According to the instructions for use, the drug "Novigan" belongs to the number of moderately painkillers, it is used for headaches and other pain syndromes of different origin. The drug belongs to the group of antispasmodics and does not have a narcotic effect. The main substance that ensures the effectiveness of the drug is ibuprofen. Use "Novigan" is allowed only after consulting a doctor.
What is made of?
Instructions for use of the drug "Novigan" indicates the presence of ibuprofen in the medicine. It is due to this compound that the medication has a pronounced analgesic and antispasmodic effect. In addition, the drug contains pitophenone and fenpiverinium bromide. The manufacturer used cellulose, glycerin and aerosil. The medication contains phosphate compounds, nutritional supplements (E572), macrogol, preservative inclusions that provide shelf life. In the manufacture used polydimethylsiloxane, titanium dioxide and a number of sorbitans, as well as P-piperidinoethoxy-O-carbomethoxybenzophenone hydrochloride.
"Novigan" is produced strictly in tablet form. Each instance has a core of the active compound and a film membrane protecting the drug from the outside. Due to this form of release, the medicine is convenient to take, as evidenced by the numerous reviews of Novigan. Instructions for use of the drug draws attention to the nuances of appearance: the product should be white, each instance is convex on both sides, round. One side of the capsule is smooth, the name of the drug is engraved on the other in Latin letters. If the appearance of the medication and its description in the accompanying instructions are different, you must contact the pharmacy that sold the product for a replacement.
Pharmacology
The instructions for the use of Novigan tablets (the price of the drug varies about 100 rubles) indicates that the drug belongs to the class of non-hormonal anti-inflammatory. It belongs to the group of combined drug formulations on ibuprofen. The substance is simultaneously an antispasmodic and analgesic. The components included in the medication have a central, peripheral anticholinergic effect.
In the instructions for use of Novigan (the price of it is quite affordable for the general population), the manufacturer mentions that the active compound inhibits the generation of prostaglandins in the body. The drug is characterized by a non-selective effect, due to which it shows a systemic inhibitory effect, affecting both centrally and peripherally. Equally, the correction affects the production of both the first and second types of COX.
The nuances of pharmacological activity
1, 2 types of COX are responsible for the transformation of arachidonic acid into thromboxanes, prostaglandins. The first type of substance is found in various tissues, activates the formation of prostaglandins, ensures the efficiency of various systems and tissues responsible for the integrity of the gastric mucosa. Thromboxine in the human body is responsible for vasoconstriction, platelet aggregation. The inflammatory process is associated with the development of a second COX, which is actively involved in the formation of prostaglandins. Due to these substances, the focus of inflammation is more pronounced, the patient suffers from a pain syndrome.
In the instructions for the use of Novigan tablets, the manufacturer mentions that the medicine contains P-piperidinoethoxy-O-carbomethoxybenzophenone hydrochloride. This substance is able to affect muscle structures. Smooth muscle tissue is primarily affected. The activity of phosphodiesterase is inhibited, the concentration of cAMP increases, the content of calcium ions at the cellular level decreases. Under the influence of the drug, smooth muscle fibers of the vascular system relax. A similar effect is observed in other internal organs.
In addition, in the instructions for use with Novigan tablets, the manufacturer indicates the ganglion-blocking effect of the drug. The tool affects parasympathetic NS, lowers tone, reduces the motility of the gastric smooth muscles, affects the ways of removing urine and bile from the body, the intestinal tract.
Is there an alternative: analogues of Novigan
The instructions for use of the drug in question indicate that the main component is ibuprofen. To some extent, other ibuprofen-based pharmaceutical products may serve as alternative products. In particular, “Combispasm” and “Vipratox” are considered to be analogues of the considered drug. The possibility of replacement must be agreed with the doctor. Sometimes the doctor recommends stopping at the Baralgin. A popular drug is Nimid. Means “Melbek”, “Sedalgin” deserve attention.
