Testimonials about Insulin Tresiba should be of interest to all patients who have encountered a serious illness such as diabetes in their life. This is a modern drug of extra long duration, which is produced by the international company Novo Nordisk, with headquarters in the suburbs of Copenhagen. Many argue that it significantly exceeds the effectiveness of many other known insulin-containing drugs, the action of each injection lasts up to 42 hours. All this makes it even easier and more reliable to maintain blood sugar levels at a stable level. In this article we will give the main points of the instructions that are attached to this drug, the reviews of patients who have already tested the drug.
Description
In the reviews of “Tulin insulin,” many argue that they have already evaluated the effectiveness and benefit of this drug. In fact, it is an analogue of human insulin. It should be understood that the entire insulin molecule is not repeated. With the help of the achievements of biotechnology, it was possible to change it, which allowed her to acquire fundamentally new properties. It is known that initially this drug was created only for patients with type 2 diabetes mellitus, but now it turned out that it has been successfully used in the first type of this disease.
The action of "Tresib Insulin" is on the human body for more than 40 hours. However, manufacturers recommend daily injections, although the drug works for more than one day.
On the territory of Russia, it is known under the two INNs "Tulin insulin" - this is Tresiba FlexTach and Tresiba Penfill. The first form is a disposable pen that is thrown away after insulin runs out. The second form is cartridges for refillable syringe pens. It is noteworthy that they are suitable not only for this drug, but also for NovoPen.
The new drug is recommended for use in diabetes of the first and second type. It is worth remembering the contraindications present, it should be used especially carefully by pregnant and lactating women, since its effects on their body have not been properly studied.
Operating principle
Tresiba FlexTouch insulin has the same operating principle as the Lantus drug, well known to many diabetics. After molecules enter the human body, they are combined into larger formations, which are also called multicameras. They create a depot of the drug. Then small pieces break off from it, which allows achieving such a long-lasting effect.
Manufacturers claim that the duration of the drug is more than 40 hours. According to some studies, it can even reach exactly two days. In this regard, it may seem that this agent can be used less frequently than regular insulin. Not every day, but once every two days. But in reality this is not so. Experts strongly advise against skipping daily injections, so as not to weaken the effect and effect produced by this drug.
Studies of the new "Treshiba Insulin" have proven that the drug equally effectively affects patients of young and old age. There were also no negative reviews from patients who are also worried about problems with the liver and kidneys.
The main active ingredient of the prolonged "Insulin Tresib" - dehydlude proved to be beneficial. Compared to the glargine used in Lantus, it causes significantly fewer cases of hypoglycemia.
Dosage
The instructions for use of "Insulin Tresiba" detail the dosage for each category of patients. The drug is administered exclusively subcutaneously, intravenous administration is contraindicated. This should be done once a day.
It is worth noting that the drug is compatible with all sugar-lowering drugs that are available in tablets, as well as with various other types of insulin. As a result, it is prescribed separately, and in some cases as part of complex therapy.
If the patient administers insulin initially, the dose should be 10 units. Then it is gradually adjusted, which will depend on the individual needs of each person.
If the patient receives some other type of insulin, and then decides to switch to Treshiba, the initial dose is calculated in a proportion of one to one. This means that insulin dehydlude should be injected exactly as much as basal insulin was injected.
If the patient for a certain time was in double mode of receiving basal insulin, then the dose should be determined with your doctor individually. It is likely that it will decrease. The same situation will be observed if the level of glycated hemoglobin in the patient is less than 8%.
Of course, in the future, the patient will definitely need an individual dose adjustment under the control of the level of sugar contained in the blood.
Side effects
The instructions to the "Tulin insulin" describe in detail the side effects that this drug can provoke. Unfortunately, you can not do without them, as with any pharmacological drug.
Among the most common problems can be found complaints of hypoglycemia. Although it is less common than with most other insulin-containing drugs.
Other side effects include:
- allergic reactions (e.g., anaphylaxis or urticaria);
- hypersensitivity reaction can occur in the form of frequent stools, numbness of the tongue, skin itching, fatigue);
- lipodystrophy, which appears at the injection site (unpleasant consequences can be avoided by regularly changing the injection site);
- local reactions and manifestations at the injection site (swelling, hematomas, connective tissue nodules, redness, thickening, itching).
In the instructions for use of "Insulin Tresib" it is advised to store it in the same conditions as other similar drugs. It is important for them to avoid freezing and overheating, otherwise they will lose almost all of their healing properties.
Indications and contraindications
The instruction for "Tresiba Insulin" unequivocally recommends the use of this drug in the treatment of diabetes in adult patients.
In this case, the drug is contraindicated in the following categories of patients:
- children and adolescents under the age of 18;
- pregnant women;
- nursing mothers;
- patients with individual sensitivity to the main active substance of the drug or any of its auxiliary components.
Structure
The drug is available in the form of a solution for subcutaneous administration. The main active ingredient is insulin degludec.
Phenol, glycerol, zinc, hydrochloric acid, and also the water necessary for injections are used as auxiliary substances in this medicine.
In one package, five syringes with 3 ml of substance in each.
Insulin degludec is able to specifically bind to the receptor of human endogenous insulin. Directly interacting with him, he realizes his pharmacological effect, which is almost similar to the action of human insulin.
