Lerivon is an antidepressant with a calming and anxiolytic effect.
The drug is available in tablet form. Capsules are film-coated. In each packing the instruction to "Lerivon" is enclosed. Tablets are oval, milky, distributed in blisters. There are twenty capsules per pack.
Structure
According to the instructions to "Lerivon", the active substance is mianserin hydrochloride, in one tablet - thirty milligrams of the active ingredient. Auxiliary trace elements are:
- a salt of magnesium and stearic acid;
- silicon dioxide;
- cellulose ether and methanol;
- starch;
- disubstituted calcium phosphate;
- titanium white;
- ethylene glycol polymer;
- hypromellose.
Pharmacological properties
According to the instructions to "Lerivon" it is known that the active substance belongs to piperazino-azepine compounds, which are not chemically related to tricyclic antidepressants. The spectrum of exposure is based on an increase in the activity of a microelement in the brain, which is ensured by the blockade of interaction with serotonin nerve endings in the central nervous system.
The activity of the drug in relation to the membrane protein is responsible for its soothing properties. In addition, the medication has an anxiolytic effect, which is especially important in the treatment of patients with anxiety diseases and sleep disorders that are associated with depression.
Good tolerance of the drug is noted by people of retirement age, as well as those with heart and vascular diseases. In therapeutic effective dosages, the medication has absolutely no effect on the cardiovascular system and in fact has no anticholinergic activity.
In case of poisoning, less cardiotoxic effects are observed. After oral administration of the drug, the active substance is instantly and well absorbed.
According to the instructions for use with Lerivon, it is known that the maximum content of an active trace element is reached in three hours. Bioavailability is approximately twenty percent. The combination of the active component with blood proteins is approximately ninety-five percent.
The half-life is from twenty-one to sixty-one hours, which is why Lerivon can be used once a day. The active substance is subjected to intense metabolism and is excreted after seven to nine days with feces and urine.
Indications. Contraindications
According to the instructions, the drug "Lerivon" is intended to eliminate depressive conditions of various origins.
Tablets have a number of prohibitions on use, for example:
- Diseases of the liver with severe dysfunction.
- Mania (mental disorder, a painful mental state with a concentration of consciousness and feelings on any one idea).
- Age to eighteen.
- Increased sensitivity to trace elements.
- Liver disease.
- Diabetes mellitus (a serious endocrine disease with severe insulin deficiency).
- Benign proliferation of prostate tissue.
- Angle-closure glaucoma (a type of chronic eye disease that is characterized and manifests itself by bouts of increased intraocular pressure).
- Chronic heart failure.
According to the results of the experiments, the active trace element does not harm the unborn child, and with milk is excreted in small quantities. Nevertheless, the possibility of using Lerivon during an “interesting position” and breastfeeding should be evaluated individually for each patient.
"Lerivon": instructions for use
In the reviews, the doctors, as well as their recommendations indicate that the tablets should be taken orally, swallowed whole and washed down with water. The amount of the drug is set individually, depending on the clinical picture.
The initial dosage is thirty milligrams per day (one tablet). If the result is insufficient, every few days the concentration of the substance is increased until a positive effect is achieved.
The average daily dose for adult patients varies from sixty to ninety milligrams (three tablets). Patients of retirement age may need less drug.
Due to the effectiveness of the drug for better falling asleep, the daily dose should be taken in one application at bedtime, but if necessary, it can be divided into several sessions.
Therapy with the prescribed drug should lead to a good clinical response after thirty days, in another situation it is necessary to increase the amount of medication. If after another month of application there is no positive dynamics, “Lerivon” should be canceled. The duration of the course is from four months to six months.
Side effects
In patients suffering from depressive disorders, there are a number of signs that may be associated with the disease. Therefore, in some situations it is difficult to determine which of the emerging negative reactions relate to taking "Lerivon", and which to any disease.
The negative points that most often occur:
- Agranulocytosis (a pathology in which there is a decrease in the level of leukocytes and granulocytes).
- Granulocytopenia (reduced granulocyte count in peripheral blood).
- Weight gain.
- Hypomania (a condition similar to mania, but less severe in its manifestations).
- Hyperkinesis (pathological, suddenly occurring involuntary movements in one or the whole muscle group, by an erroneous command of the brain).
- Cramps (involuntary sharp contraction of a muscle or muscle group).
- Hypotension (lowering blood pressure by more than twenty percent).
- Bradycardia (decreased heart rate).
- Jaundice staining of the skin and mucous membranes, which is due to an increased concentration of bilirubin in the blood.
