In this article, we will consider instructions for applying to the "Cardiket", price and reviews.
It is a drug that is used to stop and to avoid angina attacks, as well as the treatment of other symptoms of coronary insufficiency on the background of coronary heart disease.
Product release form and composition
According to the instructions for use, "Cardicet" is made in the form of round white tablets, characterized by a prolonged action. They are convex on the one hand, have the inscription SCHWARZ PHARMA, and on the other with a chamfer, mark and engraving, flat. In one blister - ten pieces, in a cardboard bundle - two or five blisters. As a part of one tablet: isosorbide dinitrate (active substance), as well as auxiliary elements: polyvinyl acetate, potato starch, lactose monohydrate, magnesium stearate, talc.
What else does the instruction for application to the Cardichet tell us? Price and analogues will be presented at the end of the article.
Indications for use
Cardicet is applied in the following cases:
- with prolonged therapy of coronary heart disease (as a prophylaxis of angina attacks);
- prevention of myocardial infarction (secondary) and treatment for angina pectoris (as part of combination therapy);
- long-term therapy of severe chronic heart failure (as part of a combination treatment with cardiac diuretics, glycosides, angiotensin converting enzyme inhibitors).
Contraindications
As indicated by the instructions for use, "Cardiket" is not recommended in the following conditions:
- Excessive sensitivity to dinositrate of eiosorbide, other excipients or nitrates.
- Acute circulatory defects (collapse, shock).
- Cardiogenic shock (in the absence of measures supporting diastolic end pressure).
- Obstructive hypertrophic cardiomyopathy.
- Cardiac tamponade.
- Constrictive pericarditis.
- Arterial severe hypotension. At what pressure do you need to drink Cardiket according to the instructions for use? When arterial systolic pressure is less than 90 mm. Hg. Art.
- Severe hypovolemia.
- Severe anemia.
- Severe subaortic, mitral and aortic stenosis.
- Minors age, since safety and effectiveness have not been established.
- Concomitant use of phosphodiesterase-5 inhibitors (including tadalafil, vardenafil, sildenafil).
- Patients with galactose intolerance from birth or malabsorption of galactose and glucose due to the presence of lactose should not take this drug.
This is confirmed by the instructions for use with the Cardicet. Caution should be used with: low pressure filling the left ventricle, including acute myocardial infarction, impaired activity of the left ventricle (for example, with its insufficiency); mitral and / or aortic stenosis of moderate and mild; diseases that are accompanied by excessive pressure inside the skull (the increase in pressure to date has been observed exclusively after the introduction of nitroglycerin in large doses into the vein); cerebral hemorrhage, increased pressure inside the eyes, including angle-closure glaucoma, severe liver and / or kidney failure, predisposition to orthostatic vascular regulation defects, hypothyroidism, malnutrition and malnutrition; bearing a child and the lactation period.
This is also described in the instructions for use. The price of "Cardicet" is of interest to many.
Dosage and route of administration
Tablets (20 mg) with a prolonged effect are prescribed one piece twice a day. If the need for medicine increases, the dosage can be increased to one pill three times a day.
Tablets (40 mg) are prescribed at the beginning of treatment, one tablet once a day or half a tablet twice a day. If the therapeutic effect is insufficient, the dosage can be increased to one pill twice a day. The second tablet is taken no later than eight hours after the previous one.
Tablets (60 mg) are prescribed at the beginning of treatment, one at a time, once a day. If necessary, you can increase the dosage to one pill twice a day. No later than eight hours after the previous one, you should drink a second tablet.
In the form of capsules, the drug is prescribed once a day for 120 milligrams.
Treatment should begin with minimal doses, gradually increase the dosage to the most effective. The decision on the duration of therapy is made by the doctor. The medicine is intended for prolonged use, you can not stop taking it without consulting a specialist.
The drug is taken orally, regardless of the meal, does not chew, washed down with liquid. To split the tablet in half, you need to lay it on a hard surface with the fault line up and push it with your thumb. It can easily be split in half.
Side effects
In accordance with the instructions for use with "Cardicet", side effects when taken may be as follows:
- The system of the heart and blood vessels: at the beginning of therapy, a headache (the so-called "nitrate") may appear, which most often disappears after a few days if the drug is used in the future. In some cases, at the first dose or with excessive dosage, reduced pressure is observed, especially in those cases when the patient got out of bed, tachycardia is possible (there may be paradoxical bradycardia), dizziness, weakness, lethargy. In rare cases, against the background of a pronounced decrease in pressure, angina attacks may increase (paradoxical increase in angina attacks). Collaptoid states are very rare, sometimes with syncope (a sharp loss of consciousness) and bradycardia.
- Digestive system: in rare cases, dry mouth, vomiting, abdominal pain, nausea, belching.
