As you can learn from the instructions compiled by the manufacturer of "Bisogamma", this drug in tablet form is intended to combat high blood pressure in the arteries. The manufacturer of this product is Verwag Pharma. Let us consider in more detail the technical features and properties of the drug.
Technical information
Verwag Pharma is a company that has registered a certificate for a medicinal product. Real production is the responsibility of the three companies. Two of them are German, the third is Romanian. The names of German manufacturers are Moyerman Artsneimitel and Artesan Pharma. Romanian company called "S.G. Master’s. ”
All plants produce the pharmaceutical product “Bisogamma” in tablet form. Each specimen is covered with a thin film painted in light yellow. The tablets are made round, one of the sides is convex, the second is supplemented with a notch, to which the surface is slightly sloping.
The main active ingredient in Bisogamma is bisoprolol in the form of hemifumarate. In each capsule, it is contained in an amount of 5 mg or twice as much volume. Additional ingredients added to the composition of the product are a fairly wide variety of chemical compounds. The manufacturer used crospovidone, starch, cellulose, magnesium, silicon, titanium compounds, hypromellose, macrogol, talc, coloring components.
Pharmacology
As you can learn from the instructions for use, "Bisogamma" has a pronounced effect on the human body. This is a drug that has a selective effect. The drug belongs to the class of beta1-blockers. The intrinsic activity of sympathomimetic is not inherent in him, there are no qualities to stabilize cell membranes. Under the influence of a pharmaceutical product, plasma renin loses its activity, the oxygen demand of the heart muscle decreases, and the frequency of contractions of the organ decreases during rest and in conditions of activity and load.
The drug product has a hypotensive effect. It is an antiarrhythmic drug with antianginal effect. When using the drug in a small volume, the activity of cardiac beta1-adrenergic receptors is inhibited, stimulation by catecholamines is reduced, and this affects the reaction of ATP to CATP transformation. The current of calcium ions inside the cell is weakened. The drug has negative ion-, batmo-, chrono-, dromotropic effects. If you increase the volume, the drug will show a beta2-adrenergic blocking result.
Pharmacological features
The manufacturer in the instructions for use of "Bisogamma" clarifies the possibility of growth of the total peripheral vascular resistance in the first day after the start of the therapeutic course. This is due to the reciprocal increase in the action of alpha-adrenergic receptors. The indicators return to normal over the next three days. If you use the medicine for a long time, OPSS gradually becomes lower.
Lowering blood pressure is explained by a decrease in blood volume per minute. The activity of the renin and angiotensin system decreases. This is especially important if the initial state of a person includes excessive production of renin. Sympathetic stimulation of blood vessels on the periphery decreases. Susceptibility is restored as a result of lowering the pressure. The drug affects the central nervous system. In the case of high blood pressure, the effect is observed after a couple of days, some have to expect the first manifestations of effectiveness up to five days. Stable effect is observed in the second or third month of the therapeutic course.
Antianginal effect and not only
In the instructions explaining why bisoprolol is especially effective, the manufacturer pays attention to the antianginal effect due to the administration of the pharmaceutical product. This is explained by the fact that the need for heart muscle in oxygen cells is reduced, since tissue contractions become less frequent, contractility decreases, in principle, and diastole becomes longer. Myocardial perfusion under the influence of the drug improves. An increase in the final diastolic pressure in the left ventricle and an increase in stretching of the muscle fibers of the ventricles can increase the need for oxygen, especially in patients with chronic heart failure
The antiarrhythmic effect of the drug is explained by the blocking of factors that can provoke arrhythmia. The speed of spontaneous excitation of various heart elements is reduced. Atrioventricular conduction becomes somewhat slower.
If the patient, following the instructions explaining how and from which bisoprolol helps best, uses the drug product in an average dose, he notes the least significant effect of the drug on the internal systems, including beta2-adrenergic receptors. The agent under consideration minimally affects the uterus, arteries on the periphery, bronchi, skeleton muscles, pancreas. In addition, the correction of carbohydrate metabolism is minimized, the accumulation of sodium ions is not observed, and the atherogenic effect corresponds to propranolol.
Kinetics
The drug "Bisogamma" is effective due to the presence of bisoprolol in the tablets. Soon after oral administration, this drug is absorbed through the digestive tract. The efficiency of the process is estimated at 80-90%. The use of the medication during the meal does not adjust the level of absorption. The maximum plasma concentration is achievable in the range from an hour to three. The ability to associate with plasma proteins is up to 30%. The substance seeps through the blood-brain barrier, the placenta, although only very small amounts pass in this way. In a small volume revealed in the secret of the mammary glands.
