"Panangin" in ampoules is a drug that can affect the metabolism in tissues and contains magnesium and potassium in its composition. The drug is recommended for patients in the treatment of pathologies in the cardiovascular system, accompanied by impaired metabolism in the myocardium. The medication is contraindicated in childhood, during pregnancy, to patients suffering from hypermagnesemia (high levels of magnesium in the blood) and hyperkalemia (high levels of potassium in the blood).
In the article, we consider the instructions for use for "Panangin" and the reviews of cardiologists.
Pharmacological forms
The manufacturer "Panangin" is available in two pharmacological forms: tablets intended for oral administration, and a solution that can be administered intravenously, either in a jet or drip. The tabletted “Panangin” has a biconvex rounded shape, has its former color and shiny surface. The drug is packaged in 50 tablets in bottles of polypropylene.
"Panangin" in ampoules is intended for intravenous administration, is a clear, colorless, sterile liquid without any impurities. Packed in 10 ml ampoules, which are packaged in 5 pieces in a cardboard box. Before jet intravenous administration, the contents of the ampoule should be diluted with 50 ml of glucose (5%). If drip administration is intended, then the drug should be diluted with saline in an amount of 200 ml.
Composition, description
The main active ingredients of the drug are potassium asparaginate and magnesium asparaginate. Each tablet contains 158 and 140 mg of substances, respectively. Each Panangin ampoule contains 452 mg and 400 mg of substances, respectively. Potassium and magnesium ions are important intracellular cations. Along with sodium and calcium, they take part in the activity of various enzymes that regulate tissue metabolic processes, including in myocardial tissues. The active components of the drug have a positive effect on the process of assimilation of oxygen, nutrients, on the ability of the heart to contract.
As additional components in the composition of the tablets used: potato starch, corn starch, magnesium stearate, povidone, silicon dioxide. The excipient in the composition of the solution is injection water. The additional ingredients contained in the preparation are necessary to improve the absorption of the active components and create the most convenient pharmacological form.
Pharmacological group
"Panangin" in ampoules is part of a group of drugs with a predominant effect on the metabolism in tissues. According to its pharmacological group, it refers to minerals containing potassium and magnesium. The drug is able to influence the processes of metabolism in the tissues of the myocardium, prevent the death of cardiomyocytes, the development of hypoxic phenomena. Against the background of the use of "Panangin", the contractility of the heart and the activity of the heart and blood vessels as a whole are normalized.
What is the action of Panangin?
Pharmacodynamics, pharmacokinetics
Magnesium and potassium ions are important cations that affect the function of enzymes that can regulate tissue metabolism. Asparaginate, which is an endogenous substance that forms strong chemical compounds with various elements, transfers cations through the membranes into the cell. The active substances of the drug enter the cell in the form of complex compounds. Their function depends on the concentration of calcium and sodium in the intercellular and cellular spaces. Cations are able to regulate the process of assimilation of nutrients and oxygen by the myocardium, as well as myocardial contractility. Deficiency of potassium and magnesium in the body can provoke pathological changes in the cardiovascular system, for example, arterial hypertension, arrhythmia, sclerosis of the myocardium, coronary arteries.
The pharmacokinetics of Panangin has not been studied by the manufacturer. It is reliably known that the absorption of active components in the digestive tract is quite high. If the drug is administered intravenously, the accumulation of substances occurs in the myocardium, while the maximum therapeutic effect develops. Potassium and magnesium aspartate is excreted mainly through the kidneys.
So what is Panangin for?
Indications for use
For adult patients, the medication is recommended for pathological abnormalities in the cardiovascular system and deficiency of cations in the body:
- Substitution therapy with a deficiency of magnesium and potassium ions of a different nature.
- Chronic form of heart failure.
- Conditions after a heart attack.
- Cardiac ischemia due to circulatory failure in the coronary arteries.
- Ventricular extrasystole.
- Atrial fibrillation.
- Heart rhythm disturbances caused by intoxication with glycosides included in the digitalis group.
- Heart rhythm disturbances, developing against a background of changes in electrolyte balance, are primarily associated with hypokalemia (a deficiency in the blood of potassium ions).
When conducting long-term therapy using Panangin, it is important to periodically monitor the concentration of potassium and magnesium ions in the blood.
For children, it is contraindicated.
During pregnancy, the use of the drug is allowed in the presence of individual indications starting from the second trimester. The use of the drug in the first trimester can lead to toxic poisoning of the fetus.
If there is a need to use the drug in the lactation period, it is recommended to temporarily suspend feeding and transfer the child to artificial mixtures.
