In the article, we will understand how Dibazol helps.
Hypertension is a chronic disease that can be maintained in a state of remission, but its cure is impossible. In the extensive list of drugs with a clear antihypertensive effect, it is necessary to highlight a time-tested drug - Dibazol, which has beneficial effects on the blood vessels (reduces tone), supplies the affected area with blood and strengthens the structure of the myocardium. This medication is one of the antispasmodic myotropic drugs, the active ingredient is bendazole.
Composition and form of release
According to the instructions, Dibazol has the following release forms:
- Tablets (blister packs contain ten pieces, one or two packs in a cardboard box; dark glass jars - 50 pieces each, in a cardboard pack of 1 or 30 containers; in dark glass jars, 80 pieces, in a cardboard pack of 1 or 25 cans) .
- Dibazol tablets for the treatment of children (non-cell contour packs contain 10 pieces).
- Solution for intramuscular and intravenous administration (5 mg per ml: two or five milliliters in ampoules with an ampoule knife, five or ten ampoules per pack; 10 mg per ml: one, two or five milliliters in ampoules with an ampoule knife, five or ten ampoules packaged).
In the composition of the drug, the active substance is present in the amount of:
- one tablet of "Dibazol" - 20 milligrams;
- one tablet is four milligrams;
- one milliliter of injection - five or ten milligrams.
Pharmacodynamics
As the instructions indicate, “Dibazole" is an antispasmodic with a myotropic effect, which is one of benzimidazole derivatives. It is characterized by an antispasmodic effect on the smooth muscles of the internal organs and blood vessels. The medication increases blood flow to those parts of the myocardium that suffer from hypoxia and ischemia. Blood pressure decreases due to a decrease in cardiac output, as well as the expansion of peripheral vessels. "Bendazole" has moderate hypotensive activity, its effect does not last too long.
The drug causes a short expansion of the vessels of the brain and improves synaptic transmission in the spinal cord. The substance has immunostimulating activity due to its participation in the regulation of the ratio of cGMP and cAMP in the cells of the immune system (the active substance increases the degree of cGMP), due to which the final cellular effector function, the proliferation of mature T and B lymphocytes, which undergo sensitization, is cooperatively activated. and their production of factors of mutual regulation.
Features of pharmacokinetics
In accordance with the instructions, Dibazol in the form of tablets is perfectly absorbed from the digestive tract. The result of metabolic processes is the formation of two metabolites with pharmacological activity. The therapeutic effect when used is observed after half an hour or an hour and lasts up to three hours. The active ingredient and its metabolites are mainly excreted by the kidneys, a small amount through the intestines.
Indications and contraindications
According to the instructions, "Dibazol" is prescribed for adult patients, while the doctor individually determines the dosage for the day and the form of release, enhancing the overall therapeutic effect and safe action in the human body. Both tablets and injections are used for intravenous and intramuscular administration. The main indications for the use of the drug are listed in the instructions: pathologies of the nervous system (including paralysis (peripheral damage) of the facial nerve and residual effects of polio transferred by the patient; hypertensive crisis; arterial hypertension; renal colic; arterial spasm (including coronary spasm, peripheral spasms arteries); hepatic colic; arterial hypertension; spasms of smooth muscles of organs inside (including colic of the intestine, peptic ulcer of the duodenum and stomach ); ulcerative pathology of the stomach; polyneuropathy; polyneuritis; spasms of the intestine and pylorus; spasms of blood vessels.
"Dibazole" cannot be used if there is an increased sensitivity to the composition of the drug.
Instructions for use of the medication: dosage and method
Tablets for adult patients must be taken orally, with a break with food intake, equal to at least two hours.
One dose can be from 20 to 50 milligrams, the frequency of use is 2-3 times a day, the duration of treatment is three to four weeks (shorter courses can also be taken). The dosage of "Dibazole" should be strictly observed.
The drug in the treatment of pathologies of the nervous system should be drunk once a day for five milligrams (can also be taken every other day), for the course - from 5 to 10 doses.
If the pediatrician prescribes the drug “Dibazol” to the child, then this is permissible, since the instructions say that the medication can be used even for the treatment of newborns in strict accordance with medical indications. This is appropriate for the elimination of postpartum injuries such as increased muscle tone, sleep disturbances, a defect in intracranial pressure, and chin tremors.
Children are prescribed Dibazol in ampoules, but the proportions prescribed by the instructions and the pediatrician must not be violated, and all age-related characteristics of the child should be taken into account. If, for therapeutic purposes, a powder substance is taken, the drug for oral administration is made in this way: combine 0.001 grams of powder with 0.3 grams of glucose, and then dilute with plain water.
The child is given the drug once a day. A single dosage depends on age. Up to one year, children are usually prescribed one milligram, from one to three years - two milligrams, from four to eight years - three milligrams, from nine to twelve years old - four milligrams, over twelve years old - five milligrams.
If necessary, the course is repeated after 3-4 weeks. In the form of an injection solution, the drug is administered 2-3 times a day intramuscularly, 2-3 milliliters. The duration of treatment is from 8 to 14 days.
Reviews about "Dibazole" are abundant.
Side effects
The drug is most often tolerated by patients without any complications. But the instructions for use speak of existing negative manifestations that limit the possibility of using the drug with hypertensives. Not all patients will benefit from treatment with this drug, but it will harm someone altogether. In order to avoid negative consequences, you need to carefully familiarize yourself with the side effects that are listed in the instructions for use: migraine attacks; allergic reaction; dizziness; nausea; excessive sweating; vomiting
Overdose
When the recommended dosage is exceeded, the following negative effects may occur: a sudden drop in blood pressure; dizziness; excessive sweating; nausea, feeling of heat. There is no specific antidote. In case of an overdose, it is advisable to take measures aimed at reducing the absorption of the drug from the gastrointestinal tract (gastric lavage, inducing vomiting, the use of enterosorbents - Polysorba, Smecta, activated charcoal, etc.) In addition, symptomatic phased treatment is required.
special instructions
The drug "Dibazole" should be used very carefully for elderly patients. It is not recommended to be used for a long time for the treatment of hypertension, especially for the elderly.
When treating drugs, you need to be careful when driving various vehicles and performing work that requires immediate psychomotor reactions and high concentration, since there is a possibility of dizziness and headache.
Use for breastfeeding and pregnancy
Since there is no information on the safety of the active substance for the fetus, it is not possible to take it during pregnancy. It is not known whether bendazole passes into breast milk, and therefore, when used for the treatment of nursing mothers, it is necessary to resolve the issue of temporary cessation of feeding during drug therapy.
Drug interaction
When taking the drug, an increase in the total peripheral vascular resistance due to beta-blockers is prevented. With the simultaneous use of antihypertensive drugs with Dibazolum, they can enhance the antihypertensive effect. With the combined use of "Phentolamine" with bendazole, the hypotensive effect of the latter is enhanced.
Analogs
The drug has the following analogues: "Dibazol-UBF"; Dibazole-Vial; "Dibazol-Darnitsa." The doctor should pick them up.
Reviews on Dibazole are presented below.
Reviews
Patients mainly leave positive feedback about the drug "Dibazol." When treating children, parents note rapid effectiveness, eliminating colic caused by spasms of smooth muscle. The drug for hypertensive crises provides an accelerated decrease in blood pressure. Negative effects are very rare, since the drug is not intended for long-term treatment and is applied situationally.
Now we know what Dibazol helps.