The pharmaceutical preparation “Papaverine” (suppositories) is considered as an application instruction by the clinical and pharmacological group of myotropic antispasmodics.
This medication has a hypotensive and antispasmodic effect. It contributes to a significant decrease in tone and relaxation of smooth muscles in the digestive tract, respiratory and genitourinary systems, and reduces the content of calcium ions.
Upon receipt of an increased amount of the drug in question, myocardial relaxation and a decrease in blood flow velocity are noted. The medication does not have a special effect on the central nervous system.
The drug "Papaverine" (candles), instructions for use notes, characterized by rapid absorption. In plasma, it binds to proteins. It was found that this drug easily overcomes the histohematological barrier. It is biotransformed in the liver. The elimination half-life can vary from thirty minutes to two hours.
Each suppository contains 0.02 grams of papaverine hydrochloride.
The drug "Papaverine." Application
This drug is used to eliminate smooth muscle spasms in the abdominal organs - cholecystitis, pylorospasm, spastic colitis, renal colic, as well as angina pectoris, cerebral spasms. In addition, the drug is used as an auxiliary for sedation.
Papaverine medication (suppositories), instructions for use informs, is contraindicated in case of hypersensitivity of the patient to the components of the drug, AV block, glaucoma, severe renal failure, in the elderly and childhood.
With extreme caution, this drug is prescribed for conditions after receiving a traumatic brain injury, as well as for renal failure in a chronic form, hypothyroidism, prostatic hyperplasia, supraventricular tachycardia.
The drug "Papaverine" (suppository), instructions for use, especially notes, can cause certain unwanted effects, including the following:
- some disorders of the cardiovascular system, such as AV blockade, lowering blood pressure, ventricular extrasystole ;
- disruptions in the functioning of the digestive tract - loose stools, constipation, activation of hepatic transaminases;
- in addition, the development of drowsiness, allergic reactions, eosinophilia is possible.
In combination with barbiturates, the antispasmodic effect exerted by the drug in question is enhanced. Its hypotensive effect is increased when used together with antidepressants (tricyclics), reserpine, quinidine and procainamide.
Symptoms of an overdose are: double vision and other visual impairment, drowsiness, weakness, lowering blood pressure. The necessary treatment is immediate gastric lavage and maintaining blood pressure.
Adult patients are shown one or two suppositories (twenty to forty milligrams) a maximum of three times a day. This form of the drug is most optimal in situations where the use of oral agents is difficult (with diarrhea or vomiting). In addition, it is suppositories that are indicated for people suffering from impaired functioning of the gastrointestinal tract.
The drug "Papaverine" with the tone of the uterus in a woman in position can improve blood supply to the muscles of this organ, and this has a positive effect on the condition of the fetus, reduces the risk of miscarriage.
It was found that the effectiveness of the medication decreases if the patient smokes. For the period of treatment should completely abandon the use of alcohol.