The drug "Cetrin" is available in suspended form in dark glass bottles of 30 ml. In the package, a measuring cup is attached to the medicine for accurate dosing. A medication is also produced in tablet form. The active substance is cetirizine.
Pharmacodynamics
The medicine is a blocker of H1-histamine receptors (such information contains instructions). "Cetrin" has an antiallergic effect. In therapeutic doses, the medication does not pass the BBB, and therefore does not have any sedative effect.
The drug does not block serotonin and cholinergic receptors. The use of the drug is effective both in the late and early stages of the development of an allergic disease.
Pharmacokinetics
With oral administration, good absorption of the drug from the gastrointestinal tract is noted. When eating food simultaneously with the use of the drug, the absorption rate does not decrease. In the blood, the maximum concentration of the drug is observed an hour after administration. The drug is actively associated with plasma proteins.
A small amount of the dose is metabolized. The decay process occurs in the cells of the liver. Withdrawal of most of the medicine is carried out unchanged in the urine.
Indications
The instruction "Cetrin" recommends for allergic rhinitis year-round and seasonal type, hay fever (hay fever) , angioedema.
Indications for use include atopic dermatitis, urticaria (including idiopathic chronic), neurodermatitis. Prescribe medication for allergic conjunctivitis. Additionally, as part of a combination treatment, “Cetrin” in suspended form for
bronchial asthma (atopic) is recommended (such information contains instructions
).Dosage regimen
The medicine "Cetrin" (tablets), the use of which is allowed from the age of six, is prescribed regardless of food. It is recommended to prescribe 10 mg per day to patients from 12 years old (once), from 6 to five milligrams twice a day.
The therapeutic course is from one to four weeks. In the chronic course of pathology, the duration of administration can be increased to six months. The instruction of the syrup "Cetrin" recommends a medicine in a dose of 10 ml to patients from six years old, from two years old - the amount of the drug is halved. In the first case, the drug is prescribed once, in the second - twice a day. If the patient has renal failure, the dose should be reduced.
Contraindications to the medicine "Cetrin"
For children, the instruction sets a limit on age - the drug is not recommended in suspended form for up to two years. General contraindications include hypersensitivity to the components. Tablets are not prescribed for patients under six years of age. Women are not recommended medication during pregnancy. If necessary, carry out therapy during the period of feeding, the doctor must warn the patient about the cessation of lactation.
Information about the side effects that the instruction contains
"Cetrin" can cause fatigue, sleep disturbance, headache, agitation. On the basis of taking the medicine, nervousness, anxiety, euphoria, dizziness, amnesia develop. Some patients have depression, depersonalization, paralysis , impaired thinking, impaired concentration. According to the instructions, "Cetrin" provokes undesirable consequences from the digestive system. In particular, dyspepsia, stomatitis, anorexia occurs on the basis of therapy, and taste perception changes.
Side effects include pain in the abdomen, gastritis, vomiting, thirst, swelling of the tongue. In some cases, liver activity can be disturbed, diarrhea, flatulence, rectal bleeding, hemorrhoids can occur. The drug negatively affects the organs of vision. When taken, conjunctivitis, glaucoma, and soreness in the eyes may develop. Rarely, due to the use of the drug, heart failure, hypertension, palpitations occur. In practice, cases of the development of nosebleeds, rhinitis, pharyngitis have been reported. In some patients, increased bronchial secretion was noted. Among the undesirable consequences, experts point to the likelihood of developing infections in the upper respiratory tract, pneumonia, and hyperventilation.
The medication can cause a delay in urination, polyuria, swelling, cystitis, dysmenorrhea, vaginitis, menorrhagia, intermenstrual bleeding. In some cases, a weakening of libido was observed when taking the drug (this is indicated by the instruction). "Cetrin" causes back pain, myalgia, arthritis, muscle weakness. Due to therapy, bubble rashes may occur, sweating may increase. With hypersensitivity, a high probability of angioedema. Undesirable effects include seborrhea, photosensitivity, erythema, hyperkeratosis. Among other frequently occurring side effects, one should mention a change (increase, in particular) in weight, diabetes mellitus, fever, general malaise, hot flashes, tenderness in the mammary glands, and dehydration. Due to the treatment, tinnitus, a sense of smell, deafness, and
emotional lability may appear
. If adverse effects occur while taking the drug, you should consult a doctor. Depending on the severity of the condition, a replacement of Cetrin is likely to be required. An analogue to the medicine is prescribed only by the doctor. A specialist can, in particular, recommend such a medication as Zirtek.
Overdose
In case of violation of the prescribed dosage regimen, drowsiness, rash and itching of the skin, anxiety, and delay in urination occur. In case of an overdose, patients also have tremors, fatigue increases, and tachycardia occurs. In the absence of a specific antidote, therapy is carried out in accordance with the clinical picture. To prevent poisoning, the recommendations contained in the instructions should be followed. "Cetrin" refers to a fairly strong means, so uncontrolled reception can lead to serious negative consequences.
Interaction with other medicines. Precautionary measures
Specialists recommend caution when taking medication with sedatives, as well as drugs that affect the central nervous system. The abstract does not contain information on the negative interaction of therapeutic doses of the drug with ethanol. However, experts recommend eliminating the use of alcohol during therapy. As the instruction warns, "Tsetrin" can affect the speed of psychomotor reactions. Therefore, it is not recommended to take funds to persons whose activities are considered potentially dangerous and associated with the management of transport or complex mechanisms. Treatment of children is carried out under the close supervision of a pediatrician. In the absence of effectiveness, the development of side effects or with exacerbation of the symptoms of the disease, you should suspend therapy and visit a specialist. The medicine is allowed for use for two years. Before taking the medication, you should consult a specialist and read the annotation carefully.