaxing muscles, inhibition of spinal reflex centers and normalization of peripheral circulation. The substance tolperisone helps to lower the pain threshold, blocking some reflexes and reducing the hypertonicity of muscles and muscles.
Despite the fact that drugs with a similar mechanism of action during prolonged use cause many adverse reactions, the pharmacological effect of Midokalma injections is carried out without a pathological effect on the hematopoietic system or kidneys.
The presented drug is well tolerated, including that it is well accepted by elderly patients, since it does not cause any cardiotoxic or sedative effect. In addition, this medicine does not provoke cognitive impairment in the form of a memory disorder, decreased mental performance, and the like.
Structure
The injection form of the drug presented is available in the form of ampoules with a solution that is intended for parenteral administration. In appearance, this solution resembles a colorless liquid, which has a specific smell. The solution contains tolperisone and lidocaine. And auxiliary components are diethylene glycol monoethyl ether, injection water and E218 preservative.
Another drug
"Midokalm Richter" is one of the varieties of the drug, which differs from the simple "Midokalm" in the dosage of the active component. The instructions for injections "Midokalm Richter" and "Midokalm" are almost identical.
If the usual drug is available in a dosage of 50 milligrams, then Midokalm Richter is supplied in a pharmacy containing 100 milligrams of the active component in one ampoule with the solution.
What is the use of Midokalm Richter injections?
This solution is also intended for intramuscular and intravenous injection. In addition to the dosage, it is no different from the standard dosage form for injections.
Instructions for use for injections "Midokalm Richter" are in each pack.
Next, we find out when the drug is suitable for use.
Cost
In one package of the drug "Midokalm" - five ampoules. The cost of this medicine in Russian pharmacies ranges from 250 to 300 rubles.
Midokalm Richter injections cost 450-550 rubles.
Indications for use
Injections are recommended for patients in the following cases:
- To eliminate muscle rigidity, and in addition, to stop hypertonicity, which is due to arthrosis of different localization. In addition, this drug is used in the presence of cervical syndrome, with osteochondrosis, and also in order to get rid of painful muscle contraction caused by spondylarthrosis or spondylosis.
- For the treatment of Little's disease and various kinds of encephalopathies among patients in childhood.
- As part of rehabilitation postoperative therapy after surgical interventions in the field of orthopedics.
- To eliminate neurological disorders that are accompanied by muscle hypertonicity in the form of various kinds of encephalitis, myelopathy, pyramidal lesions, and in addition, complications that develop as a result of acute cerebrovascular disorders.
- Diseases that are associated with the lymphodynamic process and blood flow, which occurs due to various types of thrombosis.
- Treatment of autoimmune diseases like scleroderma or various kinds of angiopathies.
- Combined therapy of angiosclerosis, trophic ulceration in the legs and thromboangiitis.
- For treatment aimed at restoring the innervation of blood vessels damaged as a result of angioedema of gait or due to insufficiency of small-capillary blood supply, which manifests itself in the form of a bluish skin tone.
- With an increased tone of muscle tissue caused by a nervous system organic damage due to spinal damage, stroke, toxic or allergic cerebral inflammation, multiple sclerosis.
- For the treatment of pathologies that are associated with dystonia of muscle tissue.
According to the instructions for use, intramuscular injections "Midokalm" should be administered slowly and carefully.
Contraindications
Regarding the use of this drug, the instructions give very few contraindications. "Midokalm" can not be used in the following cases:
- For the treatment of persons who are hypersensitive to the ingredients of the drug, that is, tolperisone and lidocaine.
- If the patient has myasthenia gravis, that is, a nervous disease characterized by excessive muscle weakness and fatigue.
- Patients suffering from hepatic or renal pathologies.
- For treating infants who are younger than one year old.
This is confirmed by the instruction for injections "Midokalm" intramuscularly.
Side effects
Often, adverse reactions appear in those patients who have an individual intolerance to this drug or with an overdose. In such cases, people may experience the following:
- The appearance of redness in the injection area.
- The occurrence of dizziness and headache.
- Onset of drowsiness or sleep disturbance.
- The occurrence of pressure surges.
- The patient develops anorexia.
- The appearance of pain in the leg muscles along with muscle weakness.
- The occurrence of digestive disorders.
- The appearance of a feeling of fatigue along with general weakness and discomfort.
- The presence of signs of impotence, that is, asthenia.
After the Midokalm injections, patients are much less likely to experience visual disturbances along with trembling hands, a depressed state, cramps, impaired attention and balance. In addition, manifestations that are associated with hypersensitivity and ear noise are not ruled out. Sometimes, after injections of this drug, the heart rate increases in patients, the pressure drops and angina pectoris is observed. In addition, cases of skin reactions in the form of rashes, redness, itching, and, in addition, excessive sweating and burning were recorded. Midokalm injections should be administered intramuscularly by a qualified specialist.