- CNS: drowsiness, decreased ability to accelerate motor and mental reactions (especially at the beginning of therapy), stiffness, blurred vision, in rare cases, cerebral ischemia.
Allergic reactions: skin rash.
Other symptoms: tolerance develops (including cross to other nitrates), hyperemia of the epidermis on the face, exfoliative dermatitis.
This information is available in the instructions for use with the Cardicet. We will consider the price, reviews and analogues below.
Overdose
Overdose signs: marked decrease in pressure, fainting, dizziness, collapse, headache, palpitations, visual disturbances, skin hyperemia, vomiting, methemoglobinemia (anoxia, cyanosis), nausea, hyperpnea, diarrhea, perspiration, dyspnea, coma, bradycardia cranial hypertension.
The treatment is as follows: the stomach is washed; if the patient has methemoglobinemia, then a solution of blue methylene 1%, 1-2 milligrams per kilogram of weight, is injected into the vein. Symptomatic therapy (while epinephrine and compounds related to it are not very effective).
Interaction with other drugs
The hypotensive effect of Cardicet may be enhanced along with the use of other vasodilator drugs (vasodilators), beta-blockers, antihypertensive agents, calcium channel blockers, phosphodiesterase 5 inhibitors, which are used to treat erectile dysfunction, antidepressants of the tricyclic group, antipsychotergic drugs, and procainamide.
The simultaneous administration of the drug with dihydroergotamine can cause a rise in the concentration of dihydroergotamine in the blood and, therefore, increase its hypotensive effect.
With the simultaneous use of symptomatic drugs, alpha-adrenergic blockers, the antianginal effect of Cardicet may decrease.
The combination of amiodarone and other drugs, for example, propranolol, nifedipine, verapamil and Cardicet, is rational for the treatment of IHD.
At the same time taking "Cardicet" and acetylsalicylic acid helps to improve coronary circulation.
Combined use with atropine (m-anticholinergic) increases the likelihood of increased pressure inside the eye.
Adsorbents, enveloping and astringent drugs reduce the absorption of the drug in the digestive tract.
Application specifics
Instructions for use with "Cardicet" 20 mg reports that during treatment with the drug should monitor heart rate and blood pressure.
With systematic continuous therapy using high dosages of Cardicet, tolerance and the emergence of cross tolerance to other nitrate group drugs may develop. To prevent a decrease in the effectiveness of the drug, you must avoid its constant use in large doses.
The use of "Cardicet" in patients with primary pulmonary diseases may cause temporary hypoxemia due to the redistribution of relative blood flow in the alveolar hypoventilated zone. In people with coronary artery disease, this condition can lead to transient type myocardial ischemia.
In acute myocardial infarction or heart failure, the drug should be used only in the case of scrupulous clinical observation of the patient.
To prevent an increase in angina attacks, sudden withdrawal should be avoided.
During therapy with "Cardicet", if there is an angina attack, in order to stop it, you must additionally use nitrates of quick action.
In order to avoid an undesirable decrease in pressure, you need to select a dosage individually.
According to the instructions for use and reviews of the "Cardicet", the pressure may decrease during treatment; dizziness appears if you suddenly switch from a lying or sitting position to a vertical one, as well as when using ethanol, hot weather, and doing exercises. There may also be an increase in angina pectoris against the background of a sudden decrease in pressure, ischemia, which can lead to myocardial infarction or sudden death.
The severity of headaches during therapy with this drug can be reduced by reducing the dosage and / or simultaneous use of agents containing menthol (Validol).
With frequent use without intervals that are free to take, addiction can occur that requires an increase in dose.
To prevent tolerance, it is advisable to observe the daily "nitrate-free interval" (best at night) for 8-12 hours. In most patients, this treatment becomes more effective than continuous.
If you maintain or have a strong expression of dry mouth or blurred vision, discontinue treatment.
During therapy, alcohol intake should be excluded. In addition, you should avoid driving a vehicle and engaging in activities that are dangerous and require a high concentration of attention, as well as accelerated psychomotor reactions.
With caution, the drug is prescribed for severe renal and hepatic insufficiency, since there is a possibility of methemoglobinemia.
We examined in detail the instructions for use. Analogs of the "Cardicet" are given below.
Analogues of the drug
Cardiket has the following structural analogues in its current component: Izo Mak TD Spray, Izoket, Aerosonit, Nitrosorbid, Diniboros, Cardiks, Izakardin, Isosorbid Dinitrate, " Iso Mack Retard, Isolong, Iso Mack Spray. They should be picked up by a doctor.
Price
The cost of the drug is from 120 - 200 rubles per package. It depends on the region and the pharmacy network.
Reviews
Patients respond more positively to Cardicet. The medicine quickly establishes the functioning of the heart muscle. High efficacy is noted.
The most common side symptoms that are observed in patients are headaches of varying degrees of intensity.
The article was presented to the drug "Cardiket" instructions for use, price and reviews.