In the article, we consider the instructions for the use of injections "Rocefin", intramuscularly administered, as well as its analogues.
This is a bactericidal agent based on the active element of ceftriaxone for parenteral use from the category of third generation cephalosporins. It has an extensive spectrum of prolonged action against gram-negative and gram-positive pathogenic microorganisms. This medication is made in the form of solutions for injections intravenously and intramuscularly. Instructions for "Rocefin" are presented below.
Ceftriaxone
Ceftriaxone is an antibacterial substance from the category of third generation cephalosporins. It is characterized by a prolonged action. The bactericidal activity of this drug is based on the suppression of the processes of synthesis of cell membranes. This active substance has a wide range of therapeutic effects in relation to gram-negative and gram-positive pathogens. This indicates a high resistance to most β-lactamases (cephalosporinases and penicillinases), which are produced by pathogenic infections.
Gram-positive aerobes to which the drug “Rocefin” is active in injections: Streptococcus pneumoniae, Streptococcus agalactiae (β-hemolytic, group B), coagulase-negative staphylococci, Streptococcus pyogenes (β-hemolytic, group A), β-hemocystic streptochemus to methicillin strains). An exception is methicillin-resistant staphylococci, which are resistant to cephalosporins. Enterococcus faecalis, Enterococcus faecium and Listeria monocytogenes are generally also resistant.
Gram-negative aerobes, to which this medication is active: Alcaligenes odorans, Plesiomonas shigelloides, Neisseria meningitidis, Neisseria gonorrhoeae, Haemophilus ducreyi, Pasteurella multocida, Haemophilus parainfluferleza, Infemiloferobes Alcaligenes faecalis, Aeromonas hydrophila, Acinetobacter anitratus, alkaligen-like bacteria, Citrobacter freundii, Citrobacter diversus, Escherichia coli, Klebsiella pneumoniae, Enterobacter spp., Moraxella spp., Proteus penneri, Morsella sppella mongellapprusmonsponii, Morganella sppella mongella pommonella, Morganella sppella monganella morppella pomegonida morganella spp. ., Vibrio spp., Providencia spp., Yersinia spp.
Some of the isolates of these species are resistant to ceftriaxone, which is mainly due to the formation of β-lactamases encoded by chromosomes. Some of the isolates of these species exhibit resistance due to the formation of plasmid-mediated beta-lactamases. Some strains of the above microorganisms are multiresistant to other antibiotics (ureidopenicillins, aminopenicillins, aminoglycosides and cephalosporins of the first and second generation) and are sensitive to this medication. It has been experimentally established that Treponema pallidum has sensitivity to ceftriaxone. According to clinical trials, the drug is effective against primary and secondary forms of syphilis.
Indications for use
The antibacterial agent "Rocefin" in injections is used in the treatment of infectious lesions provoked by pathogens that are sensitive to ceftriaxone:
- Infectious damage to the digestive tract, bile ducts, peritonitis, other infections of the organs.
- Tick-borne borreliosis at the stage of disseminated infectious process.
- Skin, joint, bone infections, soft tissue lesions, and wound lesions.
- Pathologies of infectious origin in patients with weak immunity.
- Infections of the kidneys as well as the urinary tract.
- Pneumonia, lesion of ENT organs, other infectious pathologies of the respiratory tract.
- Genital diseases (including gonorrhea).
- Sepsis.
- Meningitis.
In addition, the use of "Rocefin" is advisable for the prevention of infections in the postoperative period.
Contraindications
This pharmacological agent is prescribed with caution if there is an increased sensitivity to penicillin antibiotics, hyperbilirubinemia in newborns. During pregnancy and lactation, the medicine is prescribed if there are strict indications.
Contraindications to the use of the drug include:
- hypersensitivity;
- individual intolerance;
- allergic to the components of the composition or cephalosporins;
- viral and fungal infections.
Dosage regimen
The recommended dosing regimen for adults and children over the age of 12 years is 1-2 g with an interval of 24 hours once a day. In severe infections or infections that have caused pathogens moderately sensitive to ceftriaxone, the daily dose may be increased to 4 g. The course of therapy depends on the clinical course of the disease. However, the medication should be administered for at least another two to three days after normalizing the temperature and confirming the eradication of the pathogen. The standard course is 4-14 days. For infections provoked by Streptococcus pyogenes, a course of treatment of at least 10 days is required.
