Low working capacity, constantly bad mood, overweight or even obesity ... Hundreds of thousands of men and women are familiar with these symptoms. Over the past decade, the pharmaceutical industry has stepped far forward and today Mildronate tablets are available to every simple consumer. Instructions for use, price, contraindications, the effect of taking this drug and possible side effects - you will learn all this by reading this article.
Release form and composition
The drug "Mildronate" is produced in three dosage forms:
- syrup;
- solution for injection;
- tablets (capsules).
The most popular drug in the form of tablets. The main active ingredient of the drug, regardless of the form of release, is meldonium. The full chemical name is trimethylhydrazinium propionate dihydrate. But it is used relatively rarely. Depending on the manufacturer, in the instructions for tablets "Mildronate" can be indicated as the main active substance as the full chemical name, or simply be written "meldonium". In all cases, we are talking about a substance with the same structural formula. As auxiliary substances in tablets, titanium dioxide and silicon dioxide, gelatin, potato starch are used. Depending on the manufacturer, microcrystalline cellulose may be used. Only medical distilled water is added to the injection solution as an adjuvant.
Mildronate tablets are produced in two dosages: 250 mg and 500 mg, which corresponds to the dose of meldonium in one capsule.
The principle of action of meldonium
Initially, the drug was created as a mild anabolic steroid. However, in the course of laboratory research, scientists changed the course of their thoughts and created a substance that in effect resembles the well-known anabolics, but without affecting the hormonal system and practically without side effects.
Mildronate tablets have an effect in several directions at once:
- Cardioprotective effect (strengthening effect on the cardiovascular system, prevention of arrhythmia, heart attacks and strokes, cardiomyopathy).
- Antianginal action - reducing the need for myocardial cells in pure oxygen (this reduces the frequency of angina attacks and allows the cardiovascular system to endure long-term physical activity without problems).
- The antihypoxic effect is to reduce hypoxia (lack of oxygen is compensated by meldonium).
- Angioprotective effect is to strengthen the walls of blood vessels and increase their tone.
First of all, the effect of meldonium is to regulate oxygen metabolism. Due to this, the drug effectively increases endurance, vitality, physical performance. Due to the improvement of oxygen metabolism in the brain cells, mental performance is increased and cognitive processes are accelerated. Muscle fibers increase faster due to the synthesis of ATP and the abundant supply of each cell exposed to oxygen.
Indications for use
The instruction for Mildronate tablets suggests therapy in the following conditions:
- Ischemic cardiac pathology.
- Angina pectoris (as part of complex treatment).
- Myocardial infarction.
- Cardiomyopathies of various origins.
- Violation of the blood circulation of the brain.
- Mental retardation and delayed psycho-speech development in children.
- Chronic heart failure.
- Dyshormonal cardiomyopathy.
- Myocardial dystrophy in children and adolescents.
- Cardiopsychoneurosis.
- Strokes, cerebrovascular insufficiency.
- Retinal damage (as adjuvant therapy).
- Thrombosis of the retina of the eye or its branches (a solution for injection is used).
- Retinopathy in diabetics (injection solution is used).
- Bronchial asthma during remission.
- The period of withdrawal syndrome in chronic alcoholism and drug addiction.
- Chronic fatigue.
- Low working capacity (both physical and mental).
- The postoperative period of recovery after surgery.
Contraindications to taking "Mildronate"
Instructions for use with Mildronate tablets (the price of the package varies depending on the amount of active substance) warns of the following contraindications for use:
- increased intracranial pressure;
- period of pregnancy and lactation;
- age under twelve years;
- individual intolerance to meldonium.
Most often, Mildronate tablets are well tolerated and practically do not cause side effects.
Recommended dosage
In chronic heart failure, an intravenous solution should be used. Mildronate tablets can be used as adjuvant therapy in parallel with meldonium injections. It should be taken at 250-500 mg twice a day, regardless of food intake.
For chronic cerebrovascular accident, 500 mg should be taken two to three times a day. If the patient is under the age of 18, the dosage should be reduced to 250 mg three times a day.
For pain in the heart, arrhythmias, angina pector should use tablets as an adjuvant, take 250-500 mg three times a day. If after the course of the main treatment the pain has not passed, you should continue to take Mildronate for a month.
During the period of withdrawal syndrome, tablets should be taken for two to three weeks, 500 mg three times a day. You can use it as an independent tool, or as an auxiliary therapy.
