For a number of infectious diseases, immunostimulating drugs are used . One of these is Groprinosin. The instructions for use noted that this tool is also able to have an indirect antiviral effect. Specialists prescribe the drug to patients of different age groups. In general, most patients remain satisfied and leave positive reviews about Groprinosin. Instructions for use (annotation to the drug) confirms its effectiveness.
This tool speeds up the healing process, facilitates the course of viral diseases and makes the body more resistant to various infectious agents. Due to this property, the drug is used for immunodeficiencies (congenital and acquired), encephalitis and other viral pathologies, among which the most common are shingles, herpes, chickenpox, measles, mumps, human papillomavirus, hepatitis, etc.
Release forms and composition
At the moment, Groprinosin is produced only in the form of oral tablets. Each pill has a white (cream) color, an oblong shape, a bulge on both sides. For ease of dosage, each tablet is equipped with a risk. In the pharmacy sale there are Groprinosin packages with a different number of pills - from 20 to 50.
Inosine pranobex acts as an active component in the composition of the drug. It is no coincidence that this drug is called "Groprinosin 500": the instructions for use say that each tablet contains 500 mg of this substance. On the other hand, there is no need to name the dosage of the drug, since it is not produced in other doses.
Operating principle
Inosine-based tablets produce a powerful antiviral and immunostimulating effect. The active component of Groprinosin is a complex chemical compound with salts of 4-acetamidobenzoic acids, which improve the penetration of inosine into cells through membranes. The drug reaches the desired therapeutic result in the following way:
- penetrating into the infected cell, inosine inhibits the virus, prevents the reproduction of its genetic material (RNA and DNA);
- inhibits the activity of a pathogenic microorganism due to the connection with the ribosomes of cells of internal organs;
- increases the production of monocytes and macrophages necessary for the destruction of cells infected with viruses;
- strengthens healthy cells of the immune system, which are able to destroy the sick;
- sets a high growth rate of lymphocytes, indispensable in the fight against bacterial and viral infections;
- promotes the production of interferon, interleukin-2 and other natural immunostimulants;
- improves the ability of protective cells to recognize substances that activate their work (immunomodulators).
The instructions for the use of "Groprinosin" noted that the drug can be used to treat viral diseases in both acute and chronic stages. It has been clinically proven that the use of this agent in a comprehensive program for the treatment of influenza, hepatitis, herpes, encephalitis, rhinovirus infection and cytomegalovirus allowed to reduce the severity of clinical symptoms and shorten the recovery period. In addition, the medicine is able to strengthen the immune system, which has a positive effect on the duration of remissions for herpetic and papillomavirus infections. According to reviews, people who often suffer from colds and respiratory diseases, the incidence rate decreased.
Groprinosin has a wide range of applications, therefore it is used not only for viral infections. By the way, with herpes simplex, the drug starts regenerative processes and contributes to the speedy healing of the skin. The purpose of this immunostimulant is advisable for people who are undergoing radiation or chemotherapy. In the instructions for the use of "Groprinosin" (500 mg) for adults and children, side effects and contraindications are noted, but most patients note that the drug is easily tolerated.
What diseases are prescribed
Indications for use of this drug for children and adults do not have fundamental differences. At the same time, there is an age restriction: children under three years of age should not be given the drug. The list of diseases in which Groprinosin is recommended by doctors is as follows:
- diseases of the skin and mucous membranes caused by the human herpes simplex virus, including herpetic eruptions on the lips, genitals, ophthalmic herpes, as well as chickenpox and herpes zoster;
- papillomavirus type 16 and 18, which is manifested by the formation of papillomas and genital warts on the skin, in the region of the anus and genitals (in this case, the drug is used as an additional tool for laser therapy or treatment with Podophylline)
- immunodeficiencies against a pronounced course of measles, mumps, chickenpox, cytomegalovirus infection;
- ARVI (influenza, rhinovirus and adenovirus infections, mumps, measles);
- chronic viral bronchitis and other diseases of the respiratory and genitourinary system of viral origin;
- subacute sclerosing encephalitis.
What is the feature of the drug
Based on the contents of the instructions for use of Groprinosin 500, adult patients are prescribed the same dosage for any disease. Even the elderly are no exception. However, it is worth noting that in people over 65 years of age, while taking this medication, the concentration of uric acid in the blood and urine often increases. With prolonged use of the drug (more than 14 days), you should regularly take tests to control the level of uric acid in the body.
