The drug "Atenolol Nycomed" belongs to the class of drugs to lower blood pressure and eliminate arrhythmias, has an antianginal effect. Belongs to the group of selective beta1 blockers. The tool does not affect cell membranes and does not have an internal sympathomimetic effect.
Pharmacological features
The main component of the drug "Atenolol Nycomed" is able to block the activity of beta1 cardiac adrenergic receptors. A fairly pronounced effect is observed even when using the drug in a low dosage. Under the influence of the active compounds, production is inhibited with the participation of catecholamines CAMP, ATP. The current of calcium ions inside the cell becomes slower. The drug has negative chromo-, batmo-, dromo-, inotropic effects. Reduces heart rate. The use of the drug in a reasonable dosage helps to reduce the contractility of the heart muscle, its excitability, as well as weaken the conductivity.
In the first knocks of taking “Atenolol Nycomed”, peripheral vascular resistance increases somewhat. This is due to the reaction of the body to adrenergic blockers, a reciprocal increase in the activity of alpha category adrenoreceptors. The condition returns to normal over the next three days. With prolonged use of the drug, the peripheral vascular resistance becomes lower.
How it works: pressure control
Prescribing the drug, the doctor must tell the patient about “Atenolol Nycomed” at the patient’s appointment. Why are these pills prescribed in each case? This specialist should explain in detail. Often, the choice in favor of the drug is made due to its antihypertensive effect. In the instructions for use, the manufacturer explains that the effect on pressure is explained by a decrease in the volume of blood flow per minute, as well as a decrease in the activity of RAAS. This allows you to effectively control the pressure if the patient has an increased production of renin in the body. The susceptibility of aortic arch baroreceptors also decreases.
The use of "Atenolol Nycomed" allows equally successful control of systole, diastole. The volume of blood flow per minute and shock is reduced. Used in an average therapeutic dosage, the drug does not affect the tone of the arteries of the peripheral circulatory system. Effective elimination of hypertension is observed 24 hours from the moment the medication enters the body. If you use the product regularly, stable rates are achievable on average by the 14th day of therapy.
Efficacy: antianginal and anti-arrhythmia
According to the instructions, "Atenolol Nycomed" has a pronounced antianginal effect. When using the medication, the oxygen demand of the heart muscle is slightly reduced, since the frequency of contractions of the organ becomes lower, the diastole lengthens, and the quality of perfusion increases. The susceptibility of the heart muscle to sympathetic stimulation is reduced. Reducing the frequency of contractions is observed not only with human activity, but also at rest. The final diastole in the left ventricle rises, the muscles are stretched, which over time can lead to increased oxygen demand. To a greater extent, this is characteristic of persons suffering from heart failure in a chronic form.
The instructions for use with the "Atenolol Nycomed" tablets indicate the prevention of arrhythmias with a reasonable and stable intake of the drug. The manufacturer explains this effect as inhibition of factors that can provoke arrhythmia. The rate of spontaneous excitation of pacemakers decreases, atrioventricular conduction decreases. The most pronounced effect of suppression of pulsed conductivity is observed in the antegrade direction. In the retrograde, as well as on the secondary paths, such, too, is, although it is expressed more weakly.
Drug kinetics
The manufacturer in the instructions for use of "Atenolol Nycomed" indicates that the drug is rapidly absorbed, passing through the gastrointestinal tract. The quality of adsorption is estimated at an average of 50%, sometimes reaching 60%. Bioavailability is about 40-50%. The highest concentrations in serum are observed on average three hours after taking the tablets; deviation for an hour is possible up or down. Active ingredients do not leak well through the blood-brain barrier. Relatively small amounts can pass through the placenta. The components of the drug were found in breast milk of nursing mothers who took the pill. A rather small percentage of active compounds enters into strong bonds with protein structures. Analyzes showed that it is less than 5%.
In the instructions for use with Atenolol Nycomed, the manufacturer draws attention to the fact that in the liver the substances that make up the tablets practically do not transform. The half-life of serum is estimated at an average of seven hours, but may increase due to the individual characteristics of the body. This gap is extended in patients of advanced age. Elimination is carried out by glomerular filtration by the kidneys. From 85% of the active compound ingested to the body, up to 100% are excreted unchanged.
The nuances of kinetics
It is especially necessary to use "Atenolol Nycomed" if kidney function is found to be impaired, since in case of such failures the half-life of the active substance becomes longer. This affects the choice of dosage and frequency of use of the product. With renal impairment, a cumulative effect is possible.
