The drug "Thiodazine": instructions for use, description, indications, analogues and reviews

In the article, we consider the instructions, indications and reviews for "Thiodazine".

The drug is an antipsychotic antipsychotic medication. The main pharmacological properties of thioridazine are similar to other phenothiazines, however, its clinical spectrum differs significantly from other drugs of this class. On a special insert for the medicine you can find the composition and description of "Thiodazine" and instructions for use. Distinctive features of the drug are: low ability to cause extrapyramidal disorders and its quite pronounced sedative and anxiolytic activity.

Structure

According to the instructions for "Thiodazine", the dosage form of the drug is tablets. The pills are film-coated and have a round shape. The drug is produced in a dosage of 10, 25, 50, as well as 100 milligrams of the active substance.

The medicine exactly repeats the composition of analogues. The instruction to "Thiodazine" indicates that the active substance is thioridazine hydrochloride. Auxiliary components are microcrystalline cellulose along with starch, lactose, polyvinylpyrrolidone, magnesium stearate, sodium methyl paraben, colloidal silicon dioxide and purified talc. The tablet shell is made from a copolymer of methyl methacrylate, butyl methacrylate and dimethylaminoethyl methacrylate. You can also notice a small amount of dye in the composition of "Thiodazine". The instruction confirms this. The tablets are white due to the addition of titanium dioxide - the safest pigment.

Indications for use

The instruction to "Thiodazine" describes this section in great detail. The drug is used in various fields of medicine. It:

• Therapy of schizophrenic exacerbations.
• Treatment of chronic schizophrenia. The drug "Thiodazine" is also indicated for long-term therapy of patients who are in hospital. The presented drug is used for long-term maintenance treatment of outpatients with schizophrenia.

What are the indications for thiodazine? The instructions say that it is also used to relieve anxiety and depression syndromes:

• In the field of psychiatry, this medication is used as monotherapy or as part of a combination treatment for patients suffering from agitated depression.
• In general medical practice, this drug is used as a sedative. In addition, it is used as an anxiolytic for the treatment of various syndromes that are characterized by anxiety, and, in addition, a combination of anxiety and depression. It is also prescribed for the relief of agitation and tension, psychosomatic disorders or emotional disorders.
• For long-term treatment of mixed anxiety and depression. It is suitable for psychotic depression. The main thing to remember is that the instructions for the use of "Thiodazine" must be strictly observed.

Among other things, the tool is used in geriatric practice:

• "Thiodazine" is often used as an antipsychotic and antipsychotic. Thus, the drug is suitable for the treatment of severe cognitive and behavioral disorders in geriatric patients with the presence of organic brain damage of varying severity.
• Assign "Thiodazine" and in the role of anxiolytic or sedative for the treatment of anxiety conditions. In addition, it is used if the patient has mixed anxiety and depressive states, insomnia and senile agitation.
  

The instructions for Thiodazine describe that the medication can be used in pediatric practice. In this case, it is used for the following purposes:

• In the role of antipsychotic, in the framework of the treatment of childhood schizophrenia, and, in addition, severe behavior disorder against the background of the presence of mental retardation and organic brain damage.
• For the treatment of impaired concentration in children with pronounced deviations in behavior.
• A hyperactivity therapy that is resistant to stimulant drugs.
• Treatment of insomnia in children.

In addition to the above, there are other indications for the use of "Thiodazine":

• Treatment of severe behavioral disorders in mentally retarded patients in adulthood, and, in addition, in patients with deficient symptoms.
• In order to reduce the severity of mental manifestations in the form of anxiety, agitation, hostility and hallucinations, in the presence of alcoholic abscess syndrome.
• In the presence of vomiting of central origin.

