An effective antihypertensive drug, a selective agonist of imidazoline receptors is the drug "Physiotens". Patient reviews say that the tool helps to reduce pressure for diabetics and people with increased body weight.
Features of hypertension
Many people are affected by heart and vascular diseases. However, in women these deviations develop later than in men. But they proceed much more complicated and are characterized by increased blood pressure, more pronounced painful symptoms. Hypertension often develops along with other pathologies: obesity, diabetes, abnormalities in the liver and kidneys, and a malfunction in lipid metabolism.
Along with an increase in body weight, there is a disruption in the work of the SNA, which is the main cause of increased pressure and the formation of hypertension. The hormones secreted by the symptomatic nervous system contribute to the narrowing of the lumen of the vessels, as a result, the heart has to push blood to deliver oxygen to tissues and organs with effort, under high pressure, thus developing hypertension, which must be treated with a medication. One of the drugs to curb high blood pressure is Physiotens.
Composition and form of release
A medicine is produced in the form of film-coated tablets. The main active ingredient is moxonindine. Auxiliary components include magnesium stearate, crospovidone, povidone, lactose monohydrate.
Pharmacological properties
The active substance of the drug has a central hypotensive effect. Moxonidine in brain stem cells selectively stimulates sensitive receptors that are involved in the reflex and tonic regulation of the nervous symptomatic system. As a result, there is a decrease in peripheral symptomatic activity and blood pressure. Numerous studies (placebo-controlled, randomized, double-blind) prove the effectiveness of Physiotens. Reviews of patients confirm that the medication differs from other antihypertensive sympatholytic agents in that it does not cause dry mouth, and when it is used, there is no sedation.
Pharmacodynamics and pharmacokinetics
After internal administration, the agent is 90 percent absorbed from the gastrointestinal system. The maximum concentration of the active substance in blood plasma is observed after an hour. Eating on the pharmacokinetics of moxonidine has no effect.
The main metabolite of the active substance is dehydrogenated moxonidine, as well as guanidine derivatives. The half-life of moxonidine occurs within 2.5 hours, and after a day, the element is 90% excreted by the kidneys and through the intestines.
In patients with arterial hypertension, compared with healthy people, no changes in the pharmacokinetics of moxonidine were noted. Slightly kinetic parameters may vary in elderly patients, which is associated with a decrease in the intensity of metabolism of moxodinine, as well as its higher bioavailability.
Due to the lack of pharmacokinetic studies, the use of the drug is not recommended for patients under adulthood.
The drug "Physiotens" instructions for use
Patient reviews say that tablets should be taken orally, regardless of the use of food. Typically, the drug is used in an initial daily dosage of 200 mcg. The maximum single volume of the drug should not exceed 400 mcg, the daily amount divided into two doses is 600 mcg. Patients with moderate to severe heart failure undergoing hemodialysis are advised to take up to 200 mcg of the drug per day. With good tolerance, the volume of the drug can be doubled.
Overdose
With excessive use of the drug, various negative symptoms can occur. So, pills for pressure “Physiotens” (reviews indicate this) can provoke a headache, drowsiness, sedation. If the dosage is exceeded, the pressure can drop significantly, pain develops in the epigastric region, dry mouth, bradycardia, vomiting, asthenia, increased fatigue, dizziness are observed. In addition, patients may be disturbed by hyperglycemia, tachycardia, as well as a short-term increase in pressure.
For the treatment of signs of overdose, specific antidotes have not been developed. With arterial hypotension, it is necessary to introduce dopamine and increase the fluid content in the body. Symptoms of bradycardia can be stopped with atropine. In case of overdose, it is recommended to use alpha-adrenergic antagonists to reduce or eliminate arterial paradoxical hypertension.
Drug interaction
The combination of medicines is not always given due importance. However, when taking two or more drugs, a weakening or increased mutual effect may be observed. In the first case, the medicine will not give the expected result, in the second situation there is a risk of overdose and even poisoning.
