"Sinacten Depot" - a drug that has anti-inflammatory as well as immunosuppressive effect. The drug affects fat, carbohydrate, mineral and protein metabolism.
A medication is produced in the form of a suspension for intramuscular injection (in ampoules of 1 milliliter of the drug). The composition of Sinacten Depot according to instructions includes tetracosactide hexaacetate.
Healing properties
The active substance has an immunosuppressive, as well as anti-allergic and anti-inflammatory effect. After intramuscular administration of the drug at a dosage of 1 milligram, the cortisol content in the blood increases.
Its maximum marks are recorded within eight to twelve hours after the injection. According to the description, "Sinakten Depot" is characterized as an effective tool in the fight against many diseases.
Over the course of one day, an increased concentration of cortisol persists, then after about 48 hours the value returns to its original state. The long-term effect of the Sinacten Depot medication is due to the slow release of tetracosactide.
When a medication is prescribed
According to the instructions for use, Sinacten Depot is recommended for use in the presence of the following pathological conditions:
- Psoriatic arthritis (a severe pathological process of the musculoskeletal system, which is characterized by the appearance of severe inflammation in the joint and, as a result, by the limitation of the motor activity of the affected limb).
- Spondylitis (a systemic disease of the spine, which is characterized by ankylosis of the sacroiliac symphysis, which during progression develops into a pronounced form of kyphosis of the thoracic region).
- Rheumatoid arthritis (damage to connective tissue with predominant damage to small capillaries of the type of erosive and destructive polyarthritis of unknown origin with complex autoimmune pathogenesis).
- Non-specific infectious polyarthritis (an inflammatory process that is triggered by pathogens and develops in several joints).
- Generalized cryptogenic forms of epilepsy with hypsarrhythmia (a neurological lesion that manifests itself in a predisposition of the body to a sharp appearance of seizures).
- Multiple sclerosis (a chronic disease in which the myelin sheath of the nerve tissue of the brain and spinal cord is affected).
- Landau – Kleffner syndrome (a disease that is accompanied by symptoms of epilepsy).
- Psoriatic arthritis (inflammatory joint damage).
- Rheumatism (inflammatory lesion of the connective tissue with the main localization of the pathology in the membranes of the heart).
- Nodular periarteritis (a disease that is characterized by a general lesion of the connective tissue, as well as a change in the biochemical and immune properties of the blood, a tendency to a progressive course).
- Systemic lupus erythematosus (a serious lesion in which the body’s immune system perceives the body’s cells as foreign).
- Sarcoidosis (a disease that can affect various organs and tissues, but most often affects the respiratory system).
What other indications does the drug have
According to the instructions, "Sinakten Depot" is recommended for use in the following conditions:
- Scleroderma (damage to the connective tissue, the main manifestations of which are sclerosis of the skin and stenosis of small vessels).
- Regional enteritis (a disease in which inflammation can occur in all parts of the digestive system).
- Ulcerative colitis (an inflammatory lesion of the mucous membrane of the colon, which subsequently appears between the interaction of genetic and external factors).
- Gastrointestinal tract diseases in patients who do not tolerate oral administration of glucocorticoids.
- Oncological diseases.
- Exudative erythema multiforme (an acute disease of the skin and mucous membranes with a polymorphic rash and a tendency to repeat, usually in autumn and spring).
- Contact dermatitis (an inflammatory lesion of the skin that occurs as a result of exposure to the epidermis of various irritants or allergic substances).
- Psoriatic erythroderma (a complication of psoriasis that affects a large area of the body, and also requires mandatory therapy in a hospital, can cause oncology).
- Psoriasis (chronic non-infectious lesion, dermatosis, which affects mainly the skin).
- Common eczema (a multifactorial chronic skin pathological process that proceeds with characteristic erythematous-vesicular rashes and serous inflammation).
- True pemphigus (a chronic disease of autoimmune origin, which is characterized by the appearance of blisters on clinically healthy skin and mucous membranes).
- Disseminated erythematous lupus erythematosus (a chronic disease of the skin and subcutaneous tissue, which consists in the formation of small foci, nodules consisting of an accumulation of lymphatic bodies in the connective tissue layer of the skin).
- Lichen planus (chronically occurring dermatosis, the characteristic and only element of which is the papule).
- Toxicoderma (acute toxic and allergic inflammatory lesions of the skin, which occurs when an allergen penetrates the skin through the hematogenous route).
