In the article, we consider the instructions for use and analogues of “Kvamatel”. This medication is a histamine receptor blocker. The medicine helps to reduce the intensity of the synthesis of hydrochloric acid. In this regard, “Kvamatel” is often used to eliminate peptic ulcer and other disorders of the digestive system, which are associated with high acidity.
Features of the composition
There are only two forms of release of this medicine:
- Film-coated tablets containing 20 or 40 milligrams of active ingredient.
- Lyophilisate for the manufacture of a solution (20 mg).
According to the instructions for use with Kvamatel, the active component of the drug is the substance famotidine. Povidone and corn starch are added as additional ingredients in the manufacture of tablets. In addition, lactose monohydrate is present in these tablets. As for the lyophilisate, it includes mannitol. In addition, this drug has aspartic acid.
Cost of medicine
The price of “Kvamatel” directly depends on the dosage and the release format of the medicine. For example, twenty-eight tablets, which contain 20 milligrams of the active ingredient, will cost one hundred and sixty rubles. Fourteen tablets with a dose of 40 milligrams will cost one hundred and fifty rubles. For five ampoules of lyophilisate, you will have to pay about four hundred rubles.
Instructions for use for Kvamatel injections will be given below.
Operating principle
The active component of the drug is related to histamine receptor blockers. The substance famotidine has a predominantly selective effect on them. Due to the effect on the receptors of the gastric walls, the production of juice is reduced. In addition, the active component of the drug helps to regulate the synthesis of pepsin.
The drug "Kvamatel", as a rule, does not affect the work of the pancreas and does not affect the evacuation activity of the stomach. Also, this drug does not affect the functioning of the liver, portal blood circulation and does not affect the performance of gastrin. The main substance of this medicine does not have antiandrogenic properties.
As indicated by the instructions for use with Kvamatel, after a single use of 20-40 milligrams of the drug, the therapeutic effect lasts for ten to twelve hours. If the patient takes 10 milligrams of the drug, then he can count on a therapeutic effect for nine hours.
After oral administration, this medicine is perfectly absorbed. Indicators of bioavailability are at the level of fifty percent. The maximum concentration of the active substance in the blood plasma can be observed three hours after the drug enters the body.
The drug is metabolized in the liver, and leaves the human body through the kidneys. A small amount of medication can be excreted in the form of metabolites. Half-life takes three hours. In people who suffer from kidney failure, the half-life of the component is up to twenty hours.
Indications for use
In accordance with the instructions for use for Kvamatel, the main indications for the use of the medicine are the following diseases and conditions:
- prevention of relapse and prevention of exacerbation of ulcers;
- in the presence of an erosive form of gastroduodenitis;
- in order to prevent aspiration of gastric juice;
- as part of the prevention and treatment of symptomatic ulcers, which is caused by stressful situations, as well as the use of non-steroidal anti-inflammatory drugs and surgical intervention;
- the presence of a functional form of dyspepsia due to increased secretory activity;
- in the presence of reflux esophagitis;
- in order to prevent bleeding in the digestive system;
- the presence of Zollinger-Ellison syndrome.
Consider the instructions for use with Kvamatel tablets.
Features of the use of tablets
This medication form is intended for internal use. The dosage and duration of treatment are selected by the doctor, depending on the indications:
- In the event that the patient is diagnosed with an exacerbation of the ulcer, it is recommended to take the drug 20 mg twice. You can also take 40 mg, but once in the evening. If necessary, you can increase the daily amount of the drug to 160 mg.
- In order to prevent exacerbation of the ulcer, 20 milligrams of the drug are prescribed. It should be taken once a day. You need to do this in the evenings. Instructions for use with Kvamatel tablets need to be studied in advance.
- In the treatment of reflux esophagitis, 20 milligrams of the drug is prescribed twice a day. Take the drug for six weeks. If there is a need, you can increase the daily intake to 80 milligrams.
- Start treatment for Zollinger-Ellison syndrome with 20 mg. Instructions for use with Kvamatel indicate that the medicine is consumed every six hours. Next, the doctor reviews the dosage, depending on the patient's condition. The course is from 4 to 8 weeks.
- In order to prevent aspiration of the gastric contents during anesthesia, the drug is used in an amount of 40 milligrams. The drug should be taken on the day of intervention.
Instructions for use with Kvamatel are very detailed.
Use of lyophilisate
Lyophilisate is used to prepare the solution. It is administered intravenously. This can be done by the drip method, and also the injection technique will be suitable. The drug is used only in a hospital setting. This method of administration is relevant for complex forms of pathology or against the background of difficulties with oral use of the drug. So it is said in the instructions for use to "Kvamatel." Only a qualified specialist can administer it dropwise.
Before using the substance, the contents of the ampoule are mixed with 10 milliliters of solvent. With inkjet administration, the duration of the procedure is at least two minutes. In the event that the patient is shown infusion, the manipulation should last at least thirty minutes.
