What is Xizal Medication? An analogue of this drug, its indications, instructions for use, price, release form and composition will be presented a little further. We will also tell you about whether this drug has side effects and contraindications.
Composition, description, form and packaging
What substances does the Xizal medication contain? Instructions for use (analogues of this agent may have the same composition) states that the active substance of this drug is levocetirizine dihydrochloride. As additional substances, such a preparation contains sodium acetate, purified water, sodium saccharinate, propyl parahydroxybenzoate, propylene glycol, methyl parahydroxybenzoate, 85% glycerol and acetic acid.
In what form is the Xizal medication released? Analogs are cheaper and the drug itself can be purchased in pill form. Their film shell consists of opadra Y-1-7000 and macrogol 400. They come on sale in blisters of 7, 14, 10 or 20 pieces in one cardboard package.
In addition to tablets, there is another form of this drug. Drops for oral administration are available in dark colored bottles with a dispenser of 20 and 10 ml.
Pharmacological action of the drug
How does Xizal work? Cheap analogues and more expensive have the same effect. According to experts, such a medication is a tool with a pronounced antihistamine and anti-allergic focus. The blocking effect of this drug on histamine receptors is several times higher than that of Cetirizine.
It should be especially noted that this medication does not have any effect on the antihistamine phase of an allergic reaction. The principle of action of this drug is that it is able to prevent the development of allergies. If this condition has already occurred, then the drug noticeably facilitates its course.
What other properties does the Xizal medication have? The analogue of this tool and the drug itself has an antipruritic and antiexudative effect. The active substance of this drug slows down the movement of eosinophils, reduces the permeability of the walls of blood vessels, and also reduces the activity of cytokines and inflammatory mediators.
This drug has virtually no effect on cholinergic and serotonin receptors. He also has no sedative effect.
Pharmacokinetic features of an antihistamine
How long is Xizal absorbed? Instructions for use (price reviews, analogues of this drug are presented a bit further) indicate that when taken orally, the drug is absorbed quite quickly from the digestive tract. In this case, a slight metabolism of its active substance may be observed.
If you take the medicine with food, then the level of its bioavailability, as well as the rate of absorption do not change at all.
The highest concentration of levocetirizine in the blood is noted 60 minutes after taking the medication inside. As practice shows, the clinical effect of this drug lasts a little more than 24 hours.
The half-life of the drug in adults is 6-10 hours, and in young children a little less.
About 13% of the drug leaves the body through the intestines, and 85% through the kidneys.
In sick people who suffer from renal failure, the half-life of the drug is significantly extended. As for patients undergoing hemodialysis, they only have 10% of the active substance excreted.
It should be noted that the main component of the drug can quite easily penetrate into breast milk.
Indications for use of the drug
Why is Xizal medication needed? An analogue of the drug and the drug itself are prescribed for such conditions as:
- the presence of itching;
- Quincke's edema;
- nasal congestion;
- sneezing
- hay fever;
- lacrimation
- inflammation of the mucous membranes of the eye and nose (for example, with conjunctivitis);
- rhinorrhea;
- chronic or seasonal conjunctivitis, as well as allergic rhinitis;
- urticaria, flowing in a chronic form;
- allergic dermatoses.
Contraindications to the use of the drug
Under what conditions can the Xizal medication not be used? The analogue of the mentioned funds and the drug itself are contraindicated for people with hypersensitivity to the active substance, as well as to other elements that are part of the drug. It should also be noted that the Xizal medication is not prescribed for people with renal failure (especially with pronounced).
During lactation and during pregnancy, taking this medication is also contraindicated.
The drug "Xizal": instructions for use
We will present analogs, patient reviews about the mentioned medication at the very end of the article. As for this section, we will tell you about how and in what dosage such a drug should be taken.
Before taking Xizal drops, it is necessary to dilute in warm drinking water (in an amount of 10 ml), and then take it inside with a teaspoon.
Consider the dosage of medicinal drops:
- for children 2-6 years old, the drug is given 5 drops twice a day;
- children from 6 years old, as well as adult patients, are prescribed up to 20 drops per day (can be taken at one time).
As for the Xizal tablets, adult patients and children over 6 years old must be taken on an empty stomach or with food. In this case, the drug should not be chewed. It is simply washed down with plain water. The dosage of this form is as follows: 1 tablet 1 time per day.
Signs of a drug overdose
What symptoms can occur if you take high doses of the drug Xizal? Analogs are cheaper and more expensive, as well as the medication itself can cause undesirable symptoms such as drowsiness, irritability, increased irritability and anxiety, which turns into drowsiness.
With these symptoms, the patient must undergo a gastric lavage or provoke vomiting. After this, symptomatic and supportive therapy is required.
There is no special antidote for poisoning with such a drug.
Adverse reactions after taking the drug
The most common side effects that occur while taking the medication include fatigue, drowsiness, dry mouth, headaches, asthenic syndrome, and abdominal pain.
Very rarely, patients experience adverse reactions such as diarrhea, blurred vision, hallucinations, nausea, pruritus, cramps, dyspnea, urticaria, muscle pain, rash, shortness of breath, tachycardia, and hepatitis.
Isolated cases of weight loss, angioedema and anaphylactic shock are also noted.
Drug interaction
With the combined use of the drug "Xizal" with "Theophylline", the half-life of levocetirizine may increase.
It is highly recommended not to use alcoholic beverages during therapy with this drug, as well as medicines that have a depressing effect on the central nervous system. This is due to the fact that such a combination can cause an uncontrolled increase in their effects.
The drug "Xizal": instructions, price in pharmacies, analogues
Now you know what such a medicine as Xisal is intended for. His instructions for use and dosage have been described in detail a little higher. Now I want to tell you how much such a drug costs in pharmacies.
You can buy a medicine in tablets for 250-290 Russian rubles (1 pack of 7 tablets). If you need to buy 10 pieces, then you have to give about 270-360 rubles. The cost of a package of 14 tablets ranges from 430-530 rubles.
As for drops for oral administration, they cost between 350-420 rubles.
Now you know how much Xisal is worth. The price (we will consider the analogues of the medication right now) of this medicine is approximate and may vary depending on your place of residence and the pharmacy chain.
If the remedy mentioned is contraindicated, then you can replace it with one of such drugs as Suprastinex, Eltset, Gletset, Aleron, Cesera or Alerzin (after consulting a doctor). Almost all of them are cheaper than the original (up to 230 rubles).
Reviews of patients about the drug "Xizal"
There are a huge number of reviews about the drug "Xizal." People taking this medication for allergic reactions claim that this is the most effective and effective remedy. Also, patients note its relatively low cost and ease of administration.
In addition to the positive, negative reviews are left about the drug in question. Some patients taking Xizal speak of its strong hypnotic effect. However, experts argue that such a phenomenon can only occur when taking high doses of the drug. But, despite this, during treatment with this drug should be extremely careful when driving vehicles or working with complex mechanisms.