The article will present a list of non-steroidal anti-inflammatory drugs.
Exacerbation of diseases of the spine, as well as joints, is inevitably accompanied by pain, and, in addition, inflammatory processes. The paramount task before the appointment of further treatment is the relief of pain along with the removal of inflammatory reactions. Anti-inflammatory drugs can perfectly cope with this problem.
An extensive list of such drugs of a new generation makes it possible to choose the most effective medication in each specific situation. There is no point in discussing competitiveness due to the lack of analogues that can simultaneously provide anti-inflammatory, analgesic and antipyretic effects. In our article, we will talk about the latest anti-inflammatory drugs. With inflammation, they are indispensable.
How do these tools work?
Inflammation in most situations is accompanied by pain, swelling, redness of the tissues, fever and seizures. Prostaglandins are directly involved in enhancing such processes. The process of prostaglandin production directly depends on cyclooxygenase enzymes, which are affected by anti-inflammatory drugs. Cyclooxygenase has two active isoforms that have their own specific functions:
- In addition to being responsible for the appearance of prostaglandins, cyclooxygenase protects the gastric mucosa, affecting platelet viability. Drugs that have an indiscriminate effect and inhibitory cyclooxygenases provoke a large number of different side effects.
- Cyclooxygenase is a specific enzyme that is actually absent in the norm; it is synthesized by other mediators. The selective nature of the effects of the latest drugs is based on the blocking of this particular enzyme.
It is important to note that modern anti-inflammatory drugs produce the strongest analgesic effect, do not cause addiction and addiction.
New developments of anti-inflammatory drugs
Unlike glucocorticoids, such drugs do not contain any hormones and do not cause serious abnormalities in the form of diabetes mellitus or hypertension. But the blocking of cyclooxygenase leads not only to a decrease in pain, but also inflammatory processes, but also quite detrimental to the gastric mucosa, often causing ulcers. Drugs produced in a special shell, which does not allow them to break down in the stomach, could not withstand competitiveness because of their detrimental effect on the intestines.
A new generation of non-steroidal anti-inflammatory drugs have a selective effect and this is what distinguishes them from previous medicines. They successfully affect the production of cyclooxygenase, inhibiting the production of prostaglandins. The drugs of the new category have not lost their effectiveness, and the negative effect on blood coagulability, and, in addition, on the gastric mucosa and platelet vital activity is minimized. The latest anti-inflammatory drugs have the following properties:
- The anti-inflammatory effect is due to a decrease in the production of inflammatory mediators, and, in addition, a decrease in the permeability of the vascular walls.
- Blocking inflammatory factors significantly reduces irritation of nerve receptors, positively affecting the relief of pain.
- The effect on thermostatic centers makes it possible to cause an antipyretic effect.
Next, we consider cases in which the use of anti-inflammatory drugs is appropriate.
When should I take anti-inflammatory drugs?
The effectiveness of these drugs is observed in the treatment of diseases that are accompanied by inflammation, pain, fever or swelling. Quite often, anti-inflammatory drugs are prescribed by doctors to treat a whole list of diseases. They can also be used by patients on their own. This group of medicines is used in the following cases:
- Against the background of exacerbation of diseases of the motor system with all kinds of arthritis, and with diseases such as arthrosis, osteochondrosis, hernia of the spine and so on.
- These medications are excellent in case of injuries, bruises, sprains and so on. Anti-inflammatory drugs for joints are popular.
- In the presence of severe pain during hepatic or renal colic.
- If headaches or gynecological pains are present.
- For relief of pain in the postoperative period.
- To reduce the temperature, regardless of its origin.
- Some drugs from this group are used to prevent heart attack, stroke, and, in addition, in the treatment of neurological diseases.
It is important to keep in mind that absolutely every medication has a directed action. Self-administration of non-steroidal anti-inflammatory drugs for the treatment of various ailments can lead to unpredictable consequences.
Who should refrain from treatment with such drugs?
Even the latest developments do not completely protect drugs from unwanted effects on the body. In order to avoid certain negative consequences, it is best to refrain from using them in the following cases:
- The presence of a person's problems with blood vessels or with the heart.
- In the event that there are ailments of the stomach or intestines.
- In the presence of serious renal pathologies.
- Against the background of high blood pressure, and, in addition, if there is a problem with blood coagulation.
It is important to emphasize that such newest anti-inflammatory drugs are strictly prohibited for pregnant and lactating women.
Classification of anti-inflammatory drugs
A pharmacological study in the field of development of new drugs, which are more effective with high competitiveness due to the reduction of side effects on the body, is currently actively ongoing. On the market today there are about fifteen subgroups of drugs of this category. The classification of anti-inflammatory drugs divides them into the following two subgroups:
- The first generation of drugs presents a list that consists of medicines such as Aspirin along with Naproxen, Ibuprofen, Voltaren, Nurofen, Diclofenac, Diclac, Movimed, Metindol and Metindol Butadion. "
- The new generation of anti-inflammatory drugs includes Movalis, and, in addition, Nise with Nimesil and Celebrex.
There is another classification of non-steroidal anti-inflammatory drugs. The chemical composition of new generation medicines classifies them as acidic and non-acidic drugs:
- Salicylates include Diflunizal with Aspirin.
- Diclofenac, along with Indomethacin, Tolmetin, Sulindak, Etodolac, and Aceclofenac, is classified as phenylacetic acid.
- Pyrazolidines include a list of drugs in the form of "Phenylbutazone", "Oxyphenbutazone" and "Azapropazone".
- An anthranilic acid is considered a drug called "Mefenaminate".
- Derivatives of propionic acid include a large list of anti-inflammatory drugs, including Ibuprofen along with Ketoprofen, Nabumeton, Pirprofen, Benoxaprofen, Flurbiprofen, Fenbufen, Fenoprofen, Naproxen and Further.