- Arthralgia (joint pains that are volatile in the absence of objective symptoms of joint damage).
- Exanthema (an acute infectious disease of young children caused by the herpes virus).
With a sharp cessation of therapy in rare situations, withdrawal syndrome occurs.
Overdose
Acute poisoning, as a rule, occurs in the form of an increase in the duration of a calming effect. In exceptional cases, the following conditions are noted:
- pathological, leading to a violation of the frequency, rhythm and sequence of excitation and contraction of the heart;
- cramps
- blood pressure decrease is more than normal;
- respiratory depression.
Treatment consists of washing the stomach and taking enterosorbents.
Features
The drug is not used to treat children under eighteen years old due to the fact that, according to scientific studies, this age group is most susceptible to suicide.
In addition, there is no information about the safety of children taking the medicine regarding their growth and development. If the medical specialist prescribes Lerivon, the patient should be monitored during therapy.
According to the instructions and reviews for “Lerivon”, one must remember that depressive states are always associated with the likelihood of suicidal thoughts and actions that persist until remission. Therefore, for several weeks, until improvement occurs, patients should be supervised.
Adolescents and people with suicidal conditions are at greatest risk. Therefore, these patients during therapy should be under the constant supervision of a doctor.
Like all antidepressants, Lerivon is able to provoke hypomania in susceptible people who suffer from bipolar depression. In this situation, you must stop using the drug.
Under careful supervision during therapy should be patients with damage to the cardiovascular system, diabetes.
The drug can have a negative effect on psychomotor activity, so during the course you should refrain from the work that requires the greatest concentration of attention.
In case of kidney diseases, medication should be taken with extreme caution. In case of violations of the liver "Lerivon" is contraindicated.
Drug interaction
The drug is forbidden to be taken together with monoamine oxidase inhibitors and for fourteen days after their withdrawal. "Lerivon" can disrupt the exchange of coumarin derivatives, so if necessary, their combination, the person should be under the supervision of a doctor.
The drug does not interact with clonidine, methyldopa, as well as propranolol. However, in patients who receive antihypertensive drugs, it is recommended to monitor blood pressure. The active ingredient is able to increase the inhibitory effect of ethyl alcohol on the nervous system, so during therapy you need to refrain from alcohol, according to the instructions for use.
Lerivon: analogues
The following medicines are substitute drugs:
- Asafen.
- Miansan.
- Venlaxor.
- "Prefaxin".
- Mirzaten.
- "Pyrazidolum".
- "Simbalga".
- Mianserin.
- "Remeron."
- Neuroplant.
It is recommended to store the drug in a place inaccessible to children, at a temperature of two to thirty degrees of heat. Shelf life is sixty months. The medicine is released strictly according to the prescription.
"Pyrazidol"
A nootropic drug that can improve higher brain functions. The drug has a pronounced antidepressant effect, combining a stimulating effect on patients with apathetic depressive disorders. Pyrazidol is available in tablet form. Capsules are flat-cylindrical, milky. Tablets exist in two dosages - twenty-five and fifty milligrams. The cost of the drug varies from 190 to 350 rubles.
Neuroplant
It is a phytopreparation with antidepressant action. Neuroplant is dispensed from drugstores in the form of tablets for oral administration. Capsules are biconvex, brown in color. Tablets are packaged in blisters of twenty pieces. In total, from one to three blisters are packaged.
The main active ingredient is dry extract of St. John's wort herb, which has antidepressant, anxiolytic and sedative effects.
An active microelement has a positive effect on the functioning of the central nervous system. It is believed that the drug is able to inhibit the activity of monoamine oxidase.
The calming effect is associated with the combination of bioflavonoids with benzodiazepine nerve endings, as well as the ability to suppress the effects of adrenaline, serotonin and dopamine.
"Neuroplant" leads to a stable state of emotions, improves mood, sleep, and also helps to increase physical and mental performance.
Indications for taking the drug "Neuroplant" are considered depressive conditions of moderate and mild severity, accompanied by the following negative signs:
- apathy;
- depressed mood;
- decreased performance.
The cost of Neuroplant is 400 rubles.
Lerivon: reviews
Opinions about the drug are very diverse. Some patients note a positive trend, while others say that there is no effect. Another disadvantage is the cost of the drug, it is estimated as quite high. The price of a medicine varies from 1000 to 1300 rubles.
As a result, it can be concluded that the tablets have an individual effect. Therefore, their use can be recommended only by a neuropsychiatrist based on research and symptoms. For most patients, Lerivon is simply indispensable. Widely used in medicine.