The drug "Sumamed Forte 200" is a strong antibiotic, effective in a wide range of diseases. The tool is available in the form of a powder for suspension. The product is effective in infecting the respiratory system, skin, it is used in the initial phase of Lyme disease and in the case of ulcers associated with Helicobacter pylori colonies. For a pharmaceutical product to be effective, but not provoke complications, you need to use it correctly, clearly observing the instructions drawn up by the manufacturer.
Technical information
As you can learn from the instructions for Sumamed Fort (200/5 ml), five milliliters of the finished product contains 0.2 g of the main active ingredient azithromycin. The antibiotic is used in the form of dihydrate. As additional components, the manufacturer used flavors and silicon dioxide. The product contains phosphate compounds, gum, sucrose, cellulose. If the patient's body is prone to a sensitization reaction to any substances, before using drugs, you need to make sure that there are no dangerous components.
The drug is packaged in 50-100 ml vials. The kit includes instructions for Sumamed Fort (200 mg). 16.74 g of the medicinal product are packed in a smaller bottle, a twice as large - 29.295 g. To make the container, darkened brownish glass is used. To the bottle was hermetically sealed, it is closed with a lid of polypropylene. A measuring spoon or syringe is attached to the bottle in the kit. In some cases, the manufacturer puts both items for accurate dosing. The entire kit is placed in a cardboard box. On the outside, the exact mass of the drug, the dosage of the active ingredient, the date of manufacture and the shelf life of the medication are recorded.
Pharmacology
As you can see in the instructions for Sumamed Fort (200 mg / 5 ml), the main ingredient that guarantees the effectiveness of a pharmaceutical product is azithromycin. The substance is classified as macrolide, is an azalide. This is a bacteriostatic drug, which has a wide range of results when interacting with dangerous microflora. Azithromycin inhibits the process of generating microbial cell proteins. The substance reacts with the 50S ribosomal substance, inhibits peptide translocase at the translational stage, and inhibits protein synthesis. This complex effect ensures the slow growth of pathological microflora. The drug inhibits the ability of bacteria to multiply. If the concentration is high enough, a bactericidal effect is observed.
The tool has a pronounced effect in relation to gram-positive and negative bacteria, intracellular parasites, anaerobic life forms. You can use the drug to combat a number of other pathological microorganisms.
Names and effects
In the instructions to Sumamed Forte (200 mg / 5 ml), the manufacturer indicates the reliability of the use of the drug in the treatment of diseases provoked by aerobic life forms, when tested according to Gram showing a positive result. You can prescribe a product if infection with methicillin-susceptible staphylococcus perceiving penicillin streptococcus has occurred. "Sumamed forte" is indicated for infection with pyogenic streptococcus.
It can be used if studies have shown aerobic infection, while the pathogen when studying according to Gram shows a negative result. The drug is effective against the hemophilic shelf, Legionella and Moraxella, Pasteurella and Neisseria.
In case of anaerobic infection, it is reasonable to prescribe a drug to combat clostridia, fusobacter, and prothothella. The tool shows a reliable effect when infected with porphyriomonads. Use the product if the tests showed some forms of chlamydia, mycoplasma, and borrelia.
Does it work or not?
In the instructions to “Sumamed Forte” (200 mg / 5 ml), the fact of the possible resistance of pathological life forms to the drug is recorded. Tests have shown that resistance to the main ingredient of a pharmaceutical product can develop penicillin-resistant strains of streptococcus from the form of pneumonia. Similar risks are present if infection is detected with a strain that is characterized by an average penicillin susceptibility.
Enterococci, bacteroids are naturally resistant to azithromycin. If staphylococcus is not dangerous methicillin, he also does not perceive Sumamed forte.
From medical practice, cases of cross-resistance between some forms of streptococci from type A beta-hemolytics, some staphylococci, entercocci are known. Cross resistance covers erythro-, azithromycin, other macrolides, lincosamides.
Kinetics
As you can see from the accompanying documentation, Sumamed Forte (200 mg / 5 ml, 15 ml and other forms of release) is made using azithromycin, which can be quickly absorbed into the circulatory system after oral use. The maximum concentration in serum is achievable on average in a couple of hours. Bioavailability is estimated at 37%.
Binding to whey proteins inversely depends on the content of the active ingredient in the blood, varies between 12-52%. The volume of distribution is estimated at 31.1 l / kg.
The active ingredient is able to penetrate cell membranes, therefore it is effective in the case of intracellular microorganisms. Transportation is carried out by phagocytes, macrophages, leukocytes. With these cells, azithromycin penetrates the infectious focus, is thrown out due to the presence of bacterial invasion. The tool seeps through a variety of barriers, penetrates into organic tissues. At the cellular level, the content of the active ingredient in the tissues is approximately 50 times greater than in the blood serum. Accumulation occurs more actively in the focus of infection than in healthy zones by 24-34%.
Kinetics: Continuing Examination
The documentation compiled by the manufacturer, attached to Sumamed Fort (200 mg / 5 ml), clarifies the fact of processing the active component in the liver. Chemical demethylation reactions are localized here, due to which azithromycin ceases to be therapeutically effective.
