The drug "De-Nol" is an anti-ulcer agent, which includes bismuth subcitrate as an active component . This medicine has an effect on the processes that occur when ulcers form. Its main effect is due to astringent, antimicrobial and gastrocytoprotective properties.
Indications for the use of the drug "De-Nol"
Reviews of gastroenterologists recommend the use of a medication for various ailments of the digestive tract that occur in violation of the integrity of the mucous membrane of the stomach or duodenum. Indications include stomach and intestinal ulcers that occur as a result of exposure to Helicobacter pylori, acute and chronic gastritis or gastroduodenitis, digestive mucosal disorders associated with the use of anti-inflammatory non-hormonal drugs. With the help of this medication, functional dyspepsia is treated , as well as changes in bowel movements caused by irritable bowel syndrome.
Contraindications to the use of the drug "De-Nol"
Doctors' reviews and instructions for use prohibit the use of the drug with individual sensitivity to its components, as well as during therapy with medicines containing bismuth compounds. You should not take pills for severe renal failure, as well as children under 14 years of age.
The use of the drug during pregnancy is strictly prohibited. During lactation, breast-feeding should be stopped.
Side effects of the drug "De-Nol"
Reviews of patients taking the drug indicate some negative effects after taking the medicine. These include disorders in the digestive system, constipation or diarrhea, discoloration of the tongue, urge to vomit, allergic manifestations (urticaria, scabies, rashes). With prolonged use of the drug, it accumulates in the brain, which is fraught with the development of encephalopathy. After the end of therapy, all side effects go away on their own.
The drug "De-Nol": analogues
A remedy with a similar therapeutic effect is the preparation "Ventrisol". A similar effect is due to the presence of bismuth dicitrate in the composition of the drug . As well as the drug "De-Nol", its analogue "Ventrisol" has antiseptic and astringent properties, is prescribed for gastrointestinal pathologies and has similar contraindications and side effects.
The drug "De-Nol": a combination with other drugs
The effectiveness of the drug decreases with the simultaneous use of dairy products or antacids. Therefore, the interval between taking these drugs (products) and De-Nol should be at least half an hour. In order to prevent severe side effects, the drug can not be used together with other bismuth preparations.
Independent use of the drug is unacceptable: its dosage and duration of therapy are established only by a gastroenterologist individually for each patient. On average, take four tablets in two or four doses per day. The duration of therapy is from one month to two.
If Helicobacter is detected in the body, treatment is carried out simultaneously with the administration of tetracycline group preparations or funds based on clarithromycin, amoxicillin or metronidazole. In addition, for two weeks it is required to take the so-called proton pump inhibitors - antisecretory drugs (for example, Omeprazole).
Overdose of the drug "De-Nol"
Reviews of pharmacists and instructions for the use of this drug indicate that with an overdose of it, you can observe symptoms similar to acute poisoning. In patients, the digestive organs are disturbed, rashes appear on the oral mucosa and body, and dark spots appear on the gums. With regular intake of high doses, irreversible pathological processes in the kidneys occur. Overdose treatment is performed by standard methods: gastric lavage, intake of activated charcoal and saline laxative.