In this article, we will consider the instructions for applying Longidaza to candles. Solution for injection is another form of release of the medication.
It is an enzyme preparation with proteolytic effects, that is, promotes protein breakdown. It consists of two whole active components, namely hyaluronidase with azo oximer bromide, and diuretic mannitol as an auxiliary substance. So, let’s take a closer look at the instructions for “Longidaz”, find out what analogues the drug has and what people tell about it in their reviews.
basic information
Under the influence of the drug, the nutrition of tissues in the body improves. Thanks to him, hematomas resolve and various edemas are significantly reduced. Joints acquire mobility by increasing the elasticity of damaged tissues, and adhesions with contractures in turn completely disappear. Moreover, the medicine is considered the most effective at the initial stage of pathological processes. Due to the combination of the two main components, the drug is characterized by increased activity and a long therapeutic effect. What else does the instruction for application to Longidaza injections tell us?
In addition to a pronounced proteolytic effect, the agent has anti-inflammatory, immunomodulating and antioxidant functions. This drug is able to neutralize toxins, and in addition, bind heavy metal ions to each other. Under the influence of Longidase, the formation of connective tissues of contractures and scars is suppressed through the difficulty of forming collagen protein in the fiber.
It has almost been proven that Longidaza has no toxic, embryotoxic, mutagenic and carcinogenic properties, and does not interfere with the functioning of the immune system and reproductive system. The drug presented is generally well tolerated by all patients. In the framework of parenteral, vaginal and rectal administration, the drug is very rapidly absorbed into the blood, penetrating absolutely all tissues, and in addition, into human organs. This medicine does not accumulate in the human body. It is excreted mainly by the kidneys within five days. "Longidase" can overcome the blood-brain and blood-brain barrier in the body.
Forms of drug release
The active substance "Longidaza", according to the instructions, looks like a porous white or yellowish mass, which can easily dissolve in water. This drug is produced in the format of dry matter, which is contained in bottles, as well as in ampoules of 3000 or 1500 IU. The substance contained in ampoules and vials is intended for the preparation of injection solutions. In addition to bottles and ampoules, this medicine is available in the form of suppositories, that is, in the form of suppositories of 3000 IU, which are intended for vaginal or rectal applications.
Indications for use
As indicated by the instruction, “Longidase” is prescribed for monotherapy, and in addition, for the complex treatment of diseases that are characterized by connective tissue hyperplasia. Thus, the presented drug is very useful in many areas of medicine.
In any case, as stated in the instructions for use.
In gynecology, Longidaza is prescribed to women as part of the treatment and prevention of adhesions, which appear as a complication of a chronic inflammatory disease or are formed as a result of gynecological manipulation, for example, during artificial abortions and operations performed on the pelvic organs. In addition, in gynecology, the drug is used for the complex treatment of tubal and peritoneal infertility. Instructions for candles "Longidaza" is very detailed.
In urology, this drug is also useful and is used in a number of the following cases:
- The presence of stricture of the ureters and urethra.
- The appearance of chronic prostatitis.
- Peyronie's disease. With this disease in men, there is a curvature of the penis against the background of an erection due to the proliferation of fibrous tissue.
- The presence of benign prostate formation at the initial stage.
- The development of interstitial cystitis.
- Prevention of scarring after operations on the bladder, urethra or ureters.
In surgery, Longidazu is used in the following cases:
- Treatment and prevention of adhesions after surgery on the abdominal organs.
- The appearance of colloidal and hypertrophic scars resulting from surgery, burns, trauma or pyoderma.
- The development of adhesive disease.
- The presence of long non-healing wounds.
- The appearance of trophic ulcers.
In cosmetology and dermatovenereology, Longidaza can be useful in the following cases:
- The presence of limited scleroderma.
- The presence of hypertrophic and keloid scars resulting from all kinds of injuries, surgeries, and in addition, burns.
- The appearance of retracted scars, formed immediately after the transferred pyoderma.
- The prevention of fibrotic complications of genital infections.
The use of "Longidase" in the field of pulmonology and phthisiology:
- The presence of pneumosclerosis in patients.
- The development of interstitial pneumonia.
- The development of pleurisy.
- The appearance of fibrosing alveolitis.
- The development of siderosis.
- The appearance of tuberculosis.
In orthopedics, according to the instructions, "Longidaza" is prescribed to patients in the presence of joint contracture, arthrosis, hematomas and ankylosing spondylitis.
Contraindications for use
The presented drug has a small list of contraindications, but, nevertheless, they are still available:
- The presence of excessive sensitivity to the active components of the drug or its excipients.
- The presence of infectious diseases that are in the acute phase.