Instructions for use, price, reviews about "Novigan" and analogues - all this information is of interest to any patient whom the specialist recommended using the described composition. Determining in favor of a therapeutic course, you need to remember that the recommendations of the attending physician are the most important information, they must be followed first. Self-replacement of the recommended drug with another, even cheaper composition, can cause treatment failure.
Will it help?
The manufacturer pays attention: a safe and effective medication is only if used in accordance with the instructions for use. Reviews of Novigan tablets confirm this: those who violated the rules of admission were much more likely to experience side effects. However, the predominant percentage of patients was satisfied with the course taken - at least, these are the responses of the patients.
The drug is one of the expressed antispasmodics and shows a good analgesic effect - this is what the reviews about Novigan testify to. Instructions for use, price, rules of use, indications and contraindications - it is reasonable to study all this information before the start of the course. This will help to avoid unpleasant surprises during treatment.
Kinetics
In the instructions for use for Novigan, the manufacturer indicates the high efficiency of the ibuprofen absorption process when passing through the gastrointestinal tract. For this reason, the product is available in tablet form for oral administration. In serum, the highest content of ibuprofen is recorded on average one and a half hours after the use of the composition. Serum protein binding is estimated at 99%. Excretion is provided by the urinary system. Ibuprofen leaves the body in its original form or in the form of oxidized metabolic products - these substances are not characterized by pharmacological activity. Complete elimination of compounds from the body is possible in one day.
The combined composition of the medication provides an increase in the effectiveness of each of the substances included in the medicine. This is exactly what the manufacturer explains in the instructions for use for Novigan for pain relief, the effectiveness of muscle tissue relaxation and the elimination of heat.
When will it help?
In the list of indications listed in the instructions for use for "Novigan" - moderate pain, spasms of smooth muscle tissue. The drug is indicated for colic in the kidneys, liver. Explaining in the instructions for use, from which Novigan helps, the manufacturer indicates the effectiveness of the composition with dyskinesia of the ducts of the bile duct. The medication is used for intestinal cramps, spastic dysmenorrhea. Tablets can be used for spastic pathological conditions of a different type if smooth muscles of various internal systems and organs are affected.
You can use the drug for headaches. "Novigan" is indicated for migraines. The tool is used as an emergency aid, if necessary, to quickly relieve pain in the joints - in this case, Novigan is applicable for a short course and only to alleviate the symptoms, but not treat the causes. The medicine in question has proven itself as a method of alleviating neuralgia, myalgia, sciatica. It can be used if the patient suffers from fever, fever due to infections, inflammation, and colds.
Strongly impossible!
The instructions for use of Novigan contain an exhaustive list of contraindications for this medication. First of all, it is necessary to check the tolerability of the substances included in the composition of the drug. You can not use Novigan if the patient suffers from hypersensitivity, intolerance, an allergic reaction to any compound available in the medicine. This applies to both active components and additional substances.
You can not use Novigan if previously the use of non-hormonal anti-inflammatory was the cause of the hypersensitivity reaction. In the instructions for use for Novigan, the manufacturer indicates the impossibility of using the composition if erosion, an ulcer in the stomach or intestines, perforation or bleeding in the gastrointestinal tract were observed against the background of the use of NSAIDs.
It is forbidden to take "Novigan" with severe dehydration, severe violations of the liver, kidneys, heart, bleeding, gastrointestinal obstruction, glaucoma, blood diseases and disorders of the hematopoietic system. The drug is not suitable for patients with porphyria, tachyarrhythmia. You can not use the composition if hypertrophy of the prostate gland or a violation of the integrity, functionality of the optic nerve are established. The drug is also not suitable for people who, due to a genetic factor in the body, are deficient in glucose-6-phosphate dehydrogenase.