Contraindications
Before using Panangin in injections, it is important to consult a doctor and take into account existing contraindications, including:
- Impulse conduction in the AV node.
- Severe forms of hepatic, renal failure.
- Cardiogenic shock,
- Addison's disease.
- Metabolic acidosis.
- Hemolytic anemia.
- Dehydration of the body against the background of extensive burns, overheating, diarrhea, repeated vomiting.
- Disturbed amino acid metabolism.
- Hypermagnesemia (increased concentration of magnesium in the blood), hyperkalemia (increased concentration of potassium).
- Individual susceptibility to any of the components that make up the drug.
It is strictly forbidden to prescribe a medication in the first trimester of pregnancy, to patients of childhood.
Let us consider the dosage of Panangin in more detail.
Use of medication
A tablet preparation is recommended to be used three times a day in an amount of up to 2 tablets. If the patient has severe forms of the disease, a single dose increase of up to 3 tablets is permissible. Supportive therapy involves the use of the drug for 3 weeks three times a day, 1 tablet. Take the drug after eating, since gastric juice has a destructive effect on the active components of the drug. The tablets should be swallowed whole with a sufficient amount of liquid.
Before jet intravenous administration, the ampoule is diluted in 50 ml of glucose (5%). Before installing a dropper with Panangin, the drug is diluted with 200 ml of physiological saline. Administration should be slow. The duration of the therapeutic course is determined by the doctor, taking into account the severity of the pathological phenomenon.
When treating pregnant women, “Panangin” is prescribed according to standard schemes, taking into account the risk to the child and the therapeutic need for the mother. In the lactation period, the medication is contraindicated.
Negative impact
The following negative effects may develop during the use of Panangin: dizziness, abdominal pain, and nausea. As a rule, side effects rarely occur, and their clinical manifestations disappear without any treatment within a few days.
What is Panangin compatibility?
Its interaction with other drugs
The parallel use of the drug with potassium-sparing diuretics and ACE inhibitors can provoke the development of hyperkalemia, which increases the likelihood of severe arrhythmias and subsequent cardiac arrest.
Rapid intravenous administration of the drug causes dizziness, nausea, and redness of the face. To prevent these conditions, it is recommended to enter the medication at a slow pace.
It is important to exercise caution when prescribing the drug to patients suffering from extensive tissue damage, extensive burns, myasthenia gravis, as there is a significant risk of hyperkalemia.
Is Panangin's action always safe?
Overdose
In case of an overdose, the patient develops symptoms of hypermagnesemia and hyperkalemia: arrhythmia develops, sensitivity in the extremities is disturbed, diarrhea, repeated vomiting, redness of the face, lethargy, hypotension, convulsions, respiratory depression, and cardiac arrest are possible.
If signs of intoxication occur, you should immediately stop taking the drug, rinse the patient's stomach, ensure the intake of enterosorbents, prescribe peritoneal dialysis and hemodialysis.
Analogs of "Panangina"
If necessary, the medication can be replaced with one of the following drugs:
- Asparkam-L. It is a domestic analogue of "Panangin", produced in injection form. It is forbidden to use by minors, pregnant women, in the lactation period.
- "Potassium Magnesium." It is a dietary supplement that is not approved for use in the lactation period, during pregnancy, under the age of 14 years.
- "Potassium and magnesium asparaginate." It is a drug of German origin. It is produced in the form of a solution. Contraindications to its use are childhood, lactation, pregnancy.
- Asparkam. It is a complete analogue of "Panangin." The pharmacological form of Asparkam is tablets. It is allowed for use with caution in the lactation period and during pregnancy.
"Asparkam" or "Panangin"?
It should be noted that “Asparkam” is a complete analogue of “Panangin”, time-tested. Moreover, the cost of Asparkam is significantly lower than that of Panangin.
However, the main requirement for the drug is its effectiveness. Patients note that this indicator is higher for Panangin.
Despite this, the doctor should determine which drug should be taken - "Asparkam" or "Panangin".
Cost
The average cost of Panangin is 145 rubles per pack of solution, 140 rubles per pack of tablets. It depends on the region.
Reviews
Patients who used "Panangin" leave, as a rule, positive reviews. The drug is really effective, allows you to neutralize convulsions, facilitate the activity of the heart. In addition, against the background of the use of the drug, negative consequences rarely occur.
What are the reviews of specialists in this regard? Cardiologists are more likely to be neutral towards Panangin. Do not consider him a panacea for heart ailments. More often it is prescribed for mild rhythm disturbances as a tonic. We reviewed the “Panangin” instructions for use and reviews of cardiologists and patients.