The price of tablets "Mildronate"
The instruction warns that the dosage of meldonium may vary: 250 or 500 mg. The exact dosage can be prescribed in each individual case by an endocrinologist and a neurologist. Depending on the concentration of the active substance, the price will also change.
Mildronate tablets 250 mg - the price is from five hundred to seven hundred rubles per pack. The drug is produced both abroad and in our country. For this reason, the difference in cost.
The price of Mildronate 500 tablets varies from a thousand to one and a half thousand rubles. The dosage is doubled - therefore, the cost of the drug is almost twice as high. It is more profitable to purchase immediately a large package with tablets with the maximum dosage of meldonium - this way you can save about three hundred rubles.
The price of Mildronate tablets may vary depending on the pharmacy network, place of purchase and the availability of shares and sales.
Combination with other medicines
It is not recommended to combine reception with antidepressants and tranquilizers. Reviews on Mildronate tablets report a strong sedative effect when taken with psychotropic drugs.
Concomitant use with anabolic steroids increases the stimulating effect on the central nervous system.
Analog preparations of tablets "Mildronate"
Instructions for use and price make this drug a market leader. There are foreign drugs with meldonium in their composition, but their cost is high for ordinary Russian consumers (from five thousand per package of the drug). Here is a list of drugs with a similar effect, but with a different active substance:
- "Oxandrolone" - an anabolic steroid, was originally developed to restore patients during recovery from fatal diseases. Today it is widely used in sports. It is a potent prohibited substance. Promotes the growth of muscle tissue, increases strength and speed.
- Primobolan is an injectable drug with an anabolic effect. Affects the balance of hormones in the body. Prohibited for free sale. Exponentially increases strength, increases protein synthesis and promotes rapid growth of muscle tissue.
- Testosterone Propionate - has a much more powerful effect than Mildronate. It is a male sex hormone. Increases Strength and Stamina.
- "Angosil" - is a drug that eliminates hypoxia. Supports the work of the cardiovascular system, restores cerebral circulation. Useful for cores, but does not directly affect athletic performance and performance.
- Kudesan - produced in drops and tablets. It is a heart remedy. The principle of action on the heart and blood vessels is similar to Mildronate - it prevents the development of hypoxia. It does not directly affect athletic performance and physical performance.
Mildronate and fitness classes
No wonder drugs with meldonium were included in the list of prohibited substances for athletes preparing to compete.
An important role for ordinary fitness lovers is played by price. Mildronate tablets (instructions for use confirm this) can significantly increase strength. The drug fights off a little appetite, thereby contributing to the fast and psychologically easy process of fat burning.
Also, this drug is perfect for anyone involved in athletics. Mildronate reduces hypoxia, thereby protecting the athlete’s heart during extreme exertion. Try to run the marathon with the Mildronate - endurance and speed will increase markedly.
"Mildronate" in chronic alcoholism
During binges and abuse of ethanol-containing drinks, there is a serious violation of cerebral circulation and the death of hundreds of thousands of neurons (nerve cells). The process of hypoxia is irreversible, but if you take the drug with meldonium, you can stop it. That is why it is advisable to take "Mildronate" with a hangover. This will help to quickly return to working capacity, get rid of weakness and headache, return clarity of thought and adequacy.
Depending on the stage of development of chronic alcoholism, you need to use different dosages of Mildronate tablets. Instructions and reviews confirm that after serious binge, it makes no sense to use tablets with a concentration of meldonium less than 500 mg. It is optimal to take three to four tablets of 500 mg per day after meals. It is also important to adjust the patient's diet in order to minimize the toxic load from the organs of the gastrointestinal tract and liver.
Reviews of ordinary consumers about the drug
On the review sites, many ophthalmologist patients noted their admiration for the effect of the drug. As part of a comprehensive treatment for myopia, astigmatism, thrombosis of the retina of the eye or its branches, the drug showed its best side.
Reviews about the tablets "Mildronate" (the price of the drug depends on the amount of active substance - 250 or 500 mg) confirm the effectiveness of the drug for a hangover. People noted that literally a few hours after admission, it seems as if there was no abuse.
Children with autistic features and mental retardation are often prescribed Mildronate. The reviews of the mothers are ambiguous: in most cases, there was no obvious effect. Some children have experienced rapid vocabulary replenishment.