How to use the drug "Proxy"? Instructions for using this medication are described in the article. In it, you can find information about in what form the medication mentioned is made, whether it has analogues, for what purposes it is prescribed and so on.
Form, packaging, composition of the medicine
In what form is a drug such as Proxy produced? Instructions for use indicate that this medication is available in the form of white tablets in cardboard packs, as well as in the form of a lyophilisate with a solvent ampoule (10 ml).
The first form of the drug contains pantoprazole (40 mg), as well as additional elements. As for the vial of the lyophilisate, it also contains 40 mg of the active component + sodium hydroxide.
Pharmacodynamics of the drug
What features does the "Proxy" medicine have? Instructions for use indicate that it is an antiulcer and antisecretory agent.
After taking the drug inside, it blocks the production of hydrochloric acid. This occurs due to the inhibition of the action of the proton deposit, which is located in the parenteral cells of the stomach.
The active substance of the drug is able to reduce the basal, as well as stimulated by the enzyme pentagastrin, food and insulin, gastric secretion. In addition, the drug inhibits the vital activity of the Helicobacter pylori bacteria. As you know, it is with its active reproduction that the formation of ulcers and erosion on the mucous walls of the stomach is associated.
In addition to the above, the drug in question increases the effectiveness of other antimicrobial agents.
Pharmacokinetics of the drug
What are the pharmacokinetic properties of the drug "Proxy"? Instructions for use inform patients that after the first dose, the effect of the drug develops very quickly and lasts throughout the day.
The highest drug content in blood plasma is observed four hours after taking a standard dosage of 40 mg. The degree of binding to proteins is 98%. The half-life of the drug substance reaches two hours.
The drug is excreted through the kidneys and intestines.
Pantoprazole is absorbed in the small intestine. The bioavailability of this substance is approximately 75%.
The metabolism of the active component of the drug is carried out in the liver. In this case, conjugation, oxidation and dealkylation reactions occur with the direct participation of an enzyme such as cytochrome P450.
It should be noted that the medication in question easily overcomes the blood-brain barrier. In addition, it is excreted together with breast milk.
In elderly people, the plasma concentration and bioavailability of the drug is significantly higher than in young patients.
In the presence of cirrhosis, the drug can be excreted up to 9 hours.
When is it prescribed?
Now you know how the drug "Proxy". Instructions for use, reviews of this medicine indicate that its indications for use are the following diseases:
- a stomach ulcer, as well as a duodenal ulcer (including during periods of exacerbation);
- Helicobacter pylori treatment (taken only as part of complex therapy);
- reflux esophagitis and Zollinger-Alison syndrome;
- increased production of gastric juice;
- mild form of reflux esophagitis.
Can not be applied
Does a medication such as Proxyum (tablets) have contraindications? The instructions for use inform patients that this form of the drug should in no case be prescribed for:
- severe liver failure;
- pregnancy
- malignant tumors in the digestive tract;
- breastfeeding;
- allergies to the components of the drug;
- children under 14 years old.
As for the solution in ampoules, it is not recommended for patients with an allergic reaction to Pantoprazole. In addition, this form of medication can in no case be combined with Atazanavir.
Tablets "Proxy": instructions for use
Analogs of this antiulcer drug will be presented at the very end of the article. In the same section, we will tell you about how such a drug should be taken for certain diseases.
When prescribing the "Proxy" medication, most doctors prefer their tablet form. If the patient has problems with swallowing, then he is prescribed a solution.
The dosage of this medication, as well as the regimen, should be determined only by the attending doctor.
So how should you take the drug "Proxy 40"? The instruction (tablets of this remedy are sold in all pharmacies) states that the recommended dosage of this medicine is 40 mg per day. The medication is taken during or after a meal, drinking plenty of water.
When diagnosing ulcers or erosion of the stomach, the daily dose is increased to 80 mg.
For the treatment of duodenal ulcers, the medication is taken for 15-30 days. As for reflux esophagitis and stomach ulcers, the course of treatment for such diseases should be no more than 2 months.
In order to eliminate the Helicobacter pylori bacteria, 1 tablet is prescribed to the patient twice a day. The duration of such therapy is 2 weeks.
For patients suffering from renal failure, as well as elderly people, the daily dosage is not prescribed over 40 mg.
In severe liver failure and cirrhosis, the medicine is allowed to take 1 tablet every other day.
Proxyum solution: application instruction
In ampoules, such a drug is prescribed if oral administration is not possible.
In a bottle with lyophilisate pour 10 ml of physical solution. Some experts recommend additionally mixing such a drug with 100 ml of 5% glucose solution.
Intravenous infusion should last at least two minutes (preferably about ¼ hour).
The drug solution should be used immediately after combining all the components. If this is not required, then the drug must be placed in a refrigerator and used no later than 12 hours.
The duration of therapy with such a medication is similar to the tablet form. The maximum treatment time is 2 months.
With such a diagnosis as reflux esophagitis, the drug is prescribed in the amount of one bottle once a day.