The general rules for the use of solutions are as follows: the administration of the drug is carried out immediately after preparation. The prepared solutions retain chemical and physical stability at room temperature for six hours, at a temperature of 2-8 ° C (in the refrigerator) for a day. The color of the solution, depending on the duration of storage and concentration, can vary from amber yellow to pale yellow. Coloring does not affect the tolerance of the drug or its effectiveness.
Analogs of "Rocefina"
The list of drugs identical in composition includes:
- Ceftriaxone;
- "Azaran";
- Cefaxon
- Ceftriabol.
In order to figure out which drug from the above is more suitable in a particular case, it is necessary to consider each of them in detail.
Ceftriaxone
This is a cephalosporin antibiotic with a broad spectrum of effects of the third generation, which has a bactericidal effect by inhibiting the synthesis of cell walls of pathogenic bacteria. The absolute analogue of “Rocefin” in injections. Production - Russia. Which is better - “Rocefin” or “Ceftriaxone”? It is difficult to solve this problem, because the drugs are completely identical. True, the latter has more side effects.
The drug acetylates membrane-bound transpeptidases, disrupting the cross-linking of peptidoglycans, which is required to ensure rigidity and strength of the cell wall. The medicine is highly active against anaerobic, aerobic, gram-negative and gram-positive pathogenic bacteria. The active substance is resistant to β-lactamases.
The analogue of "Rocefin" is used in injections for infectious inflammatory diseases caused by microorganisms sensitive to ceftriaxone - cholangitis, peritonitis, meningitis, sepsis, empyema of the gallbladder, salmonella carriage, lung abscess, pneumonia, pleural empyema, shigelosis, pyritis, shigellosis, pyritis, shigellosis, joints, epidermis and soft tissues, reproductive organs, infected burns and wounds. Very often, "Ceftriaxone" or "Rocefin" are used in the postoperative period in order to prevent infections.
An antibiotic is contraindicated with a high sensitivity of the body to cephalosporins. With caution, it is prescribed for impaired renal and hepatic function, colitis, enteritis, provoked by the use of antibacterial medicines, as well as during the neonatal period with hyperbilirubinemia. The use of the drug when drinking alcohol is also contraindicated.
The price of this medication varies within 30 rubles per bottle.
"Azaran"
This medication is an analogue of "Rofecin", which is absolutely identical in terms of the active component. Drug Production - Serbia. This drug is available in the form of powders for the preparation of solutions for intravenous and intramuscular infusions.
Indication for the use of the antibiotic "Azaran" is the treatment of the following diseases of an infectious and inflammatory nature:
- infection of the upper and lower structures of the respiratory canals, including pneumonia, lung abscess, pleural empyema;
- diseases of bones and joints of an infectious nature;
- pathology of the skin and soft tissues;
- diseases of the urinary canal, including pyelonephritis, as well as organs in the pelvis;
- inflammatory pathologies of the digestive tract and bile ducts, including empyema of the gallbladder and cholangitis;
- bacterial meningitis;
- peritonitis;
- bacterial endocarditis;
- sepsis;
- salmonellosis;
- Lyme disease
- uncomplicated gonorrhea of acute course;
- shigellosis.
In addition, this antibacterial drug is used in postoperative practice for preventive and therapeutic purposes to prevent the possibility of the development of infectious complications.
Absolute contraindications to the administration of the medication are high sensitivity to cephalosporins, penicillins and carbapenems, as well as to auxiliary components of the drug "Azaran". Relative contraindications are impaired liver or kidney function, enteritis, ulcerative colitis. During pregnancy, therapy with this medication is possible only according to indications. The same applies to the lactation period.
Cefaxon
This is a cephalosporin antibiotic with a broad spectrum of effects of the third generation, which has a bactericidal effect by inhibiting the synthesis of the cell wall of pathogenic bacteria. The absolute analogue of "Rocefin", production - India. The drug acetylates membrane-bound transpeptidases, disrupting cross-linking of cross-type peptidoglycans, which is necessary to ensure rigidity and strength of the cell wall. The medicine is highly active against gram-negative, gram-positive, anaerobic and aerobic pathogenic bacteria. The active substance is resistant to β-lactamases.