If a patient had an elevated level of uric acid in the blood even before starting Groprinosin treatment, drugs that suppress its production are prescribed in parallel with this immunostimulating and antiviral agent. They are also recommended to be taken if the concentration of the purine catabolism product has increased due to the use of an antiviral drug.
If there is a reasonable need to use Groprinosin for three weeks or more, you need to monitor changes in indicators such as creatinine, the number of leukocytes, red blood cells, and platelets.
In patients with a history of chronic liver failure, uric acid levels and liver enzyme activity should be checked at least once every 10-14 days. In the instructions for the use of Groprinosin tablets (500 mg), it is recommended to reduce the dosage by a third, since in patients with liver diseases inosine pranobex is poorly excreted.
The maximum effectiveness of the drug is guaranteed in the early stages of a viral infection. This tool can be used as monotherapy or combined with other medicines. On the combination of inosine with other active substances (antibacterial, antiviral, antifungal, etc.) below.
Interaction with drugs of other groups
Restrictions on the combination of Groprinosin with other drugs are not numerous. You can use the drug in combination with any active ingredients, with the exception of:
- immunosuppressants that neutralize the immunostimulating effect;
- diuretics ("Furosemide", "Torasemide");
- drugs used to treat gout (Allopurinol).
When combined with the latter, an increase in the level of uric acid in the blood is possible. In addition, you need to know that Groprinosin increases the concentration of Zidovudine in the blood - this drug is part of the highly active antiretroviral therapy for HIV, so an additional dosage adjustment will be required before use.
How dangerous is an overdose
If you again turn to the instructions for the use of Groprinosin (a photo will give an idea of how the packaging of the drug looks), you can breathe a sigh of relief, since since the appearance of this drug on the pharmaceutical market, there have not been a single case of overdose. However, an overdose of this drug, like any other, is theoretically possible. The increased content of inosine pranobex in the blood can lead to the development of side effects, increase the level of uric acid in the body, which is manifested, as a rule, by nausea, vomiting, dizziness. With such symptoms, you should stop taking the drug and rinse your stomach.
The instructions for use of Groprinosin (500 mg) do not say anything about the effect of the drug on the patient’s ability to drive vehicles and complex mechanisms. No studies have been conducted in this area, and therefore those who are undergoing treatment should proceed with caution to work requiring an instant reaction and concentration. In addition, drowsiness and dizziness are one of the confirmed side effects from the use of "Groprinosin" (a separate item is also devoted to this issue in the instructions).
Groprinosin for children
Today, this drug is used in practice by pediatricians from all over the CIS. It is interesting that in Russia "Groprinosin" children, according to the instructions for use, are allowed to give no earlier than three years of age. These are official recommendations. For comparison: in Belarus, a medicine is prescribed for babies older than a year, and in Kazakhstan - only after 6 years. But despite such restrictions, in almost all post-Soviet states, doctors prescribe Groprinosin to children over 12 months of age, which is due to many years of monitoring the use of this drug. Pediatricians rely on purely practical conclusions about the safety of this drug for babies older than one year of life.
In most cases, the medicine is prescribed for children for the treatment of respiratory viral, colds, as well as for the purpose of prevention during periods of epidemic. Groprinosin can also be used at an early age in the treatment of measles and chickenpox. Since herpetic skin lesions in children are diagnosed in isolated cases, it is practically not used in pediatric practice to treat this disease.
Reception schedule
Tablets must be taken several times a day, it is advisable to observe equal intervals of time between doses. The medicine is taken orally after a meal and washed down with water. The optimal dosage of Groprinosin (500 mg) in the instructions for use is as follows:
- For adults and children over 12 years of age, the daily number of tablets should not exceed 6-8 pieces. The drug is drunk in 3-4 doses.
- For children under 12 years of age, the dosage is calculated on the basis of 50 mg per 1 kg of body weight. The resulting amount of inosine is divided into 3-4 doses.
Dosage can be increased for both adults and children. In the instructions for the use of Groprinosin, it is noted that for infectious diseases with a severe course, the daily dosage can reach 100 mg per 1 kg of weight, but it is recommended to divide it into several doses.