It is worth noting that the hypoglycemic property of this drug is due to the ability to significantly increase glucose utilization. This is due to the binding of insulin itself to the receptors of fat and muscle cells. It is important that in parallel with this, the rate of glucose production by the liver is significantly reduced.
Mode of application
Once again, we note that this drug is intended exclusively for subcutaneous administration. It should not be administered intravenously, as this can lead to the development of severe hypoglycemia. It is also forbidden to enter intramuscularly, since in this case there is a risk that the absorption of the main active substances changes. In this case, it is almost impossible to predict how this tool will operate in the future. Among the caveats, one thing to keep in mind is that Tresiba Insulin cannot be used in pumps.
The drug is administered subcutaneously in the region of the anterior abdominal wall, thigh, or in the region of the shoulder. Do not forget to regularly change the injection site within the same anatomical region to minimize the risk of lipodystrophy.
Externally, the drug is a pre-filled syringe pen, which is designed for use with injection disposable needles.
It is important that the drug itself and the needles are intended solely for individual use. Refilling the syringe pen cartridge is prohibited.
Monitor the condition and appearance of the solution. You can not take it if the solution has ceased to be colorless and transparent. It also loses all its beneficial properties after it has been frozen. Throw away the needle without fail after each injection.
Carefully observe local requirements that apply to the disposal of used medical supplies in your area of residence. The pen is used by the patient on his own after he has mastered its use under the supervision of a doctor or nurse.
There are several basic steps into which injection procedures can be divided. To begin with, the syringe pen should be prepared for use. To do this, start by carefully checking the dosage and name on the label of the syringe pen. Make sure it contains the medicine you need. It is especially important to pay attention to this stage if you are simultaneously or alternately taking several different types of insulin. In this case, you need not to get confused so as not to harm yourself, and the effect of using the drug was maximum. Only then remove the cap from the syringe pen.
Make sure that the drug contained in the syringe is colorless and transparent. To do this, pay attention to the window of the insulin residue scale. If the product has become cloudy, it can not be used.
Remove the protective sticker from the disposable needle. Put the needle on the syringe pen, and then rotate it so that the needle rests on it as tightly as possible. After removing the outer cap, do not discard it. You will need it after completing the injection to safely remove the needle. But the inner cap of the needle can immediately throw it away. Never try to put it back on, as in this case there is a high probability of pricking.
Make sure that a drop of insulin appears at the very tip of the needle. This must be done in order to check the drug intake in the syringe.
For each injection, use a new needle to exclude the possibility of clogging, as well as infection and the introduction of the wrong dose of the drug. Do not use the needle if you find that it is damaged or bent.
Overdose
In some cases, there is a possibility of an overdose when using this drug. It is worth noting that a specific dose, which leads to a similar effect, has not been established. Hypoglycemia, which most diabetics fear, usually develops gradually.
The patient is able to cope with mild hypoglycemia on his own by taking sugar-containing foods or glucose. Patients with diabetes are advised to carry sugar-containing products on an ongoing basis.
In case of severe hypoglycemia, when the patient is unconscious, he should be given glucagon or a dextrose solution. You should also introduce dextrose in the event that a quarter of an hour after the administration of glucagon, the patient does not regain consciousness. When consciousness recovers, it is recommended that you take carbohydrate-rich foods as soon as possible in order to prevent relapse.
Patient Reviews
Reviews of diabetics about Tresib's Insulin can often be found just enthusiastic. An injection is usually done at night. This allows a person with a normal sugar level, in a normal state, to wake up in the morning.
The main thing is that the dose is chosen correctly. In the reviews of diabetics with experience on "Insulin Tresib" it was noted that before the appearance of this variety of this drug, all previous variations acted much less time, which caused a lot of trouble. Fasting glucose was very problematic.
At the same time, in reviews and Insulin Tresibe, many emphasize that the important advantage of the drug lies in the fact that with its help it is possible to more smoothly lower blood sugar compared to many other similar means. For example, with "Lantus" or "Levemire." In addition, the risk of developing hypoglycemia is significantly reduced, although it still remains in case of overdose. This is noted in the reviews and in the instructions for use of Insulin Tresib.
Negative
With all the positive points, it is worth noting that negative opinions about this drug are still found. True, negative reviews about Tresib's Insulin are associated not with its effectiveness, but with high cost.
It should be noted that only very wealthy patients can afford it, since this drug is much more expensive than many other analogues. If you have such free money, you should discuss the transition to a new insulin with your doctor. We emphasize that with diabetes, many drugs are prescribed individually, depending on the condition of the patient. In addition, it is important to determine the dosage based on the health status of a particular patient.
It should be noted that Insulin Tresiba currently costs about three times more expensive than Levemir and Lantus, which are also actively used in diabetes mellitus by many patients.
Experts who are close to the pharmaceutical business note that in the coming years one can count on the appearance of analogues, the properties of which will be no less impressive than that of Insulin Tresib. You still have to carefully read the reviews and instructions for these drugs, but you don’t have to rely on these drugs to be cheaper. This is mainly due to the fact that in the world at present there are only a few reputable companies that are engaged in the production of modern and high-quality insulin. At the same time, there is an opinion that there is a corporate agreement between them that allows them to maintain prices at a stable high level.