This pharmacological drug is used for infectious inflammatory diseases that are caused by ceftriaxone-sensitive microorganisms - shigellosis, peritonitis, meningitis, sepsis, gallbladder empyema, salmonella carriage, lung abscess, pneumonia, pleural empyema, pyelonephritis, cholangitis, tissues, reproductive organs, bone infections, infected burns and wounds. In addition, the medication is used in the postoperative period in order to prevent infections.
The cefaxone antibiotic is contraindicated with a high sensitivity of the body to cephalosporins. With caution, it is prescribed for impaired renal and hepatic function, colitis, enteritis, provoked by the use of antibacterial medicines, as well as during the neonatal period with hyperbilirubinemia. The use of the drug when drinking alcohol is also contraindicated.
The price of this medication ranges from 30 rubles per bottle.
Ceftriabol
Russian-made antibiotic. This medication is an analogue of “Rocefin” in injections, which is absolutely identical in its active component. This drug is available in the form of powders for the preparation of solutions for intravenous and intramuscular infusions.
Indication for the use of the analogue of “Rocefin” of the antibiotic “Ceftriabol” is the treatment of the following problems of an infectious and inflammatory nature: infections of the upper and lower zones of the respiratory organs, including pneumonia, lung abscess, pleural empyema; diseases of bones and joints of an infectious nature; pathology of the skin and soft tissues; diseases of the urinary canal, including pyelonephritis, as well as organs located in the pelvis; inflammatory pathologies of the digestive tract and bile ducts, including empyema of the gallbladder and cholangitis; bacterial meningitis; peritonitis; bacterial endocarditis; sepsis; salmonellosis; Lyme disease; uncomplicated acute gonorrhea; shigellosis.
In addition, this antibacterial drug is used in postoperative practice for preventive and therapeutic purposes to prevent the possibility of the development of infectious complications.
Absolute contraindications to the administration of the analogue of “Rocefin” are high sensitivity to cephalosporins, penicillins and carbapenems, as well as to auxiliary components of the drug “Ceftriabol”. Relative contraindications are impaired liver or kidney function, enteritis, ulcerative colitis. During pregnancy, therapy with this medication is possible only according to indications. The same applies to the lactation period.
Instructions for "Rocefin" in injections and its analogues should be strictly observed.
Side effects of the drug "Rocefin"
The following adverse events were most often observed during therapy with ceftriaxone-based drugs: leukopenia, thrombocytopenia, eosinophilia, rash, increased concentration of liver enzymes, and stool disorder. Somewhat less common are such systemic manifestations:
- infectious damage to the structures of the genital organs of fungal etiology;
- pseudomembranous colitis;
- leukopenia, anemia, granulocytopenia, coagulopathy;
- dizziness, headache;
- bronchospasm;
- nausea, vomiting;
- hematuria, glucosuria;
- phlebitis, pain at the injection site;
- fever, chills, swelling.
Drug interaction
According to the instructions for use with "Rocefin" in injections, the simultaneous use of the drug with potent diuretics does not cause kidney damage. Bacteriostatic antibiotics help reduce the bactericidal effect of drugs. Do not mix infusion solutions with calcium content with these medicines. Simultaneous use with substances amsacrine, fluconazole, vancomycin, as well as aminoglycosides is unacceptable due to incompatibility.
Reviews
A huge number of reviews were left about injections of “Rocefin” in injections and its analogues on medical sites and forums, since almost everyone was treated with antibiotics. This antibacterial drug is very popular today, as it fights with almost all known infections and helps to eliminate diseases that occur in severe forms. Tolerance of “Rocefin” intramuscularly, according to patients, is good, but dyspeptic disorders are a common side effect during therapy. Almost all patients against the background of the introduction of the drug also observed stool disorders in the form of diarrhea, which is due to the death of beneficial microorganisms in the intestine, therefore, probiotics were prescribed to them simultaneously with antibacterial treatment.
As for the analogues of this pharmacological drug, the medicine Ceftriaxone, which is often used in hospital hospitals, is especially popular among them. This is due to the fact that this medication is the cheapest among all analogues and easy to use. Contraindications and side effects are similar for all identical medicines.