How should I use the drug "Aminophylline"? Instructions for use, analogues and characteristics of this tool will be discussed later.
Composition and form
What does the Aminophylline medication contain? Instructions for use states that the active element of this tool is the substance of the same name - aminophylline.
The drug goes on sale in the form of a solution for intravenous administration, as well as in the form of tablets, cream or ointments.
Pharmacological features
What is an agent like Aminophylline? Instructions for use (in ampoules this drug can be purchased at any pharmacy) reports that it is a vasodilating, antispasmodic, diuretic and bronchodilating medicine.
The active element of this medication is the theophylline ethylenediamine salt. It has a bronchodilating and bronchodilator effect, due to its direct relaxing effect on the smooth muscle fibers of the vessels of the lungs and respiratory tract. This effect is caused by selective inhibition of phosphodiesterase activity, which leads to an increase in the intracellular content of cAMP.
Drug properties
What is remarkable means "Aminophylline"? Instructions for use states that it is able to reduce respiratory tract hyperreactivity. The mechanism of this action is still unknown, but experts say that the use of the medication in question causes an increase in the number and activity of T-suppressors in the blood.
Increasing mucociliary clearance, enhancing the contraction of the diaphragm, and also stimulating the intercostal respiratory muscles, this tool activates the respiratory center, helping to improve its sensitivity, and enhances alveolar ventilation, which ultimately leads to a decrease in the frequency and severity of apnea episodes.
How else does the drug Aminophylline work? Instructions for use (ointment and solution have the same effect on the body) reports that the drug in question regulates respiratory function, thereby improving the process of saturation of blood O2 and lowering the concentration of carbon dioxide. In addition, this medication is able to stimulate ventilation of the lungs with hypokalemia.
It should be noted that "Aminophylline", the instructions for use of which is described below, activates the heart, increases the frequency and strength of the heartbeat, increases the need for heart muscle in O 2 and significantly increases cardiac blood flow.
The use of this drug helps to reduce the tone of the vessels of the brain, kidneys and skin. Experts say that the drug in question has a diuretic and peripheral veno-dilating effect, reduces the resistance of the blood vessels of the lungs, lowers the pressure in the pulmonary circulation and stimulates the blood flow in the kidneys. Also, this drug expands the bile ducts, slows down platelet adhesion and the release of mediators of hypersensitivity reactions, stabilizes mast cell walls, regulates microcirculation, reduces the risk of thrombosis and increases the stability of red blood cells.
In large dosages, the medication in question exhibits epileptogenic properties.
Kinetics
What kinetic indices are characteristic for Aminophylline? Instructions for use (for weight loss, this drug is used quite often) states that after entering the human body, the active element of this drug is metabolized, followed by the release of unbound theophylline, which subsequently binds to plasma proteins by 40%.
The agent in question is able to penetrate the placental barrier, as well as excreted along with breast milk.
Theophylline transformation takes place in the liver with the participation of the cytochrome P450 enzyme.
In its original form, the drug is excreted in an amount of 10% with urine. The half-life of this drug in non-smokers, as well as patients suffering from bronchial asthma, is 12 hours, in children - 1-5 hours, in newborns - up to 2 days, and in smokers - 4 hours.
When is it prescribed?
Indications for the use of this drug depend on the form of its release.
Parenteral administration is recommended for:
- ischemic cerebrovascular accident;
- asthmatic status;
- left ventricular failure, which was complicated by respiratory distress and bronchospasm;
- apnea of the newborn;
- chronic and acute heart failure;
- edema of renal origin.
In what cases aminofillin (tablets) is used orally? The instructions for use report that this drug works well with pulmonary heart disease, bronchial obstructive syndrome of various etiologies (for example, emphysema, bronchial asthma, COPD, obstructive bronchitis), night apnea, increased pressure in the pulmonary circulation, heart failure of a chronic or acute type .
Contraindications
When should you not use Aminophylline Medication? The instruction for use reports that it is contraindicated in:
- severe arterial hyper- or hypotension, tachyarrhythmias, gastrointestinal ulcers, including in the exacerbation phase;
- hyperacid gastritis, severe renal or liver dysfunction, hemorrhagic stroke, epilepsy, retinal hemorrhage;
- simultaneous use with ephedrine in children under the age of 3 years, hypersensitivity to aminophylline or theophylline.
The drug "Aminophylline": instructions for use
From cellulite (patient reviews will be discussed below), this remedy helps pretty well, but this is not the main purpose of the drug in question.
How should i use it? The regimen for taking this medication is individual. Treatment is developed by an experienced physician depending on the clinical picture, patient age, indications and the presence of nicotine addiction.
The drug in the form of a solution can be administered intramuscularly or intravenously, and in the form of an ointment - applied to dry and non-irritated skin.
How is it used for weight loss?
Can I use Aminophylline medication to reduce weight? Instructions for use (from cellulite, this remedy is most often used in the form of an ointment) does not contain any information on this. However, experts say that the active substance of this drug actually helps to reduce body weight, as well as partially get rid of the effect of the "orange peel". How does this happen? The fact is that aminophylline is able to enhance blood circulation in tissues, as well as improve their drainage function. Such a substance is found in many creams from cellulite (for example, Turboslim, Draine Minceur, Reflexe Minceur, Phyto-Complexe, Shape-up and others).
Schemes for the use of ointments with aminophylline depend on their complete composition and manufacturer.
Side effects
What adverse reactions can occur when using the drug in question? According to the instructions, it can cause:
- sleep disturbances, restlessness, dizziness, convulsions and tremors;
- gastroesophageal reflux, vomiting, diarrhea, nausea, heartburn, anorexia, and exacerbation of peptic ulcer;
- heart rhythm disturbances, heart pain, aggravation of the course of angina pectoris, decreased pressure, cardialgia and tachycardia;
- hematuria, albuminuria;
- itching, fever, and rash;
- hypoglycemia;
- flushing, soreness and tightness in the injection area;
- tachypnea, albuminuria, chest pain, hematuria, hot flashes, hypoglycemia, increased sweating and increased daily diuresis.
Interaction and Overdose
So far, there have been no reports of cases of overdose with this tool. If such a condition occurs, then you should stop taking the medicine and begin symptomatic treatment.
With the parallel administration of the drug with sympathomimetics, their pharmacological action is mutually activated. As for beta-blockers and lithium, then with them the action is mutually weakened.
The therapeutic effect of Aminophylline is markedly reduced when it is used simultaneously with Phenobarbital, Rifampicin, Isoniazid, Carbamazepine, Sulfinpyrazone, Phenytoin (including smokers).
The effect of the medication in question can be increased when taken together with quinolones, Lincomycin, macrolides, Cimetidine, Allopurinol, isoprenaline, beta-blockers, fluvoxamine, oral contraceptives, Disulfiram, and Viloxazin vaccine, as well as .
Enterosorbents and antidiarrheal agents reduce the adsorption of Aminophylline.
Analogs and customer reviews
Are there any analogues of the drug "Aminophylline"? Experts answer this question in the affirmative. The medication in question can be replaced with Aminophylline-Eskom, Eufillin-Darnitsa, tablets and injections of Eufillin.
What do consumers say about this product? There are quite a lot of reviews about this drug. Most patients report that Aminophylline Injection is a proven remedy. Its effectiveness and efficiency are not in doubt, including in attacks of bronchial asthma.
As for reviews regarding Aminophylline cream, they are controversial. Some consumers claim that this tool is ineffective. However, there are patients who share impressive results after applying ointment for cellulite.