In the article, we will review reviews about Mifeprex and instructions for it. It is a steroidal synthetic antigestagen drug.
This medication is released in tablet form. One tablet contains the main active element - mifepristone in a dosage of 200 mg.
Pharmacological properties
According to information from the instructions for use, the medicine "Mifeprex" has the main property to block the processes of functioning of progesterone at the level of progestogen receptors.
Antagonism with glucocorticosteroid medications is noted, does not have pronounced progestational activity. The medicine Mifeprex increases the contractile functionality of the myometrium, enhances its sensitivity to prostaglandins and increases the release of interleukin-8 in choriodecidual cells. To enhance the effect of the drug, it is often prescribed in combination with synthetic synonyms of prostaglandin.
The properties of this medication lead to desquamation of the decidual membrane, the separation of the fetal egg from it and excretion from the uterus. The use of the drug inhibits ovulatory processes, contributes to a change in the structure of the endometrium, as a result of which implantation of a fertilized zygote cannot take place. In addition, the drug helps to block progesterone receptors, which allows to suspend the growth of a malignant or benign tumor located in the area of female reproductive organs, to reduce the size of myomatous nodes.
It is interesting to know the opinions of those who interrupted pregnancy with Mifeprex. Reviews will be presented at the end of the article.
Indications for appointment
A pharmacological drug is prescribed during the medical termination of pregnancy in the early early stages (up to 42 days of delayed menstruation).
Mostly positive reviews about this drug. Those who interrupted the pregnancy with Mifeprex were satisfied with the result.
In addition, the drug is used for emergency contraception (no more than 72 hours) after unprotected contact, as well as in cases where there are doubts that the previously selected method of contraception is reliable. The use of this drug in the treatment of uterine fibroids, the size of which reaches a period of 12 weeks of pregnancy, is shown in order to prepare and induce labor activity in a full-term pregnancy.
Instructions for use
The Mifeprex drug is approved for use exclusively in specialized medical institutions where all the necessary equipment is available to monitor the patient's condition. In order to medically terminate the pregnancy process, a medication is prescribed once in the amount of three tablets in a dosage of 600 mg. The patient takes the drug orally only in the presence of a specialist. Reception must be carried out 1-1.5 hours after a meal. Tablets should be washed down with half a glass of water.
Within two hours after using the medicine, the patient is under the constant supervision of a doctor. After 1.5-2 days after taking the medication, the patient must go to the hospital for examination and for an ultrasound scan. If necessary, a woman may be prescribed medication "Misoprostol." After two weeks, she should again be recommended to undergo an ultrasound examination, and, if necessary, to take tests to determine the concentration of chorionic gonadotropin in order to confirm abortion. If the medication did not have the expected effect for 14 days (ongoing pregnancy or incomplete abortion), the patient is subjected to vacuum aspiration and the aspirate is examined through histological examination.
To stimulate the birth of this drug
In case of full-term pregnancy, Mifeprex can be prescribed according to the instructions in order to stimulate the birth process. The dosage of the drug in this case is 200 mg per day (in the amount of one tablet). Taking the medicine, as well as during abortion, is carried out in the presence of a specialist. After a day, re-use of the drug in the same dosage can be prescribed, and after 2-3 days it is necessary to assess the condition of the birth canal. If necessary, the patient is subsequently prescribed prostaglandins or medications based on oxytocin.
Side effects
According to reviews, Mifeprex can cause the following side effects:
- Digestive system: vomiting, nausea, diarrhea.
- CNS: cephalalgia, dizziness.
- The genital system: the occurrence of bloody discharge from the genital tract, amenorrhea, menstrual irregularities, a period of exacerbation of the inflammatory process in the area of the appendages and uterus, subinvolution of the uterus, lochiometer.
- Allergic phenomena: urticaria.
- Other: discomfort and soreness in the lower abdomen, severe weakness, hyperthermia.
If any of these symptoms occur, seek medical attention immediately.
Contraindications to the use of this drug
Mifeprex tablets have a fairly wide list of general contraindications, including:
- chronic or acute kidney failure, liver failure;
- prolonged use of glucocorticosteroids;
- uterine fibroids;
- adrenal insufficiency;
- age over 35 years;
- smoking;
- inflammatory process in the field of female reproductive organs;
- porphyria;
- high sensitivity to the main or auxiliary elements of the drug;
- severe forms of anemia;
- the presence of complex extragenital pathologies;
- violation of hemostasis, including as a result of anticoagulant therapy.
