In the article, we consider the instructions for use for the Ximelin preparation. It is a local vasoconstrictor drug, the use of which is indicated for the treatment of rhinitis and other diseases of the ENT organs. The main active ingredient in Ximelin is xylometazoline hydrochloride.
When it gets on the mucous membranes of the nose, Xymelin provokes a narrowing of the dilated vessels located in it, against which swelling decreases, irritation decreases, it becomes easier for the patient to breathe through the nose, mucus secretion and the frequency of sneezing are reduced.
As an additional component, Xymelin includes levomenthol, which enhances the therapeutic properties of the drug.
The composition of Xymelin Extra, in addition to xylometazoline hydrochloride, includes another active component, ipratropium bromide, which reduces the ability of the glands located in the nasal mucosa to secrete mucus.
Due to the local application of the drug, the active components practically do not enter the systemic circulation.
Pharmacological forms
According to the instructions, Xymelin is a clear, colorless liquid. The manufacturer produces in the following pharmacological forms:
- A spray intended for nasal use in children, having a dosage of the active component of 0.05%. The product is packaged in dark bottles made of glass. Each bottle contains 10 ml of medicine, has a tip and a protective cap.
- A spray intended for nasal use in adults, having a dosage of the active component of 0.1%. The product is packaged in dark bottles made of dark glass, each of which can contain 10 ml or 15 ml of the medicine. Each bottle is also equipped with a tip and a special protective cap.
- Ximelin drops according to the instructions are intended for nasal use in children with dosages of the main component of 0.05%, for nasal use in adults - 0.1%. Drops are packed in dark dropper bottles, each of which has a volume of 10 ml.
Indications for use
As indicated by the instruction, Xymelin spray and drops are indicated for use in the following cases:
- If the patient has signs of acute respiratory infections, which is accompanied by difficulty breathing, redness of the surface of the mucous membrane in the nose, its swelling, severe runny nose (for example, sinusitis or various etymologies of rhinitis).
- For the purpose of symptomatic treatment of acute rhinitis provoked by an allergy, eustachiitis (inflammatory processes in the auditory tube that cause stuffiness in the ears due to impaired ventilation), sinusitis, pollinosis.
- With otitis media, if there is a need to eliminate puffiness of the mucous membrane located in the nasopharynx.
- In preparation for a variety of diagnostic studies involving manipulations in the nasal passages.
Contraindications
In accordance with the instructions, Xymelin in any form should not be used by patients:
- With angle-closure glaucoma.
- With increased intraocular pressure.
- Under the age of 2 years.
- In the presence of individual hypersensitivity to any of the components that make up the drug.
- If there is a history of information about brain operations.
- In the presence of atrophic rhinitis.
- If the patient is diagnosed with tachycardia.
- With hyperthyroidism (if the patient's thyroid gland produces an excessive amount of hormones).
- With severe atherosclerosis.
- With arterial hypertension.
"Xymelin Eco" is contraindicated for use under the age of 10 years, as well as for pregnant women.
Xymelin Extra is not recommended before the age of 18 years and during pregnancy.
Xymelin should be prescribed with caution if the patient is pregnant, breastfeeding, and also if the following diagnoses are noted in patients:
- Impaired intestinal patency.
- The tendency to bleeding.
- Thyrotoxicosis.
- Cystic fibrosis.
- Urinary obstruction.
- Hyperplasia of the prostate gland.
- Angina pectoris.
- Lack of heart functionality.
- Diabetes.
Side effects
According to the instructions for use with Ximelin spray, the following negative effects may develop during therapy with its use: sneezing, paresthesia, burning, dryness and irritation of the nasopharynx.
If the drug is used by patients for a long period and uncontrollably, the development of a number of side effects is not ruled out.
So, the central nervous system can react with the occurrence of hand tremor, general weakness, depression, anxiety, anxiety, emotional lability, decreased visual acuity, insomnia, disturbed sleep and wakefulness, dizziness and headache.
The cardiovascular system can also negatively respond to the use of the drug by the development of tachycardia, arrhythmia, and arterial hypertension.
Among other possible negative effects of Xymelin, rhinorrhea (increased secretion of mucus from the nasal cavity), swelling of the nasal mucosa, vomiting, allergic reaction, manifested by Quincke's edema, nosebleeds should be noted.
Instructions "Xymelin"
A medication in any form should be administered intranasally. It is preliminary recommended to clear nasal passages from mucus.
Drops are instilled in the usual way.
If a spray is used, it is first necessary to remove the protective cap, carefully insert the tip of the nebulizer into the nasal passage and spray by inhalation. This will allow the drug to irrigate the entire nasal cavity. Spraying must be done in both nostrils.
The use of Xymelin is not recommended more often than three times a day. The course of therapy should not last more than a week.
Adult patients are shown the use of drops or spray with a dosage of the active substance of 0.1%. "Xymelin" drops are used no more than three times a day, 2-3 drops in each nasal passage. If a spray is used, 1 spray should be performed three times a day.
When using the spray "Xymelin Eco" containing menthol, a single or twice daily dose of one dose is prescribed in each nasal passage. The duration of therapy can reach 10 days.
When using Ximelin Extra spray, the treatment regimen is similar to Ximelin Eco.
Overdose
According to the instructions to "Ximelin", against the background of uncontrolled and excessive use of the medication, an overdose may occur, which is manifested by an increase in negative effects and can lead to:
- To oppression of the central nervous system or, conversely, to its overexcitation.
- An increase in body temperature.
- Palpitations.
- Significant rise in blood pressure or its sharp drop. A similar phenomenon is called circular collapse.
- Cramps.
- Coma.
If symptoms of an overdose are detected, the patient is shown the appointment of symptomatic therapy, which consists in taking alpha-blockers, such as Phentolamine, Tropafen, Pyroxan, Prazolin.
How to use Xymelin for children according to the instructions?
Use in the treatment of pediatric patients
The medication is strictly contraindicated in children under 2 years of age; Xymelin Extra is contraindicated in all children.
Indications for use of the drug in children are the same as in adult patients.
Children 2-6 years old are shown to use any form of Xymelin with a dosage of the active component of 0.05%. You can use the drug no more than twice a day. If drops are used, then no more than 2 drops should be administered no more than twice a day. If a spray is used, then one injection should be done twice a day.
Children from 6 years old are shown the use of a drug with a dosage of 0.1%. The instruction for Ximelin Nasal Spray confirms this.
Enter one dose of the spray or 2-3 drops. Multiplicity of applications - no more than three during the day.
Ximelin Eco menthol spray can be used in children from 10 years old. It is recommended in this case to use 1 dose twice a day.
Interaction with other medicines
Experts do not recommend the use of Xymelin in combination with tricyclic antidepressants and iMAO drugs because of the likelihood of a sharp increase in blood pressure.
The combined use of anticholinergic medicines and Xymelin Extra enhances the therapeutic effect of ipratropium bromide.
Analogs
The most famous analogues of Xymelin are: Rinorus, Brizolin, Influorin, Xylobene, Tizin Xilo, Rinonorm, Suprima, Espazolin, Snoop, Nosolin. Olint, Rinomaris, Rinostop, Sialor, Evkazolin Aqua, Galazolin, Fornos, Otrivin, Farmazolin. Replacing one drug with another should be done by a doctor.
The cost of "Xymelin"
The average cost of a spray with a dosage of 0.1% varies at the level of 160 rubles, drops - 100 rubles. Xymelin in the form of a spray with a dosage of 0.05% will cost about 180 rubles, in the form of drops - 80 rubles.