How and in what cases is the patient prescribed Sibutin? Instructions for use, reviews, analogues and indications for use are presented a little further. The article also considers the composition of this drug, its release form and prohibitions on use.
Form, description and composition
The drug "Sibutin", the instructions for use of which are listed below, are available in the form of white round tablets with a risk on one side. Their active ingredient is oxybutynin (in the form of oxybutynin hydrochloride). Also, the composition of the drug includes auxiliary ingredients, which are presented in the form of lactose monohydrate, microcrystalline cellulose, potato starch and calcium stearate.
Pharmacological properties of the drug
How does Sibutin work? Instructions for use, reviews of doctors report that the mechanism of action of this drug is completely due to the effectiveness of its active substance.
According to experts, Sibutin is a blocker of M-cholinergic receptors belonging to the tertiary amine group. Due to moderate M-anticholinergic activity, the drug in question is able to directly affect the smooth muscles of internal organs. Moreover, it has an antispasmodic and myotropic effect. In other words, this medication eliminates spasms, and also reduces the muscle tone of the following organs: biliary tract, gastrointestinal tract, urinary tract, uterus and bladder. It is worth considering that in people with neurogenic dysfunction of the latter, oxybutynin is able to relax the detrusor, reduce its spontaneous contractions, reduce the frequency of urination, and also increase the capacity of the bladder.
Kinetic features of the drug
Is an oral agent such as Sibutin absorbed? Instructions for use (the composition of the drug was indicated above) reports that after taking the tablets, oxybutynin is absorbed quite quickly from the digestive tract.
Studies have shown that the maximum concentration of this element in the blood is about 8-13 ng / ml. This indicator is typical for a dose of 7-10 mg taken by young and healthy people. Significant individual fluctuations in the amount of oxybutynin in plasma were also observed.
Due to the first passage through the liver, the absolute systemic bioavailability of this substance is about 6.2%.
The main metabolite of oxybutynin is active desethyloxybutynin. Also in the process of transformation, other derivatives are formed, including phenylcyclohexiglycolic acid, but they are inactive.
About 0.02% of the medication taken is excreted in the urine. The connection of oxybutynin with albumin is approximately 83-86%, and its half-life is two hours.
With prolonged use of the drug, its accumulation is low.
Indications for use of the drug
When can a patient be prescribed Sibutin? Instructions for use (the indications will be discussed below) states that this drug is actively used in the treatment of urinary incontinence, which is associated with unstable bladder function, which is neurogenic (for example, with detrusor hyperreflexia, spina bifida or multiple sclerosis) or idiopathic nature.
It should also be noted that the drug in question can be indicated for use with nocturnal enuresis in children from the age of five. For this purpose, the medication is used as monotherapy, and in combination with other medicines.
Bans for taking pills
When should the Sibutin medication be prescribed to a patient? The instruction for use states that the following conditions are contraindications to taking this medication:
- intestinal obstruction;
- hypersensitivity to the components of the drug;
- intestinal atony;
- pronounced process of violation of the outflow of urine from the bladder;
- myasthenia gravis;
- ulcerative colitis (severe);
- expansion of the colon;
- pregnancy;
- glaucoma;
- lactation;
- age up to five years.
The drug "Sibutin": instructions for use
Sibutin tablets are prescribed primarily for adults. They should be taken 5 mg three times a day. Elderly patients are recommended to use this drug in an amount of 5 mg twice a day.
In special cases, this medicine is prescribed for children over the age of five. If the bladder is disturbed of a neurogenic nature, the medication is used 5 mg twice a day, and with nocturnal enuresis - 5 mg three times a day. In this case, the last dose must be taken right before bedtime.
Side effects
What negative reactions does the Sibutin medication cause? Instructions for use report that most often such effects occur from the digestive tract. As a rule, they are manifested by dry mouth, constipation, nausea, discomfort in the abdominal region and diarrhea.
Also, the drug in question can cause:
- headache, decreased visual acuity, drowsiness, mydriasis, dizziness, increased intraocular pressure;
- dry skin;
- hot flashes (occur mainly in children), urinary retention, difficulty urinating, arrhythmia, decreased sweating.
Overdose cases
What are the symptoms of an overdose of Sibutin? Instructions for use state that such manifestations include the following: anxiety, increased severity of adverse reactions, agitation, respiratory and vascular insufficiency, decreased blood pressure, psychosis, coma and respiratory muscle paralysis.
For the treatment of such conditions, gastric lavage is used, as well as intravenous administration of physostigmine.
With severe excitement or anxiety, the patient is prescribed “Diazepam” (iv, 10 mg), symptomatic therapy is given for fever, propranolol (iv) is indicated for tachycardia, urinary bladder catheterization is performed for urinary retention, with respiratory muscle paralysis and the development of curariform effect provide mechanical ventilation.
How does it interact with other means?
Is it possible to use the Sibutin preparation with other means? The instruction for use states that when combined with other medicines, the drug in question can cause an increase in adverse reactions. As a rule, such an effect is observed while taking Sibutin with drugs that have an anticholinergic effect.
Sedatives and ethanol may contribute to dizziness and increase drowsiness.
While taking itraconazole, the concentration of oxybutynin in the blood rises.
Pregnancy period
Is it possible to use the medication in question while waiting for a child? The safety of using Sibutin in the indicated period has not been established. In this regard, this category of patients mentioned tool is not prescribed. It should also be noted that oxybutynin can pass into breast milk, so it can not be used during lactation. If this is nevertheless necessary, then breastfeeding must be stopped.
Special information
What should the patient know before using the Sibutin medication? Instructions for use (analogues are indicated below) states that with special care this medicine should be prescribed to weakened elderly patients, as well as patients with severe ailments of the kidneys and liver and neurocirculatory dystonia.
As with other anticholinergics, during the use of Sibutin, caution should be exercised for people with a hernia of the diaphragm (esophageal opening), which is accompanied by reflux esophagitis.
Against the background of the use of this medication in a patient, it is possible to increase the clinical manifestations of arrhythmia, hyperthyroidism, prostatic hyperplasia, coronary heart disease and chronic heart failure.
An increased ambient temperature when using the drug can provoke the development of fever, as well as disturbances in the functioning of the heart (as a result of a decrease in sweating).
People who engage in hazardous jobs that require special attention and quick reactions should be warned that the medication in question can cause a decrease in visual acuity and drowsiness.
Reviews and analogues
The analogues of the drug under consideration are the following: “Vesikar”, “Detruzitol”, “Dream-Apo”, “Spazmeks”, “Driptan”, “Zevesin”, “Uroholum”, “Urotol” and others.
There are a lot of reviews about this medication. Some patients were satisfied with the effectiveness of the drug. They claim that this drug helps control urination, including at night. However, many people complain of headaches and allergies, as well as other adverse reactions. In this regard, they are forced to replace this tool with safer analogues.