Contraindications

As the instruction describes, “Thiodazine” has a lot of different contraindications for use. The main ones are:

• The patient’s presence of increased individual sensitivity to thioridazine hydrochloride (the main component of Thiodazine), or any other substance of the drug.
• The presence of coma or severe inhibition of the nervous system.
• With anamnestic information about serious hematological pathologies, in particular, against the background of inhibition of bone marrow hematopoiesis.
• With anamnestic information about the hypersensitivity reaction, for example, against the background of severe photosensitivity or individual sensitivity to other phenothiazines.
• Concomitant use with drugs that extend the QT interval.
• The presence of congenital lengthening of the QT interval (time of repolarization of the ventricles of the heart), and, in addition, a history of arrhythmias.
• With the simultaneous administration of inhibitors or substrates of CYP2D6 isoenzymes.
• Against the background of severe depression of consciousness, including with a coma of any etiology, for example, after using drugs.
• The presence of severe arterial hypertension.
• The presence of arterial hypotension in the patient.
• The presence of severe heart diseases, especially with clinically significant arrhythmias, for example, against the background of ventricular tachycardia.
• The patient has a lactase deficiency along with lactose intolerance.
• The presence of galactose malabsorption.
• Against the background of pregnancy.
• In childhood, up to three years.

All this is described in detail in the instructions for use with "Thiodazine". Reviews about this tool are presented below.

When should the drug be used with caution?

With great care, the drug presented should be used in the following cases:

• Against the backdrop of alcoholism, and in the case of a person's predisposition to hepatotoxic reactions.
• In the presence of pathological changes in the blood, for example, impaired blood formation.
• In the presence of breast cancer. The fact is that due to phenothiazine-induced prolactin secretion, the potential risks of the progression of this disease increase. In addition, the resistance of the therapy to endocrine and cytostatic drugs increases.
• The presence of angle-closure glaucoma.
• Against the background of prostatic hyperplasia with a clinical manifestation.
• If the patient has kidney and liver failure.
• Against the background of peptic ulcer of the stomach and intestines, especially during periods of exacerbation.
• The presence of diseases that are accompanied by an increased risk of thromboembolic complications.
• If the patient has Parkinson's disease, since in this case the extrapyramidal effect is significantly enhanced.
• Against the background of epilepsy, myxedema or chronic diseases accompanied by respiratory failure, especially in children.
• If the patient has Reye's syndrome, as children and adolescents are at increased risk of developing hepatotoxicity.
• Against the background of cachexia and vomiting. The fact is that the antiemetic effect of phenothiazines can mask vomiting, which is associated with an overdose of any other drugs.
• Among other things, this drug is not advisable in old age.

What else does the instruction manual for Thiodazine tell us?

Dosage of drug

The dosage and time of taking this drug must be selected individually, depending on the type of disease and the severity of its symptoms. It is recommended to start therapy with doses that are at the lower boundary of the designated range. Further, in the course of treatment, the dosage is gradually increased to the maximum effective rate. After reaching the maximum therapeutic effect, the dosage is gradually reduced to maintenance therapy. The daily dose is usually divided into two to four doses.

So, we will consider how to take "Thiodazine" for schizophrenia and other psychoses:

• Against the background of exacerbations of schizophrenia, adult hospitalized patients are prescribed from 100 to 600 milligrams of the drug per day. In this case, the maximum dose is 800 milligrams.
• In the presence of chronic schizophrenia, doctors usually prescribe from 100 to 600 milligrams to hospitalized patients, and from 50 to 300 outpatients.

According to the instructions for use with the drug "Thiodazine", in the treatment of anxiety syndrome and depression, it is prescribed in the following order:

• In the field of psychiatric practice, patients with agitated depression are prescribed from 25 to 200 milligrams per day.
• In the field of general medical practice, in the role of a sedative and anxiolytic, patients are prescribed from 10 to 75 milligrams per day.

In the field of geriatric practice, “Thiodazine” is taken as follows: 25-200 milligrams are prescribed as antipsychotic and antipsychotic drugs.

In the pediatric field, this medicine is taken as follows:

• As a neuroleptic for the treatment of severe mental and emotional disorders in children over the age of three, 4 milligrams per kilogram of patient weight is prescribed.
• As a sedative in children older than three years, this medicine is prescribed at 2 milligrams per kilogram of the child’s weight.

As for the other indications, Thiodazine is prescribed as follows:

• For the treatment of severe behavioral disorders in mentally retarded adults and patients with deficient symptoms, 100 to 600 milligrams are prescribed. The maximum dose is 800 milligrams.
• In order to reduce the severity of mental disorders in the presence of alcohol withdrawal syndrome, 100 to 200 milligrams of the drug is prescribed per day.