- The appearance of hemoptysis or pulmonary hemorrhage.
- Recently occurred vitreous hemorrhage.
- The development of acute renal failure.
- The presence of malignant neoplasms in the body.
- Patient under the age of eighteen. Contraindication for this age group exists due to the fact that no clinical studies on this subject have yet been conducted.
- It is forbidden to administer the medicine to the place where the tumor or inflammatory process is localized.
Side effects of the drug
According to the instructions and reviews for Longidaza suppositories (and injections), as a side reaction, a slight feeling of pain may occur along with redness of the skin and swelling. In addition, allergic reactions are not excluded.
It should be noted that adverse reactions, as a rule, pass spontaneously, which occurs within two days. In the event of an allergic reaction, drug therapy should be completely discontinued, notifying the doctor.
Drug overdose
Signs of an overdose of the drug presented may manifest as chills, fever, decreased pressure, or dizziness. If symptoms appear that indicate an overdose, drug therapy should be stopped immediately, starting symptomatic treatment.
Conducting treatment. How to apply "Longidaz"?
This drug is administered subcutaneously near the affected area or directly under the scar. In addition, it can be administered intramuscularly. The dose along with the course of treatment and the method of administration of the drug is determined by the doctor depending on the severity of the disease and the age of the patient. Therapy with the drug can be repeated after two months.
Against the background of a chronic pathological process, which is characterized by heavy active growth of connective tissues, after the usual course of therapy, long-term support by Longidaza is required with weekly intervals between injections.
In order to enhance the effect of local painkillers, Longidazu is administered at a dosage of 1,500 IU in the same body area fifteen minutes before the use of the main anesthetic drug. As part of therapy, the contents of the bottle in a dosage of 3000 IU are diluted in 2 milliliters of saline or water for injection. To enhance the effect of anesthetics, 2 milliliters of saline are injected into a bottle with a drug of 3000 IU. At the same time, 1 milliliter is introduced into the 1500 IU bottle.
The drug can be used for electrophoresis and inhalation. For electrophoresis, the contents of the vial are diluted with distilled water. And for inhalation, the contents are diluted with a 0.8% sodium chloride solution. The resulting solution is used only in fresh form. You can not store it. The medication should not be administered intravenously.
This is confirmed by the instructions for use. In gynecology, Longidaza suppositories are consumed once a day, which is performed at night. Only one course will require from ten to twenty suppositories. Treatment with the drug is allowed to be stopped at the same time, without gradually decreasing the dosage. It does not affect the ability to drive a car and other complex mechanisms.
This is also confirmed by the instructions for applying to the candles "Longidaza".
Drug dosage
In order to prevent the development of scars and adhesive pathologies after surgery, "Longidaza" is prescribed intramuscularly every three days in an amount of 3000 IU. The course of preventive therapy should be five injections, with an interval between them from three to ten days. In the event that the drug for prophylaxis is administered only once every five days, then the total duration of the therapeutic course can be increased to ten injections.
Drug treatment regimens
Depending on the sphere of therapy in which this drug is used, there are certain treatment regimens. Let's consider them in detail. For example, in gynecology suppositories "Longidaza" according to the instructions are used according to the following scheme:
- For the treatment of adhesions occurring in the pelvis, 3000 IU is applied every five days intramuscularly. The course of treatment will require fifteen injections.
- For the treatment of tubal and peritoneal infertility, 3000 IU is used intramuscularly. A total of fifteen injections will be required for the course of treatment, and the first five of them must be performed every three days. All subsequent ones are held once every five days.
- As part of suppository treatment, one suppository is used every two days. A total of ten introductions per course are required.
So it says in the instructions. Reviews about Longidaz are mostly positive.
Application in urology
In urology, the drug is used according to the following scheme:
- For the treatment of chronic prostatitis, 3000 IU is applied every five days intramuscularly. The course of treatment will require fifteen injections.
- For the treatment of interstitial cystitis, the dosage of the drug is the same as in the previous case. The course of treatment will require ten injections.
- In accordance with the instructions for use with Longidaza candles, one thing is used every other day. A total of ten introductions are required. Then the introduction is carried out every two days. Only one course of treatment will need twenty candles.
Surgical Application
In surgery, the medication is used according to the following scheme:
- For the treatment of adhesive disease, 3000 IU is used every five days intramuscularly. The course of treatment will require ten injections. This information contains instructions for injections "Longidazy".
- For the treatment of poorly healing wounds, 1,500 IU is used every five days intramuscularly. The course of treatment will require ten injections.
- For suppository treatment, apply one suppository every two days. The course of treatment will require fifteen injections. Instructions for use with Longidaza candles can confirm this.