- Amizon is mainly attributed to isonicotinic acid preparations. The list of anti-inflammatory drugs does not end there.
- A derivative of pyrazolone is the well-known “Analgin”.
- Oxycams are the most effective non-steroidal anti-inflammatory drugs. The list of such medicines includes Meloxicam, along with Piroxicam, Tenoxicam and Lornoxicam. The action of these funds on the body is usually very long. And even despite their significant cost due to proven effectiveness, one can reason about their competitiveness.
- Non-acidic drugs include "Rofecoxib" along with "Nimesulide" and "Celecoxib."
What anti-inflammatory drugs for colds are best taken, only the attending physician can correctly determine. The effectiveness of therapy always depends on many individual factors.
The choice of drugs of different directions
Carrying out the comparative characteristics of non-steroidal anti-inflammatory drugs makes it possible to identify the best of them by their strength of exposure in various situations:
- A pronounced anti-inflammatory effect can be achieved against the background of treatment with “Diclofenac”, “Indomethacin”, “Flurbiprofen” and “Piroxicam”.
- Ketorolac, Ketoprofen, Indomethacin and Diclofenac are highly competitive in pain management.
- Effectiveness against the background of a decrease in temperature is noted in such medicines as Aspirin, Nurofen and Nise.
It should be borne in mind that the trade name of medicines may differ significantly from the international name. In this regard, when purchasing drugs, you need to pay attention to the active ingredients in the composition.
New generation anti-inflammatory drugs
The medicines that belong to the last generation are highly effective in terms of their effect. Due to the fact that against the background of their use, certain complications are minimized, these medications are also very competitive.
But it is important to consider that even the most harmless drug can carry a health hazard, therefore, you can not start taking the drug without reading the annotation, contraindications and without consulting a doctor. Next, consider the latest anti-inflammatory drugs.
The drug "Movalis"
The leader among anti-inflammatory drugs can rightfully be called a drug called Movalis, which has an extended exposure period and is allowed for prolonged use.
This tool has a pronounced anti-inflammatory effect, which makes it possible to take it against the background of osteoarthritis, ankylosing spondylitis, rheumatoid arthritis and so on. This medication is also not without painkillers, and at the same time antipyretic properties. Movalis protects cartilage tissue well. This tool is used for toothaches and headaches. The determination of dosage along with the method of administration directly depends on the severity, and, in addition, on the type of disease.
The use of Nimesulide
This drug surpasses many of its analogues in the analgesic effect of action. Its effectiveness is achieved in twenty minutes. Its properties are used to relieve paroxysmal pain. This medicine relieves inflammation, having an antioxidant effect on the body, positively affecting collagen fibers and cartilage tissue in parallel.
This drug is prescribed against a background of traumatic, arthritic and toothache, as well as with nerve infringement. This medication is very well tolerated by patients. Its use rarely causes dizziness, headache, drowsiness, heartburn, nausea, or hives.
Xecofam treatment
"Xecofam" refers to the group of oxycams. This remedy has an extended excretion time. The effect of the drug on the body lasts up to twelve hours. This remedy relieves pain so well that it is often compared with morphine. The medication is not addictive and does not affect the nervous system. The decision on the frequency of use is made depending on the individual indicators of the patient.
What anti-inflammatory non-steroidal joint preparations to choose?
The use of Rofecoxib
The more common name for this medication is Denebol. This drug will relieve pain, inflammation and swelling. It is prescribed for chronic polyarthritis, bursitis, rheumatoid arthritis, various injuries and so on. The presented tool helps people to eliminate pain against the background of neuralgia, osteochondrosis, radicular syndrome and toothache. True, this medication is not recommended for use by those who have suffered a heart attack, and, in addition, to children under twelve years of age. It is not suitable for pregnant women and those patients who have heart or kidney problems.
Nonsteroidal anti-inflammatory drugs for joint treatment can be purchased at any pharmacy.
Treatment with celecoxib
This drug can significantly alleviate the condition of the patient in the presence of osteochondrosis, arthrosis and other diseases. The presented medication well relieves pain in humans, and, in addition, effectively copes with inflammation. The side effect of Celecoxib on the digestive system is usually minimal or absent.
Currently, anti-inflammatory drugs remain indispensable assistants in the treatment of many ailments. But do not forget that they only remove the symptoms that negatively affect the well-being, and the treatment of a disease should be carried out with other drugs and techniques.
What is important to know when conducting treatment with modern anti-inflammatory drugs?
All anti-inflammatory drugs for the treatment of new generation joints are very widespread. In osteochondrosis, such drugs are prescribed in the form of injections, and tablets with capsules are used as part of oral administration. Suppositories are available directly for rectal use, and for external use there are many different gels and ointments.
But these medications can be contraindicated if patients have increased individual intolerance to certain components of the medicine. In particular, patients who are in old age should be extremely careful when taking such medications. And against the background of treatment, these patients require the control of the attending physician, who will monitor the condition of their kidneys and liver.
It is not recommended to use anti-inflammatory drugs for the treatment of patients whose work requires increased attention, accuracy, quick reaction and coordination of movements, since exposure to such drugs can cause drowsiness along with weakness and headaches.
It must be borne in mind that using only anti-inflammatory drugs in the treatment of osteochondrosis, and, in addition, arthritis and other similar diseases, it is simply impossible to achieve an absolute cure, since such drugs are intended only to relieve pain and relieve inflammation. For the effective treatment of a particular disease, other drugs and various treatment methods are required.
It is important not to forget that prolonged use of anti-inflammatory drugs for the treatment of various ailments can lead to undesirable side effects, therefore, without prescribing and regular monitoring by the attending physician, therapy with these agents is unacceptable.