What you need to know before using a drug such as Kulchek? Instructions for use of the medication are required to read. In it you will find indications and contraindications for the use of this medication, and also find out if it has analogues and side effects.
Form, composition and packaging
Do you know in what form you can buy the medicine “Kalkek”? Instructions for use inform us that this drug is available only in tablet form. The composition of the medication includes such an active component as amlodipine besilate (5, 2.5 and 10 mg). As for additional substances, they include dibasic calcium phosphate, corn starch, sodium starch glycolate, purified talc, colloidal silicon dioxide and magnesium stearate.
The tablets are in blisters (10 pcs.), Which are placed in cardboard boxes.
Pharmacological properties of a medical product
How does the medicine "Kalkek" work? Instructions for use states that this medication is a selective blocker of calcium channels of the 2nd class. It has antianginal, antihypertensive, vasodilating and antispasmodic effects. The medicinal elements that make up this drug are able to block the flow of calcium ions into the cells of smooth muscle vessels.
The antihypertensive properties of the drug are due to its direct relaxing effect on the smooth muscles of blood vessels. As for the antianginal effect, the medication in question is able to expand arterioles (peripheral). Subsequently, this leads to a decrease in OPSS, which, in turn, leads to a decrease in myocardial demand for O 2 (oxygen).
However, it should be noted that sometimes, under the influence of this agent, oxygen supply, on the contrary, increases. This occurs due to the expansion of the coronary arteries (for example, with angiospastic angina pectoris).
It should be specially noted that Kalekok tablets do not have a negative effect on the lipid composition of the blood. They have antithrombotic and anti-atherosclerotic activity, increase the filtration rate (glomerular), and also have a mild natriuretic effect.
With diabetic nephropathy, the drug is not able to increase the severity of microalbuminuria.
Pharmacokinetic properties of the drug
Where is the absorption of the “Kulchek” medication? Experts say that the absorption of this drug comes from the digestive tract (approximately 90%). Its highest concentration in the blood is observed after 7-12 hours. The bioavailability of the drug is approximately 63-65%.
The active substance of the drug penetrates the BBB, and is also excreted along with breast milk. Amlodipine is biotransformed in the liver (inactive metabolites are formed).
In unchanged form, less than 10% of the drug is excreted. As for inactive metabolites, they are excreted in an amount of 60% together with urine and about 20-25% through the intestines and together with bile.
Indications for use
What diseases can the Kalechek tablets be prescribed for? Instructions for use (analogues of this tool are presented below) informs about the following indications:
- stable angina pectoris;
- angina is unstable;
- arterial hypertension (used as monotherapy or in combination therapy with ACE inhibitors, thiazide diuretics, beta and alpha-blockers);
- angiospastic angina (or the so-called Prinzmetal angina).
Contraindications
In the presence of what conditions the patient can not be prescribed tablets "Kulchek"? Instructions for use contain the following contraindications:
- arterial hypotension;
- hypersensitivity to the main active ingredient of the drug.
It should also be noted that the drug cannot be used for those patients who have hypersensitivity to dihydropyridine derivatives.
The drug "Kalkchev": instructions for use
Tablets "Kulchek" for angina pectoris and arterial hypertension are prescribed in a dosage of 5 mg per day. If necessary, then an increase of up to 10 mg is possible.
For patients with a diagnosis such as dilated cardiomyopathy, treatment begins with a dosage of 2.5 mg per day. If the drug is tolerated relatively well, then a gradual increase in dose is possible (no more than 10 mg per day).
When using tablets as part of a combination treatment with beta-blockers, thiazide diuretics or ACE inhibitors, dosage adjustment is not required.
Signs of an overdose and treatment process
What are the signs of an overdose if you take the KALCHEK medication incorrectly? Analogs and the drug itself can cause severe arterial hypotension. As a treatment, the patient must be given a horizontal position, as well as slightly raise his legs. In addition, support for the functioning of blood vessels and the heart, monitoring of indicators of pulmonary function, monitoring of urine output and BCC are required.
To restore vascular tone, the patient is given vasoconstrictor drugs. To eliminate the effects of calcium channel blockade, calcium gluconate is administered to the patient (intravenously) .
Drug interaction
The simultaneous administration of Kalekok tablets and Warfarin does not cause a significant change in the prothrombin period in healthy men.
With the simultaneous use of the medication in question and the Digoxin medication, no changes in the concentration of the latter in the blood, as well as its renal clearance, are noted.
The simultaneous use of the drugs "Kalkek" and "Cimetidine" does not have any effect on the pharmacokinetic properties of amlodipine.
Lactation and pregnancy
Is it possible to take “Kalechek” tablets during lactation and gestation? Instructions for use, reviews of doctors inform that the effectiveness and safety of this drug during pregnancy and lactation has not been established.
Side effects of the drug
What side effects can Callec tablets cause? The instructions for using this tool confirm the fact that its administration can cause unwanted reactions in the body. Among them, the following are especially common:
- Vessels and heart: shortness of breath, palpitations and flushing.
- Nervous system (peripheral and central): mood changes, dizziness, muscle cramps, headache, visual impairment, drowsiness, asthenia, fatigue, paresthesia and myalgia.
- Alimentary tract: abdominal pain, dyspepsia, cholestatic jaundice, nausea, increased activity of transaminases (hepatic).
- Skin: erythema multiforme, pruritus, skin rash.
- Other: gingival hyperplasia, gynecomastia, increased urination, impotence and edema.
Special instructions for taking the drug
What nuances of the drug in question should be known before taking the “Kalchek” tablets? Reviews of experts suggest that this medication should be used with extreme caution for people with impaired liver function, as well as heart failure (chronic) and stenosis of the aortic mouth.
Concomitant use of the “Kulchek” medication with non-steroidal drugs, nitrates, antibiotics and hypoglycemic drugs (oral) is possible.
There is no experience with the clinical use of the drug in young children.
Pills "Kulchek" do not have any effect on the patient's ability to drive a car.
Terms and conditions of storage of the drug
The drug "Kalechek" (5, 10 and 2.5 mg) must be stored in a cool, dry and dark place, out of the reach of small children. The shelf life of the tablets is 2 years.
Reviews about the drug, its analogues and cost
What can replace such a tool as "Kalkek"? Analogues of this drug are available in almost all pharmacies. Among the most common drugs are the following medications: Agen, Tenox, Adipin, Stamlo, Akridipin, Omelar Cardio, Amlo, Normodipin, Amlodipin, Norvask, Amlovas, Amlorus, Norvadin, Amlodigamma, Cordy Kor, Amlodil, Korvadil, Amlodipharm, Karmagip, Amlokard-Sanovel, Cardilopin, Amlong , Vero-Amlodipine, Amlotop, Amlonorm.
What is the cost of the tool in question? The average price of this drug is 175-190 Russian rubles (5 mg, 30 tablets).
As for the patient reviews, for the most part they are positive. According to those who have ever used this medication, it effectively fights against angina pectoris and hypertension. It should also be noted that a large number of patients are pleased and the fact that this drug is tolerated relatively well by them. Although in some cases, Kalekok tablets still cause side effects such as headaches, abdominal pain, dizziness, nausea, and allergic skin reactions.