In acute forms of infections, therapy usually lasts 10-14 days. After the symptoms disappear, the drug should be continued for the next several days, depending on the indications. With recurrent pathologies of a viral nature, treatment is carried out in courses, each of which averages 5-10 days. Between treatment periods, a weekly interval must be observed.
If you use "Groprinosin" as a drug to maintain immunity and prevent viral infection, the duration of use is an average of one calendar month. In this case, the doctor reduces the dosage by 2-3 times.
These tablets can be broken, crushed, dissolved in water. The instructions for use of Groprinosin 500 for children of three years of age indicate the minimum dosage, but despite this, it is very difficult for babies to give bitter pills, so before each use it is necessary to stock up with enough water, sweet juice, compote, weak herbal tea.
Adverse reactions
Usually, there are no problems with the use of Groprinosin (500 mg). In the instructions, children and adults are advised to take the drug after meals to exclude all kinds of gastrointestinal upsets. And although with prolonged use, the drug is tolerated normally, side effects from various organs and systems can occur:
- headache and dizziness;
- fatigue and weakness;
- general malaise;
- nervousness and irritability;
- increased drowsiness or, conversely, sleep disturbances;
- loss of appetite;
- dyspeptic disorders;
- epigastric pain;
- enlarged liver;
- itching and rashes on the skin;
- frequent urination;
- exacerbation of gout.
Groprinosin can cause allergies, which are manifested by urticaria or angioedema. With individual intolerance to inosine or excipients of the drug, its further use is unacceptable.
Who should not take Groprinosin 500
In the instructions for use, there are specific contraindications to the use of this tool. Groprinosin should not be treated with children and adults with a history of diseases such as:
- gout;
- urolithiasis disease;
- severe renal failure.
This antiviral drug is not used during pregnancy and lactation, but if the benefit to the mother outweighs the risk to the baby, the woman may be prescribed this medication in an individual dosage. Groprinosin is recommended with caution to patients with angina pectoris.
Drugs to choose from, analogues
The instructions for the use of "Groprinosin" indicate its active substance - inosine pranobex. Today in Russian pharmacies you can find another medication, which contains this component - this is Isoprinosine. The product is in the form of tablets, it has the same principle of action as Groprinosin.
Other analog preparations are made on the basis of other active substances, but have similar properties. These include "Allokin-alpha lyophilisate", which is made in the form of a solution for injection, tabletted "Alpizarin", "Amiksin", "Arbidol", "Hyporamine", "Kagocel". Some drugs are available in the form of a gel, suppository, and intravenous solution (for example, Panavir, Proteflazid, Ergoferon, Ferrovir).
Patient opinions on the drug
Instructions for use "Groprinosina" does not allow to obtain objective conclusions and to understand whether the drug helps in therapeutic practice. The answers to those who have already taken this tool will help answer this question. Mostly there are positive reviews about the Groprinosin 500.
The instructions for use noted that the drug can be taken in order to suppress the activity of the human papillomavirus. Women who underwent treatment note that colorless moles and genital warts stopped growing, and even several months after the course of treatment, new formations did not appear.
There are patients who express their dissatisfaction after the use of "Groprinosin" from genital herpes and flu. Allegedly, the remedy was ineffective, did not bring any tangible result. Negative feedback about the drug is left by those to whom the drug seemed unsafe and "toxic." Most likely, such an impression is formed due to the likelihood of side effects, which are described in the instructions for use of Groprinosin (500 mg). The reviews describe cases of allergic reactions, due to which further administration of the drug was impossible.
What they say about the treatment of Groprinosin babies
Can not be called unambiguous and reviews about this drug for children. Parents who were satisfied with the use of the drug note that the medicine helps to quickly overcome respiratory diseases and strengthens the immune system, which makes children sick much less often, constantly attend preschool institutions, and do not miss classes at school. Particularly noteworthy are reviews in which parents note that it was Groprinosin that helped cure the child of chronic respiratory diseases (sinusitis, tonsillitis).
Negative comments are subjective, as they are due to individual factors. So, for example, some parents complain about the inefficiency and supposedly complete uselessness of the remedy. And yet, if in a particular case the drug did not help a particular child, this does not mean at all that the medicine is not able to give the proper therapeutic result. - . . «» (30 ) 650-800 .
Before taking the drug, you must consult your doctor. Self-medication is unacceptable.