What do patients say about Ladisan? Instructions for use, reviews will be discussed later. We will also talk about why this remedy is needed, whether it has contraindications and side reactions.
Form, composition
In what form is the Ladisan medicine made? Instructions for use informs that this tool can be purchased in the following dosage forms:
- Round-shaped tablets, coated and containing 50 or 25 mg of the active ingredient - maprotiline hydrochloride.
Also, the drug in question includes such additional substances as lactose, corn starch, talc, calcium phosphate, dyes, gelatin, colloidal silicon dioxide , polysorbate-80 and hypromellose. On sale, this medicine comes in blisters that are packed in cardboard boxes.
- Solution for infusion "Ladisan". The instruction reports that it has full transparency, and also has no color and is intended for intravenous infusions.
1 ml of the drug solution contains maprotiline methanesulfonate in an amount of 5 mg. Also, the composition of the medication includes auxiliary components in the form of water for injection, mannitol and methanesulfonic acid. The drug goes on sale in 5 ml ampoules made of colorless glass.
Pharmacology of a medical product
What is Ladisan medicine? Instructions, reviews indicate that this is a drug that belongs to the group of norepinephrine and serotonin reuptake inhibitors. In other words, this medication is an antidepressant of a tetracyclic structure.
The pharmacological action of the active component of this agent is to suspend the reuptake of (neuronal) norepinephrine and serotonin neurotransmitters with presynoptic membranes of brain neurons.
The medication in question is distinguished by the correct combination of all the main properties of drugs from depression. The use of this medicine raises the patient's mood, eliminates the usual feelings of fear, helps to eliminate an excited state, and also removes various somatic disorders and psychomotor inhibition, which are characteristic of masked depression.
How quickly does the Ladisan medication take effect? Instructions for use states that this drug exhibits its properties quite quickly. The therapeutic effect after using the drug can be observed after a few days.
It should also be noted that the antidepressant in question is quite well tolerated by the human body. That is why it has received the widest distribution in outpatient treatment.
Indications for the use of the medication
In what cases can a patient be prescribed a drug such as Ladisan? Reviews of doctors say that this tool is advisable to use for various types and manifestations of depression:
- endogenous (cyclic, involutional and periodic);
- somatogenic (organic and symptomatic);
- psychogenic (depression of exhaustion, reactive and neurotic);
- masked forms of depression;
- menopause depression.
It should also be noted that this medicine can be used for other disorders that are accompanied by the following symptoms:
- apathy;
- irritability or dysphoria;
- feeling of fear.
According to patients' reviews, this medication favorably affects psychosomatic and somatic disorders that arose against the backdrop of longing or a sense of fear.
Contraindications
The medication in question cannot be used in the following cases:
- first trimester of pregnancy;
- convulsions;
- hypersensitivity to the main component;
- acute myocardial infarction;
- Heart arythmy.
Special recommendations
When should you not prescribe the Ladisan antidepressant? The instructions for use report that with special care this medicine is recommended for patients with impaired renal or hepatic function, as well as for high blood pressure (intraocular) and urination disorders (including prostate diseases).
If this medication is used for a long time, then patients should regularly undergo an ECG and monitor the work of the heart. This is especially true for those who suffer from cardiovascular diseases, including elderly patients.
Patients who are prone to orthostatic hypotension are required to regularly check their blood pressure while taking the drug.
It must be borne in mind that, like other psychotropic drugs, this antidepressant significantly reduces a person's tolerance to alcohol.
What else should you know before using Ladisan? Reviews of patients say that the drug in tablet form negatively affects their psychophysical reactions, especially if it was taken simultaneously with ethanol or medicines with a depressive effect on the central nervous system.
It should be noted that when using the Ladisan infusion solution, attention and reactions are very often disturbed in patients. Therefore, during the period of therapy with this tool, patients are prohibited from driving vehicles and operating hazardous mechanisms.
Antidepressant "Ladisan": instructions for use
The dosage of the drug in question is selected individually for each patient. This usually depends on the severity of the disease.
Experts say that lowering or increasing the evening dosage of this drug is allowed only if the daily dose is increased or decreased. Also, the daily amount of the drug can be taken at a time, preferably in the evening.
After achieving a positive effect, doctors recommend lowering the dose of the drug. However, with the manifestation of repeated symptoms of depression, you must immediately return to the previous regimen.
So how should you use Ladisan tablets? Instructions for use informs that this form of the drug is intended for oral administration.
As a rule, with outpatient treatment of depression, the drug in question is prescribed in an amount of 25 mg three times a day or 50-75 mg once, in the evening.
In the event that depression is very difficult, then its treatment should be carried out in a hospital. With this diagnosis, the daily dosage of the drug can be increased to 150 mg.
As for the infusion solution, it is usually recommended to administer it with freshly diagnosed severe depression or in the event that treatment with the oral form of the drug did not bring the desired effect.
The daily dose of the drug with drip intravenous infusion is about 25-100 mg. To prepare a medicinal solution, the contents of two ampoules should be dissolved in 250 ml of a solution of sodium chloride or glucose. Next, the finished drug must be slowly injected into a vein (over 2 hours).
If the patient needs a high dose of the drug, then the time of its infusion is increased to 3 hours.
Usually, after the first 2 weeks of treatment with an antidepressant, the patient is transferred to an oral treatment regimen using an infusion solution.
Adverse reactions
According to the reviews of most consumers, in the first days of the use of the Ladisan preparation it can cause fatigue, as well as anticholinergic effects such as dry mouth, constipation, disturbed accommodation and dizziness.
In very rare cases, with the use of the medication in question, the patient has a decrease in blood pressure and tachycardia. Skin reactions that are associated with the patient's hypersensitivity to maprotylene are also possible. In this case, you must stop taking the medicine.
Overdose cases
According to the instructions, if used incorrectly, the Ladisan antidepressant can cause overdose symptoms. As a rule, they develop 4 hours after taking the drug and reach their maximum after 24 hours.
The following conditions are referred to signs of an overdose:
- depression or agitation of the central nervous system (including cramps, restlessness, muscle stiffness, drowsiness, stupor, and coma);
- disorders of the vessels and heart (tachycardia, arrhythmia, arterial hypotension and heart failure).
Sometimes an overdose of the drug in question can provoke vomiting, fever, cyanosis, mydriasis, anuria, increased sweating and oliguria. In this case, symptomatic treatment should be carried out immediately.
The drug "Ladisan": patient reviews
There are not very many reviews about the Ladisan antidepressant. In those that are, patients argue that this drug is quite effective and effective. When used correctly, the medication helps to eliminate depressive disorders, as well as apathy, feelings of fear and irritability. However, it should be noted that this tool can cause adverse reactions, so only an experienced specialist should prescribe it.