The drug "Rosamet" is an analogue of the Russian "Metronidazole". The ointment is applied topically, has an antimicrobial effect. "Rosamet" is used in the fight against acne, acne, rosacea, providing an anti-inflammatory effect. The drug is also used to treat vulvovaginitis and balanoposthitis. There are several analogues of Rosamet cream. It is believed that the mechanism of action is associated with microorganisms sensitive to DNA damage.
Analogs
There are many similar products on the market. Cream "Rosamet" - an analogue of Russian cream. What users are at a loss for is a wide assortment. Manufacturers offer not only creams and ointments, but also medicines in the form of suppositories and tablets. The price range is wide enough - you can buy from very cheap drugs to expensive analog creams. Cheaper "Rosameta" can be purchased, for example, Hungarian tablets "Klion", the tool is also available in the form of ointments and suppositories. Along with Rosamet, users also recommend tablets or Trichopol ointment. French cream "Rosex" is one of the most expensive drugs. The French company also produces vaginal suppositories with the active substance metronidazole, the price of which is five times higher than Rosamet.
A cheap analogue of the cream is the Russian Metronidazole. The cost of the ointment is less than ten rubles.
These are the most popular and well-known analogues of the drug. In addition to the above, there are dozens of similar medicines. But all of them are united by one thing - metronidazole contained in the composition.
Structure
The active substance of all these drugs is metronidazole, which belongs to a group of substances called antiprotozoal and antibacterial agents. Basically, Rosamet's analogues include excipients: emulsion wax, glycerin, methyl parahydroxybenzoate, propyl parahydroxybenzoate, propylene glycol, liquid paraffin, and purified water.
Analogues of the cream, like the drug itself, have a uniform consistency and do not contain a pronounced smell.
Pharmacotherapeutic group and action
Metronidazole is a synthetic derivative of nitroimidazole with an antibacterial and antiprotozoal effect used to treat inflammatory dermatitis. The drug causes a decrease in inflammatory lesions and redness of the skin. The substance stops the synthesis of nucleic acids. It also has antioxidant activity, thereby reducing oxidative stress in the focus of inflammation. Metronidazole does not act against vascular veins that are marked with pink acne. A topical preparation is practically not absorbed. Data on the metabolism and excretion of the active substance after topical application are not provided. The substance is metabolized in the liver and excreted by the kidneys.
Indications for use
Indications also apply to counterparts. Rosamet ointment is used to treat:
- Rosacea
- blackheads
- balanoposthitis,
- inflammatory diseases of the vagina.
Contraindications to metronidazole
Analogues of Rosamet cream cannot be used for hypersensitivity to the components of the cream base. Patients should be careful to use drugs for liver diseases.
During pregnancy and lactation, the feasibility of using the drug must be discussed with the doctor. If you need to use the cream during lactation, you need to stop breastfeeding during the treatment.
A drug with metronidazole is usually considered contraindicated during the first trimester of pregnancy.
It is not recommended for use by children under 12 years of age, since the effectiveness and safety of the drug in this age group have not been investigated.
Mode of application
Before applying the cream, the affected area of the skin should be washed with warm water or a mild non-irritating cleanser. It is also necessary to clean the skin when using analogues.
Rosamet is applied in a thin layer, which is then easily rubbed into the affected areas of the skin (inflammatory lesions and erythema rosacea) twice a day - in the morning and in the evening. To reduce the risk of local irritation, it is recommended to take a break of 15 to 20 minutes between cleansing the skin and applying the drug.
Clinical improvement occurs within three weeks. The course of treatment is from three weeks to two months. After achieving the appropriate clinical effect, the treatment adapts to the course of the disease. In rare cases, the course can be increased to four months.
In the treatment of genital diseases, the drug must be applied twice a day to the lesions with a clean cotton swab after hygienic procedures. The course of treatment lasts no more than 10 days.
Side effects
Side effects when using "Rosamet" and analogues are rare and manifest in a mild form, so the treatment is characterized by good tolerance.
The most common side effects are local skin reactions, characterized by short-term redness, a feeling of dryness, burning, irritation, skin rash. The manifestation of allergic reactions can be delayed.
In general, it is quite difficult to assess the body's response to metronidazole, since most of the symptoms described above also appear with rosacea.
The possibility of manifestation of systemic side effects of the drug practically does not exist due to extremely low concentrations of substances.
An overdose of the drug applied to the skin does not cause life-threatening symptoms. Exceeding the therapeutic dose of metronidazole is unlikely. When administered locally, the substance is absorbed in small quantities, without having a systemic effect.
Precautions
The medicinal analogues of the described preparation are intended exclusively for external use. Eye contact should be avoided to avoid irritation of the mucous membrane of the eye. If the drug does get into the eyes, they must be thoroughly washed.
If local skin irritation occurs, Rosamet or analogues containing metronidazole should be temporarily canceled or completely discontinued. When using these medicines, exposure to direct sunlight should be avoided.
The use of creams does not affect the ability to manage and concentrate.
Interaction
The interaction of creams and tablets with other drugs has not been identified. At the same time, caution is advised while using this and other drugs. Metronidazole enhances the anticoagulant effect of warfarin and other coumarin anticoagulants. This leads to a longer period of prothrombin formation.
In combination with amoxicillin, preparations with metronidazole are not recommended for patients under 18 years of age. During the treatment period, it is necessary to regularly monitor the structure of peripheral blood. To avoid the development of a disulfiram-like reaction during therapy, you should refrain from drinking alcohol.
Reviews
The rating of the drug among buyers is quite high - 4.5 points. Reviews about "Rosamet" are mostly positive: the ointment is very suitable for combating acne, inflammation, dry skin. In addition, side effects after using the ointment in patients are not observed. The visible effect of the ointment appears within a few weeks.
However, Rosamet cream was not suitable for everyone: there are also negative comments. Some patients note that after using the cream, new acne began to appear, the old ones dried out, but did not disappear. If the drug did not fit, people bought its analogues. Some were helped by the cheapest Metronidazole, others by Klion or Trichopol.