High blood pressure is one of the most common ailments. In medicine, this condition is called hypertension. It does not appear immediately, the period of exacerbation is accompanied by a rapid jump in blood pressure. In addition, there is weakness, dizziness, loss of sleep.
Such conditions require immediate correction. Fortunately, modern medicine has a sufficient arsenal of tools that help cope with high blood pressure. Our article will talk about one of these drugs. You will find out what is part of Indapamide, what it is used for, how to use it.
Description
According to the annotation, the medicine is a diuretic with a pronounced antihypertensive effect, which is recommended for use by patients to eliminate hypertension.
The medication is in tablet form, it is prescribed for oral administration of the drug. As part of the Indapamide Retard:
- indapamide;
- lactose;
- magnesium stearate;
- povidone;
- sodium lauryl sulfate.
The medication is packaged in blisters of 10 pieces, a total of thirty tablets in a pack. What instructions for use, reviews and analogues does Indapamide have? Let's consider everything in order.
What are the positive properties of the drug
"Indapamide" refers to diuretics that have a pronounced antihypertensive effect. After using the medication, the pharmacological effect persists for another day.
Persistent antihypertensive effect occurs a week after the start of treatment and reaches a maximum by the end of the second month of therapy with Indapamide tablets. The composition of the drug includes only one active substance. With its help, hypertrophy of the left ventricle of the heart is reduced, and the elasticity of the walls of the arteries is also improved. According to the instructions for use with Indapamide, the drug contains the same substance.
What is Indapamide for? The drug is necessary to eliminate hypertension in adults.
Who should not use Indapamide
From the instructions for use, it is known that the medication can be taken only as directed by the doctor. Before treatment, the patient must carefully read the annotation that is attached to the drug, since Indapamide has a number of the following limitations:
- Lactase deficiency (a condition characterized by the body's inability to digest milk sugar due to insufficient production of the lactase enzyme in the intestine).
- Breast-feeding.
- Lactose intolerance.
- Hypokalemia (decrease in the concentration of potassium ions).
- Pregnancy.
- Severe impaired renal and hepatic function.
- Age to eighteen.
- Individual intolerance to substances.
With extreme caution, this drug is prescribed for patients with a violation of the water-salt balance in the body, as well as for people with diabetes mellitus and impaired thyroid function and gout.
Method of admission
The drug is taken orally once a day in the morning, regardless of food intake. It is better to swallow the tablet immediately, without chewing, with water.
Daily dosage is 2.5 milligrams. If after a month from the start of treatment a person does not have a positive effect, then another antihypertensive medication that is not related to diuretics is added to Indapamide so as not to provoke the occurrence of hyponatremia and hypokalemia in the body.
If initially two antihypertensive drugs were prescribed to a person at once, then in any situation the daily concentration of Indapamide remains unchanged - 2.5 milligrams.
In patients of retirement age, treatment is carried out taking into account the following indicators:
Depending on these values, the frequency of administration of the drug and the maximum dosage vary. "Indapamide" is also prescribed for people with normal or moderately impaired renal function.
Pregnancy and lactation
The drug is forbidden to be used by women during the period of bearing a child due to a lack of information regarding the safety of this medicine for the development of an unborn child.
It is also impossible to use "Indapamide" during breastfeeding, if therapy is necessary, you must stop breast-feeding.
Does the medicine have side effects
The instructions indicate that during treatment with a drug a person may develop the following negative manifestations:
- Lack of appetite.
- Violation of the stool.
- Dry mouth.
- Nausea.
- Vomiting.
- Abdominal pains.
- Impaired liver function.
- The inflammatory process in the pancreas.
- Drowsiness.
- Lethargy.
- Dizziness.
- Lethargy.
- Anxiety.
- Unreasonable feeling of fear.
- Cough.
- Rhinitis (runny nose).
- Decreased libido.
- Depressive disorders.
- Sinusitis (damage to the mucous membrane of the sinuses).
- Conjunctivitis (inflammation of the mucous membrane of the eye caused by an allergic reaction or infection).
- Hemorrhagic vasculitis (aseptic inflammatory lesion of the vessels of the microvasculature with damage to the skin, joints, stomach and kidneys).
- Arrhythmia (a pathology that leads to a violation of the frequency, as well as the rhythm and sequence of excitation and contraction of the heart).
- Anorexia (a lesion based on a nervous and mental disorder, which is manifested by an obsessive desire for weight loss, as well as a fear of obesity).
- Gastralgia (an unpleasant sensation that is characterized with a real or possible tissue damage).
According to the instructions for use and reviews about Indapamide, it is known that in addition to the above negative manifestations, the medication can also cause the following conditions:
- Bronchospasm (a pathological condition that occurs when contracting smooth muscles of the bronchi and reducing their lumen).
- The development of inflammatory processes.
- Hyponatremia (a disease based on a decrease in sodium ions in the blood to a level below the standard).
- Pharyngitis (an inflammatory process in the mucous membrane and lymphoid tissue of the pharynx).
- Hyperglycemia (a disease that indicates an increase in serum glucose compared to normal).
- Rhinorrhea (an ailment that is accompanied by increased mucus formation in the nasal cavity, and the expiration of the formed secret).
- Orthostatic hypotension (a disease that is justified by a violation of the body’s ability to maintain a normal level of blood pressure in an upright position).
- Cardiopalmus.
