In the form of a solution for infusion, tablets for oral use, a liquid for treating organs of vision, the drug “Ciprolet” is on sale. The use of the medication is possible strictly under the supervision of a doctor - the substance belongs to the class of antimicrobials, has a rather strong effect, therefore it requires compliance with safety rules. It is important to follow the manufacturer's recommendations listed in the instructions. Let's consider it in more detail.
general information
The instructions for the antibiotic "Ciprolet" indicate: the main active component that ensures the effectiveness of the application is ciprofloxacin. It is available in different versions, so it can be used as a therapeutic agent in a wide range of diseases. The mechanism of influence on the human body is approximately the same for all variants of the drug, the distinguishing features are associated with the rules of dosage, use, application of the substance.
Quite often, doctors recommend staying on an infusion solution. In the instructions for use of the Ciprolet antibiotic in this form of release, the manufacturer indicates that one bottle contains 100 ml of the drug, of which 200 mg is the active substance. Additional compounds were also used that simplify the use of the drug and provide it with a long shelf life. These are lactic and hydrochloric, citric acids, sodium compounds, special purified water.
What else do you have?
Eye drops “Cyprolet” are on sale. The instruction to them clarifies that the drug is also based on ciprofloxacin, is available in the form of a colorless liquid or substance with a slight yellowish tinge. Drops should be transparent, without sediment. In addition to the active component, for 1 ml added in an amount of 3 g, the drug contains additional substances. These are various acids, sodium compounds, purified water. The substance is packaged in five-milliliter bottles with dispensers placed in cardboard boxes. In addition to the medication itself, there is definitely an instruction for drops of Cyprolet.
Finally, the antibiotic is available in tablet form. This option is intended for oral use. There are three release options: 250 mg of the active compound and twice as much, as well as a combination preparation containing 500 mg of ciprofloxacin and 600 mg of tinidazole. Tablets are packed with blisters in cardboard boxes. In one blister - a dozen capsules, in one box - one blister. The manufacturer completes all forms of release instructions for use. Ciprolet 250 mg, 500 mg, 500 + 600 mg has proven itself to be a reliable drug, but before the initial use it is necessary to carefully read the accompanying documentation, to familiarize yourself not only with the list of indications, but also with contraindications, as well as possible negative consequences of use.
Is there an alternative?
There are quite a few Tsiprolet analogues on sale. The instruction for this drug mentions that the main active ingredient is ciprofloxacin. He is also present in the medicines "Ciprofloxacin", "Cifran". Among the possible substitutes for the funds in question are also “Basigen”, “Betaciprol”, “Ifipro”. The choice of drug for replacement must be agreed with the doctor, given which particular application format is preferred for a particular patient. For example, if an antibiotic is needed for oral use, possible alternatives to the Ciprolet under consideration are Quintor, Protsipro, Tseprova.
If it is impossible to purchase the funds prescribed by the doctor, you need to see a doctor and explain the reasons why you cannot buy Tsiprolet. Instructions for the use of analogues contain fairly detailed information about the technical features of the drugs, but it is almost impossible to select the optimal replacement without a specific education. Sometimes the doctor recommends staying with Ophthsipro ointment or drops of Rocip, in other cases, the best solution would be Nircip or Ciprinol.
To some extent, the replacement described is considered to be drops for instillation in the ears of Tsipromed, for the eyes - Tsiprolon, tablets Tsiprobid and Ecocifol. The well-known tablet versions of Cipropan and Cifloxinal are distinguished. For injective administration, the doctor can offer alternatives to the drug in question, sold under the names "Ciprobay", "Ciproxil", "Ciprofloxabol", "Cifracid", "Ciprolaker".
Tsiprolet: technical aspects
As follows from the instructions for "Tsiprolet" (250 mg and other dosages, all forms of release), the drug belongs to the class of antimicrobial fluoroquinolones. It has a wide range of effectiveness. The active component is the product of the transformation of fluoroquinolone. Under its influence, the gyrase of the DNA of the pathological bacterial cell is inhibited, the synthesis of the molecule is disrupted, the development and reproduction of the pathogen is disrupted. Tsiprolet provokes morphological cellular changes, which will soon lead to the death of the pathogen.
In the instructions for Ciprolet (eye drops, tablets, and injection), the manufacturer indicates that the substance has a bactericidal effect on gram-negative life forms. Tsiprolet is effective both against those at rest, and against those that are currently at the stage of division. The breadth of the spectrum of action is explained by the fact that not only is the DNA gyrase influenced, but cell lysis is also observed. If the infection occurred with gram-positive microscopic life forms, the active substance of Ciprolet will affect them only at the time of cell division.