Elimination is relatively slow. The half-life of tissues is estimated at three days with a possible deviation to the larger and smaller side for a day. A therapeutically effective amount of an antibiotic is observed in the body up to a week after receiving the last portion of the drug. Elimination is mainly carried out by the intestinal tract in its original form. Up to 12% of the substance is excreted by the renal system.
Special occasion
Using Sumamed Forte (200, 15 ml and another release option) in case of weakness of the renal system, it is necessary to remember about the possibility of changing kinetic parameters. If creatinine clearance is less than 10 units, the elimination half-life is increased by a third. If kidney failure is established, it is necessary to conduct a case very responsibly. It is important to regularly check indicators in order to control the concentration of the antibiotic in the body.
When is it shown?
"Sumamed Forte" (200 mg) is recommended for use in detecting infection, a disease accompanied by inflammatory processes. The drug is prescribed if the microflora that provoked the disease is susceptible to azithromycin. You can prescribe a remedy for tonsillitis, sinusitis, as well as other infectious diseases, covering the upper airways to the lungs. Allowed the appointment of funds with the penetration of an infectious agent into the lower zones of the respiratory tract. In this case, among the indications it is worth noting acute bronchitis, a relapse of the chronic course of this disease, as well as pulmonary inflammation that developed in a community-acquired form.
You can use the medicine for Lyme disease. The pharmaceutical product is well established in its initial stages. It is prescribed if migratory erythema is established. A suspension can be prescribed to a person suffering from infectious pathologies of the skin, soft tissues. Often, “Sumamed Fort” is resorted to if it is necessary to treat erysipelas, dermatosis, secondarily affected by an infectious agent. The indication for the appointment of the drug is impetigo.
Terms of use
The drug "Sumamed Forte" (200/5) is prescribed for internal use. The tool is used once a day. It is advisable to take the drug an hour or a couple of hours before a meal. Shortly after receiving the medication, the child should drink a few sips of water. This makes swallowing the remaining powder easier. Before the next use, you need to carefully, but carefully mix the contents of the container so that the substance becomes as homogeneous as possible. If the required amount is not measured in the next third of an hour, you must first mix the product again, only then use inside.
To measure the desired volume, use a syringe or a spoon, which the manufacturer applies to the product. The division price is a milliliter, the maximum volume is 5 ml. 2.5-5 ml fit in one spoon. After use, the product is washed. If a syringe is used, it must first be disassembled. For washing, running water is used. The item is dried, left in storage in a clean place, protected from dust.
Cooking nuances
You can learn how to breed Sumamed Forte (200/5) if you familiarize yourself with the manufacturer's instructions attached to the product. If the bottle is intended for the preparation of 15 ml of the drug, it is necessary to draw with a syringe 9.5 ml of pure water and enter into the container. The product is thoroughly mixed until the product becomes homogeneous. The finished product in the volume will be about 20 ml - that is, more than the nominal volume by 5 ml. This is necessary to exclude losses caused by dosing. The prepared product is stored in an environment heated to a level of no more than 25 degrees. Shelf life - up to five days.
It’s no harder to figure out how to breed Sumamed Forte 200 mg if a person has a bottle for 30 ml of the drug. Measure with a syringe 16.5 ml, inject this liquid into the container. Everything is thoroughly mixed so that the product becomes homogeneous. The finished product will be in the amount of about 35 ml. An extra 5 ml is provided to compensate for losses caused by dose metering. The finished product is stored for no more than ten days. Temperament mode - 25 degrees.
Finally, you can consider how to breed Sumamed Forte 200, if the capacity is 37.5 ml. In this case, 20 ml are injected into the vial with a syringe. The procedure is as described above, including thorough shaking. The finished product will be larger than the nominal in volume in order to prevent losses caused by dosing. Prepared for reception, the product is stored for no more than 10 days.
Doses and Age
If infection, inflammation is established, "Sumamed forte 200" for children is prescribed, focusing on the weight of the patient. For each kilogram, 10 mg of the drug is indicated. The drug is taken once a day. Duration of use - a three-day program. In total, the patient receives 30 mg per kilogram of weight per course. To determine the optimal volume for a single dose, it is taken into account that for a weight of up to 14 kg, 2.5 ml or 0.1 g of an antibiotic is shown, for a mass of 10 kg more, the dose is doubled. Children whose weight varies between 25-34 kg are prescribed 7.5 ml of the drug, which corresponds to 0.3 g of antibiotic. For weights up to 44 kg inclusive, 10 ml is used at a time, i.e. 0.4 g of azithromycin.
If Sumamed Forte 200 is prescribed for children weighing more than 45 kg, it is necessary to use 12.5 ml of a pharmaceutical product containing 0.5 g of antibiotic. This dosage is appropriate for adults.
Diagnoses and Doses
In the event that pyogenic streptococcus has caused tonsillitis, pharyngitis, Sumamed Fort 200/5 mg is used in an amount of 20 mg / kg per day. Duration - three days, just for the course of the patient receives 60 mg of the drug for each kilo of weight. The maximum per day is 0.5 g. If treatment is indicated for children whose weight is less than 10 kg, you should abandon the specified form of release and use half as saturated.
