"Longidase" is a medication that is intended for vaginal and rectal use and is prescribed as monotherapy or as a component of the combined treatment of disorders caused by the development of connective tissue hyperplasia. This tool is widely used in dermatology, pulmonology, urology, gynecology, surgery and phthisiology. Reviews about "Longidaz" are abundant.
Composition, production form and packaging
Rectal and vaginal suppositories have a torpedo shape, light yellow in color, a weak specific aroma of cocoa butter. Marble staining is allowed.
The composition of these suppositories includes the main active element azoximer bovgyaluronidase (longidase). An additional component is cocoa butter.
This pharmacological product is packaged in blister packs, 4, 2 or 1 each in a cardboard box.
Reviews about the candles "Longidaza" consider below.
Pharmacological properties
The medicinal product has enzymatic (hyaluronidase) activity of long-term exposure, as well as chelating, immunomodulating antioxidant and moderately active anti-inflammatory properties. The prolonged action is due to the covalent binding of the enzyme to the azoximer (biologically active polymer carrier). This medication exhibits an anti-fibrotic effect, weakens the acute stage of the inflammatory process, and is also able to increase or decrease, depending on the initial level, the production of inflammatory mediators (interleukin-1 and TNFα), enhances the humoral response of the immune system and resistance to infectious pathogens.
According to reviews, Longidaza suppositories in gynecology are very effective.
The pronounced antifibrotic property of the pharmacological preparation is achieved due to conjugation of hyaluronidase with a carrier, which significantly increases the resistance of enzymes to the denaturing effect and the properties of inhibitors: the enzymatic functionality of the Longidase agent is maintained at a temperature of 37 ° C for three weeks, and native hyaluronidase under the same conditions already loses its activity during the day.
This drug provides the simultaneous presence of the hyaluronidase enzyme and a carrier that is able to bind the components of the matrix released during hydrolysis of the enzyme inhibitors that stimulate the synthesis of collagen (copper, iron ions, heparin, etc.). Due to these properties, this medication has a good ability to depolymerize the matrix of connective tissues in fibrous and granulomatous formations and suppress the reverse reaction, which is directed to the production of elements of connective tissue.
The substrate of hyaluronidase is glycosaminoglycans (hyaluronic acid, chondroitin, chondroitin-4-sulfate,), which are the basis of the matrix. Due to depolymerization, glycosaminoglycans change their significant properties: viscosity decreases, the ability to bind liquid, metal ions, temporarily increases the permeability of tissue barriers, the movement of fluids in the intercellular space increases, the elasticity of the tissue increases, which can manifest itself in a decrease in swelling, flattening of scars, and an increase in the volume of motion, a decrease in the severity of the adhesive process.
It was proved by immunological, biochemical, histological and microscopic tests that the Longidaza medical device does not damage the connective tissue, but provokes the destruction of tissue in the fibrous region, which has an altered structure and composition.
It is not able to have mutagenic, teratogenic, embryotoxic and carcinogenic effects.
The drug is well tolerated by patients, there are no general and local allergic manifestations.
The use of Longidaza in therapeutic dosages during or after surgery does not contribute to the deterioration of the postoperative process of recovery or progression of an infectious disease, and also does not slow down the regeneration of bone tissue.
Reviews about the use of "Longidaza" are mostly positive.
Pharmacokinetics
A study of pharmacokinetics made it possible to determine that with rectal administration, this medication is characterized by a rapid distribution in the body, good absorption in the systemic circulation, and reaching maximum blood concentrations one hour after application. The bioavailability of this drug with this method of administration is quite high - about 89%. The half-life is approximately 30 minutes. The drug has the ability to penetrate into all tissues and organs, through the blood-ophthalmic barrier and the BBB. The half-life of the active elements of the drug is from 40 to 80 hours, which are excreted through the operation of the urinary system.
Reviews and analogues to the Longidaza candles will be presented at the end of the article.
Indications for appointment
Prescribe this medication to children after 12 years of age and adults as an independent or complex therapy of diseases that are accompanied by proliferation of connective tissue (including inflammatory processes).
In the field of urology - with interstitial cystitis, chronic prostatitis, Peyronie’s disease, stricture of the ureters and urethra, the initial stages of development of benign prostate hyperplasia, and also to prevent the formation of scar formation after operations on the urethra, ureters or bladder.
In the field of gynecology - for the prevention and treatment of adhesions in the pelvis with infectious and inflammatory pathologies of the internal reproductive organs in the chronic course, for the prevention and treatment of adhesions in the pelvis after any gynecological procedures (including artificial abortion, previous surgical interventions); with intrauterine synechia, tubal and peritoneal infertility, chronic endomyometritis.
In the field of dermatovenerology - with limited scleroderma, for the prevention of fibrotic complications of STIs.
In the field of surgery - for the prevention and treatment of adhesions after surgical interventions on the peritoneal organs, with non-healing wounds.
In the field of pulmonology and phthisiology - with pneumofibrosis, tuberculosis (cavernous fibrous, infiltrative, as well as tuberculoma), fibrosing alveolitis, interstitial pneumonia, pleurisy, siderosis.
In addition, this tool can be used to increase the bioavailability of antibacterial treatment in pulmonology, urology, dermatovenerology, gynecology, surgery.
The injections of "Longidaza" are also used. According to reviews, they are also very effective.
Dosage regimen
Suppositories are recommended for intravaginal or rectal use 1 time per day (at night). The treatment course is 10-20 days.
At the age of 12-18 years, suppositories are used only rectally, after cleansing the intestines.
The treatment regimen may be adjusted depending on the stage, severity and duration of the pathology. Perhaps the appointment of a drug every other day or 2-3 days.
Adverse reactions
According to reviews, “Longidaza" can provoke the development of the following negative phenomena: local - in the form of redness, swelling, itching in the perianal zone, vaginal itching due to the high sensitivity to the active elements of the drug.
In the event of such symptoms, as well as the appearance of reactions not described in the instructions, you should seek the advice of a treating specialist.
Contraindications
Restrictions on the use of this medication are:
- pulmonary hemorrhage and hemoptysis;
- vitreous hemorrhage;
- malignant neoplasms;
- acute kidney failure;
- lactation, pregnancy;
- age less than 12 years;
- high sensitivity to drugs containing hyaluronidase.
Reviews about "Longidaz" in gynecology will also be presented.
Special recommendations
If allergic reactions occur, discontinue use of this drug. When used during an exacerbation of an infection, to prevent its spread, it is necessary to prescribe Longidaza medication simultaneously with antimicrobial medicines.
The drug should not be prescribed with visual signs of its unsuitability (suppository defects). In cases of skipping a dose, then the agent should be used in the usual mode.
The use of this medication does not affect the ability to concentrate. Analogues and reviews about Longidaz are of interest to many.
Analogs
Medicines similar to the drug in composition and therapeutic effect are:
- "Lidase."
- "Lidase M".
- "Ronidase."
- "Biogial".
- "Polyoxidonium."
Reviews in Longidaz
Judging by the reviews of the people who were prescribed this medication, they are widely used in the field of clinical gynecology, and has proven itself in the best way. Patients note its high efficiency, especially in the development of pathological processes such as post-inflammatory adhesions in the uterus and appendages, with infertility associated with obstruction of the fallopian tubes, etc.
In addition, women note that they prescribe this medicine also in the stage of acute inflammation, as a combination treatment and prevent the development of adhesions. In general, patients with this medication are very satisfied and observed its significant effectiveness.
The reviews about "Longidaz" indicate that this drug practically does not provoke side effects and is well tolerated by women, even in the presence of some concomitant diseases.