The nuances of using
The instructions for the Tsiprolet tablets, drops, solution for injection indicate that the substance is toxic to a small extent to a macroorganism. This is due to the fact that DNA gyrase is inherent only in pathological forms of life. Studies have shown that penetration of an active component into the body does not lead to the formation of resistance to other antimicrobial substances working in a different scenario. Experiments have proven that Ciprolet is effective in infecting life forms that are immune to the penicillin, tetracycline, cephalosporins and aminoglycosides. The effectiveness of antibiotic treatment and other diseases was observed, the causative agents of which were resistant to a wide range of drugs available to humans.
In the instructions for Tsiprolet (tablets, solution, drops), the manufacturer indicates that the use of the drug for infection with gram-negative life forms, including a wide range of enterobacteria, moraxella and pseudomonas, has been proven. Tsiprolet can be used against neysseries. It is allowed to use when infected with intracellular life forms: Legionella, Listeria, Corynebacterium. The effectiveness of the course of treatment for infection with Staphylococcus, Streptococcus has been proven.
Effective and not too
In the instructions of “Ciprolet” (500 mg, 250 mg, solution, drops) it is mentioned that the preparation is ineffective against staphylococci, which are resistant to methicillin. Treponema, ureaplasma, clostridia and some other life forms are also resistant to the substance. To verify the effectiveness of using Ciprolet in a particular case, it is reasonable to preliminarily make an analysis in order to identify the features of microscopic flora.
Studies have shown (and this is recorded in the instructions for “Ciprolet” 500 mg and other forms of release), pathological forms of life may develop resistance to ciprofloxacin, but the process is very slow. This is due to the fact that after the use of the substance there are practically no persistent cells. In addition, bacterial cells cannot produce enzymes that inhibit ciprofloxacin activity.
What is going on in the body?
According to the instructions for “Tsiprolet” for injective administration, shortly after penetration into the vein of 200-400 mg of the active ingredient, the maximum concentration in the blood is reached. Indicators - 2.1 μg / ml for a lower dose, for a twice as large - 4.6 μg / ml. On average, one hour is required to achieve such indicators. The active substance by 20-40% enters into strong bonds with plasma proteins. The volume of distribution is estimated at 3 l / kg, in some - a little less, in some patients - a little more.
In the instructions for Ciprolet 500 mg tablets and other dosages, for injection, the manufacturer draws attention to the ability of ciprofloxacin to distribute well in organic tissues. The exception is fat structures, therefore Tsiprolet does not affect nerve tissue. On average, in tissues, the accumulation of the active component exceeds the inherent blood serum by 2-12 times. Sufficient concentrations for the presence of a pronounced therapeutic effect are observed in body fluids (secretion of salivary, seminal glands, bile). “Tsiprolet” affects the organs of the reproductive, endocrine, respiratory system, kidneys and the urine excretion system from the body, bones, and muscle structures. There is an accumulation of ciprofloxacin in the synovial fluid, in the cartilage of the joints, in the skin.
Important Features
Ciprofloxacin has relatively low penetration abilities (as follows from the instructions for Ciprolet 500 mg tablets and other antibiotic release options) relative to spinal fluid. If there are no foci of inflammation in the tissues of the membranes of the brain, the concentration on average is up to 10% relative to the inherent blood serum. In the presence of foci of inflammation, a rise of up to 37% is possible.
It was revealed that ciprofloxacin can penetrate into the eye fluid, bronchial secretion, and into the lymphatic system. The substance can pass through the placenta, which explains certain restrictions on the use of the drug, prescribed in the instructions for “Ciprolet”. In blood neutrophils, concentration indicators are 2-7 times higher than in blood plasma.
Reaction features
In the instructions of Tsiprolet, the manufacturer indicates that the transformation of the active component predominantly takes place in the liver, about one third of the total dose received is converted. The reaction products have weak pharmacological activity. At present, information is being taken into account about four reaction products capable of showing at least some pronounced effect on the patient's condition.
The half-life, according to the Ciprolet instruction, is estimated at 5.5 hours on average. If a patient suffers from chronic kidney failure, the interval can be extended up to 12 hours. Elimination is mostly carried out by filtration and secretion through the tubules. Up to 70% of the active component are excreted unchanged from the body, one tenth of the amount with urine in the format of reaction products. Other volumes leave the patient through the intestinal tract.
