In this article, instructions for use will be presented to the medicine "Arthrosan".
This is a non-steroidal medicine that has anti-inflammatory, antipyretic and analgesic effects. It is classified as oxycam. This drug is a derivative of enolic acid. Instructions for use "Arthrosan" is very detailed.
Drug Release Form
The drug is available in two pharmaceutical forms:
- In the form of yellow cylindrical tablets that contain 7.5 or 15 milligrams of the active component of meloxicam. Excipients, in turn, are lactose monohydrate along with trisodium citrate, magnesium stearate, potato starch, povidone and silicon dioxide. Contour packs contain twenty tablets of Arthrosan. Instructions for use are in each pack.
- A greenish, clear solution for intramuscular administration, which contains 6 mg of meloxicam per milliliter. This form of the drug is available in ampoules of 2.5 milliliters. Three or ten ampoules can be in one package.
- Ointment. Instructions for use with the ointment "Arthrosan" is also attached to the drug.
Pharmacological effects
According to the instructions for use, "Arthrosan" is characterized by its ability to have anti-inflammatory, antipyretic and analgesic effects. The direct mechanism of its work is associated with inhibition of prostaglandins, which occurs as a result of inhibition of the activity of enzymes involved in the biosynthesis of substances in the area of inflammation.
Against the background of prescribing drugs in high doses, as well as with prolonged use, the selectivity of COX-2 decreases. To a lesser extent, the drug affects cyclooxygenase of the first category, that is, on COX-1, which is involved in the synthesis of prostaglandins, which protect the mucosa of the digestive system and contribute to the regulation of blood flow in the region of the kidneys. Due to the suppression of the activity of COX-2, this drug is less likely to provoke erosive and ulcerative lesions of the digestive system in comparison with other similar drugs.
Pharmacokinetics of the drug
As indicated by the instructions for use with Arthrosan, the binding of the drug to plasma proteins is almost one hundred percent. The drug can penetrate the histohematological barrier, its concentration in the composition of the synovial fluid is fifty percent. In the liver, the drug presented is almost completely metabolized.
The plasma clearance of the drug is approximately 8 milliliters per minute. In elderly people, the clearance of the drug may decrease. The presence of hepatic, as well as renal failure, does not significantly affect the pharmacokinetics of this drug. The drug is excreted in equal proportions with feces and urine, which mainly occurs in the form of metabolites. Through the intestines, less than five percent of the daily dose is excreted unchanged. As for urine, in it in an unchanged form, the medicine is found exclusively in residual quantities.
This is confirmed by the instructions for use of Arthrosan.
Indications for use
Doctors prescribe this drug for the symptomatic treatment of inflammatory, degenerative pathologies of the muscle and joint system, which are accompanied by pain. Thus, the presented drug is usually prescribed for the following diseases:
- The development of osteoarthritis.
- Rheumatoid arthritis.
- Ankylosing spondylitis, or in another way it is also called ankylosing spondylitis.
- The presence of osteochondrosis in patients.
Now we find out which of this drug have contraindications for use.
What else does the instruction for use with Arthrosan tablets tell us?
Contraindications to the use of the drug
This drug is characterized by a large number of various contraindications, which should be familiarized with before using it:
- The presence of hypersensitivity to the main component of the drug meloxicam, its auxiliary components.
- The development of decompensated heart failure.
- Stay of the patient in the early postoperative period after coronary artery bypass grafting.
- The presence of a complete or incomplete combination of bronchial asthma with recurrent nasal polyposis and intolerance to acetylsalicylic acid. It is forbidden to take medicine in the presence of exacerbation of peptic ulcer of the stomach and intestines. Also, the drug is contraindicated in the presence of active gastric and intestinal bleeding.
- The appearance of inflammatory bowel diseases in the form of ulcerative colitis, as well as Crohn's disease at the stage of its exacerbation.
- The presence of cerebrovascular and other bleeding.
- The presence of hemophilia and other disorders associated with blood coagulation.
- The presence of severe liver failure or active liver disease.
- The appearance of chronic renal failure in patients who underwent hemodialysis. The presence of progressive kidney disease, including confirmed hyperkalemia.
- Children's age of patients is up to eighteen years. This drug is prohibited during pregnancy, as well as with breastfeeding.
When to take the drug with extreme caution
In accordance with the instructions for use, Arthrosan ampoules and tablets with extreme caution are prescribed by doctors to patients who are in old age, as well as to those who suffer from the following conditions:
- The presence of coronary heart disease.