For the treatment of bleeding that occurred with an ulcer of the duodenum and stomach, as well as for the prevention of relapse, the drug is used 80 ml intravenously (bolus).
The introduction of this medication is indicated using an infusion of 8 mg per hour.
With Zollinger-Ellison syndrome and hypersecretion, the drug is prescribed 80 mg. If necessary, the doctor can increase the dosage to 160 mg. In this case, it must be divided into 2 doses.
To quickly reduce the acidity of gastric juice, 80 mg of the drug is usually used twice a day.
Overdose cases
What symptoms arise when taking high doses of the drug "Proxy" (40 mg)? The instruction states that there are currently no reports of such cases.
With the introduction of the drug intravenously (no more than 240 mg), it is well tolerated by patients. If you have used a larger amount of the drug, then you need to use supportive and detoxification therapy.
Experts suggest that an overdose of Proxyium tablets can lead to an increase in the strength and frequency of side effects. In this case, the pill is stopped.
Adverse reactions
What undesirable effects can occur while taking Proxyium 40? The instruction states that the use of this tool often leads to:
- constipation, abdominal pain, diarrhea and flatulence;
- cephalgia.
Sometimes patients have:
- itching and rashes on the skin;
- vomiting
- arthralgia;
- dry mucous membranes;
- increased appetite;
- belching;
- Quincke's edema;
- weakness and drowsiness;
- dizziness.
Cases of development of the following deviations were also recorded:
- depression, myalgia, Lyell syndrome, urticaria, Stevens-Johnson syndrome;
- increased activity of liver enzymes, jaundice, damage to hepatocytes, fever, nephritis;
- sensitivity to light, thrombocytopenia, leukopenia;
- thrombophlebitis (refers to the solution, occurs at the injection site);
- tremor, nervousness, hearing and vision loss;
- acne, baldness, hyperglycemia.
Drug interaction
What properties of the drug should the patient know before taking the “Proxyium” medicine? The instruction of this tool indicates the following features:
- The medication in question can be combined with Diclofenac, caffeine, Glibenclamide, ethanol, Phenytoin, Metoprolol, Diazepam, Nifedipine, Carbamazepine, Theophylline, Digoxin, and also contraceptive , Naproxen, and Digoxin.
- It is highly undesirable to take this drug with Atazanavir.
- Coumarin-type anticoagulants such as Fenprocoumon and Warfarin, when combined with Proxy, can lead to a decrease in IPT.
- No clinically significant drug interactions with Metronidazole, Amoxicillin, and Clarithromycin have been identified.
- Pantoprazole reduces the absorption of drugs, the bioavailability of which is directly affected by the hydrogen index of the gastric juice (for example, “Posaconazole”, “Ketoconazole”, “Itraconazole”, “Atazanavir”, “Erlotinib”).
- The combination of the medication in question with Methotrexate often leads to an increase in the toxicity of the latter.
Special recommendations
What features of the drug should a doctor inform before prescribing a medicine such as Proxy (tablets) to her patient? The instructions attached to this medication are required to read. It indicates that this drug is prohibited for people with nervous dyspepsia.
If you take the medicine for more than three months, the patient may develop hypomagnesemia. Symptoms of this disease are: cramps, fatigue, tetany, delirium, ventricular arrhythmia, and dizziness. In the event of such symptoms, the medication should be canceled and consult a doctor immediately.
Before therapy and after its completion, gastroendoscopy is mandatory to determine the state of the digestive tract. It should be borne in mind that pantoprazole can quite easily mask the signs of malignant neoplasms.
The maximum dose per day for the elderly, as well as for patients with impaired renal function, is 40 mg. For patients with cirrhosis, the daily amount of this medication should be halved.
Therapy with the agent under consideration in rare cases leads to the development of campylobacteriosis and salmonellosis.
Proton pump inhibitors increase the risk of bone fractures in the elderly by about 30% (with long-term treatment).
Analogues and synonyms of a drug
Now you know what constitutes and how to take the drug "Proxy". Instructions for using this tool have been described in detail above.
If for some reason this medication does not suit you, then it can be replaced with such common analogues as Barol, Emanera, Geerdin, Esomeprazole, Diaprazole, Orthanol, Nexium, " Rabeprazole ”,“ Veloz ”,“ Sanpraz ”,“ Lansoprazole ”,“ Ezolong ”,“ Gasek ”,“ Ultop ”,“ Dexilant ”,“ Pariet ”,“ Zulbeks ”,“ Omeprazole ”,“ Omelik ”,“ Ozol ” , “Losek”, “Omez”, “Epicurus”, “Omealox”.
Also, the drug "Proxyum" has synonyms: "Control", "Pantaz", "Panzol", "Panum", "Nolpaza", "Penta", "Pantex", "Pulse", "Ultra".
Reviews about the drug
Almost all reviews of the drug in question are positive. Patients claim that the "Proxy" medication promotes the rapid healing of erosion and ulcers, and also prevents the development of relapses.
As for the side effects, the most frequently manifested patients include nausea and problems with stools.