If creatinine clearance is estimated at 35 ml / min. and less, the half-life reaches 27 hours. With indicators of 15 ml / min. and less than a gap of more than 27 hours. In anuria, an approximate estimate of the time period is 144 hours. Withdrawal is possible by blood dialysis.
Pills: what and from what?
On sale is "Atenolol Nycomed" 50 mg, 100 mg. The numbers indicate the content of the active compound in one tablet. The active substance is atenolol.
The manufacturer used talc, gelatin and propylene glycol as additional components in the manufacture of the drug. A coloring component and substances have been added to ensure a long shelf life. In the accompanying documentation for the tablets, the manufacturer gives a complete list of all the compounds used in the manufacture of a particular batch of product. It is important to study this list if there is an allergic reaction to any substance common in the pharmaceutical industry. This will prevent a negative response of the body to therapy.
On average, the cost of one package of the drug is 40-50 rubles.
Mutual influence
Using "Atenolol Nycomed" and diuretics, it must be borne in mind that such a combination increases the effect on pressure. The combination of the considered drug and substances for inhalation anesthesia increases the risk of a depressing effect on the cardiac system, which can cause hypotension. The simultaneous ingestion of alkuronium chloride and the described substance in the body can cause hypotension, bradycardia - similar cases have been observed in clinical practice.
It is known that the combination of "Atenolol Nycomed" and funds containing verapamil activates a negative inotropic effect. The patient has bradycardia, interruptions in the heart rate, cardiac conduction disturbances. From clinical practice, cases of hypotension and left ventricular failure are known. Some patients complained of a headache. Cases of lethargy are known. Verapamil practically does not correct the pharmacokinetic characteristics of atenolol, but a case of AUC growth has been recorded.
Too much!
When writing out the drug, the doctor will tell you at the reception how to use it correctly, in what quantity to take, and also pay attention to adequate pharmacy prices, instructions for use with "Atenolol Nycomed". Reviews about the drug as a whole are positive - people who used the medication under the supervision of a doctor and in accordance with his recommendations achieved a positive change in state; arrhythmia, high blood pressure remained in the past for the entire period of use of the drug. But those who took pills in excess, faced with the negative consequences of an overdose.
Excessive use of the drug is indicated by bradycardia and atrioventricular block, heart failure, the symptoms of which are gradually worsening. Pressure drops beyond measure. The patient has difficulty breathing, bronchospasm, dizziness, rhythm and heart rate are disturbed. Perhaps fainting, cyanosis, convulsions.
What to do?
In case of an overdose, it is urgently necessary to rinse the patient’s stomach and give the patient absorbent drugs. If there is a spasm of the bronchial system, salbutamol is injected into a vein or by inhalation.
Terms of use
Non-compliance with the instructions for the use of "Atenolol Nycomed" price - an increased likelihood of side effects. In order not to run into them, you must strictly follow the doctor’s recommendations and the manufacturer’s advice. It is strictly forbidden to prescribe a drug for yourself, since the layman will not be able to choose a dosage, take into account all important aspects. The amount of funds per day is prescribed by the doctor, taking into account the nuances of the disease and other characteristics of the patient’s health.
As a rule, adults “Atenolol Nycomed” is indicated for oral administration in the amount of 25-50 mg per day. If this volume does not give a pronounced effect, solve the question of increasing the dosage. It is unacceptable to take more than 200 mg per day. The daily dose is taken at a time or divided into two doses.
Contraindications, indications and nuances
It is forbidden to use the described medication for heart block and asthma. The tool is not taken if the frequency of contraction of the heart muscle per minute is 55 strokes or less.
Cancel the drug within one or two weeks, gradually reducing the dosage. The effectiveness of the medication decreases when combined with substances for stopping inflammatory foci and relieving pain. Concomitant use with drugs to combat diabetes can cause their increased effect.
Indications for the use of "Atenolol Nycomed" include hypertension. The drug is prescribed for cardiac arrhythmias. To receive "Atenolol Nycomed" in the testimony also includes the failure of the heart. The drug is effective if the patient is disturbed by excessive measures of frequent heartbeat. According to the instructions for Atenolol Nycomed, the indication for taking the pills is coronary heart disease. But here it is important to remember that only a doctor should prescribe a medicine.
How to replace? Analogs
Atenolol Nycomed, as the manufacturer indicates in the accompanying documentation, is based on atenolol. This compound is also found in preparations:
- "Ormidol";
- "Prinorm";
- "Atenosan."