It is worth noting that the described drug must be administered to patients by the drip method. In the event that the rules for injecting are violated and injections are made jet, then signs of arterial hypotension are likely to manifest. During the study of this drug, it was possible to fix isolated cases of anaphylactic shock along with a sharp decrease in heart rate and an increase in creatinine in the blood. In addition, against the background of the use of injections in patients, the bone mineral density decreases and an unquenchable and unnatural feeling of thirst can occur.
So it says in the instructions. Analogs of injections "Midokalm" will be presented below.
Instructions and dosage of the drug
The instructions report that injections are administered intramuscularly or intravenously. Intravenous injections are administered very slowly. Moreover, their introduction is carried out every day in one ampoule. During the day, you can apply no more than 100 milligrams of the active substance. Intramuscularly, the drug is prescribed to patients in one ampoule, but twice a day.
For children, the dosage of this drug is prescribed in accordance with their weight indicators. The duration of the course of treatment with injections, as a rule, is determined by the attending doctor in accordance with the disease, the age of the patient and his general condition.
As part of the studies, experts found that patients with diseases of the liver or kidneys when using Midokalma injections can often develop various undesirable reactions than those patients who do not have any problems with these organs. In this regard, such patients are prescribed an individual determination of the dosage of the drug. People who suffer from severe damage to the kidneys or liver, the use of injections "Midokalm" is strictly prohibited.
Drug overdose
The medicine very rarely causes an overdose in patients, as it has a high therapeutic threshold. If the recommended therapeutic dosage is exceeded in patients, the following clinical picture may occur:
- Respiratory distress.
- The occurrence of sudden attacks of convulsive seizures.
- The appearance of severe muscle weakness, which is accompanied by a lack of motor coordination of individual muscle tissues.
Since there is no antidote in the main active component of Midokalm, therapy in case of an overdose is aimed at eliminating symptoms and supporting treatment.
Use of the drug during pregnancy
To date, there have been many studies in the field of the use of these injections for the treatment of pregnant women. The results confirm the absence of a negative effect of this drug on the fetus, but nevertheless, the medication is not prescribed for women in the first trimester. In the later stages, it is prescribed only if the therapeutic effect is significantly higher compared with possible complications for the fetus.
As for nursing ladies, due to the lack of reliable information, it is better to refrain from prescribing Midokalm injections during this period or to transfer the baby to artificial feeding for the duration of therapy.
Drug interaction
This injection solution must not be mixed with any other means. It is recommended to enter it only separately from other medicines. Given that this medicine does not have a sedative effect, it is allowed to be used as part of a comprehensive treatment with sedative or hypnotic drugs, and in addition, with medicines that contain alcohol (ethanol).
In the event that it is necessary to combine the injections of Midokalm with other muscle relaxants, the daily dosage of injections is reduced. In addition, in the case of simultaneous use with non-steroidal anti-inflammatory drugs, their dosage must be reduced, since Midokalm can enhance the pharmacology of these drugs. The therapeutic effect of the drug is enhanced by psychotropic drugs, and in addition, “Clonidine”, general anesthesia medicines and other muscle relaxants.
Analogs of injections "Midokalma"
Among the analogues of this drug, medications in the form of “Tolperil” and “Tolperizon” should be distinguished. The cost of these drugs is almost no different from the drug we are describing. In this regard, we can confidently say that analogues of Midokalm injections, which are much cheaper, are currently missing.
Now we turn to the reviews about this drug and find out what people write about it in various forums and sites.
Reviews of patients and doctors
Currently, the drug "Midokalm" is very actively discussed at various forums that relate to pediatrics and children's health, especially hypertonicity in infants. According to reviews, it can be said that the predominant number of parents claim the absolute inefficiency of Midokalm in the treatment of children. Therefore, young mothers prefer to base the therapy of children on massage and physiotherapeutic procedures. This also applies to Midokalm Richter injections.
As for older patients who suffer from various supporting and motor pathologies, their opinion about this drug is mixed. However, in general, patients report that the treatment of osteochondrosis pain with this medication is very successful, and most patients will soon feel much better.
What other reviews are there about Midokalm Richter injections?
Unfortunately, a lot of patients write in their comments that after Midokalm Richter they felt very bad. For example, it is reported that against the background of its use, the sharpness of the image disappears, everything is floating, dizzy, coordination is disturbed, and in addition, sharp flashes of sweating begin and some incomprehensible inadequacy in the state appears.
Others, on the contrary, claim that Midokalm helped them in the treatment of osteochondrosis of the neck. It is noted that after a course of injections against the background of this disease, it becomes much easier for patients, and no side effects are observed.
Thus, judging by the reviews, we can say that this drug is quite controversial. But in any case, immediately before using it, you must first consult with a specialist, and in the process of treatment, inject the solution drip, strictly observing the dosage.
We reviewed the instructions for use for injections "Midokalm" and analogues of the drug.