A low percentage of ciprofloxacin is found in breast milk.
After the drug is injected into a vein in urine, the concentration of the first couple of hours is more than in the blood serum, about a hundred times. These values are many times greater than the minimum dose that could inhibit the vital activity of pathogenic agents that infect the urinary tract.
The nuances of using
The clearance in the kidneys is estimated at 3-5 ml / kg per minute. General - about 8-10 ml / kg per minute. If creatinine clearance is greater than 20 ml / min, the percentage of medication eliminated by the kidneys decreases. There is no cumulative effect, ciprofloxacin is not stored in the tissues. In chronic renal failure, the metabolism of the active substance increases, a larger percentage is excreted through the intestinal tract, which compensates for the imperfection of the renal system.
When will it help?
For adults, “Ciprolet” is indicated for infection with bacteria, regarding which tests confirm sensitivity to the active substance. It can be used for diseases of the respiratory system, ENT organs, infection of the kidneys, urine excretion routes. If chronic prostatitis due to bacteria is detected, Ciprolet is used after confirming the effectiveness of the drug in a particular case. You can use the drug for gonorrhea, if the disease is not accompanied by complications, with typhoid, shigella infection, infection of soft tissues, skin, bone and joint structures. “Ciprolet” is indicated for septicemia, an infection that develops when the immune status is suppressed. As a prophylactic, Tsiprolet is used if an operation is planned or if there is a high risk of anthrax infection. You can use the drug to treat this disease, localized in the lungs. In combination with metronidazole, the medication is indicated for intra-abdominal infection.
According to the instructions for children, “Tsiprolet” can be used if cystic fibrosis is detected, against which complications developed, and microflora tests showed Pseudomonas aeruginosa. The drug is approved for patients from the age group of 5-17 years. Also in childhood, the medication can be used as a means of preventing and eliminating anthrax localized in the respiratory system. The drug is effective if a person is infected with Bacillus anthracis.
Strongly impossible!
It is not allowed to use Ciprolet if increased susceptibility to the active component of the drug or to any other substances used by the manufacturer in the manufacture of one form or another is established. You can not use the drug with increased susceptibility of other drugs from the class of fluoroquinolones.
"Tsiprolet" is prohibited for pregnant women and nursing mothers, since the drug penetrates the placental barrier, excreted in breast milk. Until adulthood, the drug can be used only if there are strict indications mentioned above. Use of the substance by children can lead to undesirable effects, as the skeleton has not yet been formed. An exceptional situation is cystic fibrosis, which led to bacterial complications, as well as the possibility of developing anthrax. Even with such diagnoses and dangers, Ciprolet is not used in the treatment of children under the age of five.
You can not use "Tsiprolet" and drugs containing tizanidine. Such a combination can cause a strong decrease in pressure in the arteries. The patient is irresistibly drawn to sleep.
You can, but very carefully
It is allowed to use Ciprolet if it is possible to control the patient’s condition when there are problems of blood flow in the brain, mental disorders, cerebral arteriosclerosis, epilepsy. If possible, to constantly keep the patient’s condition under control can be prescribed for treatment “Tsiprolet” with insufficient liver and kidney function in a pronounced form. They use the remedy with care in the treatment of elderly people, as well as people suffering from heart diseases or an electrolyte imbalance in the body.
The combination of Ciprolet and a number of medicines requires caution from the doctor and patient. These primarily include drugs that can change the duration of the QT interval. Gently combine Cyprolet and agents that affect chemical reactions using the CYP 450 1A2 enzyme. If in the past a person suffered a violation of the functionality of the tendons against the background of the use of quinolones, ciprofloxacin is allowed only with the possibility of constant monitoring of important indicators of the body.
How to use the solution?
One of the most effective forms of release of Ciprolet is a liquid for injection into a vein. The drug is poured over half an hour if the dosage shown is 200 mg. If the doctor recommended using twice as large volumes, the procedure is extended to an hour. Solutions prepared for use can be combined with the products of Ringer-lactate, Ringer, sodium chloride, dextrose, fructose. It is allowed to use a mixed preparation in which Ciprolet for infusion is combined with sodium chloride and dextrose at the same time.
Features of the course, frequency and dosage are determined by the doctor, based on the age, condition of the patient, diagnosis, severity of the disease. In particular, with infection of ENT organs, Tsiprolet is shown twice a day with a ten-day program, the dose being 200-400 mg. , . , , 400 . .
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