In the article, we consider the instructions for use with "Oxamp" in capsules and injections.
When it is necessary to get rid of an infectious disease that provokes the development of the inflammatory process, antibacterial drugs are prescribed. To increase the effectiveness of treatment, drugs with a wide antimicrobial spectrum are used. Most pathogenic microorganisms are sensitive to these antibiotics. In addition, complex treatment is prescribed or combined drugs are used. One of the last - “Oxamp” - combines the effectiveness of two antimicrobial substances.
Structure
According to the instructions for use, “Oxamp” is included in the group of antibiotics from the category of penicillins and is a combined preparation. The ratio of active components - ampicillin and oxycillin, differs depending on the form of release of the drug. In capsules, the ratio of both substances is the same. In the powder, 1 part of oxacillin and 2 parts of ampicillin are used to prepare the solution. "Oxamp" is dispensed in pharmacies after presenting a prescription from a doctor.
The properties
The combination of ampicillin and oxycillin can significantly expand the spectrum of antibacterial effects of Oxamp. Active components have an inhibitory effect on the synthesis of the bacterial cell wall, thereby adversely affecting the causative agents of harmful microflora.
Ampicillin is active against the following bacteria:
- Strains of staphylococci gram-positive type, except penicillinase, as well as enterococci, streptococci and bacteria that do not form spores.
- Strains of gram-negative bacteria, such as Escherichia coli and Haemophilus influenzae, Neisseria, Shigella, Salmonella and pertussis pathogens.
Oxacillin, in turn, acts on the following harmful microorganisms:
- Gram-positive, which produce penicillinase, streptococci and pneumococci, as well as pathogens of diphtheria.
- Gram-negative bacteria such as gonococci and diphtheria bacillus.
- Anaerobic bacteria, spore-forming bacilli and actinomycetes.
Two antibacterial substances complement each other's properties. Ampicillin is active against many gram-negative microorganisms, and oxycillin shows resistance to penicillinase. Thus, it is possible to expand the spectrum of antimicrobial activity of the drug and treat many inflammatory diseases with the help of Oxamp.
Indications
As indicated by the instructions for use with Oksamp, the combination of two antibacterial substances allows you to expand its antimicrobial effect. The drug is prescribed for the treatment of inflammatory diseases of infectious origin of various localization, including:
- Infectious diseases of the respiratory system, namely pleurisy, bronchitis, pneumonia, bronchiectasis, etc.
- Diseases of the ENT organs caused by bacterial damage: otitis media, inflammation in the sinuses, tonsillitis, etc.
- Bacterial damage to the skin and other tissues that occurs against the background of infection of wounds, dermatoses, impetigo, erysipelas and burn disease.
- Inflammation in the urinary tract and reproductive system, in the kidneys, bladder, urethra and cervical canal.
- Infectious lesions of the biliary tract and digestive system, such as dysentery, salmonellosis, cholangitis and cholecystitis.
- Inflammatory processes of a local or generalized type that are life-threatening - sepsis, endocarditis, meningitis, etc.
In addition, Oksampa injections, according to the instructions for use, are used for prophylactic purposes, for example, in the field of surgery, as well as in the infection of amniotic fluid to prevent aspiration-type pneumonia in newborns.
Contraindications
Any antibiotic from the category of penicillins has a slight toxic effect, so its administration is possible even for children immediately after birth. The main contraindications for injections of Oxampa according to the instructions for use are hypersensitivity to penicillins, mononucleosis and lymphocytic leukemia.
Instructions for use
The medication has a number of pharmacological features, it is rapidly excreted and does not have the ability to accumulate in the body, which necessitates its frequent administration. The daily dose of the drug can be divided into four injections, which must be done at regular intervals. Reception of capsules is more convenient and simpler, but not always feasible. Therefore, Oxampa injections are often used. The choice of dosage form should be made by the doctor when prescribing the drug.
The powder must be diluted with water for injection and injected intramuscularly or into a vein (jet or drip). This method is convenient for treating a child in the first year of life. Per day, children at this age are prescribed 100-200 mg per kilogram of weight. From one year to seven years, the dosage is 100 mg per kilogram of body weight, and from seven to 14 years old - 50 mg per kilogram. In the future, the dosage per day can range from two to four grams of active components. If necessary, the dosage can be doubled. However, any prescribed daily volume should be divided into 3-4 injections. Moreover, the duration of treatment is from 5 days to two weeks.
Powder Dilution Rules
According to the instructions for use with Oksamp injections for adults, a number of rules should be followed when diluting powder for injection. It is recommended to dilute the drug with water for injection, with water first being collected, which is then introduced into the vial with the antibiotic and shaken well until the powder is completely dissolved. For intramuscular injection, the resulting solution is drawn into a syringe and injected into the buttock.
If the patient is shown droppers with "Oxamp", the resulting solution is introduced into a bag with 200 ml of saline or 5-10% glucose solution. If the introduction is indicated to the child, then the volume of saline is reduced to 30-100 ml. Do not mix the drug with other drugs in the same dropper or syringe.
To reduce pain when administered intramuscularly, specialists may recommend diluting the powder with novocaine or lidocaine. For this, for one injection, you need to take 5 ml of anesthetic in the form of a solution. Lidocaine should be 1%, and novocaine 0.5%. If the child has an allergic reaction to the anesthetic, you can dilute it with injection water in a 1: 1 ratio.
This is confirmed by the instructions for use with Oksamp.
Analogs
The medication has a number of analogues that have an identical composition. These drugs include:
- Oksamsar.
- Ampioks.
- "Oxampicin".
- "Ampicillin + Oxacillin."
- Ampiox Sodium.
Other antibiotics from the penicillin category also have a similar effect. If Oxamp is not suitable for any reason, it can also be replaced by Amoxiclav, Flemoxin Solutab, Augmentin, etc. The specialist should choose an analogue of the drug based on the patient's indications and contraindications.
Reviews
Oxamp, according to reviews, is a safe and effective antimicrobial agent. The drug quickly eliminates the symptoms of the disease, while there are practically no adverse reactions. In rare cases, digestive upsets, including dysbiosis, have been observed. The undoubted advantage of the drug is its low cost - about 10 rubles per bottle with powder for injection.
We reviewed the antibiotic "Oxamp" instructions for use.