Do you know what “Furazolidone” is? Why are these pills prescribed by doctors and how to take them? We will answer these and other questions in the materials of this article.
The form of release of the drug, its composition
About what “Furazolidone” helps, we will tell below.
According to the instructions, said agent is made in the form of tablets. Their main component is furazolidone. Also, the drug contains such an auxiliary substance as lactose.
In what packaging is Furazolidone medicine sold? Instructions for use (analogues of this tool are listed below) of these tablets are contained in a cardboard box. As for the drug itself, it is packaged in cell or non-cell packaging.
Mechanism of action
What helps Furazolidone? According to the instructions, it is an antibacterial drug. Its pharmacological effect directly depends on the prescribed dosage. When using a small amount of furazolidone, the medication exhibits a bacteriostatic effect. If the dosage of the drug is increased, then it has a pronounced bactericidal effect.
Speaking about the drug "Furazolidone" (from which these pills, we learn below), we can not say that this product is characterized by some immunostimulating effect.
The antimicrobial effect of the drug in question is explained by the ability of its nitro groups to recover to the amino group. This happens under the influence of bacterial enzymes.
The components that were formed during the restoration of the nitro group have a toxic effect. In addition, they block a number of biological and chemical processes in bacterial cells, and also violate the integrity and structure of their shell.
When using furazolidone, a blockade of (irreversible) NADH is observed, as well as inhibition of the tricarboxylic acid cycle. Such an effect contributes to the disruption of the cellular respiration of microorganisms, the functioning of the cytoplasmic membrane, as a result of which the death of harmful microorganisms occurs.
Features of the tool
Due to the ability of the furazolidone molecule to form complex compounds with nucleic acids, this agent disrupts the synthesis of proteins in bacterial cells, which inhibits the reproduction and growth of harmful microorganisms.
What helps Furazolidone? This tool works well with reduced immunity. Such properties of the drug are associated with its ability to increase activity (phagocytic) and leukocyte complement titer. In addition, the main substance of this agent reduces the production of toxins by bacteria, as a result of which the overall clinical picture improves much earlier than microbiological tests show a negative result.
Drug properties
What properties are characteristic for the drug "Furazolidone"? What does this remedy help with? Specialists have proven that furazolidone is able to inhibit monoamine oxidase. This feature of the drug leads to the development of mild excitement in patients.
It should also be said that the said drug increases the body's sensitivity to ethanol. This can lead to the development of vomiting and excessive nausea when the drug and alcohol are used together.
So what helps Furazolidone? This drug is highly effective in the treatment of diseases of an infectious nature that are caused by strains of bacteria that are sensitive to the effects of furazolidone. In addition, the aforementioned agent works well with respect to protozoa and candida fungi. However, it should be noted that before prescribing this medicine, sensitivity tests must be performed.
According to doctors, the medication in question has almost no effect on the causative agents of anaerobic as well as purulent infections.
The drug "Furazolidone": what helps?
Tablets with this name are often used to treat people with infectious diseases in the urogenital area. In addition, they are very effective in the presence of diseases of the digestive tract and skin.
Answering the question of what “Furazolidone” treats, one can safely list the following conditions: typhoid, bacillary dysentery, food poisoning, paratyphoid, diarrhea of infectious origin, vaginitis, enterocolitis, urethritis, giardiasis, Trichomonas infection, Trichomonas colitis, cystitis, cystitis wounds and burns, pyelitis.
Drug bans
Are there any contraindications for Furazolidone tablets (this remedy helps cystitis very well)? According to the instructions, the medication in question cannot be used for:
- lactase deficiency and lack of glucose-6-phosphotdehydrogenase;
- hypersensitivity (individual) to the components of the drug;
- chronic renal failure (including in the terminal stage) ;
- under the age of one month;
- breastfeeding;
- impaired kidney function;
- pregnancy
- diseases of the liver and NA;
- driving and working with dangerous machinery.
Instructions for use of tablets "Furazolidone"
The medication in question helps very well from diarrhea. This is due to the fact that it is able to inhibit the growth and reproduction of bacteria that contribute to the development of dysbiosis.