- The appearance of congestive heart failure.
- The presence of cerebrovascular disease.
- The presence of diseases of the peripheral arteries.
- The development of dyslipidemia, diabetes mellitus and chronic renal failure.
- The appearance of ulcerative lesions in the digestive system along with Helicobacter pylori infection.
- A bad habit is smoking.
- The presence of severe somatic diseases.
This drug should be used with caution against the background of prolonged use of other non-steroidal anti-inflammatory drugs, in addition, with alcohol abuse. It is not quite suitable for concomitant treatment with anticoagulants, for example, during therapy with the drug "Warfarin". You should not use it with simultaneous treatment with antiplatelet agents, for example, when using acetylsalicylic acid or Clopidogrel.
With oral administration of glucocorticosteroids and selective inhibitors in the form of “Citalopram”, “Fluoxetine”, “Sertraline” and “Paroxetine” this medicine should also be used with caution. In order to reduce the risk of adverse events from the digestive organs, the minimum effective dosage should be taken in a short course. Next, consider what dosages to take the drug. Now we will tell you how to do, according to the instructions for use, intramuscular injections "Arthrosan".
Drug dosage
Intramuscular administration of the drug is prescribed to patients in the first few days of treatment. Further therapy continues with the use of the oral version of the drug, that is, in the form of tablets. The recommended dose is 7.5 or 15 milligrams once a day. It depends on the intensity of pain, in addition, on the severity of the inflammatory processes. Given that the potential risk of side effects directly depends on the dosage and duration of therapy, the smallest effective amounts of the drug should be used within the shortest possible courses.
In patients who suffer from severe kidney failure and are on hemodialysis, the intramuscular dosage of “Arthrosan”, according to the instructions for use, should not exceed 7.5 milligrams per day. This drug is administered by deep intramuscular injection. The contents of the ampoule are not recommended to be mixed with other drugs in the same syringe. The presented drug is not allowed to be administered intravenously.
Side effects during use
The digestive system can respond with nausea, vomiting, abdominal pain, diarrhea, constipation, and flatulence. Patients may also burp along with esophagitis, a stomach or intestinal ulcer. Gastric or intestinal bleeding in a latent as well as explicit form is not excluded. Perhaps the appearance of stomatitis, perforation of the digestive organs, colitis, hepatitis or gastritis. Hematopoietic organs can react with leukopenia or thrombocytopenia.
The condition of the skin can be noted by the appearance of itching, rash or urticaria. Bullous eruptions can also be observed along with erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis. Failure of the respiratory system is likely to manifest itself in the occurrence of bronchospasm.
The nervous system may respond with dizziness, headaches, tinnitus and drowsiness. Less commonly, patients experience emotional lability with confusion and disorientation. Cardiac and vascular activity may be accompanied by peripheral edema, increased pressure and hyperemia of the face.
Malfunction of the urinary system is usually expressed in the appearance of hypercreatininemia, an increase in the concentration of urea and acute renal failure. The occurrence of interstitial nephritis, albuminuria and hematuria is not ruled out. The sensory organs can react with the appearance of conjunctivitis and blurred vision. Allergic reactions are usually expressed in the form of angioedema. Anaphylactic reactions are not excluded.
Drug overdose
In case of drug overdose, symptoms may appear in the form of impaired consciousness, nausea, vomiting, epigastric pain, digestive bleeding, acute renal failure, respiratory arrest and asystole.
This is described in the instructions for use. Reviews about Arthrosan will be presented at the end of the article.
Drug interaction
Against the background of the simultaneous use of Arthrosan with other non-steroidal anti-inflammatory drugs, the risk of erosive and ulcerative lesions increases along with bleeding in the digestive system. In the framework of simultaneous use with antihypertensive drugs, a decrease in their effectiveness is likely. With simultaneous use with lithium preparations, cumulation is likely to develop with an increase in the toxic effects of this substance. Thus, doctors are advised to monitor the concentration of lithium in the blood.
With simultaneous use with methotrexate, side effects on the hematopoietic system may increase. In this case, there is a danger of developing anemia or leukopenia, in connection with which patients are shown periodic passage of a blood test. Against the background of simultaneous use with diuretics and Cyclosporine, the risk of formation of renal failure increases. With simultaneous use with intrauterine contraceptive medications, a decrease in their effectiveness is likely.
