In the article, we consider the instructions for use of Bromhexine. It is a mucolytic medication that has an expectorant effect. The main active ingredient in its composition is bromhexine hydrochloride. Depending on the pharmacological form of the drug, it may contain such auxiliary substances as U-104, E-171, glucose syrup, talc, magnesium carbonate, calcium carbonate, sucrose, silicon dioxide, lactose monohydrate, magnesium stearate, gelatin, starch.
Pharmacological forms
The manufacturer produces the drug in tablet form and in the form of syrup. Each pack may contain a different number of tablets - 10-100, bottles with syrup have a volume of 50, 60, 100 ml.
"Bromhexine" refers to a group of expectorant, secretolytic, antitussive drugs.
Pharmacokinetics, pharmacodynamics
In what cases is it advisable to use Bromhexine? A mucolytic (secretolytic) and expectorant effect is characteristic of the drug. Due to these properties, the medication is indicated for use for the treatment of dry type cough in patients of the adult and children's category. The secretolytic property of the active component of the drug is due to its ability to depolymerize and thin the mucopolysaccharide and mucoprotein fibers of the secretion secreted by the bronchi.
In addition, the ability to stimulate the formation of surfactant (a substance having a surface-active nature lining the pulmonary alveoli from the inside) plays an important role in the productivity of Bromhexine therapy, as a result of which the protective forces of the pulmonary system increase. In addition to its main effects, the drug is also characterized by a weak antitussive effect.
With oral administration of Bromhexine, the substance is almost completely adsorbed in the digestive tract in 30 minutes. Due to the fact that the drug has the effect of the first passage through the liver tissue, its bioavailability is relatively low - about 20%. The active component binds well with plasma proteins, has the ability to overcome the blood-brain and placental barriers. The substance is metabolized by dimethylation and oxidation. The elimination half-life reaches 15 hours. The main part of the dose taken by the kidneys is evacuated. Bromhexine can accumulate in the body. Excretion of metabolites in renal dysfunctions is impaired.
Indications for use
Indicated for use "Bromhexine" for the treatment of painful conditions of the bronchopulmonary system, in which there is difficulty in sputum discharge:
- Pneumonia.
- Obstructive bronchitis.
- Tuberculosis.
- Bronchiectasis
- Cystic fibrosis.
- Pneumoconiosis.
- Bronchial asthma.
- Emphysema.
- Tracheobronchitis.
In addition, the medication is often used as a means of rehabilitation of the bronchial tree in the preoperative period, with the aim of prophylactic removal of sputum accumulated in the bronchi in the postoperative period, if necessary, therapeutic and diagnostic intrabronchial procedures are performed.
Contraindications
As the instructions for use for Bromhexine Berlin Chemi indicate, before starting therapy, it is necessary to study the manufacturer's annotation and familiarize yourself with the contraindications to the use of the medicine.
Among the absolute contraindications for use:
- Sugar intolerance.
- Individual hypersensitivity to the components.
- Age up to 2 years (in case of using syrup) and up to 6 years (in case of using tablets).
- The first trimester of pregnancy.
- Periods of exacerbation of ulcerative pathologies of the digestive tract.
- The lactation period.
The main relative contraindications are:
- Second, third trimester of pregnancy.
- Bronchopulmonary pathological conditions characterized by the accumulation of excessive amounts of secretion.
- The tendency to develop bleeding in the digestive tract.
- Diabetes.
- Pathological violations of the functionality of the kidneys, liver.
Negative impact
In accordance with the instructions for use with Bromhexine 8 Berlin Chemie, some side effects may develop during its use, including:
- Increased activity of liver enzymes.
- Manifestations of an allergic nature (angioedema, rhinitis, itching, skin rash, etc.).
- Headaches.
- Exacerbations of gastrointestinal ulcer pathologies.
- Feeling dizzy.
- Attacks of nausea, vomiting.
- Manifestations of a dyspeptic nature.
If this side symptom occurs, it is recommended to consult a doctor.
The use of Bromhexine 8 Berlin Chemi should be careful.
Drug use
In the case of using a tablet preparation, the drug should be taken orally. You can take it, regardless of the time of eating, drinking water in an amount of 0.1-0.2 liters. Adult patients are shown to take 8-16 mg of the drug three or four times a day. Patients 6-14 years old are shown to take 8 mg of the medicine three times a day. The therapeutic effect is observed after 4-6 days of using Bromhexine. If it is absent, consult a physician.
How to use Bromhexine syrup according to the instructions for use for adults and children?