If it is not possible to purchase the medicine chosen by the doctor, it is necessary to coordinate the replacement issue with the doctor. At a price, the analogues of Atenolol Nycomed are on average close. Some cost a little cheaper (prices start at five rubles), there are more expensive options - up to one hundred rubles per package.
Reviews: classic application
According to reviews, “Atenolol Nycomed” has a pronounced effect after the first five days after the start of drug therapy. The tool can not be used as a medicine for ambulance, but as a source of long-term action, it shows a pronounced effect on pressure. Persons who have used "Atenolol Nycomed" note that side effects are quite rare, while effectiveness is observed in most cases.
A study of the responses shows that some have experienced a reaction of individual intolerance, but such cases are quite rare.
Reviews: non-classic application
Quite interesting information about the effectiveness of the medication in question can be found by studying the responses about its use. It is known that "Atenolol Nycomed" helps to cure hemangioma. On the World Wide Web you can even find stories of people who used pills to treat hemangiomas in a very young child. Cauterization with nitrogen does not always show the result, so some parents are forced to look for additional, less traditional means of dealing with the problem. The complexity of the case is caused by the fact that a failed treatment with liquid nitrogen provokes an expansive growth of the neoplasm, and soon the hemangioma turns into a large tumor that deforms the patient's face.
Drug treatment of hemangiomas in the framework of the theory of a number of specialists is carried out by beta-blockers. The prolonged use of such drugs, as experience has shown them, helps to slow down the development of tumors and stimulates the destruction of already formed pathological areas.
To believe?
Treatment of hemangiomas "Atenolol Nycomed" is carried out in a clinical setting. Those in need are hospitalized in a Moscow clinic practicing this approach to eliminating pathology. The use of the drug in question is preceded by a study of the vital signs of the body. It is taken into account that the medication affects the heart and blood vessels, has a number of contraindications, which is especially important in the treatment of infants.
According to reviews, the initial (in the hospital) treatment of hemangiomas with the help of Atenolol Nycomed tablets takes six days. All this period must be under medical supervision, since taking funds can cause complications and side effects. Only qualified medical personnel can prevent them.
Parents of treated children say that “Atenolol Nycomed” is prescribed as a solution. The substance is pre-diluted in glucose, the child is given in a syringe. The medicine is used twice a day at twelve-hour intervals, strictly maintaining the exact time.
After using the product (after 30 minutes), the heart performance is checked. The child should be constantly monitored by a pediatric cardiologist. According to reviews, the first improvements can be noticed already a few days after the start of the intake, and on the sixth, the results are obvious with ultrasound: the neoplasm is reduced in volume by a third, its appearance changes.
How to achieve a complete cure?
After discharge, you will have to give Atenolol Nycomed to the child for at least six months. According to reviews, parents, in order to provide children with safety, regularly check their heart rate at home. The correct technique is taught in the clinic before discharge. It is also necessary to check the blood for glucose. Many note that even after a month of constant intake of tablets, the hemangioma almost completely disappears.
At the same time, reviews indicate that prolonged use of the product for the heart can cause negative changes in the work of this system, which is reflected in the cardiogram.
Negative consequences: what to prepare for?
"Atenolol Nycomed" can cause side effects. This is most often observed with incorrect admission and a dosage inconsistent with the doctor, but other causes are possible, including individual intolerance.
It is known that patients taking the pills experienced muscle weakness and asthenia. Occasionally, sleep disturbances were observed, others were drawn to sleep in the daytime, others could not fall asleep at night. Complaints of a headache, bad dreams, psychoses, hallucinations were rarely recorded. Sometimes dizzy, impaired perception of taste. In rare cases, short-term patients lost their memory or clarity of consciousness was impaired. Perhaps a depressed, depressed state, concern. There are cases of convulsions and paresthesias, myasthenia gravis (extremely rare).
A fairly common side effect of taking pills is an excessive decrease in pressure. Its probability is especially high if the dosage is improperly selected and the drug is used without consulting a doctor. There is a risk of atrioventricular blockade, bradycardia, arrhythmia, swelling, fainting, soreness in the chest. Some noted that their feet were getting colder.
In rare cases, taking the drug provoked shortness of breath, bronchospasm and wheezing. This is possible when using the drug in high dosage and the presence of predisposing factors. Possible nasal congestion. Sometimes pills provoke pain in the abdomen and stool, nausea and vomiting.