In the article, we consider the dosage of Ambrobene for children. A fast-acting mucolytic medication treats and eliminates a symptom of respiratory pathologies in children, such as coughing. As the instructions for its use tell us, an hour after administration, the therapeutic effect begins. Ambrobene is rapidly absorbed through the gastrointestinal tract, and the active substances that make up it enter the bloodstream, which explains such a good result. After using the drug, the effect lasts about six hours.
Pharmacology
"Ambrobene" for children is a mucolytic and expectorant drug.
Its main substance is ambroxol, which is benzylamine, a metabolite of bromhexine, but differs by a hydroxyl group in the para-trans position of the cyclohexyl ring and the absence of a methyl group. It has secretolytic, secretomotor and expectorant properties.
Clinical trials have proved that Ambroxol stimulates serous cells in the glands of the mucous membranes of the bronchi, activates ciliated epithelial cells, reduces the viscosity of sputum, improves mucociliary transport.
In addition, this substance activates the formation of surfactant and has a direct effect on the alveolar pneumocytes belonging to the second type, as well as Clara cells located in the small airways.
Ambroxol promotes the formation of a special substance (surfactant), which is active on the surface of the alveoli and bronchi. In addition, the substance has an antioxidant effect.
If the drug is used together with antibiotics (Cefuroxime, Amoxicillin, Erythromycin, Doxycycline), this medication will increase their concentration in sputum and bronchial secretions.
Pharmacokinetics of the drug
"Ambrobene" for children when ingested is almost completely absorbed from the stomach and intestines. The full bioavailability of the active component will decrease by about three times. The metabolites formed in this process are excreted by the kidneys.
High binding to plasma proteins and a slow redistribution in blood from tissues are noted, therefore, the substance is not excreted during forced diuresis or dialysis.
In severe liver pathologies, the ambroxol clearance will be reduced by 30-40%, and in case of serious renal ailments, the effect of the metabolites of this active substance increases.
How does this medication work?
Ambroxol on the body of the child has the following effects:
- Splits sputum, reduces its density.
- Activates the natural withdrawal of sputum.
- Improves immune defense.
- It works as an antioxidant.
- Relieves inflammation.
When is it indicated for children?
In accordance with the instructions, the Ambrobene solution inside children is prescribed by doctors from an early age. It will be effective in:
- Bronchial asthma.
- Bronchitis.
- Pathological processes occurring in the lungs.
- Pneumonia.
- The need to remove sputum.
- Distress syndromes in premature babies.
The drug "Ambrobene" for children treats diseases, the symptom of which is a dry cough. The main active substance eliminates such manifestations of ailments, which helps to significantly alleviate the condition of the child, normalize respiratory processes.
What is the dosage of Ambrobene for children, we will tell below.
Instructions and dosages
There are several forms of release for this medicine, however, for the treatment of cough in children, the drug is used in:
- Pills from the age of five.
- Syrup from 1 month of life.
- Capsules from the age of 12 years.
- Inhalation solutions - suitable for children over 6 months old.
- Drops - you can from birth.
"Ambrobene" in the form of syrup and tablets
The most suitable and popular dosage form of this drug for dry cough in children is syrup. It has a very pleasant taste and smell, so it is taken even by children who do not like to drink medicine. The drug is released in glass bottles. Each package has a measuring cup for convenience.
Dosages of Ambrobene for children are as follows:
- At the age of two years, half a teaspoon once a day.
- From two to five years - half a teaspoon, but 3 times a day. The dosage of Ambrobene syrup for children should be strictly observed.
- From five to twelve years - 1 teaspoon three times a day.
- From 12 years - 2 teaspoons of the drug, three times a day in the first days of therapy, in the future - no more than twice a day.
The dosage of Ambrobene for children is determined by the doctor. The specialist will detail the scheme and regimen of taking the medication. These recommendations must be followed strictly.
On average, treatment lasts five days. Reception can be canceled earlier if the baby has improved.
In tablet form, the drug is also used in children. In this case, the pill can be crushed or dissolved in water. The reception schedule is also determined by a specialist.
Also often prescribed in the form of inhalation to a child at 2 years of age, “Ambrobene”. We will tell about dosages further.
Use of solution for inhalation
The most effective form of the drug is a solution for inhalation. This requires the presence of a special device - a nebulizer. It can be purchased at the pharmacy. You will also need a saline solution, with which the medicine is mixed in certain proportions.
This is confirmed by the instructions for Ambrobene for inhalation for children. The dosage is described in detail in the instructions.
Liquids with saline should be at room temperature.
The procedure lasts a total of 5-7 minutes and takes place in four stages:
- Using a special glass, measure the required amount of medicine.
- The dosage of the Ambrobene inhalation solution for children depends on the child's age and body weight.
- The resulting mixture is heated to the desired temperature and poured into the apparatus.
- Proceed to the inhalation procedure.
