Functional disorders of the gastrointestinal tract were encountered by each person. Most often, discomfort in the epigastric region occurs due to poor and improper nutrition. To improve digestion and accelerate gastric emptying, gastroenterologists recommend taking special medications. One of them includes the Domidon medication. Instructions for use, reviews and indications of this drug are presented below.
Form, composition, packaging of the medicinal product
The drug "Domidon", the instruction of which is in a package of cardboard, is available in the form of tablets. They contain domperidone, as well as ingredients such as lactose monohydrate, povidone, corn starch, microcrystalline cellulose, titanium dioxide, pregelatinized starch, magnesium stearate, sodium lauryl sulfate, polyethylene glycol 4000, hydroxypropylmethyl cellulose 75 or sepifancilm.
On sale this tool comes in contour cells.
Pharmacology
What is a medicine like Domidon (tablets)? Instructions for use claims that it is a stimulant of gastrointestinal motility. Its principle of action is explained by the ability to block D2-dopamine receptors. As a result of this effect, the duration of peristaltic movements in the duodenum and antrum of the stomach increases. The emptying of these organs is also accelerated and the tone of the esophagus (lower sphincter) increases.
This medication does not have any effect on gastric secretion. Its antiemetic effect is explained by a combination of gastrokinetic effect, as well as antagonism to dopamine receptors in the trigger region of chemoreceptors, which are located outside the BBB. In addition, this drug eliminates hiccups and nausea.
Kinetic characteristics
What kinetics is typical for the Domidon medication? Instructions for use reports that this tool is quickly and fully absorbed from the intestine. It undergoes metabolism in the liver and the walls of the digestive tract, as a result of which it has low bioavailability (about 15%).
The reduced acidity of the gastric juice and food intake significantly slow down and reduce the absorption of domperidone. Its peak plasma concentration is reached one hour after administration.
The relationship of this medication with plasma proteins is about 91-94%. It penetrates poorly through the BBB, but it passes into breast milk well (its level is approximately 1/4 of the total concentration in the blood).
Biological transformation of the drug is carried out by N-dealkylation and hydroxylation.
The half-life of the drug is 7-10 hours. With renal failure (severe), this indicator increases.
The medicine is removed from the body along with feces and urine.
Indications for admission
In what cases are adults prescribed Domidon tablets? The use of this medication is indicated for vomiting and nausea, as well as pain in the upper abdomen, a feeling of fullness of the stomach and heartburn.
As for children, they recommend this remedy only for nausea and vomiting.
Contraindications
When should you not use the drug "Domidon" (instructions for use, and why it is needed - all this will be described in this article)? Contraindications of this tool are:
- gastrointestinal bleeding;
- hypersensitivity;
- intestinal / stomach perforation ;
- mechanical intestinal obstruction;
- pituitary tumor (prolactin-secreting);
- combination with oral forms of "Erythromycin", "Ketoconazole" or other CYP 3A4 inhibitors, as well as agents that extend the Q – T interval.
The drug "Domidon": instructions for use
The tablets in question should be taken only by mouth, before meals. When taking medicine after a meal, their absorption slows down somewhat.
For children from 12 years of age and adults, this medication is prescribed 10-20 mg three times a day. The maximum daily dose of the drug is 80 mg.
The duration of primary therapy is 4 weeks. If further use of the drug is necessary, consult a doctor.
With the development of renal failure, the frequency of administration of the drug should be reduced. As for liver failure, in this case it is not prescribed.
Side effects
Does the drug "Domidon" contribute to the appearance of adverse reactions? Instructions for use report that such undesirable effects do occur:
- increased prolactin levels;
- anaphylactic reactions ;
- nervousness, agitation;
- edema, lengthening of the Q – T interval, palpitations, disturbance of the rhythm and heart rate;
- dry mouth, extrapyramidal disorders, headache, thirst, insomnia, irritability, dizziness, drowsiness, lethargy, convulsions;
- gastrointestinal disorders;
- gynecomastia, galactorrhea, amenorrhea;
- itching, dysuria;
- frequent urination, skin rash;
- stomatitis, conjunctivitis;
- asthenia, leg pain;
- increased levels of AsAT, AlAT and cholesterol.
Special recommendations
What should the patient be informed about before prescribing Domidon? Instructions for use states that this tool can not be combined with antisecretory and antacid drugs.
For the treatment of children under the age of 12 years with a body weight of less than 35 kg, this medication should not be used.
During therapy with this drug, it is necessary to refrain from driving vehicles and working with dangerous mechanisms.
Consumer Reviews
Now you know what features are characteristic of the Domidon medication. Instructions for use, and why it is needed, we also described above.
Most consumers using this remedy report that it effectively eliminates heartburn, hiccups, and nausea. This drug also promotes rapid emptying of the stomach, minimizing the feeling of heaviness and discomfort.
The only drawback of the medication in question is the presence of a large number of side effects.