"Retabolil": instructions for use, analogues, reviews

In the article, we consider the instructions and reviews for the "Retabolil" drug.

This is an anabolic drug for systemic use. It is highly effective in the treatment of various types of osteoporosis, cachexia, protein metabolism disorders. It is used to increase catabolism, which depletes the body’s resources (injuries, burns, surgical interventions, radiation therapy), as well as for serious infectious diseases.

pharmachologic effect

According to the instructions, Retabolil is a steroidal anabolic agent, a chemical derivative of testosterone. Compared with testosterone, it has a higher, longer (3-4 weeks when decanoate ester is used) anabolic and decreased androgenic activity.

The medicine helps to fix calcium in bone tissue, increase bone mass with the development of osteoporosis, increase appetite, increase muscle mass with a corresponding increase in body weight.

This is confirmed by the instructions for use. In bodybuilding "Retabolil" is used very often.

This medication accelerates the growth, development of male genital organs and the formation of secondary sexual characteristics of the male type. It also stimulates the secretory function of androgen-dependent glands - male sex (activation of sperm production), sebaceous; in high doses, it provokes suppression of Leydig cells and reduces the synthesis of endogenous sex hormones as a result of inhibition of synthesis by the pituitary gland of LH and FSH (negative feedback).

It increases the level of absorption of amino acids from the lumen of the small intestine (against the background of a strict diet enriched with proteins), contributing to a positive nitrogen balance.

As indicated by the instructions for use with Retabolil, the anabolic effect of this pharmacological agent is manifested by the activation of the reparative process in the epithelium (glandular and integumentary), muscle and bone tissue due to the stimulation of the synthesis of proteins and structural elements of cells.

This drug stimulates the synthesis of erythropoietin and activates the anabolic process in the bone marrow, which, with the concomitant administration of iron preparations, can exhibit an antianemic effect.

The instructions for injections "Retabolil" are very detailed.

The drug disrupts the synthesis of vitamin K-dependent blood coagulation factors in the liver, changes the plasma lipid profile, enhances the reabsorption of water and sodium in the kidneys, and contributes to the formation of peripheral edema. Effective when used in women with disseminated breast carcinoma.

Release forms and composition

As the instruction manual for Retabolil tells us, the only dosage form of this pharmacological agent is an oil solution intended for intramuscular use: greenish-yellow, transparent, with a specific smell, without any visible extraneous mechanical impurities. Pour the solution into 1 ml ampoules. The product is packed in 1 ampoule in cardboard boxes or 1 ampoule in contour plastic packaging (pallets), 1 pallet in a cardboard bundle.

The solution contains the main active element - nandrolone decanoate and additional substances - sunflower oil, benzyl and isopropyl alcohols.

Indications for appointment

In accordance with the instructions for Retabolil, the pharmaceutical preparation is used to treat diseases in which prolonged use of anabolic drugs is indicated (to avoid complications, taking the medication is possible strictly according to the prescription of a specialist). The list of indications for prescribing this medication includes the following pathological conditions:

• osteoporosis of various etiologies;
• disturbances in protein metabolism, which is provoked by serious burns, surgical operations, injuries, radiation therapy, infectious pathologies;
• Verdnig-Hoffmann spinal amyotrophy;
• muscle dystrophy in a progressive stage;
• cachexia of various nature of origin;
• glomerulonephritis, programmed hemodialysis in chronic renal failure;
• diabetic retinopathy;
• disseminated breast cancer in women (as a palliative therapeutic technique).

Perhaps the simultaneous use of the drug "Retabolil" with glucocorticoids, tuberculostatic and cytostatic pharmacological agents.

Contraindications

According to the instructions, the drug "Retabolil" can not be used for the following diseases:

• oncological tumors of the prostate and breast in men;
• chronic or acute prostatitis;
• nephrotic syndrome;
• severe liver damage;
• liver failure on the background of cancer pathologies or metastases in this organ;
• pregnancy, lactation;
• high sensitivity to the main elements of the drug.

Dosage and administration

According to the instructions, "Retabolil" must be administered intramuscularly. It is prescribed as part of inpatient and outpatient treatment. The specialist determines the dosage of the drug individually. The average adult single dose is up to 50 mg, the infant is determined at the rate of 0.4 mg / kg of weight. The frequency of administration is once every 3-4 weeks. With myopathy, it is possible for a doctor to determine individual dosages. With oncological pathologies, the adult dose is 50 mg once every 5 days, with severe kidney failure, such a dose is administered once every seven days.

What else can you learn from the instructions for use for retabolil injections?