Application Nuances
If possible, the combination of Novigan and other NSAIDs should be excluded. This is especially true for a high dosage of drugs. The restriction applies not only to non-selective, but also selectively inhibiting the second type of COX drugs. Such conditions are explained by an increased likelihood of a negative heart response (up to a stroke), since there is a risk of a cumulative effect.
During pregnancy, Novigan is used very carefully in the first two-thirds of the term. In the last trimester, the drug is strictly prohibited. Do not use it to treat breast-feeding mothers. "Novigan" is allowed to use from the age of sixteen. For children younger than the drug is not suitable.
Mutual effect
The combination of Novigan and non-narcotic pain medication can double the negative toxic effects. A similar result is possible while taking non-hormonal anti-inflammatory and the composition in question. Extremely carefully use the described tool when using anticoagulants, since NSAIDs can enhance the effectiveness of this group of drugs.
The simultaneous use of drugs to lower blood pressure, diuretics and NSAIDs can lead to a weakening of the effectiveness of the first two groups. There are cases when, against the background of renal impairment, the use of ACE inhibitors, antagonists of the second angiotensin, and COX inhibitory drugs, the kidneys became worse. The risk of insufficient functioning of this body in acute form increases. Mostly the condition is reversible. It is necessary to take into account the risks of its formation, choosing a therapeutic course. The dangers are higher for elderly patients.
Continued use of "Novigan" compels a responsible attitude to the issue of providing the body with water. Starting a combination treatment, the first time you should regularly check the kidneys, in the future, slightly reducing the frequency of such tests.
Nuances of combinations
Diuretics can activate Novigan’s negative effects on the kidneys. The combination with corticosteroids is associated with a greater likelihood of ulceration, bleeding in the digestive tract. Preparations from the antiplatelet class, SSRIs in combination with the described medication are more likely to cause bleeding in the stomach or intestines. The simultaneous ingestion of the described drug and cardiac glycosides into the body can cause an exacerbation of heart failure, a decrease in the rate of filtration in the glomeruli of the kidneys, and an increase in the concentration of glycosides in the blood serum.
Lithium preparations against a background of non-hormonal anti-inflammatory drugs are more slowly excreted from the body. Therefore, the toxicity of these compounds increases, and the concentration in the blood serum increases.
Combining Novigan and Methotrexate, one must take into account that the elimination of the second compound is weakening, which means it becomes more dangerous for the body. The toxic effect for the kidneys increases with a combination of the described composition and cyclosporins. The use of antimicrobial compounds of the quinolone series simultaneously with non-hormonal anti-inflammatory drugs is associated with an increased likelihood of a convulsive condition. "Mifepristone" on the background of NSAIDs is ineffective, therefore, the simultaneous use of these drugs is prohibited. Anti-inflammatory compounds begin to be taken one and a half to two weeks after the cessation of treatment with Mifepristone.
How to use?
The manufacturer draws attention in the accompanying documentation to "Novigan" that the tool must be used in that minimum dosage, which allows to achieve the desired effect. The drug is intended for relief of symptoms, suitable for short-term use, is not a means to treat the root cause of the pathological condition. If the symptoms are disturbing for five days or more or the condition becomes worse, it is important to see a doctor as soon as possible.
The manufacturer recommends using Novigan one hour before the meal or three hours after ingestion of food. Tablets should be drunk abundantly. It is not allowed to violate the integrity of the shell, chew the drug or grind in another way. To minimize the negative effect on the gastrointestinal tract, it is worth drinking the substance with milk.
Novigan use one tablet at a time. Maximum daily use is no more than three tablets. If it is necessary to repeat the intake between sets, five-hour intervals should be maintained (a deviation of one hour up or down is possible). More than 1.2 g of ibuprofen should not enter the body per day.
When prescribing a course of treatment for people of advanced age, a special dosage regimen is not required. For persons under the age of sixteen, the product is not suitable. In the presence of moderate renal, hepatic impairment or a tendency to high blood pressure, the drug is used only under the supervision of a doctor, regularly checking vital signs of the functioning of the body.