So, when using antihypertensive drugs (thiazide diuretics, calcium slow channel blockers) together with the Physiotens medication (reviews warn about this), a hypotensive additive effect may develop. The concomitant use of tricyclic antidepressants reduces the effectiveness of central anti-hypertensive drugs, so they should not be used with the Physiotens medicine.
In addition, the tool allows you to improve cognitive impaired function in patients taking the drug "Lorazepam". The use together with benzodiazepines can cause an increase in the sedative effect. When prescribed with the drugs "Digoxin", "Glibenclamide", "Hydrochlorothiazide" there is no pharmacokinetic interaction.
Use during pregnancy
Various drugs adversely affect the fetus or embryo, leading in some cases to malformations of the child. Also, the components of the drugs taken with breast milk are able to enter the infant body and act on it. Therefore, during pregnancy and lactation, it is necessary to take medications with increased caution.
Not an exception - and the drug "Physiotens". Its reception is permissible only after consultation with a specialist, carefully weighing the possible benefits for the mother and harm for the child. Since the active ingredient passes into breast milk, during the feeding of the baby, it is necessary to abandon its use or stop feeding the baby.
Experimental studies conducted on animals have not revealed a direct or indirect effect of the drug on pregnancy, embryonic (embryonic) or postnatal development.
Side effect
Like most medicines, Physiotens tablets (reviews indicate this) cause negative reactions from the body. Usually this occurs when using the drug in maximum quantities, over a long period or with individual intolerance of the active component.
The nervous system reacts to the use of the drug with headache, drowsiness or insomnia, dizziness. These symptoms are observed quite often. On the part of the cardiac and vascular system, negative reactions occur in rare cases, are manifested by a sharp drop in pressure, orthostatic hypotension. In addition, patients after taking the medicine experience dry mouth, nausea, and they may experience dermatological reactions in the form of angioedema, itching, or skin rash. If there are side effects, the medication should not be canceled, negative symptoms after three weeks of use, as a rule, disappear. However, it is still necessary to contact a specialist.
Contraindications
Not in all cases, you can take the medicine "Physiotens". Reviews of doctors say that it is not recommended to take the medication for:
- severe bradycardia (heart rate less than 50 beats per minute);
- SSSU;
- hereditary intolerance or malabsorption of galactose (glucose)
- lactase deficiency;
- hypersensitivity to the components of the product;
- children and adolescents until adulthood.
With caution, prescribe a drug in the terminal stage or severe degree of renal failure, patients who are on hemodialysis, with severe liver failure.
Physiotens tablets: indications for use, reviews, special instructions
The main diagnosis in which doctors prescribe a medicine is arterial hypertension. It should be borne in mind that during therapy it is necessary to carry out systematic monitoring of the states of blood pressure, ECG and heart rate. If you need to cancel the medication, then this should be done gradually.
The tool does not adversely affect the ability to drive mechanisms and vehicles. However, the Physiotens preparation (patient reviews indicate this) must be taken with caution, since it can cause dizziness and drowsiness. This fact must be taken into account by people involved in dangerous, requiring constant concentration of attention, activities.
Storage conditions, analogues and price
Tablets must be kept in a place where children cannot reach. Subject to storage rules (temperature up to 25 degrees C, a dark dry place), the medicine will not lose its pharmacological properties within two years. You can buy the Physiotens medication (reviews confirm this) by prescription in pharmacies. The price of packing tablets (0.2 mg) is 275 rubles. If for some reason there was no medicine in the pharmacy, then you need to look at the analogues: Cint, Moxonitex, Moxonidine, Moxogamm.
Reviews on the drug "Physiotens"
Many patients speak of this medicine as a quality effective remedy. People say that they have been taking it for many years, the drug lowers blood pressure well, and there is no side effect. Some attribute the disadvantages to the high cost of Physiotens tablets. Reviews indicate good compatibility with other hypertensive drugs.