Application in dermatology and cosmetology
In dermatology and cosmetology, Longidaza is used according to the following scheme:
- For the treatment of limited scleroderma, 4500 IU are used every five days intramuscularly. The course of treatment will require twenty injections. Moreover, it is worth noting that a course with a dosage is selected by the doctor individually in each case. This, first of all, depends on the localization of the pathology, its clinical course and stage.
- For the treatment of scars of various etiologies (hypertrophic, colloid or retracted), 4500 IU is used every three days subcutaneously. The course of treatment will require fifteen injections. If necessary, the doctor can extend the course of therapy to twenty-five injections with an interval of once every five days. In the event that a large area of the skin is affected, as well as when the scar is old, the course of treatment is extended to twenty injections. In this case, the intramuscular and subcutaneous administration method alternates.
- For suppository treatment, one suppository is administered every two days. The course of treatment will require twenty injections.
So it is said in the instructions for applying to the candles "Longidaza".
Application in the field of pulmonology and phthisiology
In pulmonology and phthisiology, the drug is used according to the following scheme:
- For the treatment of pneumosclerosis, 3000 IU is used every five days, which is done intramuscularly. The course of treatment will require ten injections.
- For the treatment of fibrosing alveolitis, 3000 IU is used every five days intramuscularly. The course of treatment will require fifteen injections.
- For the treatment of tuberculosis, 3000 IU is used intramuscularly, this is done every five days. The course of treatment will need twenty-five injections. It should be noted that the treatment of this disease is long and primarily depends on the severity of the course. Therapy can last up to a year.
- According to the instructions for use with Longidaza suppositories, one thing is administered every two days. A total of ten administrations will be required for a therapeutic course.
Orthopedics Application
In orthopedics, "Longidaza" is used according to the following scheme:
- For the treatment of joint contracture, 3000 IU is used every three days, which is done subcutaneously, not far from the affected area. The course of treatment will require fifteen injections.
- For the treatment of ankylosing spondylitis, the dosage and area of administration is similar to the scheme described above. The course of treatment will require fifteen injections.
- For the treatment of hematomas, the dosage is the same. The course of treatment will require five injections.
What other information does the application guide for Longidaz contain?
Drug interaction
This drug can be combined with antibiotic, cytostatic, glucocorticosteroid, antiviral and antifungal medications, and bronchodilators. Against the background of the simultaneous administration of "Longidaza" with diuretics and painkillers, their effect is enhanced.
Longidase should not be prescribed simultaneously with large dosages of antihistamines, but also with salicylates, estrogens and cortisone, as its enzymatic activity decreases. It is forbidden to combine "Longidase" with medicines containing phenytoin along with benzodiazepine or furosemide.
This can be confirmed by the instructions for use.
Analogues of "Longidazy"
According to the current component, structural analogues of the presented medical product include such drugs as, for example, Ronidase along with Lidase-M and the usual Lidase. These analogues outperform Longidaza due to their lower cost, but are inferior in efficiency.
"Polyoxidonium" - its main field of application is the fight against genital and gynecological ailments, such as urethritis, cystitis, pyelonephritis and prostatitis. It can also be used for vaginal dysbiosis.
Contraindicated in case of hypersensitivity to the composition, also for pregnant and lactating women. If there are severe renal ailments, then a means of admission is not recommended. It is well tolerated, but in some cases allergic reactions may develop.
"Chymotrypsin" - a lot of evidence. It relieves diseases of the respiratory organs (tracheitis, bronchitis, bronchial asthma, pneumonia, lung abscesses and exudative pleurisy). Heals burns, purulent wounds. Also effective in ophthalmic diseases.
An allergy can develop as an adverse reaction. In addition, the appearance of pain at the injection site is likely.
"Lidase" - as part of enzymes, the source of which is the testes of cattle. Among the indications are scars with traumatic, thermal and surgical origin. Accelerates healing of ulcers. It is used for spondylitis, severe diseases of the lower back disc, osteoporosis and poor joint mobility. It also accelerates the recovery of patients with tendovaginitis, complicated by damage to the bronchi with tuberculosis, neuritis and plexitis.
It is contraindicated in children, patients with severe infectious and inflammatory ailments who have suffered bleeding before.
An allergic reaction in the form of itching and urticaria is not excluded.
Next, we find out what people who happened to use it for treatment say about this drug.
Drug Reviews
Most of the reviews that patients leave about this drug are exclusively positive. Based on them, it can be said that only a few units could not help this tool.
Among the main shortcomings of this medication, injection pain is often mentioned. But first of all, customer dissatisfaction is associated with the high cost of the drug, which ranges from one and a half to two thousand rubles.
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