A syrup preparation is used, as a rule, for the treatment of pediatric patients, that is, in the field of pediatrics, but this does not exclude the possibility of using the drug for the treatment of adult patients. In this case, it is recommended to take the syrup in the same way and at the same dosages as the tablets.
Syrup is produced with a mass fraction of the active component of 4 mg / 5 ml. As a rule, a syrup bottle is equipped with a measuring spoon or glass, which facilitates the dosing of the product.
In accordance with the instructions for use of Bromhexine syrup, children are shown to take it three times a day:
- 2-6 years - 2.5-5 ml.
- 7-10 years - 5-10 ml.
- Older than 10 years - 10 ml.
Using the child's form of the drug, it is recommended to carry out parallel postural drainage procedures or vibrational massage in order to further facilitate the process of sputum discharge.
The duration of Bromhexine therapy in any form may take 4-28 days. During treatment, it is important that the patient consume a sufficient amount of fluid. This will support a productive secretological impact.
Overdose
As indicated by the instructions for use of Bromhexine Chemie, in case of intoxication the patient may develop nausea, turning into vomiting (in some cases, it is absent), diarrhea, and other dyspeptic disorders.
If symptoms of intoxication are detected, vomiting should be induced in the patient within 2 hours, gastric lavage should be performed. After that, treatment with symptomatic medications is recommended.
Instructions for use with Bromhexine Berlin Chemi tablets and syrup should be strictly observed.
Interaction with other medications
"Bromhexine" should not be used in parallel with antitussive drugs, for example, codeine-containing, as this can cause difficulty in discharge of bronchial secretions.
When used together with non-steroidal anti-inflammatory drugs, the irritating effect on the mucous membranes of the gastrointestinal tract increases, the formation of ulcerative and erosive lesions is not excluded.
The use of Bromhexine Berlin Chemi tablets promotes the penetration of antibiotic and sulfonamide drugs, such as Cephalexin, Amoxicillin, Erythromycin, Oxytetracycline, into the sputum.
Analogs
If necessary, Bromhexine can be replaced by one of the following analogues: Fluimucil, Fluditec, Flavamed, Acetylcysteine, Bronchosan, ACC, Ambroxol, Bronchoxol. Ascoril, AmbroGexal, Lazolvan, Atsestin, Libexin, Ambrobene, Bronchorus, Abrol, Mukolik, Haliksol, Pektolvan Ts, Pulmozyme. Erdomed, Carbocysteine, Bronchobos.
It is important to remember that all of the indicated analogues of Bromhexine have their own contraindications and can provoke the development of specific side symptoms. In this regard, it is necessary to coordinate with the doctor the possibility of replacing the drug.
Use in the treatment of children
Syrup is prohibited for use in the treatment of children under 2 years old, tablets - up to 6 years.
Most often, in the treatment of children 2-6 years old, a syrup form of the drug is used, since it is easier to dose, it is easier to swallow small children. Use the medicine in strict accordance with the recommendations of the doctor.
The use of "Bromhexine" during pregnancy, in the lactation period
In the first trimester, the drug in any form is contraindicated. From the second trimester, the drug can be prescribed, but only if there is an emergency.
If Bromhexine treatment is required in the lactation period, breast-feeding for the period of therapy must be suspended.
The cost of this drug
The cost of the medicine depends on the manufacturer, the volume of the vial, the number of tablets in the package, the region of distribution, the price policy of the pharmacy.
A package of Bromhexine, containing 50 tablets with a dosage of 8 mg, will cost, on average, 25-50 rubles, syrup in a 150 ml bottle - 150 rubles.
Reviews about "Bromhexine"
Most often, the responses of adult patients who have experienced treatment with Bromhexine are positive. The medicine effectively dilutes sputum, which contributes to its rapid elimination, practically does not provoke the development of side symptoms (only in exceptional cases). Quite controversial are reviews of the experience of using Bromhexine for the treatment of children. This is usually due to the fact that mothers who want to cure a cough as soon as possible and do not get the desired effect in the first days of use respond negatively to the medicine.
Thus, it should be remembered that Bromhexine is not intended for cough therapy, but for thinning bronchial secretions, and a variety of bronchopulmonary pathologies may require treatment with medicines of various pharmacological groups, usually in combination. Therefore, you should not engage in self-treatment of a child - it is important to contact a pediatrician and observe his appointment strictly.
Separately, the low price and availability of the drug, which can be purchased in almost every pharmacy, are noted.