Approximately half of the dose received by the patient is metabolized in the liver. The reaction proceeds with the generation of products that do not have pharmacological activity. Up to half the dose is eliminated with urine in the form of the original molecule. The half-life is estimated at 10-12 hours.
When will it help?
For taking Bisogamma, the indication is arterial hypertension. In addition, the drug is prescribed for cardiac ischemia. A tablet pharmaceutical product is considered a reliable measure to prevent angina attacks. In each individual case, the doctor decides on the appointment of the drug, evaluating the features of the course of the disease and the presence of additional pathologies.
Admission Rules
In order for the Bisogamma tablets to give the maximum result, it is necessary to use the medicine correctly. Each capsule is swallowed completely without chewing. You can not break the integrity in other ways - crush, crush the drug. When prescribing medicine, a person in old age is recommended to use standard volumes. Additional dose adjustment is not necessary.
Normally, use the drug first daily in the morning at 5 mg, taking the medication on an empty stomach. If monitoring the patient's condition determines the need for large volumes, increase the dose by half. Maximum per day, you can use no more than 20 mg of the drug.
With renal impairment and creatinine clearance of less than 20 units, the daily maximum of the drug is 10 mg. This is the same maximum dose for people suffering from severe liver problems.
Unwanted effects
Side effects of "Bisogamma" can be observed by different systems and organs. Some complained that while taking the pills my head was sick and dizzy, my condition was weak, and sleep disturbances were observed. Perhaps a depressed state, anxiety, confusion, and a brief loss of memory. Cases of asthenia, paresthesia, convulsions, tremors, myasthenia gravis, hallucinations have been recorded. There is a risk of impaired vision, dry eyes, less active production of tear fluid. There is a risk of bradycardia, atrioventricular block, low blood pressure, angiospasm, tenderness in the sternum. There are known cases of worsening myocardial conduction, palpitations, the appearance or worsening of cardiac weakness in the form of a chronicle.
Some were disturbed by the sensation of dryness of the oral mucosa, stool disturbances; vomiting, nausea. The stomach can hurt. Perhaps a temporary perversion of taste. There are cases when breathing became complicated, stuffy nose, laryngo-bronchial spasms developed. This was recorded with a patient's predisposition or the use of drugs in high doses. There is a danger of hyperglycemia against the background of a diabetic disease, hypothyroid status, leuko-, thrombocytopenia, agranulocytosis. Some had back pain, joints; lower limbs were cramped. Allergies are possible, there is a danger of decreased sexual activity. There is a risk of hair loss. There are known cases of withdrawal syndrome, an increase in the concentration of triglycerides in the blood. The drug can affect the fetus of a woman.
When not
The instruction "Bisogamma" is strictly prohibited in the case of SSSU, cardiomegaly. You can not prescribe a remedy if the heart is weak, the condition is chronic, decompensated failure. You can not take pills in the acute form of organ failure. The drug is not prescribed for pulmonary edema, shock, collapse. Contraindications are sinoatrial, atrioventricular block (2, 3 levels). You can not use the medicine for Prinzmetal angina and low blood pressure in the arteries when the systole is less than a hundred units. It is especially important to comply with this prohibition in case of a heart attack. Do not use tablets with severe bradycardia, severe bronchial asthma and other pathologies accompanied by obstruction of the airways. The medicine is not prescribed if depression, pheochromocytoma is diagnosed.
You can not use the tool if the patient is prescribed IMAO, except for type B. It is forbidden to prescribe the drug to people under the age of eighteen. Contraindication is metabolic acidosis. The medication is contraindicated if Raynaud's disease is detected. They are not used with a pronounced degree of failure of blood flow in the periphery. In the instructions to “Bisogamma”, contraindication indicates intolerance of the main asset or additional components, increased sensitivity to substances used by the manufacturer.
Use with caution
In some cases, the Bisogamma instruction is recommended for extremely accurate use, accompanied by a regular check of the patient’s working capacity. Diagnoses requiring such attention include liver failure. With caution, a remedy is prescribed to persons with kidney failure. It is necessary to carefully monitor the state of the body of a person with a myasthenia gravis or a diabetic disease. Caution requires the appointment of a drug against psoriasis. Carefully monitor the condition of the patient with the first degree of atrioventricular block. It is necessary to monitor the condition if there is a mention of depression or allergies in the medical history. For elderly people, the pharmaceutical product in question is allowed, but it is recommended to constantly monitor the patient's condition.
