Given the fact that the modern food culture does not contribute to the normal functioning of the digestive tract, more and more people are faced with problems such as ulcers or gastritis. One of the most effective drugs for the treatment of these diseases is De-Nol. The composition of the product is designed in such a way as not only to eliminate the symptoms, but also to influence the cause of their appearance.
About the drug
The composition of the De-Nol tablets is based on bismuth subcitrate, which acts as an active substance. It is an astringent drug that has a wide range of properties. Antimicrobial and gastrocytoprotective effects are especially noted. This is due to the complex effect on all links of peptic ulcer and gastritis. Once in the body, bismuth subcitrate precipitates proteins due to the formation of chelate bonds. Due to this, a protective membrane forms on the walls of the digestive organs.
Experts note the targeted effect of the drug "De-Nol." Reception promotes the formation of a protective film exclusively on those parts of the internal organs where erosive changes are observed. This helps to eliminate the effects of acids and other substances, and therefore tissue scarring is much faster. Thus, the acidic environment of the stomach does not irritate the damaged areas, but rather acts as a catalyst for the effects of the drug.
The instructions will help to obtain comprehensive information about the drug "De-Nol". The composition contains components that are credited with the ability to suppress Helicobacter pylori. Penetrating into the cellular structure of this microorganism, the drug blocks its fermentation, which eventually leads to the death of the bacteria. In addition, there is a decrease in the mobility of other microbes. Bismuth subcitrate dissolves well, and therefore penetrates quite deeply into the mucous membrane, where pathogens can be contained. Thus, not only treatment occurs, but also the prevention of recurrence of peptic ulcer. To date, specialists have not identified varieties of bacteria that would have resistance to the active substance of the drug.
Release form
In the form of tablets, De-Nol is available. The composition determines the white color with a barely noticeable cream tint. The tablets are round, and also have a bulge on both sides. A kind of protection against fakes is an extruded pattern in the form of a square with rounded corners and intermittent sides. The tablets have no aroma, but in some cases a faint odor of ammonia is possible.
The drug "De-Nol": composition
The manufacturer of the drug claims that it contains substances that can overcome not only the signs of ulcers and gastritis, but also the cause - Helicobacter pylori. This is what determines the popularity of De-Nol. Its composition is as follows:
- bismuth tripotassium dicitrate ;
- bismuth oxide;
- corn starch;
- povidone;
- sodium polyacrylate;
- macrogol;
- magnesium stearate;
- hypromellose;
- macrogol.
Mechanism of action
High efficiency is characterized by "De Nol". Acceptance of this drug is associated with the occurrence of a gastrocytoprotective effect, which is due to such mechanisms:
- stimulation of prostaglandin production, which stimulates the formation of substances that form a protective barrier on the mucous membrane;
- improvement of blood microcirculation in the area of the duodenum and stomach, which helps to accelerate cell regeneration;
- a decrease in the rate of production of hydrochloric acid by the corresponding glands of the stomach;
- the drug is characterized by a cumulative effect due to a gradual increase in the amount of active substance in the blood;
- the drug is completely excreted from the body with feces.
Indications for use
One of the most popular drugs for the treatment of gastritis and other gastrointestinal diseases is De-Nol. Indications for the administration of this drug are as follows:
- stomach ulcer or duodenal ulcer in acute form;
- gastritis and gastroduodenitis in acute or chronic form;
- irritable bowel syndrome, which is accompanied by a disorder of the stool (diarrhea);
- damage to the mucous membrane and walls of the stomach after the use of anti-inflammatory non-steroidal agents;
- functional dyspepsia, which is not associated with gastrointestinal problems.
The main contraindications
Before drinking “De-Nol” for gastritis, you should make sure that you have no contraindications to this drug. The instructions indicate the following restrictions:
- renal failure;
- pregnancy and lactation;
- age up to 4 years;
- individual intolerance or hypersensitivity to the components of the drug.
Drug use
Well-proven tablets "De-Nol". The instruction contains comprehensive information about the method of application and dosage. So, adults should take 1 tablet four times a day. The first 3 receptions are carried out half an hour before meals, and the last - before bedtime. A scheme is also acceptable when twice a day take 2 tablets half an hour before meals.
Children under 12 years of age are prescribed daily use of 2 tablets of the drug. As in the previous case, eating is possible half an hour after taking the medicine.