Dosage for children "Ambrobene" solution for inhalation
For children from two years to six, the mixture is prepared as follows: 2 ml of the drug is diluted in 1 ml of saline. For adults and children from 6 years old, this recommendation is suitable: dilute 2-3 ml in 2-3 ml of saline.
In what cases can not be used?
The mucolytic drug Ambrobene for children has certain contraindications. So, the drug is not prescribed for:
- Intolerance to the substances that make up the drug.
- Epilepsy
- With diseases of the liver and kidneys.
- In the presence of insufficient motility of the bronchi. Ambrobene
Possible adverse reactions of the body
If the dosage of Ambrobene inhalation solution for children is correctly observed, then negative manifestations occur very rarely. But sometimes a child may suffer:
- Dry oral mucosa.
- Allergic forms of rhinitis.
- Violation of the urination process.
- Stool disorder in the form of diarrhea or constipation.
- Skin rashes.
- Dyspeptic syndrome (nausea, abdominal pain).
- General weakness.
- Cephalgia.
If such signs are found, it is not always necessary to cancel the mucolytic drug, so it is better to consult a specialist. Use a medicine with other medicines that prevent sputum excretion is not worth it. Concomitant therapy is not recommended with agents that reduce the intensity of coughing, which can lead to the formation of congestion in the bronchi.
Usually this drug is tolerated very well if the dosage of Ambrobene is respected. Children inside should be taken with great care.
Overdose Signs
This also happens in very rare cases and may occur:
- deterioration in the well-being of the child;
- bouts of nausea with vomiting;
- severe stool in the form of diarrhea;
- lowering blood pressure;
- excessive salivation.
The use of the drug should be stopped immediately and a doctor should be called immediately. If the dosage of Ambrobene oral solution for children has been exceeded, the consequences are usually treated in a hospital.
How to replace this drug if necessary?
The active substance that is part of the medication has a very high efficiency and rapid therapeutic effect. It is for this reason that the pharmacological market is full of analogues of the Ambrobene drug. For children, only a doctor should select a replacement. Experts usually recommend choosing:
- Abrolet.
- Ambroxole Fort;
- "Ambroxol hydrochloride";
- "Bronchovale";
- Mukoangine;
- Ambroxole;
- Ambrosane
- Ambroxole Extra;
- Medox;
- Ambrotard;
- "Milistan";
- Flavamede
- Ambroxole Retard;
- Ambrohexale;
- "Mukolvane";
- Flavamed Forte;
- Neo-bronchial.
These drugs also have different dosage forms for use in childhood, however, not everyone can be used in the treatment of cough in newborns and infants.
Which drug is the most effective and cheapest of analogues? For children, "Ambroxol" is most often prescribed, its composition is absolutely identical to "Ambrobene", and its price is much cheaper. Both drugs are used to treat the same diseases in babies.
A very common analogue of Ambrobene for children is Lazolvan, it is this syrup that is often prescribed by specialists. The composition of these funds is also the same, and the therapeutic properties are similar, the contraindications and side effects coincide, and the difference lies only in the manufacturer.
Interaction with other drugs
This mucolytic drug "Ambrobene" in a dosage for a child of 3 years of age has poor compatibility with agents exhibiting antitussive activity. Sputum in these cases worse departs, since cough is suppressed.
Against the background of the use of the medication, antibiotics penetrate better into the respiratory tract and lung tissue. For this reason, it is often prescribed to enhance the therapeutic effect simultaneously with antibacterial drugs (erythromycin, azithromycin, etc. are popular).
Storage conditions and dispensing from pharmacies
The drug in all dosage forms, except for syrup, is stored at a temperature of up to 25 degrees. For syrup, the temperature will be optimal from 8 to 25 degrees. Ideal for Ambrobene, a dry, closed, inaccessible place for children. A prescription is not needed to purchase a drug.
We learn what parents think about the Ambrobene solution for inhalation for children and the dosage. Syrup is less popular.
Reviews about the drug
You can find a large number of reviews about this drug. Basically, they are left by parents who used the medication for dry cough in their babies.
The drug has been known on the pharmacological market for a long time, it is used both for the treatment of adults and children. Experts recommend it to their patients, since it is highly effective.
Positive reviews confirm that recovery on the background of admission occurs very quickly. Moreover, the drug eliminates cough of various etiologies.
Parents especially like inhalations when the drug is administered by breathing directly into the baby’s bronchi. There is a dilution of sputum and expectoration in the first days of the use of this drug. Syrup, judging by the reviews, acts somewhat slower. The effect occurs on the third day.
Specialists most often prescribe it with a dry cough. After all, the drug is most effective, especially in acute infections. It works best with antibiotics.
There are fewer negative reviews, but they are also available. When using it, the child experiences an increase in the cough reflex, especially in the evening. After all, the bronchi work actively, and sputum is intensely formed.
Some children noticed the manifestation of side effects of the drug. Rashes, itching, muscle weakness, headache, dyspepsia, and nausea occasionally occurred.