- Shortness of breath.
- Changing the electrocardiogram.
- Hypochloremia (a decrease in the content of chlorine in the blood serum).
- Nocturia (an unpleasant sign of various diseases in which nighttime urination prevails over daytime).
- Polyuria (a human condition in which, due to a violation of the water balance, an increase in urine production and urination frequency occurs).
- Nettle rash.
- Itching
- Rashes.
- Hyperemia (blood overflow of capillaries of the circulatory system of an organ).
- Burning.
- Hypokalemia (a disease that is characterized by a low concentration of potassium in the tissues).
- Decreased platelet and white blood cell counts.
In people with systemic lupus erythematosus, treatment with a medication may exacerbate the ailment.
The elimination of the symptoms of poisoning is gastric lavage, as well as the use of enterosorbents. If necessary, carry out complex therapy, which is aimed at restoring the water-electrolyte balance.
Drug interaction
With the combination of Indapamide with laxatives, as well as cardiac glycosides, glucocorticoids and mineralocorticoids, the likelihood of hypokalemia increases.
With the simultaneous use of a medication with drugs of a non-steroidal anti-inflammatory group, a decrease in hypotensive effect is possible. With the combination of Indapamide with ACE inhibitors, the risk of orthostatic hypotension and kidney disease increases.
When contrasting iodine-containing components are introduced into the patient’s body during antihypertensive therapy, the person is more likely to develop dehydration.
Sedatives, as well as barbiturates and antipsychotics, increase the risk of orthostatic hypotension, which is important to consider when treating with these drugs.
Recommendations of specialists
Individuals who are forced to consume cardiac glycosides should be regularly monitored for potassium and creatinine levels with Indapamide therapy.
People with impaired liver function during drug therapy must be constantly monitored by a medical specialist, since they are at risk for the development of hepatic coma.
Diabetic patients may need to adjust their daily concentration of hypoglycemic drugs. During treatment with antihypertensive drugs, patients need to regularly monitor blood glucose.
At the beginning of Indapamide therapy, the patient needs to drink more fluid to prevent an electrolyte imbalance. The medication can not be used to treat children under the age of eighteen years, since the safety of the drug is not proven.
Since dizziness, weakness and lethargy often occur at the beginning of drug therapy, it is forbidden to drive vehicles.
Generics
The following drugs are endowed with similar pharmacological properties with Indapamide:
- Lorvas.
- "Ionic".
- Arifon.
- Indap.
- Tenzotran.
- "Frantel".
- "Acrylamide".
- Arindap.
- "Oxodolin."
- "Leskoprid".
They, as a rule, have an identical spectrum of effects and lead to the same antihypertensive effect, which helps lower blood pressure to a normal level.
"Indapamide" is dispensed from pharmacies according to the prescription of a medical specialist. The drug must be kept away from children, at a temperature of no more than twenty-five degrees. Next, we will consider the characteristics of the most effective drugs.
Indap
The drug is recommended for use by people to regulate blood pressure. Indap belongs to a thiazide-like diuretic. Under the influence of the active component, the tone of the smooth muscles of large blood vessels decreases, and a weak diuretic effect is also observed.
According to the instructions for the Indapamide analogue, it is known that the hypotensive effect of the drug occurs by the end of the first week after the start of treatment and reaches its peak after 2-3 months from the start of therapy. After using Indapa, the pharmacological effect persists for another day, which makes it possible to take the drug only once a day.
The drug is not recommended to be taken simultaneously with medicines that contain lithium, as this can lead to toxic kidney damage.
According to the instructions for use with the Indapamide analogue, it is known that when this medicine is combined with Erythromycin, Amiodarone, Sotalol, a decrease in the antihypertensive effect and a change in the electrocardiogram indicators are observed.
With the simultaneous use of Indapa with medicines from the group of non-steroidal anti-inflammatory drugs or glucocorticoids, a decrease in the antihypertensive effect may be observed.
With the combination of Indapa with laxatives or cardiac glycosides, the risk of hypokalemia increases.
Tenzotran
Antihypertensive agent, which is produced in tablet form. The active substance is moxonidine. According to the instructions for use with the Indapamide analogue, it is known that it is necessary to stop using Tenzotran gradually. During therapy, patients should constantly monitor blood pressure, heart rate and electrocardiogram.
If it is necessary to cancel the simultaneously used “Tenzotran” and beta-blockers, the second ones are stopped to be used in the first place, and the first one can be canceled after a few days.
Arifon
The drug has a gentle effect, reduces blood pressure. It affects the capillaries and tissue of the kidneys, activates a significant relaxation of smooth muscles in the walls of blood vessels. In addition to lowering blood pressure, a decrease in the load on the heart and blood vessels can be observed.
According to reviews, the analog of Indapamide - the drug Arifon - contributes to a more enhanced release of chlorine and potassium with urine, so the volume of the liquid increases greatly. The pharmacological effect will be noticeable even at dosages that do not significantly increase the frequency of urination.
The positive effect of the drug can be observed in people who are on hemodialysis. Arifon is rapidly absorbed from the stomach and intestines.
How do patients and doctors respond about the drug
Opinions of people about Indapamide confirm that the tool copes with the task. It effectively helps with hypertension. Patients, as a rule, tolerate taking the drug well.
According to reviews, adverse reactions are extremely rare and are characterized by weak severity. Most patients with hypertension take pills for life.