This drug is taken orally. The tablet must be swallowed in its entirety, without crushing and chewing, but only with plenty of liquid.
The drug should be taken only after a meal. The duration of their treatment, as well as the dosage of the drug, is determined by the attending doctor individually for each patient (depends on the nature of the disease and individual characteristics of the person).
Will Furazolidone help with rumbling in the stomach? Of course it will help. For adult patients, 2-3 tablets of the drug are prescribed four times a day for the treatment of foodborne infections, paratyphoid and dysentery. The duration of the course depends on the severity of the disease and is approximately 5-10 days.
The medication in question can be used in cycles. In this case, it is prescribed at 0.1-0.15 g four times a day for 3-6 days, after which they take a short break of 3-4 days. Further, medication is resumed according to the same scheme.
For the treatment of giardiasis, this drug is prescribed (for adults) at 0.1 g four times a day.
For the treatment of trichomonas urethritis , 2 tablets of the drug with the same multiplicity are used. The duration of the course in this case is 3 days.
For the treatment of trichomonas colpitis, adult patients are recommended to take 0.1 g of the drug three times a day. For the best therapeutic effect, the drug in question is combined with drugs that also contain furazolidone, but only in the form of rectal and vaginal suppositories. The duration of the general course of therapy with this drug is 1-2 weeks. In this case, the duration of oral administration of the drug should not exceed three days.
The maximum dosage (single) for adults is 0.2 g, and the daily dosage is 0.8 g.
For children for the treatment of foodborne illness, paratyphoid and dysentery, the dose of this drug is determined depending on body weight and age. The maximum duration of therapy in this case is 10 days.
For the treatment of giardiasis, children are usually prescribed 10 mg / kg of the drug per day. It is advisable to divide the above amount of medication into 4 doses.
For the treatment of infected burns and wounds, the drug is recommended to be used in the form of wet-drying gauze dressings or irrigation. To do this, you must first prepare a solution of furazolidone, the concentration of which will be 1: 25000.
Side effects
According to the instructions, the agent in question is low toxic. Although in some cases, against the background of its administration, such side effects as:
- anorexia, skin rash, nausea, urticaria;
- vomiting, itching, pain in the epigastric region, Quincke's edema.
In order to reduce the severity of such phenomena, the drug is recommended to drink plenty of fluids. Antihistamines and B vitamins should also be used.
In case of severe adverse reactions, the medication should be discontinued, after which he will immediately contact the attending doctor.
With prolonged use of the drug, the patient may develop hemolytic anemia and methemoglobinemia (mainly in newborns and infants). In addition, the drug under consideration is characterized by adverse reactions such as shortness of breath, cough, hyperthermia, and neurotoxic effects.
Overdose of pills
In case of an overdose of this agent, toxic liver lesions are observed in people, including acute toxic hepatitis. It is also possible the development of polyneuritis and hematotoxic effects of the active substance.
Drug Interactions
When taking Furazolidone together with drugs that change the pH of urine, a change in the rate of excretion of its active substance is observed.
With the simultaneous use of tetracycline and aminoglycosides enhance the pharmacological effects of furazolidone, and when combined with “Ristomycin” and “Chloramphenicol”, the process of hematopoiesis is inhibited.
When taking furazolidone with alcohol, disulfiram-like reactions develop.
The drug in question is not prescribed together with antidepressants, ephedrine, monoamine oxidase inhibitors, tyramine, amphetamine and phenylephrine. This is associated with a risk of hypertensive effects.
Analogs and reviews
You can replace the drug in question with such means as Betadin, Lactozhinal, Geksikon, Chlorhexidine, Hypozol, Trichomonacid, Daphnegin, Macmirror, Depantol, Iodoxide, Iodovidone ".
Reviews of patients about this medication are mostly positive. They claim that "Furazolidone" proves to be a very effective antibacterial drug. It well eliminates the signs of cystitis, and also copes with other problems in the genitourinary area and treats dysbiosis.
In addition to positive messages, negative reviews are left about this drug. They say that Furazolidone tablets cause side effects such as vomiting, skin rash, nausea, and urticaria.