Another scheme works for kids up to 8 years old. The daily rate is defined as 8 mg per kilogram of a child’s body. The number of doses is equal to the number of tablets (or parts thereof) that meet the norm.
The composition of the drug "De-Nol" is determined by the fact that treatment should last 4-8 weeks. In the next 2 months, treatment with any other drugs containing bismuth is prohibited. To make the fight against pathogenic bacteria that provoke erosive changes more effective, it is permissible to combine De-Nol with antibacterial agents.
Exceeding Recommended Dosage
Only in case of strict observance of all recommendations is it possible to have a positive effect from taking De-Nol. The composition of the drug is such that with an overdose a number of unpleasant symptoms may occur. The instructions noted a violation of the kidneys, which can be eliminated after drug withdrawal.
In order to alleviate the symptoms of an overdose, the first thing they resort to is washing the stomach. Next, symptomatic therapy is performed. So, in most cases, chelating agents are prescribed that contribute to the restoration of renal function. If a serious violation in their work is noted, they resort to the hemodialysis procedure.
Interaction with other drugs
It is necessary to observe some caution, combining the drug "De-Nol" with other means. The composition of the drug is such that it is able to block the absorption of tetracycline. Any other medicines, liquids and food products (especially antacids, fruits, dairy products) significantly reduce the effectiveness of De-Nola. Thus, a half-hour interval should be present between their use.
The drug "De-Nol": side effects
Before using the drug, you need to carefully read the instructions. So, the composition of the De-Nol tablets causes the following adverse reactions:
- nausea and vomiting;
- frequent stools;
- constipation
- itching
- skin rash;
- encephalopathy.
These symptoms are temporary and are caused by the accumulation of the active substance in the body. In most cases, unpleasant manifestations disappear as soon as the patient stops treatment with the drug.
additional information
The main characteristic that determines the effectiveness of a drug like De-Nol is composition. Instructions for use contain such additional information:
- long-term use of the drug for more than 8 weeks is not allowed;
- It is not recommended to exceed the daily dose (this applies not only to children, but also to adults);
- the drug can not be taken simultaneously with other agents that contain bismuth;
- during treatment, staining in black stool is possible;
- sometimes there is a slight darkening of the tongue;
- at the moment there is no data on the influence of De-Nol on the ability to drive vehicles;
- during treatment "De-Nol" is not recommended to drink alcohol;
- dispensed in a pharmacy without a prescription.
Complex treatment
Often the treatment of ulcers and gastritis requires an integrated approach. De-Nol, Amoxicillin and other drugs are taken together to provide a comprehensive impact on the problem. So, the complex treatment regimen may be as follows:
- twice a day, half an hour before a meal, drink "De-Nol";
- twice a day you need to drink 500 mg of Clarithromycin;
- according to the same schedule, but already at 1000 mg, Amoxicillin is taken.
Sometimes a slightly different scheme is used to treat ulcers and gastritis:
- twice a day, half an hour before a meal, drink "De-Nol";
- four times a day take 500 mg of "Tetracycline";
- in a similar dosage, but already three times a day, drink Metronidazole;
- Omeprazole, Lanzoprazole or other proton pump inhibitors are taken as directed.
If you decide to undergo complex treatment using the drug "De-Nol", the medication should continue for 1-2 weeks. Complex therapy can not be abruptly stopped. After completing the course, the reception of "De-Nola" can be continued up to 8 weeks. This will accelerate the regeneration of the mucous membrane.
Popular counterparts to De Nola
The main disadvantage of advertised drugs is the high price. The most important characteristic of De-Nol is the composition of the drug. Analogs with similar components can cost an order of magnitude cheaper. At the same time, their effectiveness remains as high. So, the most popular substitutes for "De Nola" are such means:
- "Misoprostol" is a synthetic analogue of prostaglandins, which are hormone-like substances. The action of this tool is aimed at protecting the stomach from erosive changes by reducing the amount of produced gastric juice. In turn, the production of mucus and bicarbonate is significantly increased. Blood flow also improves.
- Carbenoxolone is a licorice-based drug. Its action is aimed at enhancing the secretion of mucus and increasing its viscosity, which positively affects the condition of the walls of the stomach.