Against the background of simultaneous use with anticoagulants in the form of Heparin and Warfarin, in addition, with thrombolytic drugs and antiplatelet agents such as Ticlopidine, along with Clopidogrel and acetylsalicylic acid, the risk of bleeding increases. In this regard, patients require periodic monitoring of blood coagulation.
With simultaneous use with "Colestyramine", the excretion of the main component of meloxicam through the digestive system can be accelerated. Against the background of simultaneous use with selective inhibitors, the risk of bleeding in the stomach or intestines increases.
There is other information in the instructions for use for injections "Artrozan".
special instructions
The drug can change the properties of platelets, but it does not replace the preventive effect of acetylsalicylic acid in the presence of heart or vascular diseases. Particular caution should be exercised in the application of the drug to patients with a history of certain indications of peptic ulcer of the stomach or intestines. The same applies to patients who are on anticoagulant treatment. In such patients, the risk of developing erosive and peptic ulcer diseases of the digestive system is increased.
Extreme caution should be observed, in addition, to control renal function in case of using the drug in elderly patients and those who have reduced glomerular filtration. Thus, this drug is prescribed with caution to patients suffering from dehydration, cirrhosis, nephrotic syndrome, clinically severe kidney disease, as well as those who take diuretics.
In case of signs of liver damage in the form of skin itching, yellowing of the integument, nausea, vomiting, abdominal pain, darkening of urine, persistent and significant increase in transaminases and changes in other indicators of the functions of this organ, the drug should be stopped immediately, contacting as soon as possible to the attending physician.
According to the instructions for use for injections of "Arthrosan", after two weeks of using the drug, control over the activity of liver enzymes is required. Among patients with a slight or partial failure of renal function, dosage adjustment is not required. Patients who take diuretics with meloxicam at the same time should drink enough fluids.
When observing allergic reactions in the form of pruritus, rash, urticaria, or photosensitization during therapy, you should consult a doctor to resolve the issue of stopping treatment with this drug. The active substance "Arthrosan" - meloxicam, like other non-steroidal anti-inflammatory drugs, can hide the symptoms of infectious diseases.
The use of meloxicam, as well as other drugs that block the synthesis of prostaglandins, can affect fertility, and therefore it is not recommended for women who are planning a pregnancy. You should not use this medicine at the same time as other non-steroidal anti-inflammatory drugs.
It is also worth noting that the use of this drug can cause headaches, dizziness and drowsiness. When such symptoms appear, you should refuse to drive a car, as well as to perform other activities that require special attention and quick response.
Such information is contained in the instructions for use with Arthrosan injections.
Storage conditions for the drug
This pharmaceutical preparation should be kept exclusively in a dark place at a temperature which should not exceed 25 ° C. In addition, the storage location should not be accessible to children. The total shelf life of the drug is about five years.
This is confirmed by the instructions for use with Arthrosan tablets.
Analogs
The most popular analogues of this drug include drugs such as Movalis along with Actamelox, Meloxicam, Mesipolum, Mirloxom, Movasin, and Amelotex.
Drug Reviews
In their reviews, people call "Arthrosan" a good drug with an analgesic effect. Patients consider it to be a fairly effective drug in the treatment of various pain syndromes, in particular, it is widely used in the presence of vertebrogenic radiculopathies, in addition, in the development of osteoarthralgia and muscle pain syndromes. Doctors advise using it in combination with muscle relaxants, which helps to achieve persistent anti-inflammatory and analgesic effects. It is also indicated in the instructions for use with the tablets.
Reviews about “Arthrosan” do not end there. Some people write that this drug is not inferior in its effectiveness to Movalis, while the medicine is two times cheaper: from one hundred fifty to five hundred rubles.
People also call "Arthrosan" a good drug for combination therapy of moderate muscular and articular inflammatory process. Thus, it is excellent for the treatment of arthrosis, arthritis and myositis. According to consumers, Arthrosan can relieve pain on the fourth day.It is noted that immediately after parenteral administration of the drug, the patient needs to be transferred to the oral form, which is used for another week. This information can be found in the instructions for use. Reviews about the injections of "Arthrosan" are also available from doctors.
Specialists, in turn, note that the drug is the best tool for the combination therapy of severe muscle inflammation. According to doctors, "Arthrosan", compared with other non-steroidal anti-inflammatory drugs, side effects from the digestive system gives much less. Thus, according to experts, this drug is by far the most commonly prescribed means to relieve inflammation in the joints and muscles.
We examined the "Arthrosan" injections instructions for use, analogues and reviews.