Side effects

When using a pharmaceutical product, according to the recommended dosage regimen, the manifestation of negative side reactions is unlikely. With prolonged use or in the case of a substantial excess of dosages, the following side symptoms may occur:

• the progression of atherosclerotic changes (an increase in LDL and a decrease in HDL);
• peripheral edema;
• Iron-deficiency anemia;
• dyspeptic symptoms (epigastric pain, nausea);
• impaired liver function, accompanied by yellowness of the skin;
• leukemoid syndrome (pain in the tubular bones, leukemia);
• hypocoagulation with the development of bleeding;
• hepatonecrosis, with the occurrence of such phenomena as dark feces, cephalalgia, vomiting with impurities of blood, discomfort, respiratory distress);
• hepatocellular carcinoma;
• cholestatic hepatitis (sclera and skin jaundice, pain in the right hypochondrium, dark urine, discolored feces);
• hepatic purpura (fecal discoloration, dark urine, skin rashes, macular or pinpoint hemorrhagic rashes, tonsillitis, pharyngitis);
• increased secretion of the sebaceous glands;
• fever;
• change in libido;
• diarrhea;
• feeling of fullness of the stomach, flatulence;
• sleep disturbance, cramps;
• virilism phenomena in women (enlargement of the clitoris, hoarseness or coarsening of the voice, amenorrhea, excessive hair growth, oily skin, acne steroid);
• hypercalcemia (dyspepsia, central nervous system depression, excessive fatigue);
• virilism in men (penis enlargement, acne, priapism, the formation of secondary sexual characteristics);
• growth retardation or arrest;
• idiopathic increased skin pigmentation;
• mammalgia;
• prostatic hypertrophy;
• gynecomastia.

Instructions for ampoules "Retabolil" must be strictly observed.

Special recommendations

To achieve the desired therapeutic effect, during treatment, the patient should receive the necessary amount of vitamins, minerals and proteins with food. Due to androgenic activity, the drug “Retabolil” can be prescribed to women and children only in cases where the expected benefit is higher than the potential risk. The use of high dosages of this medicine in the puberty can lead to early closure of growth zones or its complete stop. In addition, this medication can lead to a delay in the body's fluid and sodium, so it must be used with caution in the presence of arterial hypertension, heart or kidney failure, migraine, epilepsy, glaucoma (as well as if there are similar indications of these pathological situations in the anamnesis) .

During treatment, careful monitoring of intraocular pressure is necessary. Before prescribing the Retabolil medication, as well as during the therapeutic course, rectal control of the size of the prostate gland is necessary. In some cases, during treatment, a violation of the liver function tests may be observed, as a result of which monitoring of liver function is recommended every month.

With diabetes and oncology

In diabetes mellitus, this pharmacological drug can provoke an increase in glucose tolerance, thereby reducing the body's need for oral hypoglycemic drugs and insulin.

With oncological metastases of the breast into the bone tissue, hypercalcemia may occur. In such cases, the use of a medical product is possible only after stabilization of the level of calcium in the blood.

The use of the drug "Retabolil" to stimulate athletic abilities is unacceptable, as this can lead to severe disorders.

Drug interaction

What else can you learn from the instructions for use with Retabolil?

With some caution, this pharmaceutical drug should be prescribed during complex treatment with the following medical devices:

1. Hypoglycemic drugs - due to the possibility of enhancing their hypoglycemic effect.
2. Indirect anticoagulants - due to the risk of increased exposure.
3. It weakens the effect of somatotropic hormones and their derivatives (enhances the mineralization of the epiphyseal areas of growth of tubular bones).
4. Corticotropin, GCS and MKS, sodium-containing medicines and foods enriched with sodium mutually enhance fluid retention in the body, significantly increase the risk of swelling and the severity of acne.
5. The simultaneous use of a drug with hepatotoxic drugs increases the likelihood of developing impaired liver function.

Cost

The price of this pharmacological agent is approximately 230-250 rubles per package. It depends on the region and the pharmacy network.

In the instructions for use, the analogues of "Retabolil" are not indicated.

Analogs

Analogues of a medicinal product are:

• Abolon;
• "Superball";
• Deca-Durabolin;
• "Fortabolin";
• Decanabol
• Turinabol-Depot;
• "Nandrolone Decanoate";
• "Decanandrolin";
• Anabozan-Depot;
• Eubolin;
• Gormoretard;
• Nortestosterone decanoate.
  

Reviews

There are not very many reviews about this pharmaceutical drug, since it is prescribed in extremely rare cases and is a medication of a specific direction of action. Due to the fact that this is a steroid drug, it is rarely prescribed for children and women, since the harm from it can be more pronounced than good.

Patients who were prescribed this medication noted its positive effectiveness after a single application, and they observed a significant improvement in the condition and pronounced signs of normalization of the pathological process. Basically, this tool was prescribed to middle-aged and young men.

Many patients in the reviews about this medication complain of numerous negative symptoms, in the form of side effects that developed in them with the use of this medication. The most common of these were disorders of the digestive organs, dizziness, excessive spread of acne.

We reviewed the “Retabolil” preparation instructions and reviews.