Therapy of patients with weight deficiency and impaired renal function, as well as the treatment of elderly patients and children, is recommended to be carried out under strict control. The instructions for use with "Thiodazine" indicate that therapy of this category of patients should be started with especially small dosages, increasing them very slowly.

In patients with schizophrenia who are in hospital treatment, a noticeable positive effect is achieved, as a rule, after three weeks from the start of therapy. In patients with chronic psychosis, it may take from six weeks to six months to achieve the maximum effect. But in patients with acute psychosis, improvement can be noted after two days.

In accordance with the instructions for use with the drug "Thiodazine", in the case of prolonged treatment, it is recommended to reduce its dosage gradually, over a couple of weeks. Sudden abandonment of the drug in patients who received it for a long time or in high dosage can lead in some cases to side effects in the form of nausea, vomiting, tremor, dizziness, anxiety, agitation and insomnia. Transient dyskinesias are not excluded. Such reactions can create the erroneous impression that a patient has depressed or psychotic conditions.

Side effects

Adverse reactions with the use of the drug, as with other drugs based on phenothiazine, are directly dependent on the dosage and, as a rule, are caused by the pronounced pharmacological effect of the drug. If this medicine is used within the recommended dose range, adverse reactions in most situations are mild and have a transient character. Severe adverse reactions are usually noted due to the use of high dosages.

According to the instructions and reviews for “Thiodazine”, the nervous system can react with sedation and drowsiness, dizziness along with impaired consciousness, psychomotor agitation, hallucinations, increased irritability and headache are also possible. In addition, convulsions are quite likely, and, in addition, extrapyramidal symptoms in the form of tremor, muscle rigidity, akathisia, dyskinesia and dystonia. The appearance of depression, insomnia, malignant antipsychotic syndrome and the like is not ruled out.

The autonomic nervous system can respond to this medication with the appearance of anticholinergic effects in the form of dry mouth, blurred vision, paresis of accommodation and nasal congestion. This is confirmed by the instructions for use with "Thiodazine" and reviews. In addition, nausea, vomiting, diarrhea, constipation, loss of appetite, retention or urinary incontinence, pallor of the skin and tremor are possible. Very rarely paralytic bowel obstruction can be observed.

The work of the heart and blood vessels may be accompanied by orthostatic hypotension, changes in the electrocardiogram, tachycardia and arrhythmia. It is extremely rare that ventricular flutter and flicker, and, in addition, sudden death.

With long-term use of Thiodazine, the endocrine system can respond with hyperprolactinemia, galactorrhea, amenorrhea, menstrual irregularities, changes in body weight, erectile dysfunction and ejaculation. In addition, priapism is possible along with engorgement of the mammary glands, gynecomastia and peripheral edema.

In addition, peripheral blood changes in the form of leukopenia, agranulocytosis, thrombocytopenia, anemia and leukocytosis can be observed. Liver function may be accompanied by abnormal enzyme activity and hepatitis. The skin can react with dermatitis, an allergic rash, urticaria, increased photosensitivity and angioedema. Among other adverse reactions, edema in the area of ​​the parotid gland is possible along with hyperthermia and respiratory depression.

Such information is contained in the instructions for use with Thiodazine. Analogs should be selected by the doctor if this drug is not suitable for the patient.

Overdose

With long-term treatment with Thiodazine, there were reports of cases of pigmented retinopathy, which developed in patients who received the drug at a dosage exceeding the recommended maximum values, that is, more than 800 milligrams per day.

Against the background of an overdose, side effects and the development of an acute antipsychotic reaction are possible. In particular, it should alert the fever, which may be one of the symptoms of the development of malignant antipsychotic syndrome. In more severe cases of overdose, various forms of impaired consciousness and even coma are possible. Overdose care measures should be as follows:

• Discontinuation of treatment with thiodazine and any similar antipsychotic medications (ie antipsychotics).
• Stopping the use of correctors, that is, central anticholinergic blockers.
• High doses of activated carbon should be prescribed along with gastric lavage.
• In case of seizures, the patient requires intravenous administration of Diazepam with glucose solution, nootropic drugs and vitamins B and C.
• A thorough monitoring of the functions of the cardiac, respiratory, vascular and nervous systems.
• Conducting symptomatic therapy.