- "Novobismol" is a domestic analogue of the drug in question, which is also made on the basis of bismuth. This is an antiulcer drug that has an astringent, enveloping and antimicrobial effect. This is one of the few analogues that, like De Nol, inhibits Helicobacter pylori. Despite the fact that the product has a composition similar to the original, it is dispensed only by prescription. This is due to the insufficient amount of excipients that soften the action of the main component.
- Ulkavis is similar to De Nol in terms of the concentration of the main active substance. This tool also provides an enveloping, regenerating and antibacterial effect. The medicine is dispensed without a prescription, but it is advisable to carry out therapy under the supervision of a doctor, since an excess of the drug concentration in the blood can lead to the development of encephalopathy. As a rule, this drug is 2 times cheaper than De-Nola, but not inferior to it in terms of quality.
- "Ventrisol" refers to gastroprotective drugs. Like De Nol, the drug works selectively, affecting only damaged tissue. In places where there is no epithelial tissue, the active component reacts with proteins, forming a protective layer to prevent further destruction, as well as for the purpose of subsequent regeneration.
- "Vis-Nol" is a preparation based on bismuth colloidal subcitrate. The action of the drug is based on the formation of a protective film, which will contribute to the process of scarring of ulcers.
- "Vicalin" is a domestic preparation, the composition of which is dominated by natural ingredients. In addition to the astringent and antiseptic effect, it also has an antispasmodic and laxative effect. A decrease in acidity is also noted.
- "Ventrisol" is a Polish preparation based on bismuth tripotassium dicitrate. Reduces acidity and fights Helicobacter pylori. Stimulates the active production of mucus, which serves to form a protective membrane.
Positive reviews
Of course, before using any drug should consult with specialists. Nevertheless, doctors often prescribe a prescription based only on advertising data, and not on the experience of use. Thus, before starting the reception, it is advisable to get acquainted with the opinions of users. So, you can hear the following positive reviews about the drug:
- during treatment, the drug affects not only erosive changes, but also kills the pathogenic microflora in the intestine;
- after adaptation to the drug, side effects disappear without cancellation;
- despite the fact that the drug kills gastric bacteria, it does not belong to antibiotics, and therefore its reception is not accompanied by problems characteristic of this group of drugs;
- after completing the full course, the problem of Helicobacter pylori is solved, which is confirmed by appropriate analyzes before and after taking the medicine;
- To protect yourself from buying a fake, you can call the manufacturer’s hotline, which will confirm or deny the authenticity of the batch number indicated on the package;
- reduces acidity, which not only contributes to the recovery process, but also eliminates heartburn;
- improves the digestive system as a whole;
- most patients have good tolerance to the drug;
- In the instructions for the drug, a comprehensive treatment scheme is given.
Negative reviews
Treatment with the same drug can have a different effect on patients. So, about the drug "De-Nol" there are a number of negative reviews. The most significant are the following:
- the result does not occur immediately, and significant relief is noted only after 2 months from the start of administration;
- in case of serious problems with the gastrointestinal tract, De-Nol itself may be ineffective and requires the use of an additional complex of drugs;
- in the first 5-10 days of treatment, side effects described in the instructions may be observed;
- some patients have a metallic taste in the mouth;
- high price;
- long course of treatment;
- the tablet is difficult to break in half and into smaller parts, which is required when treating small children, and therefore the medicine simply crumbles and deteriorates;
- given the high cost and popularity of the drug, there are many fakes on the market;
- in some cases, 2 or more courses of treatment may be needed to fully recover;
- immunity from re-infection of Helicobacter pylori is not formed;
- during treatment with "De-Nol" dairy products should not be consumed.
Conclusion
For a long time, diseases such as gastritis and ulcers were difficult to treat. A significant step forward was the discovery of the bacterium Helicobacter pylori, which is the cause of such problems. So, recently, one of the most popular and effective drugs is De-Nol. This tool is characterized not only by antimicrobial, but also astringent and regenerative function. Thus, an “attack” on gastrointestinal diseases occurs on several “fronts” at once, which allows us to solve the problem completely.
Nevertheless, taking De-Nol alone is not enough to completely cure gastritis and ulcers. Comprehensive treatment using a number of other drugs (including antibiotics) is recommended. In addition, therapy is often lengthy, which largely depends on the degree of development of the disease. And given the high cost of the drug, a full course may require significant material costs. Nevertheless, as practice shows, none of the analogues known at the moment can boast the same high efficiency as De-Nol.