If the drug "Mifeprex" is prescribed for abortion, it is contraindicated in use in the following situations:
- pregnancy for more than 42 days in the absence of menstrual bleeding;
- ectopic pregnancy or suspicion of it;
- unconfirmed pregnancy;
- pregnancy that occurred during the use of intrauterine contraception (spiral) or immediately after taking contraceptives of a hormonal composition.
In accordance with the instructions for use with Mifeprex, if this medication is used to prepare and initiate childbirth, it is contraindicated in such cases:
- eclampsia;
- severe gestosis;
- incorrect fetal position;
- preterm or postponed pregnancy;
- preeclampsia;
- the presence of spotting from the vagina during pregnancy of an unknown etiology;
- mismatch in the size of the pelvis of a woman and the head of the fetus.
Cautious use of this drug
With caution, this drug is used in patients with bronchial asthma, arrhythmia, obstructive pulmonary pathologies, arterial hypertension, chronic heart failure. If these recommendations are not followed, serious complications ensue. This is confirmed by numerous reviews.
Those who interrupted pregnancy with Mifeprex report that such an abortion is rare, but can negatively affect health.
Drug interaction
A medication weakens the therapeutic properties of glucocorticosteroid drugs, therefore, when used together, it is recommended to increase the dosage of the latter. In addition, you can not combine the use of this medication with anti-inflammatory non-steroidal drugs.
Special recommendations
Patients who use this pharmacological drug Mifeprex to terminate pregnancy through medication should be aware that if the medication does not have the desired effect for two weeks, and the pregnancy continues anyway, it must be stopped by another method, since the fetus is highly likely to form congenital malformations.
The use of the Mifeprex drug by patients with endocarditis of an infectious nature of origin or artificial heart valves should occur in combination with antibacterial therapy. The medication is not able to prevent the development of genital infections. The drug is not used as a permanent contraceptive.
Analogues of this drug
The effect of this medication is identical to the therapeutic properties of the following agents:
- "Agesta" is a Russian-made synthetic antigestagen steroid drug that blocks the effects of progesterone and does not have progestational activity. Depending on the phase of the cycle, it causes an increase in the contractile function of the myometrium, stimulates the release of interleukin-8, increases the sensitivity of this substance to prostaglandins, as a result of which desquamation of the decidual membrane and the exit of a fertilized egg are observed. It causes a change in the endometrium, inhibition of ovulation, prevents the implantation of the fetal egg.
- "Ginepriston" is a drug that is produced by a Russian pharmaceutical company and has an anti-gestagen effect. It is used to interrupt pregnancy, the excitation of the birth process. The absolute analogue of the drug "Mifeprex"
- Ginestril is a Russian counterpart, an anti-gestagen hormone in the form of tablets.
The actions of Mifeprex and Mifegin are identical. The drug "Mifegin" was created artificially, it has an antiprogestogenic effect, and its active substance is mifepristone, which blocks the effects of progesterone at the level of hormones and the pituitary gland. This action allows you to take pills to prepare for an abortion and stimulate the expansion of the uterus, but only with the permission of a doctor.
Mifeprex reviews
Abortion today is a fairly common gynecological procedure, and women who interrupted pregnancy with a medication left a lot of reviews about the drug.
Patients note that this medication is a highly effective means for terminating pregnancy and for emergency contraception after unprotected sexual intercourse. Despite this, many women avoid using this tool, since when it is used, many side effects develop that are very pronounced and unpleasant. Those who drank Mephiprex, according to reviews, observed the occurrence of severe pain in the abdomen, the development of intense uterine bleeding. Drawing and cutting pains in the uterus, severe nausea and vomiting, and stool disorders were noted. Some women were forced to observe bed rest while taking the drug. In addition, they had severe weakness and mental disorders.
Another category of patients who tolerated the medication well, note that they did not notice any pathological symptoms against the background of abortion. They also had bleeding from the genital tract, however, severe pain, disturbances in general condition, dyspeptic symptoms were not noticed. They left positive reviews about this drug, in which they say that the medicine is safe and has high efficacy and good tolerance.
We examined the reviews of women about Mifeprex and the instructions for it. Have you or your friends had to deal with this drug?