The finished solution can remain stable throughout the day provided that it is kept at room temperature. At a time, you can apply no more than 20 milligrams of the drug. The average daily rate is 40 mg, which are administered twice a day. The interval between the procedures is twelve hours.
When treating Zollinger-Ellison syndrome in a hospital, the initial dosage, according to the instructions for use with Kvamatel, is 20 mg. This amount is used at intervals of six hours. Subsequently, the dosage is adjusted. The amount of medicine depends on the condition of the patient and the synthesis of hydrochloric acid in his body.
In order to prevent aspiration, you need to enter 20 milligrams of the drug intravenously. This is usually done in the evening or a few hours before surgery. When the opportunity arises, the patient is transferred to oral medication. This is confirmed by the instructions for use for Kvamatel. It should be administered intravenously very carefully.
Against the background of deviations in the work of the kidneys, accompanied by creatinine clearance to 30 milliliters per minute, the daily dosage should be reduced to 20 milligrams. In the event that the usual volume is required, the interval between the use of the substance should be forty-eight hours. It also describes the instructions for use with Kvamatel in ampoules.
Contraindications
Key prohibitions on using this tool include the following conditions:
- during pregnancy;
- in childhood;
- during lactation;
- in the presence of sensitivity to the drug.
With caution, “Kvamatel” is prescribed for people who are diagnosed with renal failure.
Side effects
According to the instructions for use and reviews of "Kvamater", the following reactions are the main side effects:
- Against the background of damage to the digestive organs, a feeling of dry mouth can occur along with pain in the abdomen, nausea and vomiting. There is also a risk of flatulence, impaired stool and a significant loss of appetite. This drug can lead to various forms of hepatitis, acute pancreatitis.
- Disturbances in the functioning of the hematopoietic system can manifest itself in the form of leukopenia along with agranulocytosis and pancytopenia. There is also a risk of developing aplasia or thrombocytopenia.
- Hives, skin rashes, bronchial spasms and itching are possible.
- There is also a risk of atrioventricular block, arrhythmia and bradycardia.
- The nervous system can respond to the use of the drug with dizziness, fatigue, as well as impaired consciousness and the occurrence of hallucinations. Some patients have increased drowsiness with headaches.
- Loss of vision is likely along with tinnitus.
- The reproductive system can respond to prolonged use of the drug by weakening attraction to the opposite sex. There are also risks of gynecomastia.
- Against the background of damage to bone and muscle tissue, spasms and arthralgia occur.
- Dermatological symptoms can occur in the form of acne and excessive dryness of the skin.
Overdose
With excessive use of “Kvamatel” there is a risk of symptoms of overdose in the form of vomiting, trembling of the extremities, decreased pressure, a state of collapse, motor excitement and a rapid heartbeat. After first aid, the doctor should prescribe symptomatic treatment. Specific drugs in this case are selected depending on the following criteria:
- against the background of slowing of the heartbeat, Atropine must be administered;
- in case of seizures, “Diazepam" is administered intravenously;
- when arrhythmias are introduced, "Lidocaine".
special instructions
Before prescribing this medicine, the doctor must make sure that the patient has no malignant tumors. “Kvamatel” usually hides the symptoms of such pathologies. During therapy, a person is strictly contraindicated in drugs and products that can irritate the gastric mucosa. It is forbidden to abruptly stop the use of this medication. This can cause withdrawal symptoms. In this regard, doctors advise lowering the dosage gradually.
With prolonged treatment, there are risks of joining the bacterial pathology of the stomach. This, as a rule, contributes to stress and weakening of the body. For people with functional liver damage, this medicine is prescribed with extreme caution. In such situations, a low volume of the substance is indicated.
Analogs
If necessary, you can pick up analogues "Kvamatela". To date, it can be replaced by the following drugs: Famosana, Gasterogen, Ulfamida, and Famotidine. The doctor should pick them up.
Drug Reviews
A large number of positive reviews about Kvamater, which are found on the network, confirm the high effectiveness of this drug.
People say that with the help of this medication, you can quickly cope with any exacerbation of gastritis or gastric ulcer. Patients confirm that Kvamatel perfectly eliminates excessive acidity. But it is very important to adhere to the prescribed dosage.
Patients are confident that Kvamatel is a very effective drug that reduces the secretion of gastric juice. People say that they regularly take it to prevent exacerbations of peptic ulcer. Many patients note that they are very satisfied with the results of their treatment. Those who took Kvamatel for treatment write that a stomach ulcer after such therapy no longer resembles itself.
Thus, today the drug "Kvamatel" is a very effective tool that helps to cope with many different pathologies of the digestive system. But in order to achieve a good result, it is necessary to strictly adhere to the prescribed treatment regimen (dosage, course duration) and all the doctor's related recommendations regarding the use of this medication.