With erythema migrans, indicating the primary step of Lyme disease, you need to use the drug on the first day in an amount of 20 mg per kilo, from the second day to the fifth, use the product in half. In total, during the course for each kilo the patient receives 60 mg of the drug.
Do I need to adjust?
If Sumamed Forte 200/5 mg is prescribed against a background of weak kidney function, while creatinine clearance exceeds 10 units, specialized correction of volumes is not necessary. If the liver function is mild or moderate, it is also not necessary to adjust the volumes of the pharmaceutical product received by the patient.
For elderly people, Sumamed Forte is prescribed in standard amounts. It is recommended to carefully monitor such a patient, as there is a danger from the factors that provoke arrhythmia. Together with the drug course, this can increase the risk of arrhythmias, including those proceeding according to the pirouette type.
Undesirable effects: what to be prepared for?
The use of Sumamed forte 200 suspension can cause candidiasis, localized on the oral, genital mucous membranes. There is a risk of respiratory diseases, runny nose, inflammatory processes in the throat, lungs. In a vanishingly small percentage of those receiving the pharmaceutical product, pseudomembranous colitis was observed. An antibiotic can cause neutro, thrombocyte, and leukopenia. Its use can provoke anemia, eosinophilia. Anorexia, anaphylactic, angioneurotic response, and sensitization of the body were occasionally recorded.
Against the background of receiving a suspension of eosinophilia, some patients noted that they were sick and dizzy. Feelings of anxiety, irritation without cause are possible. Cases of sleep disturbance, paresthesia, temporary malfunction of the taste buds have been recorded. With an unknown frequency, fainting, worsening of smell and a perversion of this perception, delirium and hallucinations are possible. Occasionally, patients worsened vision. There is a risk of hearing impairment, palpable heartbeat, hot flashes, and decreased pressure. Possible bleeding from the nose, shortness of breath. The drug can provoke stool disorders, increased gas formation, abdominal pain, pancreatitis, hepatitis and jaundice.
While receiving a suspension of Sumamed Forte 200, some developed itchy, reddened lesions on the skin. There is a risk of urticaria, activation of sweat glands, sensitivity to light. Erythema, necrolysis, myalgia, arthralgia are possible. There is a risk of osteoarthritis. Occasionally, the product provoked dysuria, metrorrhagia, nephritis, asthenia, swelling of the face, and fever.
Laboratory indicators and medication
Under the influence of azithromycin contained in Sumamed Fort, specific changes in blood quality indicators are possible when they are studied in laboratory conditions. There is a possibility of a reduced concentration of lymphocytes and an increase in the content of eosinophils. The number of neutro-, basophils, monocytes may increase. There are cases when, with the drug, the saturation of blood serum with bicarbonates decreased. Excessive liver enzyme activity is occasionally observed. There is a chance of an increase in the content of bilirubin, urea, creatinine. Some have changed potassium, perchloric, glucose, sodium concentrations in blood serum. Perhaps an increase in hematocrit.
Sometimes you can’t
It is strictly forbidden to prescribe Sumamed Forte to children under six months of age. The drug is not used if hepatic impairment is very pronounced. It is forbidden to prescribe a drug with increased susceptibility to erythro-, azithromycin, macrolides, ketolides. Do not use Sumamed Forte in a sensitization reaction to other components used by the manufacturer. The tool is prohibited in case of a lack of isomaltase, sucrose in the body. It is not suitable if the human body does not tolerate fructose. "Sumamed forte" is not used if glucose-galactose malabsorption syndrome is detected. You can not use the drug if the patient is forced to receive ergotamine, dihydroergotamine.
In some cases, Sumamed Forte may be used, if there is no other alternative, more secure. Such use requires maximum caution. , , , , , . « », , . , , . , . , « », , , , .
During pregnancy, Sumamed Forte is prescribed if the obvious benefit is significantly greater than the possible harm. The doctor must warn the expectant mother about the risks associated with the use of an antibiotic. Strict restrictions are due to lactation. If a woman is breastfeeding, it is necessary to refuse to take the product in question. If this is not possible, for the period of treatment you need to transfer the baby to an alternative diet.
Features and rules of use
If there is a need to prescribe an antibacterial course for diabetics, it is necessary to take into account the fact that the Sumamed Fort suspension contains sucrose. This fact is important for all others who are forced to adhere to a low-calorie nutrition program.
If you missed the reception, you need to recover the pass as quickly as possible. Each subsequent portion is consumed at daily intervals between doses.
It should be used for an hour or a couple of hours after receiving antacids to patients.
In case of weak liver function of a weak, moderate level, the reception of "Sumamed Forte" is accompanied by the danger of the formation of hepatitis and aggravation of organ failure. If symptoms of hepatic pathologies are observed, asthenia intensifies, urine darkens, organ encephalopathy is observed, the course of the antibiotic is stopped. The patient should receive an adequate clinical examination of the liver to evaluate functionality.