If the patient has seizures, the use of barbiturates should be avoided, since they can enhance respiratory depression, which will be caused by the phenothiazine derivative.

Drug interaction

Medications like Cimetidine, Fluoxetine, Paroxetine, and Moclobemide can enhance and lengthen the effects of Thiodazine. The simultaneous administration of tricyclic antidepressants with phenothiazine derivatives can lead to an increase in the plasma concentration of all these medical devices, which can cause arrhythmia.

The substance thioridazine, like other phenothiazines, can lower the threshold for convulsive readiness. In the case of the simultaneous use of anticonvulsants with thioridazine, an increase or decrease in the concentration of phenytoin in the serum is likely, and therefore, it may be necessary to adjust its dosage. As part of the combined use of Thiodazine and Carbamazepine, the concentration of these drugs in serum does not change.

What else can you learn from the instructions for the drug "Thiodazine"?

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With the simultaneous use of thioridazine with antiparkinsonian drugs, for example, with Levodopa, the effects of both medicines can be weakened. Due to its adrenergic blocking property, thioridazine can weaken the pressor effect of vasoconstrictor drugs, such as: Epinephrine, Dopamine, Ephedrine and Phenylephrine. Against the background of the simultaneous use of "Quinidine" and "Thiodazine", the inhibitory effect of the first medicine on the myocardium is possible.

Phenothiazines, including Thiodazine, can cause changes in the electrocardiogram, such as lengthening the QT interval. The simultaneous use of "Thiodazine" with thiazide diuretics can lead to the development of severe arterial hypotension. In addition, hypokalemia caused by diuretics can enhance the cardiotoxic effect of “Thiodazine”.

The substance thioridazine has an effect on carbohydrate metabolism, and therefore, its use may impair the patient's tolerance to glucose, which was achieved during therapy with hypoglycemic agents. Antacids and antidiarrheal medicines can reduce the absorption of thioridazine from the digestive system. This is confirmed by the instructions for use with the tablets “Thiodazine”.

Special instructions for use

Against the background of treatment, alcohol is strictly prohibited, and in addition, driving vehicles. The drug has a direct effect on the nervous system, and therefore, it is better not to attend work and public places during treatment.

We examined the indications for "Thiodazine" and instructions.

Analogs

If necessary, the presented medicinal product should be replaced with the following analogues, depending on the medical recommendations: “Melleril”, “Ridazin”, “Sonapax” or “Tyson”. These medicines should be selected by a doctor, self-medication is fraught with serious consequences.

The detailed instructions for the analogues of "Thiodazine" will almost exactly repeat the one that was considered today in the article.

Now let's go directly to the reviews and find out what people write about this drug.

Reviews on "Thiodazine"

Reviews on the drug "Thiodazine" are diverse, since the drug affects the body of each patient individually. It is noted that this medicine can significantly improve sleep, relieve anxiety, fear, and, in addition, emotional upset.

But sometimes among the reviews there are complaints that there is no positive effect even with prolonged use of tablets. There are many perturbations associated with side effects, for example, people write that blood pressure is often reduced while taking this medication. There are also complaints about the development of arrhythmia and tachycardia. Anyway, I must say that people are scared by a huge list of side effects.

It is noted that when treating with these pills, people have an extremely passive state, patients honor themselves as squeezed lemon. In addition, people say that the drug "Thiodazine" causes a feeling of depression along with constant drowsiness.

In fact, in the reviews, many people complain about side effects and a large number of various contraindications. Not everyone receives the expected result from this medication. But in almost every patient there are some undesirable reactions in health. Some report that they have caused this drug to be severely allergic.

Thus, on the basis of most reviews, it can be said that this drug is rather weak in its effectiveness, since it does not help everyone, and in addition it is guaranteed to cause side effects.

The article presented instructions, reviews for "Thiodazine", as well as possible analogues of the drug.