Special cases
The specific instructions given in the Bisogamma instructions apply to pregnant women and nursing mothers. The prescription of the prescription of the medicinal product is indicated only if the obvious benefit for an adult significantly exceeds the potential risks to the bearing fetus or nursing child.
In case of insufficient liver activity, the drug is used, but very carefully. The weakness of renal work in the form of a chronicle also requires this. For minors, the drug is strictly contraindicated.
It is necessary to regularly monitor the condition of the patient receiving the tablets in question. Determine the pressure indicators, heart rate. First you need to do a check every month, then the frequency is changed to one event in a third or a quarter of a year. From time to time, a person is referred for an ECG and analysis to detect blood sugars if a diabetic disease is established. In old age, three times a year check the performance of the kidneys.
It is important to teach the patient to independently calculate heart rate. If the indicators become less than 50 reductions per minute, you should consult a doctor. The task of the doctor is to convey to the patient the importance of timely visits to the clinic with such indicators of heart function.
The nuances of using
Medical research and statistical analysis show that approximately one in five suffers from angina pectoris, drugs from the class of beta-blockers do not give the desired effect. In the instructions to Bisogamma, the manufacturer specifies what are the most typical causes of failure. This can be coronary atherosclerosis, proceeding in severe form, accompanied by a lowered ischemic threshold. A high final volume of diastole of the ventricle of the heart on the left is possible, because of which the quality of the subendocardial blood flow suffers.
The appointment of the drug against the background of pheochromocytoma is accompanied by the danger of paradoxical high blood pressure. This is possible if previously failed to achieve a successful blockade of alpha-adrenergic receptors.
If a person is sick with thyrotoxicosis, the use of the medication in question can hide the clinical manifestations of the disease. Sudden refusal of pills with such an initial diagnosis is strictly prohibited, since the symptoms can increase unpredictably greatly.
Also, the instructions for "Bisogamma" specify the ability of the active ingredient to hide tachycardia due to hypoglycemia, which is especially important for people with diabetes. The medication in question differs from non-selective drugs of the same type, since it does not provoke an increase in hypoglycemia due to insulin. In addition, it does not correct the recovery processes, due to which the blood sugar level is normalized.
Is it worth using?
As you can conclude from the reviews, "Bisogamma" is a reliable drug. Persons who used the drug under the supervision of a physician noted stabilization of pressure. The problem of angina pectoris is practically solved. But the reviews about the "Bisogamma", used at its discretion, are far from so encouraging. Since people had not previously visited a doctor who would choose the right product, they sometimes faced with the ineffectiveness of the medication chosen for themselves. Side effects also more often occurred precisely in those who use pharmaceutical products at their discretion, without a specialized recommendation of the attending physician.
Is there an alternative?
The modern pharmaceutical market is ready to offer customers several analogues of Bisogamma. These include drugs:
- "Bisoprolol."
- Aritel.
- Bidop.
- "Biol."
The choice of replacement must be agreed with the doctor. In some cases, the doctor will consider that it is better to replace the drug with “Biprol” or “Biskard,” “Concor” or “Bisomor” may advise other patients. The Corbis and Cordinorm medicinal products have a good reputation. With a number of diagnoses, the doctor may prescribe as an alternative to the drug under consideration the funds “Coronal”, “Niperten”. Sometimes it is advised to take Tirez.
Combination treatment
If the patient receives any medications or the diagnosis revealed requires multicomponent treatment, before the formation of a comprehensive program, the nuances of drug interaction must be taken into account. Bisogamma is more likely to provoke an allergic reaction if allergens used for immunotherapy are administered to a person. The risk of strangulation and systemic severe sensitization reactions increases. The iodine-containing contrast medications used to get the x-ray are more likely to cause an anaphylactic reaction if a person receives Bisogamma.
Intravenous administration of drugs containing phenytoin, common painkillers administered through an inhaler, is accompanied by inhibition of cardiac activity and a decrease in pressure. , . , , .
«» , , . , - .
Note
If taking the drug is accompanied by the development of depression, you need to abandon the medication in question. If the drug is prescribed to a person of advanced age, bradycardia is aggravated, the pressure is greatly reduced, you need to either abandon the drug in question, or reduce the dose. When prescribing a course, it is taken into account that a smoking person's performance is below average. The combination with clonidine obliges you to abandon this drug only after completing the course of bisoprolol - there are several days of pause between the first and second drug.