- Prurigo (a chronic polyetiological disease from the group of neuroallergic dermatoses, the primary morphological elements of which are papulo-vesicles, as well as urticarial papules, hemispherical papular and nodular elements, the occurrence of which is accompanied by severe itching).
- Neurodermatitis (chronic skin lesion of the neurogenic-allergic type, which occurs with remissions and exacerbations).
- Diseases of the visual organs of rheumatic, as well as allergic and inflammatory genesis.
- Bronchial asthma (chronic damage to the respiratory organs with the participation of different cellular elements).
Contraindications
According to the instructions, Sinacten Depot has certain restrictions on the use, for example:
- Adrenogenital syndrome (a serious disorder that threatens both your peace of mind, health and life, and the condition of your children).
- Acute psychoses (a pronounced violation of mental activity, which manifests itself in a distorted perception of real events and oneself, while a person loses control over his behavior).
- Pregnancy.
- Breast-feeding.
- Children's age up to three years.
- Increased sensitivity to the components of the drug.
- Intestinal anastomosis (a complex risky operation to connect parts of a hollow organ).
- Diabetes mellitus (endocrine disease, which is associated with impaired glucose uptake and appears as a result of absolute or relative insulin deficiency).
- Bronchial asthma (a chronic inflammatory disease of the respiratory tract involving a variety of cellular elements).
- Arterial hypertension (persistent increase in blood pressure).
- Myasthenia gravis (a lesion characterized by pathologically rapid fatigability of striated muscles).
- Diverticulitis (a bowel disease characterized by inflammation of the diverticulums).
- Osteoporosis (a chronic disease of the skeleton, which manifests itself in other ailments that are characterized by a decrease in bone density).
Mode of application
Sinacten Depot should be administered strictly intramuscularly. At the beginning of treatment, the medicine must be used every day. After about three days, they go into intermittent mode. For adult patients, the medication is prescribed in an initial single concentration of 1 milligram (once a day).
In oncological diseases and in acute situations, a single dosage can be used once every twelve hours. After improvement, as a rule, they switch to the introduction of a single concentration of the drug every two to three days. If a persistent pharmacological effect occurs, the dosage can be reduced to a minimum - every 0.5–3 milligrams every day or 1 mg once a week.
Dosage regimen for children:
- Babies aged three to six years are prescribed 0.25-0.5 milligrams daily. Maintenance therapy - 0.25-0.5 mg once every two to eight days.
- School children from six to fifteen years old are recommended for treatment on a daily basis from 0.25-1 milligrams. Maintenance therapy - 0.25-1 mg once every eight days.
Side effects
According to reviews and instructions to the Sinacten Depot, it is known that the drug, if not dosed correctly, can provoke some undesirable reactions. These include:
- Allergy.
- Water and sodium retention.
- High blood pressure.
- Hypokalemia (a pathological condition characterized by a decrease in the concentration of potassium ions in the blood plasma).
- Myopathy (chronic progressive neuromuscular disease characterized by primary muscle damage).
- Hyperglycemia (a clinical symptom indicating an increase in serum glucose compared to normal).
What are the negative effects of the drug
A medication can provoke the following conditions:
- Decrease in resistance to infections.
- Mental illness.
- Damage to the stomach and intestines.
- Pigmentation of the skin.
- Itching
- Hyperemia (overflow of blood vessels of the circulatory system of any organ or body area).
- Rashes.
In children who take Sinacten Depot for a long time in high doses, heart muscle hypertrophy and stunted growth can occur.
The use of the drug in childhood
Treatment with Sinacten Depot is contraindicated in children less than three years old due to the presence of benzyl alcohol in the suspension, as there is a high risk of toxic reactions, including death. With prolonged treatment in children, it is necessary to constantly monitor growth. Younger babies often need echocardiography.
Generics
The following medicines are similar drugs with Sinacten Depot:
- "Somatropin".
- "Biosome".
- "Genotropin".
- "Rastan."
- Omnitrop.
But the instructions and prices at Sinakten Depot are different with their analogues. Keep the drug away from light and children at a temperature of two to eight degrees.
Sinacten Depot is released on prescription. Shelf life - 36 months, according to the instructions for use.
Sinakten Depot: reviews, price
There are not so many responses about the drug. Most of them tell about the use of medicine in children as an anticonvulsant drug. As a rule, there is a positive trend, although the effect of therapy does not appear immediately.
There are responses that indicate the occurrence of side effects, other people note an insufficient pharmacological effect. The cost of the drug varies from 2500 to 3000 rubles.